Antidepressant drugs and the response in the placebo group: the real problem lies in our understanding of the issue

In a recent paper, Horder and colleagues (Horder et al., 2010, J Psychopharmacol 25: 1277–1288) have suggested that the mainproblem in the Kirsch analysis is methodological. We argue that the results are similar irrespective of the method used. In our opinion the data suggest that placebo and drug effects are non-additive: antidepressants act independently of depression severity, while the placebo effect is present only in milder cases. While the response in the placebo group is due to unstable ‘noise’ and ‘artefacts’, the medication effect is reliable, valid and stable

A rigorous approach to the magnetic response in disordered systems

This paper is a part of an ongoing study on the diamagnetic behavior of a 3-dimensional quantum gas of non-interacting charged particles subjected to an external uniform magnetic field together with a random electric potential. We prove the existence of an almost-sure non-random thermodynamic limit for the grand-canonical pressure, magnetization and zero- field orbital magnetic susceptibility. We also give an explicit formulation of these thermodynamic limits. Our results cover a wide class of physically relevant random potentials which model not only crystalline disordered solids, but also amorphous solids.Comment: 35 pages. Revised version. Accepted for publication in RM

New players in the interaction between beetle polygalacturonases and plant polygalacturonase-inhibiting proteins: Insights from proteomics and gene expression analyses

Plants possess various defense strategies to counter attacks from microorganisms or herbivores. For example, plants reduce the cell-wall-macerating activity of pathogen- or insect-derived polygalacturonases (PGs) by expressing PG-inhibiting proteins (PGIPs). PGs and PGIPs belong to multi-gene families believed to have been shaped by an evolutionary arms race. The mustard leaf beetle Phaedon cochleariae expresses both active PGs and catalytically inactive PG pseudoenzymes. Previous studies demonstrated that (i) PGIPs target beetle PGs and (ii) the role of PG pseudoenzymes remains elusive, despite having been linked to the pectin degradation pathway. For further insight into the interaction between plant PGIPs and beetle PG family members, we combined affinity purification with proteomics and gene expression analyses, and identified novel inhibitors of beetle PGs from Chinese cabbage (Brassica rapa ssp. pekinensis). A beetle PG pseudoenzyme was not targeted by PGIPs, but instead interacted with PGIP-like proteins. Phylogenetic analysis revealed that PGIP-like proteins clustered apart from “classical” PGIPs but together with proteins, which have been involved in developmental processes. Our results indicate that PGIP-like proteins represent not only interesting novel PG inhibitor candidates in addition to “classical” PGIPs, but also fascinating new players in the arms race between herbivorous beetles and plant defenses

The repulsion between localization centers in the Anderson model

In this note we show that, a simple combination of deep results in the theory of random Schr\"odinger operators yields a quantitative estimate of the fact that the localization centers become far apart, as corresponding energies are close together

A Nyström method for a class of integral equations on the real line with applications to scattering by diffraction gratings and rough surfaces

We propose a Nystr¨om/product integration method for a class of second kind integral equations on the real line which arise in problems of two-dimensional scalar and elastic wave scattering by unbounded surfaces. Stability and convergence of the method is established with convergence rates dependent on the smoothness of components of the kernel. The method is applied to the problem of acoustic scattering by a sound soft one-dimensional surface which is the graph of a function f, and superalgebraic convergence is established in the case when f is infinitely smooth. Numerical results are presented illustrating this behavior for the case when f is periodic (the diffraction grating case). The Nystr¨om method for this problem is stable and convergent uniformly with respect to the period of the grating, in contrast to standard integral equation methods for diffraction gratings which fail at a countable set of grating periods

Early Memories of Individuals on the Autism Spectrum Assessed Using Online Self-Reports

"When I was one and a half years old, I was on a ferry lying on red seats" - while several autobiographical accounts by people with autism reveal vivid memories of early childhood, the vast amount of experimental investigations found deficits in personal autobiographic memory in autism. To assess this contradiction empirically, we implemented an online questionnaire on early childhood events to compare people on the autism spectrum (AS) and non-autistic people with respect to their earliest autobiographical episodic memories and the earliest semantic know event as told by another person. Results indicate that people on the AS do not differ from non-autistic people in the age of their earliest know events but remember events from an earlier age in childhood and with more sensory details, contradicting the assumption of an overall deficit in personal episodic memory in autism. Furthermore, our results emphasize the supporting influence of language for memory formation and give evidence for an important role of sensory features in memories of people on the AS.publishe

Preheating after N-flation

We study preheating in N-flation, assuming the Mar\v{c}enko-Pastur mass distribution, equal energy initial conditions at the beginning of inflation and equal axion-matter couplings, where matter is taken to be a single, massless bosonic field. By numerical analysis we find that preheating via parametric resonance is suppressed, indicating that the old theory of perturbative preheating is applicable. While the tensor-to-scalar ratio, the non-Gaussianity parameters and the scalar spectral index computed for N-flation are similar to those in single field inflation (at least within an observationally viable parameter region), our results suggest that the physics of preheating can differ significantly from the single field case.Comment: 14 pages, 14 figures, references added, fixed typo

The First INTEGRAL AGN Catalog

We present the first INTEGRAL AGN catalog, based on observations performed from launch of the mission in October 2002 until January 2004. The catalog includes 42 AGN, of which 10 are Seyfert 1, 17 are Seyfert 2, and 9 are intermediate Seyfert 1.5. The fraction of blazars is rather small with 5 detected objects, and only one galaxy cluster and no star-burst galaxies have been detected so far. A complete subset consists of 32 AGN with a significance limit of 7 sigma in the INTEGRAL/ISGRI 20-40 keV data. Although the sample is not flux limited, the distribution of sources shows a ratio of obscured to unobscured AGN of 1.5 - 2.0, consistent with luminosity dependent unified models for AGN. Only four Compton-thick AGN are found in the sample. Based on the INTEGRAL data presented here, the Seyfert 2 spectra are slightly harder (Gamma = 1.95 +- 0.01) than Seyfert 1.5 (Gamma = 2.10 +- 0.02) and Seyfert 1 (Gamma = 2.11 +- 0.05).Comment: 17 pages, 12 figures, accepted for publication in Ap