7,930 research outputs found

    Antidepressant drugs and the response in the placebo group: the real problem lies in our understanding of the issue

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    In a recent paper, Horder and colleagues (Horder et al., 2010, J Psychopharmacol 25: 1277–1288) have suggested that the mainproblem in the Kirsch analysis is methodological. We argue that the results are similar irrespective of the method used. In our opinion the data suggest that placebo and drug effects are non-additive: antidepressants act independently of depression severity, while the placebo effect is present only in milder cases. While the response in the placebo group is due to unstable ‘noise’ and ‘artefacts’, the medication effect is reliable, valid and stable

    A rigorous approach to the magnetic response in disordered systems

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    This paper is a part of an ongoing study on the diamagnetic behavior of a 3-dimensional quantum gas of non-interacting charged particles subjected to an external uniform magnetic field together with a random electric potential. We prove the existence of an almost-sure non-random thermodynamic limit for the grand-canonical pressure, magnetization and zero- field orbital magnetic susceptibility. We also give an explicit formulation of these thermodynamic limits. Our results cover a wide class of physically relevant random potentials which model not only crystalline disordered solids, but also amorphous solids.Comment: 35 pages. Revised version. Accepted for publication in RM

    The repulsion between localization centers in the Anderson model

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    In this note we show that, a simple combination of deep results in the theory of random Schr\"odinger operators yields a quantitative estimate of the fact that the localization centers become far apart, as corresponding energies are close together

    Preheating after N-flation

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    We study preheating in N-flation, assuming the Mar\v{c}enko-Pastur mass distribution, equal energy initial conditions at the beginning of inflation and equal axion-matter couplings, where matter is taken to be a single, massless bosonic field. By numerical analysis we find that preheating via parametric resonance is suppressed, indicating that the old theory of perturbative preheating is applicable. While the tensor-to-scalar ratio, the non-Gaussianity parameters and the scalar spectral index computed for N-flation are similar to those in single field inflation (at least within an observationally viable parameter region), our results suggest that the physics of preheating can differ significantly from the single field case.Comment: 14 pages, 14 figures, references added, fixed typo

    Low lying spectrum of weak-disorder quantum waveguides

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    We study the low-lying spectrum of the Dirichlet Laplace operator on a randomly wiggled strip. More precisely, our results are formulated in terms of the eigenvalues of finite segment approximations of the infinite waveguide. Under appropriate weak-disorder assumptions we obtain deterministic and probabilistic bounds on the position of the lowest eigenvalue. A Combes-Thomas argument allows us to obtain so-called 'initial length scale decay estimates' at they are used in the proof of spectral localization using the multiscale analysis.Comment: Accepted for publication in Journal of Statistical Physics http://www.springerlink.com/content/0022-471

    The First INTEGRAL AGN Catalog

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    We present the first INTEGRAL AGN catalog, based on observations performed from launch of the mission in October 2002 until January 2004. The catalog includes 42 AGN, of which 10 are Seyfert 1, 17 are Seyfert 2, and 9 are intermediate Seyfert 1.5. The fraction of blazars is rather small with 5 detected objects, and only one galaxy cluster and no star-burst galaxies have been detected so far. A complete subset consists of 32 AGN with a significance limit of 7 sigma in the INTEGRAL/ISGRI 20-40 keV data. Although the sample is not flux limited, the distribution of sources shows a ratio of obscured to unobscured AGN of 1.5 - 2.0, consistent with luminosity dependent unified models for AGN. Only four Compton-thick AGN are found in the sample. Based on the INTEGRAL data presented here, the Seyfert 2 spectra are slightly harder (Gamma = 1.95 +- 0.01) than Seyfert 1.5 (Gamma = 2.10 +- 0.02) and Seyfert 1 (Gamma = 2.11 +- 0.05).Comment: 17 pages, 12 figures, accepted for publication in Ap

    Early Memories of Individuals on the Autism Spectrum Assessed Using Online Self-Reports

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    "When I was one and a half years old, I was on a ferry lying on red seats" - while several autobiographical accounts by people with autism reveal vivid memories of early childhood, the vast amount of experimental investigations found deficits in personal autobiographic memory in autism. To assess this contradiction empirically, we implemented an online questionnaire on early childhood events to compare people on the autism spectrum (AS) and non-autistic people with respect to their earliest autobiographical episodic memories and the earliest semantic know event as told by another person. Results indicate that people on the AS do not differ from non-autistic people in the age of their earliest know events but remember events from an earlier age in childhood and with more sensory details, contradicting the assumption of an overall deficit in personal episodic memory in autism. Furthermore, our results emphasize the supporting influence of language for memory formation and give evidence for an important role of sensory features in memories of people on the AS.publishe
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