Ab-Initio Fragment Method for Calculating Molecular X-ray Diffraction

A fragment-based approach for the prediction of elastic X-ray scattering is presented. The total diffraction pattern is assembled from anisotropic form factors calculated for individual molecular fragments, optionally including corrections for pairwise interactions between fragments. The approach is evaluated against full ab initio scattering calculations in the peptide diphenylalanine, and the optimal selection of fragments is examined in the ethanol molecule. The approach is found to improve significantly on the independent atom model while remaining conceptually simple and computationally efficient. It is expected to be particularly useful for macromolecules with repeated subunits, such as peptides, proteins, DNA, or RNA and other polymers, where it is straightforward to define appropriate fragments

Robust inversion of time-resolved data via forward-optimisation in a trajectory basis

An inversion method for time-resolved data from ultrafast experiments is introduced, based on forward-optimisation in a trajectory basis. The method is applied to experimental data from x-ray scattering of the photochemical ring-opening reaction of 1,3-cyclohexadiene and electron diffraction of the photodissociation of CS2. In each case, inversion yields a model that reproduces the experimental data, identifies the main dynamic motifs, and agrees with independent experimental observations. Notably, the method explicitly accounts for continuity constraints and is robust for noisy data

Ultrafast x-ray scattering and electronic coherence at avoided crossings: complete isotropic signals

Nonadiabatic transitions at conical intersections and avoided crossings play a pivotal role in shaping the outcomes of photochemical reactions. Using the photodissociation of LiF as a model, this theoretical study explores the application of gas phase nonresonant ultrafast x-ray scattering to map nonadiabatic transitions at an avoided crossing, utilizing the part of the scattering signal that probes electronic coherence directly. The presented scattering signals are rotationally averaged and calculated from two- rather than one-electron (transition) densities, which inherently accounts for all possible electronic transitions driven by the x-ray photon. This approach provides quantitative predictions of the experimental signals, thereby facilitating future experimental endeavors to observe nonadiabatic effects and coherent electron dynamics with ultrafast x-ray scattering