3,139 research outputs found
KINEMATIC GAIT VARIABLES OF ELDERLY WOMEN WITH DIFFERENT LEVEL OF PHYSICAL ACTIVITY
The aging of populations is an international phenomena caused by the decline of birthrate and the progress of medical science. According to WHO individuals older than 65 years in developed countries and older than 60 years in developing countries are considered elderly. The aging process is characterized by the decrease of muscle mass, strength and power, one of the most important reasons for the decrease of functional abilities and the increase of falling risk (Zhong et al., 2007). Nevertheless, physical activity may retard this process. The principal changes in kinematic gait variables are the decrease of gait velocity, stride length and single support time with an increase of double support time (McGibbon,2003). These changes in gait pattern observed in the elderly population may arise from functional declines of aging and may be even more significant in the absence of appropriate regular physical exercises. Considering the higher proportion of women in the elderly population (WHO, 2002), it is important to understand the changes in gait patterns of elderly women related to physical activity. Therefore, the purpose of this study was to identify the effects of different intensities of physical activity on the cinematic gait variables in older women
Multiple Components in Narrow Planetary Rings
The phase-space volume of regions of regular or trapped motion, for bounded
or scattering systems with two degrees of freedom respectively, displays
universal properties. In particular, drastic reductions in the volume (gaps)
are observed at specific values of a control parameter. Using the stability
resonances we show that they, and not the mean-motion resonances, account for
the position of these gaps. For more degrees of freedom, exciting these
resonances divides the regions of trapped motion. For planetary rings, we
demonstrate that this mechanism yields rings with multiple components.Comment: 4 pages, 7 figures (some in colors
Rattus Model Utilizing Selective Pulmonary Ischemia Induces Bronchiolitis Obliterans Organizing Pneumonia
Bronchiolitis obliterans organizing pneumonia (BOOP), a morbid condition when associated with lung transplant and chronic lung disease, is believed to be a complication of ischemia. Our goal was to develop a simple and reliable model of lung ischemia in the Sprague-Dawley rat that would produce BOOP. Unilateral ischemia without airway occlusion was produced by an occlusive slipknot placed around the left main pulmonary artery. Studies were performed 7 days later. Relative pulmonary and systemic flow to each lung was measured by injection of technetium Tc 99m macroaggregated albumin. Histological sections were examined for structure and necrosis and scored for BOOP. Apoptosis was detected by immunohistochemistry with an antibody against cleaved caspase 3. Pulmonary artery blood flow to left lungs was less than 0.1% of the cardiac output, and bronchial artery circulation was ~2% of aortic artery flow. Histological sections from ischemic left lungs consistently showed Masson bodies, inflammation, and young fibroblasts filling the distal airways and alveoli, consistent with BOOP. In quantitative evaluation of BOOP using epithelial changes, inflammation and fibrosis were higher in ischemic left lungs than right or sham-operated left lungs. Apoptosis was increased in areas exhibiting histological BOOP, but there was no histological evidence of necrosis. Toll-like receptor 4 expression was increased in ischemic left lungs over right. An occlusive slipknot around the main left pulmonary artery in rats produces BOOP, providing direct evidence that ischemia without immunomodulation or coinfection is sufficient to initiate this injury. It also affords an excellent model to study signaling and genetic mechanisms underlying BOOP
Field theoretic description of charge regulation interaction
In order to find the exact form of the electrostatic interaction between two
proteins with dissociable charge groups in aqueous solution, we have studied a
model system composed of two macroscopic surfaces with charge dissociation
sites immersed in a counterion-only ionic solution. Field-theoretic
representation of the grand canonical partition function is derived and
evaluated within the mean-field approximation, giving the Poisson-Boltzmann
theory with the Ninham-Parsegian boundary condition. Gaussian fluctuations
around the mean-field are then analyzed in the lowest order correction that we
calculate analytically and exactly, using the path integral representation for
the partition function of a harmonic oscillator with time-dependent frequency.
The first order (one loop) free energy correction gives the interaction free
energy that reduces to the zero-frequency van der Waals form in the appropriate
limit but in general gives rise to a mono-polar fluctuation term due to charge
fluctuation at the dissociation sites. Our formulation opens up the possibility
to investigate the Kirkwood-Shumaker interaction in more general contexts where
their original derivation fails.Comment: 12 pages, 9 figures, submitted to EPJ
Change and Aging Senescence as an adaptation
Understanding why we age is a long-lived open problem in evolutionary
biology. Aging is prejudicial to the individual and evolutionary forces should
prevent it, but many species show signs of senescence as individuals age. Here,
I will propose a model for aging based on assumptions that are compatible with
evolutionary theory: i) competition is between individuals; ii) there is some
degree of locality, so quite often competition will between parents and their
progeny; iii) optimal conditions are not stationary, mutation helps each
species to keep competitive. When conditions change, a senescent species can
drive immortal competitors to extinction. This counter-intuitive result arises
from the pruning caused by the death of elder individuals. When there is change
and mutation, each generation is slightly better adapted to the new conditions,
but some older individuals survive by random chance. Senescence can eliminate
those from the genetic pool. Even though individual selection forces always win
over group selection ones, it is not exactly the individual that is selected,
but its lineage. While senescence damages the individuals and has an
evolutionary cost, it has a benefit of its own. It allows each lineage to adapt
faster to changing conditions. We age because the world changes.Comment: 19 pages, 4 figure
Analysis of path integrals at low temperature : Box formula, occupation time and ergodic approximation
We study the low temperature behaviour of path integrals for a simple
one-dimensional model. Starting from the Feynman-Kac formula, we derive a new
functional representation of the density matrix at finite temperature, in terms
of the occupation times of Brownian motions constrained to stay within boxes
with finite sizes. From that representation, we infer a kind of ergodic
approximation, which only involves double ordinary integrals. As shown by its
applications to different confining potentials, the ergodic approximation turns
out to be quite efficient, especially in the low-temperature regime where other
usual approximations fail
User guide for the British Geological Survey Stream Sediment Geochemistry (500m grid) dataset
This report is the user-guide to the content and application of the national scale Stream Sediment Geochemistry maps produced by the British Geological Survey (BGS) at a 500m grid. This map release, referred to as ‘BGS_SedGC_500m’, provides the spatial distribution of element concentrations across the United Kingdom as measured and interpolated from the chemical analysis of stream sediments. The purpose of this user guide is to enable those downloading this dataset to have a better appreciation of how the dataset has been created and therefore a better understanding of the potential applications and limitations that the dataset may have
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