Alien Registration- Kirkwood, Winefred M. (Livermore Falls, Androscoggin County)

https://digitalmaine.com/alien_docs/27057/thumbnail.jp

Alien Registration- Kirkwood, Winefred M. (Livermore Falls, Androscoggin County)

https://digitalmaine.com/alien_docs/27057/thumbnail.jp

Adjuvant therapy of melanoma with interferon: lessons of the past decade

The effect of interferon alpha (IFNα2) given alone or in combination has been widely explored in clinical trials over the past 30 years. Despite the number of adjuvant studies that have been conducted, controversy remains in the oncology community regarding the role of this treatment

Propagation of Exchange Bias in CoFe/FeMn/CoFe Trilayers

CoFe/FeMn, FeMn/CoFe bilayers and CoFe/FeMn/CoFe trilayers were grown in magnetic field and at room temperature. The exchange bias field $H_{eb}$ depends strongly on the order of depositions and is much higher at CoFe/FeMn than at FeMn/CoFe interfaces. By combining the two bilayer structures into symmetric CoFe/FeMn($t_\mathrm{FeMn}$)/CoFe trilayers, $H_{eb}^t$ and $H_{eb}^b$ of the top and bottom CoFe layers, respectively, are both enhanced. Reducing $t_\mathrm{FeMn}$ of the trilayers also results in enhancements of both $H_{eb}^b$ and $H_{eb}^t$. These results evidence the propagation of exchange bias between the two CoFe/FeMn and FeMn/CoFe interfaces mediated by the FeMn antiferromagnetic order

4-Aminoquinoline-hybridization en route towards the development of rationally designed antimalarial agents

The resistance of Plasmodium falciparum, the causative agent of malaria, against quinine and chloroquine along with the lack of malaria vaccines has encouraged the development of various synthetic strategies towards biologically active scaffolds. An emerging strategy in medicinal chemistry, termed molecular hybridization, involves the covalent fusion of two or more drugs, active compounds, and/or pharmacophoric units into a hybrid compound, with fascinating activities and multiple but not essentially simultaneous pharmacological targets. 4-Aminoquinolines are considered as promising antimalarials and 4-aminoquinoline hybridization is considered as an attractive and feasible approach for the development of new molecular frameworks for averting and delaying the emergence of drug resistance along with improved efficacy. The present review article describes the recent developments on the 4-aminoquinoline-hybridization towards the development of new antimalarials

Quantitative relation between PMSE and ice mass density

Radar reflectivities associated with Polar Mesosphere Summer Echoes (PMSE) are compared with measurements of ice mass density in the mesopause region. The 54.5 MHz radar Moveable Atmospheric Radar for Antarctica (MARA), located at the Wasa/Aboa station in Antarctica (73° S, 13° W) provided PMSE measurements in December 2007 and January 2008. Ice mass density was measured by the Solar Occultation for Ice Experiment (SOFIE). The radar operated continuously during this period but only measurements close to local midnight are used for comparison, to coincide with the local time of the measurements of ice mass density. The radar location is at high geographic latitude but low geomagnetic latitude (61°) and the measurements were made during a period of very low solar activity. As a result, background electron densities can be modelled based on solar illumination alone. We find a close correlation between the time and height variations of radar reflectivity and ice mass density, at all PMSE heights, from 80 km up to 95 km. A quantitative expression relating radar reflectivities to ice mass density is found, including an empirical dependence on background electron density. Using this relation, we can use PMSE reflectivities as a proxy for ice mass density, and estimate the daily variation of ice mass density from the daily variation of PMSE reflectivities. According to this proxy, ice mass density is maximum around 05:00–07:00 LT, with lower values around local noon, in the afternoon and in the evening. This is consistent with the small number of previously published measurements and model predictions of the daily variation of noctilucent (mesospheric) clouds and in contrast to the daily variation of PMSE, which has a broad daytime maximum, extending from 05:00 LT to 15:00 LT, and an evening-midnight minimum