Role of Bharatiya Nirdeshak Dravya (BND®) in Development of Indian Reference Materials for Quality Assurance of Products

The benchmark of life and quality infrastructure of a nation is mainly dependent on the measurement system of country. The growth of nation in addition to its science & technology is highly influenced by measurement of any physical quantities or policies. The ancient as well as modern sciences predominantly rely on the measurement procedure and its accuracy. One can say that science starts from measurements hence it can be considered as one of the basic aspect of science and its growth. To perform these measurements which are basis of life, simple to sophisticated equipment's are used. The results from these instruments may be not accurate and precise if it is not calibrated. With calibration there is need of comparable measurement to attain the unbroken chain of measurements. Now Certified Reference Materials (CRMs) played critical role in calibration of instrument and to get the comparable measurements which are traceable to national or world-wide standards. The outcomes of sophisticated instruments may be wrong without its calibration. So now it is the time for the scientific and new innovations world to calibrate the sophisticated instruments using these certified reference standards. These CRMs are generally produced and maintained by "National Measurement Institute (NMI)" of the country. In India, Bharatiya Nirdeshak Dravya (BND®) division of National Physical Laboratory (NPL) is continuously working in developing the Indian Reference Materials (IRMs). Now these IRMs can be defined as those substances which are key factors for maintaining a healthy measurement system and to get very precise value. With this these are cost effective IRMs which will improve the quality of products and will help in economic growth of the country. In this article, we are discussing about that measurements which are attached to each steps of our life. But it is necessary that measurement should be accurate and precise and traceable to some true value. CSIR-NPL is continuously focused on the development of IRMs for calibration of instrument, improvement in quality of life, industrial production, global trade and to get accurate and precise measurements

The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set

Background Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables. Methods Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set. Results Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001). Conclusions The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy

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Not AvailableGenetic parameters were estimated for growth and pond survival of Penaeus monodon using full-sib families from wild brood females collected from Tamil Nadu and Andhra Pradesh of the Indian coastline. The post larvae were reared, tagged, and thereafter communal-reared in two ponds. There was a moderate phenotypic correlation between stocking weight and harvest weight (0.39). A linear mixed model, when fitted to the harvest weight, revealed significant sex and pond effects and a heritability estimate of 0.27 ± 0.07. This estimate is likely to over-estimate the true heritability, as full-sib families were initially reared in separate tanks, although tagging weight was fitted as a covariate in an attempt to remove this effect. Correlation of family breeding values for harvest weight between the two ponds suggested little genotype × environment interaction. Heritability of pond survival was 0.21 ± 0.06, with unusually low levels of survival in the experiment, likely contributing to the high level of genetic variance observed. The correlation between family breeding values for harvest weight and pond survival was low (0.05) and not significantly different from zero. However, the correlation was not antagonistic, suggesting that P. monodon broodstock with high breeding values for both traits could be selected.Not Availabl