173 research outputs found
Health-related quality of life advantage of long-acting injectable antipsychotic treatment for schizophrenia: a time trade-off study
<p>Abstract</p> <p>Background</p> <p>This study was undertaken to estimate utility values for alternative treatment intervals for long acting antipsychotic intramuscular injections for the treatment of schizophrenia.</p> <p>Methods</p> <p>Vignettes were developed using the published literature and an iterative consultation process with expert clinicians and patient representative groups. Four vignettes were developed. The first was a vignette of relapsed/untreated schizophrenia. The other three vignettes presented a standardised picture of well-managed schizophrenia with variations in the intervals between injections: once every 2-weeks, 4-weeks and 3-months. A standardised time trade off (TTO) approach was used to obtain utility values for the vignettes. As a societal perspective was sought, a representative sample of individuals from across the community (Sydney, Australia) was recruited. Ninety-eight people completed the TTO interview. The vignettes were presented in random order to prevent possible ordering effects.</p> <p>Results</p> <p>A clear pattern of increasing utility was observed with increasing time between injections. Untreated schizophrenia was rated as very poor health-related quality of life with a mean (median) utility of 0.27 (0.20). The treated health states were rated at much higher utilities and were statistically significantly different (<it>p </it>< 0.001) from each other: (1) 2-weekly: mean (median) utility = 0.61 (0.65); (2) 4-weekly: mean (median) utility = 0.65 (0.70); (3) 3-monthly: mean (median) utility = 0.70 (0.75).</p> <p>Conclusions</p> <p>This study has provided robust data indicating that approximately a 0.05 utility difference exists between treatment options, with the highest utility assigned to 3-monthly injections.</p
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Proof of concept for an innovative pump fishway design to move fish upstream over dams
Reversing worldwide declines in freshwater fish while making sustainable use of water resources will require effective and economical fishways to restore fish migrations. Mitigation of barrier effects at dams and weirs is too often impeded by poor fishway performance and high costs, so that many fish migrations continue to be obstructed. Improved and less-costly designs are urgently needed. Our innovative pump fishway concept combines fish-behaviour insights, proved fishways techniques and aquaculture’s pumping methods for safe upstream transport of living fish. We ran a series of experimental trials using several scale-model fishway designs with young, hatchery-bred fish. Our horizontal-cylinder design successfully combined volitional-passage functions of existing fishways with non-volitional transport in a conduit carrying pumped water. Several key principles of fish behaviour in fishways led to design improvements: disturbed fish often seek refuge at depth; fishes’ escape reactions strongly motivate swimming into flows; and curved structures aid passage by reducing delays. Replicated trials finally produced an average of 98% successful passage, within brief cycling periods. The pump fishway concept offers potential for effective upstream fish passage at new and existing sites \u3e~2m high, with low construction and maintenance costs and highly adaptable operation in variable flow regimes. Development beyond the concept-trial phase is now a priority
Engineering a crisis in a Ramsar wetland : the Coorong, Lower Lakes and Murray Mouth, Australia
Threatened but not conserved: flying-fox roosting and foraging habitat in Australia
Conservation relies upon a primary understanding of changes in a species' population size, distribution, and habitat use. Bats represent about one in five mammal species in the world, but understanding for most species is poor. For flying-foxes, specifically the 66 Pteropus species globally, 31 are classified as threatened (Vulnerable, Endangered, Critically Endangered) on the IUCN Red List. Flying-foxes typically aggregate in colonies of thousands to hundreds of thousands of individuals at their roost sites, dispersing at sunset to forage on floral resources (pollen, nectar, and fruit) in nearby environments. However, understanding of flying-fox roosting habitat preferences is poor, hindering conservation efforts in many countries. In this study, we used a database of 654 known roost sites of the four flying-fox species that occur across mainland Australia to determine the land-use categories and vegetation types in which roost sites were found. In addition, we determined the land-use categories and vegetation types found within the surrounding 25 km radius of each roost, representing primary foraging habitat. Surprisingly, for the four species most roosts occurred in urban areas (42-59%, n = 4 species) followed by agricultural areas (21-31%). Critically, for the two nationally listed species, only 5.2% of grey-headed and 13.9% of spectacled flying-fox roosts occurred in habitat within protected areas. Roosts have previously been reported to predominantly occur in rainforest, mangrove, wetland, and dry sclerophyll vegetation types. However, we found that only 20-35% of roosts for each of the four species occurred in these habitats. This study shows that flying-fox roosts overwhelmingly occurred within human-modified landscapes across eastern Australia, and that conservation reserves inadequately protect essential habitat of roosting and foraging flying-foxes
Defending the scientific integrity of conservation-policy processes
Government agencies faced with politically controversial decisions often discount or ignore scientific information, whether from agency staff or nongovernmental scientists. Recent developments in scientific integrity (the ability to perform, use, communicate, and publish science free from censorship or political interference) in Canada, Australia, and the United States demonstrate a similar trajectory. A perceived increase in scientific‐integrity abuses provokes concerted pressure by the scientific community, leading to efforts to improve scientific‐integrity protections under a new administration. However, protections are often inconsistently applied and are at risk of reversal under administrations publicly hostile to evidence‐based policy. We compared recent challenges to scientific integrity to determine what aspects of scientific input into conservation policy are most at risk of political distortion and what can be done to strengthen safeguards against such abuses. To ensure the integrity of outbound communications from government scientists to the public, we suggest governments strengthen scientific integrity policies, include scientists’ right to speak freely in collective‐bargaining agreements, guarantee public access to scientific information, and strengthen agency culture supporting scientific integrity. To ensure the transparency and integrity with which information from nongovernmental scientists (e.g., submitted comments or formal policy reviews) informs the policy process, we suggest governments broaden the scope of independent reviews, ensure greater diversity of expert input and transparency regarding conflicts of interest, require a substantive response to input from agencies, and engage proactively with scientific societies. For their part, scientists and scientific societies have a responsibility to engage with the public to affirm that science is a crucial resource for developing evidence‐based policy and regulations in the public interest
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