Tectonics, volcanism, landscape structure and human evolution in the African Rift

Tectonic movements and volcanism in the African Rift have usually been considered of relevance to human evolution only at very large geographical and chronological scales, principally in relation to longterm topographic and climatic variation at the continental scale. At the more loca1 scale of catchment basins and individual sites, tectonic features are generally considered to be at worst disruptive and at best incidental features enhancing the preservation and exposure of early sites. We demonstrate that recent lava flows and fault scarps in a tectonically active region create a distinctive landscape structure with a complex and highly differentiated topography of enclosures, barriers and fertile basins. This landscape structure has an important potential impact on the co-evolution of prey-predator interactions and on interspecific relationships more generally. In particular, we suggest that it would have offered unique opportunities for the development of a hominid niche characterised by bipedalism, meat-eating and stone tool use. These landscape features are best appreciated by looking at areas which today have rapid rates of tectonic movement and frequent volcanic activity, as in eastern Afar and Djibouti. These provide a better analogy for the Plio-Pleistocene environments occupied by early hominids than the present-day landscapes where their fossil remains and artefacts have been discovered. The latter areas are now less active than was the case when the sites were formed. They have also been radically transfomed by ongoing geomorphological processes in the intervening millennia. Thus, previous attempts to reconstruct the local landscape setting adjacent to these early hominid sites necessarily rely on limited geological windows into the ancient land surface and thus tend to filter out small-scale topographic detail because it cannot be reliably identified. It is precisely this local detail that we consider to be of importance in understanding the environmental contribution to co-evolutionary developments

Insulin resistance:Impact on therapeutic developments in diabetes

Insulin resistance has a broad pathogenic impact affecting metabolic, cardio-renal and other disease areas. Extensive studies to dissect the mechanisms of insulin resistance have provided valuable insights to shape current clinical awareness and advance therapeutic practice. However, the development of direct interventions against insulin resistance has been hindered by its complex and highly variable presentations, especially in type 2 diabetes. Among glucose-lowering agents, metformin and thiazolidinediones provide cellular actions that counter some effects of insulin resistance: reduced glucotoxicity and weight-lowering with antidiabetic therapies also improve insulin action, except that endogenously- or exogenously-created hyperinsulinaemia may partially compromise these benefits. Increasing awareness of the pervasiveness and damaging ramifications of insulin resistance heightens the need for more specifically targeted and more effective therapies

RR Lyrae Variables in the Globular Cluster M55. The First Evidence for Non Radial Pulsations in RR Lyr Stars

We present the results of a photometric study of RR Lyrae variables in the field of the globular cluster M55. We have discovered nine new RR Lyrae stars, increasing the number of known variables in this cluster to 15 objects. Five of the newly discovered variables belong to Bailey type RRc and two to type RRab. Two background RRab stars are probable members of the Sagittarius dwarf galaxy. Fourier decomposition of the light curves was used to derive basic properties of the present sample of RR Lyrae variables. From an analysis of the RRc variables we obtain a mean mass of $M=0.53\pm0.03 M_\odot$, luminosity $\log L=1.75\pm0.01$, effective temperature $T_{eff}=7193\pm27$ K, and helium abundance $Y=0.27\pm0.01$. Based on the $B-V$ colors, periods and metallicities of the RRab stars we estimate the value of the color excess for M55 to be equal to $E(B-V)=0.11\pm0.03$. Using this value we derive the colors of the blue and red edges of the instability strip in M55. The blue edge lies at $(B-V)_0=0.20$ mag and the red edge lies at $(B-V)_0=0.38$ mag. We estimate the values of the visual apparent and dereddened distance moduli to be $13.65\pm0.11$ and $13.31\pm0.11$, respectively. The light curves of three of the RRc variables exhibit changes in amplitude of over 0.1 mag on the time scale of less than a week, rather short for the Blazhko effect, but with no evidence for another radial pulsational frequency. However we do detect other periodicities which are clearly visible in the light curve after removing variations with the first overtone radial frequency. This is strong evidence for the presence of non-radial pulsations, a behavior common for $\delta$ Scuti stars but not yet observed among RR Lyr variables.Comment: submitted to Astronomical Journal, 33 pages with 11 figure

Rapid variability of accretion in AM Herculis

We present the last pointed observation of AM Her carried out during the life of the BeppoSAX satellite. It was bright at the beginning of the observation, but dropped to the lowest X-ray level ever observed so far. The X-ray emission during the bright period is consistent with accretion occurring onto the main pole of the magnetized white dwarf. The rapid change from the active state to the low deep state indicates a drop by a factor of 17 in the accretion rate and hence that accretion switched-off. The short timescale (less than one hour) of this variation still remains a puzzle. Optical photometry acquired simultaneousy during the low state shows that the white dwarf remains heated, although a weak emission from the accretion stream could be still present. Cyclotron radiation, usually dominating the V and R bands, is negligible thus corroborating the possibility that AM Her was in an off-accretion state. The X-ray emission during the inactive state is consistent with coronal emission from the secondary late type star.Comment: 6 pages A&A-Latex, 6 Figures, accepted for publication in A&

The Three Dimensional Structure of EUV Accretion Regions in AM Herculis Stars: Modeling of EUV Photometric and Spectroscopic Observations

We have developed a model of the high-energy accretion region for magnetic cataclysmic variables and applied it to {\it Extreme Ultraviolet Explorer} observations of 10 AM Herculis type systems. The major features of the EUV light curves are well described by the model. The light curves exhibit a large variety of features such as eclipses of the accretion region by the secondary star and the accretion stream, and dips caused by material very close to the accretion region. While all the observed features of the light curves are highly dependent on viewing geometry, none of the light curves are consistent with a flat, circular accretion spot whose lightcurve would vary solely from projection effects. The accretion region immediately above the WD surface is a source of EUV radiation caused by either a vertical extent to the accretion spot, or Compton scattering off electrons in the accretion column, or, very likely, both. Our model yields spot sizes averaging 0.06 R$_{WD}$, or $f \sim 1 \times 10^{-3}$ the WD surface area, and average spot heights of 0.023 R$_{WD}$. Spectra extracted during broad dip phases are softer than spectra during the out-of-dip phases. This spectral ratio measurement leads to the conclusion that Compton scattering, some absorption by a warm absorber, geometric effects, an asymmetric temperature structure in the accretion region and an asymmetric density structure of the accretion columnare all important components needed to fully explain the data. Spectra extracted at phases where the accretion spot is hidden behind the limb of the WD, but with the accretion column immediately above the spot still visible, show no evidence of emission features characteristic of a hot plasma.Comment: 30 Pages, 11 Figure

The Red Sea, Coastal Landscapes, and Hominin Dispersals

This chapter provides a critical assessment of environment, landscape and resources in the Red Sea region over the past five million years in relation to archaeological evidence of hominin settlement, and of current hypotheses about the role of the region as a pathway or obstacle to population dispersals between Africa and Asia and the possible significance of coastal colonization. The discussion assesses the impact of factors such as topography and the distribution of resources on land and on the seacoast, taking account of geographical variation and changes in geology, sea levels and palaeoclimate. The merits of northern and southern routes of movement at either end of the Red Sea are compared. All the evidence indicates that there has been no land connection at the southern end since the beginning of the Pliocene period, but that short sea crossings would have been possible at lowest sea-level stands with little or no technical aids. More important than the possibilities of crossing the southern channel is the nature of the resources available in the adjacent coastal zones. There were many climatic episodes wetter than today, and during these periods water draining from the Arabian escarpment provided productive conditions for large mammals and human populations in coastal regions and eastwards into the desert. During drier episodes the coastal region would have provided important refugia both in upland areas and on the emerged shelves exposed by lowered sea level, especially in the southern sector and on both sides of the Red Sea. Marine resources may have offered an added advantage in coastal areas, but evidence for their exploitation is very limited, and their role has been over-exaggerated in hypotheses of coastal colonization

FUSE and HST/STIS far-ultraviolet observations of AM Herculis in an extended low state

We have obtained FUSE and HST/STIS time-resolved spectroscopy of the polar AM Herculis during a deep low state. The spectra are entirely dominated by the emission of the white dwarf. Both the far-ultraviolet (FUV) flux as well as the spectral shape vary substantially over the orbital period, with maximum flux occurring at the same phase as during the high state. The variations are due to the presence of a hot spot on the white dwarf, which we model quantitatively. The white dwarf parameters can be determined from a spectral fit to the faint phase data, when the hot spot is self-eclipsed. Adopting the distance of 79+8-6pc determined by Thorstensen, we find an effective temperature of 19800+-700K and a mass of Mwd=0.78+0.12-0.17Msun. The hot spot has a lower temperature than during the high state, ~34000-40000K, but covers a similar area, ~10% of the white dwarf surface. Low state FUSE and STIS spectra taken during four different epochs in 2002/3 show no variation of the FUV flux level or spectral shape, implying that the white dwarf temperature and the hot spot temperature, size, and location do not depend on the amount of time the system has spent in the low state. Possible explanations are ongoing accretion at a low level, or deep heating, both alternatives have some weaknesses that we discuss. No photospheric metal absorption lines are detected in the FUSE and STIS spectra, suggesting that the average metal abundances in the white dwarf atmosphere are lower than 1e-3 times their solar values.Comment: ApJ in press, 12 pages, 11 figure

From the micro to the macro to improve health: microorganism ecology and society in teaching infectious disease epidemiology

Chronic and emerging infectious diseases and antimicrobial resistance remain a substantial global health threat. Microbiota are increasingly recognised to play an important role in health. Infections also have a profound effect beyond health, especially on global and local economies. To maximise health improvements, the field of infectious disease epidemiology needs to derive learning from ecology and traditional epidemiology. New methodologies and tools are transforming understanding of these systems, from a better understanding of socioeconomic, environmental, and cultural drivers of infection, to improved methods to detect microorganisms, describe the immunome, and understand the role of human microbiota. However, exploiting the potential of novel methods to improve global health remains elusive. We argue that to exploit these advances a shift is required in the teaching of infectious disease epidemiology to ensure that students are well versed in a breadth of disciplines, while maintaining core epidemiological skills. We discuss the following key points using a series of teaching vignettes: (1) integrated training in classic and novel techniques is needed to develop future scientists and professionals who can work from the micro (interactions between pathogens, their cohabiting microbiota, and the host at a molecular and cellular level), with the meso (the affected communities), and to the macro (wider contextual drivers of disease); (2) teach students to use a team-science multidisciplinary approach to effectively integrate biological, clinical, epidemiological, and social tools into public health; and (3) develop the intellectual skills to critically engage with emerging technologies and resolve evolving ethical dilemmas. Finally, students should appreciate that the voices of communities affected by infection need to be kept at the heart of their work

Sexual risk reduction interventions for patients attending sexual health clinics: a mixed-methods feasibility study

Background: Sexually transmitted infections (STIs) continue to represent a major public health challenge. There is evidence that behavioural interventions to reduce risky sexual behaviours can reduce STI rates in patients attending sexual health (SH) services. However, it is not known if these interventions are effective when implemented at scale in SH settings in England. Objectives: The study had two main objectives: 1. develop and pilot a package of evidence-based sexual risk reduction interventions that can be delivered through SH services; 2. assess the feasibility of conducting a randomised controlled trial (RCT) to determine effectiveness against usual care. Design: The project was a multi-stage mixed methods study, with developmental and pilot RCT phases. Preparatory work included a systematic review; analysis of national surveillance data, and development of a triage algorithm; interviews and surveys with SH staff and patients to identify, select and adapt interventions. A pilot cluster RCT was planned for eight SH clinics; the intervention would be offered in four clinics, with qualitative and process evaluation to assess feasibility and acceptability. Four clinics acted as controls; in all clinics, participants would be consented to a 6-week follow-up STI screen. Setting: SH clinics in England. Participants: Young people (aged 16-25 years old) and men who have sex with men. Intervention: A three-part intervention package: 1. triage tool to score patients as high or low risk of STI infection using routine data; 2. a study-designed webpage with tailored sexual health information for all patients, regardless of risk; 3. a brief one-to-one session based on motivational interviewing for high risk patients. Main outcome measures: The three outcomes were: acceptability of the intervention to patients and SH providers; feasibility of delivering the interventions within existing resources; and feasibility of obtaining follow-up data on STI diagnoses (primary outcome in a full trial). Results: We identified 33 relevant trials from the systematic review, including: videos, peer support, digital, and brief one-to-one sessions. Patients and SH providers showed preferences for one-to-one and digital interventions, and providers indicated these intervention types could feasibly be implemented in their settings. There were no appropriate digital interventions that could be adapted in time for the pilot; therefore, we created a placeholder for the purposes of the pilot. The intervention package was piloted in two SH settings, rather than the planned four. Several barriers were found to intervention implementation, including a lack of trained staff time and clinic space. The intervention package was theoretically acceptable, but we observed poor engagement. We recruited patients from six clinics for the follow-up, rather than eight. The completion rate for follow-up was lower than anticipated (16% versus 46%). Limitations: Fewer clinics were included in the pilot than planned limiting the ability to make strong conclusions on RCT feasibility. Conclusion: We were unable to conclude whether a definitive RCT would be feasible due to challenges in implementation of a pilot, but have laid the groundwork for future research in the area