SU(3) family symmetry and neutrino bi-tri-maximal mixing

The observed large mixing angles in the lepton sector may be the first signal for the presence of a non-Abelian family symmetry. However, to obtain the significant differences between the mixing of the neutrino and charged fermion sectors, the vacuum expectation values involved in the breaking of such a symmetry in the two sectors must be misaligned. We investigate how this can be achieved in models with an SU(3) family symmetry consistent with an underlying GUT. We show that such misalignment can be achieved naturally via the see-saw mechanism. We construct a specific example in which the vacuum (mis)alignment is guaranteed by additional symmetries. This model generates a fermion mass structure consistent with all quark and lepton masses and mixing angles. Neutrino mixing is close to bi-tri-maximal mixing.Comment: References added; typos correcte

Effect of exercise training on liver function in adults who are overweight or exhibit fatty liver disease: a systematic review and meta-analysis

ObjectiveExercise training has been shown to have beneficial effects on liver function in adults overweight or with fatty liver disease. To establish which exercise programme characteristics were likely to elicit optimal improvements.DesignSystematic review and meta-analysis of randomised, controlled trials.Data sourcesPubMed, CINAHL and Cochrane controlled trials registry searched (1966 to 2 October 2015).Eligibility criteria for selecting studiesExercise intervention, with or without dietary intervention, versus usual care in adults undertaking, exercise training, who were overweight, obese or exhibited fatty liver disease (non-alcoholic fatty liver disease or non-alcoholic steatohepatitis).ResultsWe included 21 randomised controlled trials, totalling 1530 participants. Exercise intervention studies with total exercise programme workload &gt;10 000 kcal produced significant improvements in intrahepatic fat, −3.46% (95% CI −5.20% to −1.73%), p&lt;0.0001, I2=73%; effect size (standardised mean difference, SMD) −1.77 (−3.11 to −0.42), p=0.01, I2=77%. When data from only exercise studies were pooled, there was a reduction in fasting free fatty acids (FFAs) −74.15 µmol/L (95% CI −118.47 to −29.84), p=0.001, I2=67% with a large effect size (SMD) −0.94 (−1.36 to −0.52), p&lt;0.0001, I2=0%. When data from only exercise studies were pooled, there was a significant reduction in insulin MD −1.88 UL (95% CI −3.43 to −0.34), p=0.02, I2=31%. The liver enzymes, alanine aminotransferase, aspartate aminotransferase and γ-glutamyl transpeptidase, were not significantly altered with exercise.ConclusionsExercise training reduces intrahepatic fat and FFAs while increasing cardiorespiratory fitness. An aggregate exercise programme energy expenditure (&gt;10 000 kcal) may be required to promote reductions in intrahepatic fat.</jats:sec

The Effect of Radial Head Hemiarthroplasty Stem Fit on Radiocapitellar Contact Mechanics: Is Loose Fit better than Rigidly Fixed?

Background/Methods: Radial head hemiarthroplasty is commonly employed to manage comminuted displaced fractures. With regards to implant fixation, current designs vary with some prostheses aiming to achieve a tight \u27fixed\u27 fit, and others utilizing a smooth stem with an over reamed \u27loose\u27 fit. The purpose of the present study was to evaluate the effect of radial head hemiarthroplasty stem fit on radiocapitellar contact using a finite element model which simulated both fixed (size-for-size) and loose (1, 2 & 3mm over reamed) stem fits. Hypothesis: It was hypothesized that a loose stem fit would improve radiocapitellar contact mechanics, with increased contact area and decreased contact stress, by allowing the implant to find its \u27optimal\u27 position with respect to the capitellum. Results/Discussion: This data suggests that the loose smooth stem radial head implant may be functioning like a bipolar implant in optimizing radiocapitellar contact. The \u27loose\u27 over reamed stem provided optimal contact mechanics of the metallic axisymmetric radial head implant compared to the \u27fixed\u27 stem. The 1mm over reamed stem reduced maximum contact stress without affecting contact area. Over reaming of 2mm provided the greatest decrease in maximum contact stress, albeit with a significant reduction in contact area. Over reaming of 3mm produced a larger amount of stress concentrations on the capitellum suggesting there may be a limit to how loose a smooth stem implant should be implanted

A SQUAMOSA MADS-box gene involved in the regulation of anthocyanin accumulation in bilberry fruits

Anthocyanins are important health promoting phytochemicals that are abundant in many fleshy fruits. Bilberry (Vaccinium myrtillus L.) is one of the best sources of these compounds. Here we report on the expression pattern and functional analysis of a SQUAMOSA (SQUA) class MADS-box transcription factor, VmTDR4, associated with anthocyanin biosynthesis in bilberry. Levels of VmTDR4 expression were spatially and temporally linked with colour development and anthocyanin-related gene expression. Virus induced gene silencing (VIGS) was used to suppress VmTDR4 expression in bilberry resulting in substantial reduction in anthocyanin levels in fully ripe fruits. Chalcone synthase was used a positive control in the VIGS experiments. Additionally, in sectors of fruit tissue in which the expression of the VmTDR4 gene was silenced, the expression of R2R3 MYB family transcription factors related to the biosynthesis of flavonoids were also altered. We conclude that VmTDR4 plays an important role in the accumulation of anthocyanins during normal ripening in bilberry; probably through direct or indirect control of transcription factors belonging to the R2R3 MYB family

Barriers to EMS assimilation in the US, Australia, Hong Kong, Norway and Switzerland: A Cross regional comparison

Electronic Meeting Systems (EMS) have the capabilities to support group members in task collaboration. While there have been many case studies and lab experiments on how EMS can support group tasks, large scale macro investigations exploring EMS adoption and use have been practically non-existent. Furthermore, while several EMS assimilation barriers have been suggested, their validation across organizations remains unexplored. In this paper, we describe a global initiative to explore information technology support for task-oriented collaboration in the US, Australia, Hong Kong, Norway and Switzerland. We focus specifically on EMS and investigate their adoption, use and assimilation barriers in organizations across the five regions. Our results suggest that EMS adoption and use is limited across all the regions. A further investigation in EMS assimilation barriers suggests that these barriers differ across the regions and there is little agreement over how they are ranked. Implications of our findings are discussed for practitioners and researchers

On the Fundamental Line of Galactic and Extragalactic Globular Clusters

In a previous paper we found that the Globular Clusters of our Galaxy lie around a line in the log(Re), SBe, log(sigma) parameter space, with a moderate degree of scatter and remarkable axi-symmetry. This implies the existence of a purely photometric scaling law obtained by projecting such a line onto the log(Re), SBe plane. Such photometric quantities are readily available for large samples of clusters, as opposed to stellar velocity dispersion data. We study a sample of 129 Galactic and extragalactic clusters on such photometric plane in the V-band. We look for a linear relation between SBe and log(Re) and study how the scatter around it is influenced by age and dynamical environment. We interpret our results as a test on the evolutionary versus primordial origin of the Fundamental Line. We perform a detailed analysis of surface brightness profiles, which allows us to present a catalogue of structural properties, without relying on a given dynamical model. We find a linear relation between SBe and log(Re), in the form SBe = (5.25 +- 0.44) log(Re) + (15.58 +- 0.28), where SBe is measured in mag/arcsec^2 and Re in parsec. Both young and old clusters lie on the scaling law, with a scatter of approximately 1 mag in SBe. However, young clusters display more scatter and a clear trend of such scatter with age, which old clusters do not. Such trend becomes tighter if cluster age is measured in units of the cluster half-light relaxation time. Two-body relaxation therefore plays a major role, together with passive stellar population evolution, in shaping the relation between SBe, log(Re), and cluster age. We argue that the log(Re)-SBe relation and hence the Fundamental Line scaling law is not primordially set at cluster formation, but rather is the result of combined stellar evolution and collisional dynamical evolution.Comment: Accepted for publication on Astronomy and Astrophysics, official acceptance date November 2, 200

Sex-partitioning of the <i>Plasmodium falciparum</i> stage V gametocyte proteome provides insight into <i>falciparum</i>-specific cell biology

One of the critical gaps in malaria transmission biology and surveillance is our lack of knowledge about Plasmodium falciparum gametocyte biology, especially sexual dimorphic development and how sex ratios that may influence transmission from the human to the mosquito. Dissecting this process has been hampered by the lack of sex-specific protein markers for the circulating, mature stage V gametocytes. The current evidence suggests a high degree of conservation in gametocyte gene complement across Plasmodium, and therefore presumably for sex-specific genes as well. To better our understanding of gametocyte development and subsequent infectiousness to mosquitoes, we undertook a Systematic Subtractive Bioinformatic analysis (filtering) approach to identify sex-specific P. falciparum NF54 protein markers based on a comparison with the Dd2 strain, which is defective in producing males, and with syntenic male and female proteins from the reanalyzed and updated P. berghei (related rodent malaria parasite) gametocyte proteomes. This produced a short list of 174 male- and 258 female-enriched P. falciparum stage V proteins, some of which appear to be under strong diversifying selection, suggesting ongoing adaptation to mosquito vector species. We generated antibodies against three putative female-specific gametocyte stage V proteins in P. falciparum and confirmed either conserved sex-specificity or the lack of cross-species sex-partitioning. Finally, our study provides not only an additional resource for mass spectrometry-derived evidence for gametocyte proteins but also lays down the foundation for rational screening and development of novel sex-partitioned protein biomarkers and transmission-blocking vaccine candidates

On the accretion mode of the intermediate polar V1025 Centauri

The long white-dwarf spin periods in the magnetic cataclysmic variables EX Hya and V1025 Cen imply that if the systems possess accretion discs then they cannot be in equilibrium. It has been suggested that instead they are discless accretors in which the spin-up torques resulting from accretion are balanced by the ejection of part of the accretion flow back towards the secondary. We present phase-resolved spectroscopy of V1025 Cen aimed at deducing the nature of the accretion flow, and compare this with simulations of a discless accretor. We find that both the conventional disc-fed model and the discless-accretor model have strengths and weaknesses, and that further work is needed before we can decide which applies to V1025 Cen.Comment: 9 pages, 8 figures, To appear in MNRAS, includes low-res figures to reduce siz

A SEPALLATA gene is involved in the development and ripening of strawberry (Fragaria xananassa Duch.) fruit, a non-climacteric tissue

Climacteric and non-climacteric fruits have traditionally been viewed as representing two distinct programmes of ripening associated with differential respiration and ethylene hormone effects. In climacteric fruits, such as tomato and banana, the ripening process is marked by increased respiration and is induced and co-ordinated by ethylene, while in non-climacteric fruits, such as strawberry and grape, it is controlled by an ethylene-independent process with little change in respiration rate. The two contrasting mechanisms, however, both lead to texture, colour, and flavour changes that probably reflect some common programmes of regulatory control. It has been shown that a SEPALLATA(SEP)4-like gene is necessary for normal ripening in tomato. It has been demonstrated here that silencing a fruit-related SEP1/2-like (FaMADS9) gene in strawberry leads to the inhibition of normal development and ripening in the petal, achene, and receptacle tissues. In addition, analysis of transcriptome profiles reveals pleiotropic effects of FaMADS9 on fruit development and ripening-related gene expression. It is concluded that SEP genes play a central role in the developmental regulation of ripening in both climacteric and non-climacteric fruits. These findings provide important information to extend the molecular control of ripening in a non-climacteric fruit beyond the limited genetic and cultural options currently available

Beyond MFV in family symmetry theories of fermion masses

Minimal Flavour Violation (MFV) postulates that the only source of flavour changing neutral currents and CP violation, as in the Standard Model, is the CKM matrix. However it does not address the origin of fermion masses and mixing and models that do usually have a structure that goes well beyond the MFV framework. In this paper we compare the MFV predictions with those obtained in models based on spontaneously broken (horizontal) family symmetries, both Abelian and non-Abelian. The generic suppression of flavour changing processes in these models turns out to be weaker than in the MFV hypothesis. Despite this, in the supersymmetric case, the suppression may still be consistent with a solution to the hierarchy problem, with masses of superpartners below 1 TeV. A comparison of FCNC and CP violation in processes involving a variety of different family quantum numbers should be able to distinguish between various family symmetry models and models satisfying the MFV hypothesis.Comment: 34 pages, no figure