Stability and BPS branes

We define the concept of Pi-stability, a generalization of mu-stability of vector bundles, and argue that it characterizes N=1 supersymmetric brane configurations and BPS states in very general string theory compactifications with N=2 supersymmetry in four dimensions.Comment: harvmac, 18 p

Computing exponentially faster: Implementing a nondeterministic universal Turing machine using DNA

The theory of computer science is based around Universal Turing Machines (UTMs): abstract machines able to execute all possible algorithms. Modern digital computers are physical embodiments of UTMs. The nondeterministic polynomial (NP) time complexity class of problems is the most significant in computer science, and an efficient (i.e. polynomial P) way to solve such problems would be of profound economic and social importance. By definition nondeterministic UTMs (NUTMs) solve NP complete problems in P time. However, NUTMs have previously been believed to be physically impossible to construct. Thue string rewriting systems are computationally equivalent to UTMs, and are naturally nondeterministic. Here we describe the physical design for a NUTM that implements a universal Thue system. The design exploits the ability of DNA to replicate to execute an exponential number of computational paths in P time. Each Thue rewriting step is embodied in a DNA edit implemented using a novel combination of polymerase chain reactions and site-directed mutagenesis. We demonstrate that this design works using both computational modelling and in vitro molecular biology experimentation. The current design has limitations, such as restricted error-correction. However, it opens up the prospect of engineering NUTM based computers able to outperform all standard computers on important practical problems

The spectrum of BPS branes on a noncompact Calabi-Yau

We begin the study of the spectrum of BPS branes and its variation on lines of marginal stability on O_P^2(-3), a Calabi-Yau ALE space asymptotic to C^3/Z_3. We show how to get the complete spectrum near the large volume limit and near the orbifold point, and find a striking similarity between the descriptions of holomorphic bundles and BPS branes in these two limits. We use these results to develop a general picture of the spectrum. We also suggest a generalization of some of the ideas to the quintic Calabi-Yau.Comment: harvmac, 45 pp. (v2: added references

A Spectroscopic Study of Mass Outflows in the Interacting Binary RY Scuti

The massive interacting binary RY Scuti is an important representative of an active mass-transferring system that is changing before our eyes and which may be an example of the formation of a Wolf-Rayet star through tidal stripping. Utilizing new and previously published spectra, we present examples of how a number of illustrative absorption and emission features vary during the binary orbit. We identify spectral features associated with each component, calculate a new, double-lined spectroscopic binary orbit, and find masses of 7.1 +/- 1.2 M_sun for the bright supergiant and 30.0 +/- 2.1 M_sun for the hidden massive companion. Through tomographic reconstruction of the component spectra from the composite spectra, we confirm the O9.7 Ibpe spectral class of the bright supergiant and discover a B0.5 I spectrum associated with the hidden massive companion; however, we suggest that the latter is actually the spectrum of the photosphere of the accretion torus immediately surrounding the massive companion. We describe the complex nature of the mass loss flows from the system in the context of recent hydrodynamical models for beta Lyr, leading us to conclude RY Scuti has matter leaving the system in two ways: 1) a bipolar outflow from winds generated by the hidden massive companion, and 2) mass from the bright O9.7 Ibpe supergiant flowing from the region near the L2 point to fill out a large, dense circumbinary disk. This circumbinary disk (radius ~ 1 AU) may feed the surrounding double-toroidal nebula (radius ~ 2000 AU).Comment: 41 pages with 7 tables and 11 figures, accepted to Ap

Fusion of multispectral imagery and spectrometer data in UAV remote sensing

High spatial resolution hyperspectral data often used in precision farming applications are not available from current satellite sensors, and difficult or expensive to acquire from standard aircraft. Alternatively, in precision farming, unmanned aerial vehicles (UAVs) are emerging as lower cost and more flexible means to acquire very high resolution imagery. Miniaturized hyperspectral sensors have been developed for UAVs, but th

Multiple universes, cosmic coincidences, and other dark matters

Even when completely and consistently formulated, a fundamental theory of physics and cosmological boundary conditions may not give unambiguous and unique predictions for the universe we observe; indeed inflation, string/M theory, and quantum cosmology all arguably suggest that we can observe only one member of an ensemble with diverse properties. How, then, can such theories be tested? It has been variously asserted that in a future measurement we should observe the a priori most probable set of predicted properties (the ``bottom-up'' approach), or the most probable set compatible with all current observations (the ``top-down'' approach), or the most probable set consistent with the existence of observers (the ``anthropic'' approach). These inhabit a spectrum of levels of conditionalization and can lead to qualitatively different predictions. For example, in a context in which the densities of various species of dark matter vary among members of an ensemble of otherwise similar regions, from the top-down or anthropic viewpoints -- but not the bottom-up -- it would be natural for us to observe multiple types of dark matter with similar contributions to the observed dark matter density. In the anthropic approach it is also possible in principle to strengthen this argument and the limit the number of likely dark matter sub-components. In both cases the argument may be extendible to dark energy or primordial density perturbations. This implies that the anthropic approach to cosmology, introduced in part to explain "coincidences" between unrelated constituents of our universe, predicts that more, as-yet-unobserved coincidences should come to light.Comment: 18 JCAP-style pages, accepted by JCAP. Revised version adds references and some clarification

Stent placement compared with balloon angioplasty for obstructed coronary bypass grafts. Saphenous Vein De Novo Trial Investigators.

BACKGROUND: Treatment of stenosis in saphenous-vein grafts after coronary-artery bypass surgery is a difficult challenge. The purpose of this study was to compare the effects of stent placement with those of balloon angioplasty on clinical and angiographic outcomes in patients with obstructive disease of saphenous-vein grafts. METHODS: A total of 220 patients with new lesions in aortocoronary-venous bypass grafts were randomly assigned to placement of Palmaz-Schatz stents or standard balloon angioplasty. Coronary angiography was performed during the index procedure and six months later. RESULTS: As compared with the patients assigned to angioplasty, those assigned to stenting had a higher rate of procedural efficacy, defined as a reduction in stenosis to less than 50 percent of the vessel diameter without a major cardiac complication (92 percent vs. 69 percent, P\u3c0.001), but they had more frequent hemorrhagic complications (17 percent vs. 5 percent, P\u3c0.01). Patients in the stent group had a larger mean (+/-SD) increase in luminal diameter immediately after the procedure (1.92+/-0.30 mm, as compared with 1.21+/-0.37 mm in the angioplasty group; P\u3c0.001) and a greater mean net gain in luminal diameter at six months (0.85+/-0.96 vs. 0.54+/-0.91 mm, P=0.002). Restenosis occurred in 37 percent of the patients in the stent group and in 46 percent of the patients in the angioplasty group (P=0.24). The outcome in terms of freedom from death, myocardial infarction, repeated bypass surgery, or revascularization of the target lesion was significantly better in the stent group (73 percent vs. 58 percent, P = 0.03). CONCLUSIONS: As compared with balloon angioplasty, stenting of selected venous bypass-graft lesions resulted in superior procedural outcomes, a larger gain in luminal diameter, and a reduction in major cardiac events. However, there was no significant benefit in the rate of angiographic restenosis, which was the primary end point of the study

2020-04-06 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM case updates. Several NM policy and legislative actions. Federal vs. state conflict over medical supply lines. Healthcare workers sleep in cars to prevent family exposure. Same-day in-house testing at Cedars-Sinai. Debate over hydroxychloroquine Tx. Death rate differences: Germany and Italy. African innovations. Testing recommended with mild symptoms. CDC guidelines for law enforcement PPE. New WHO first responder training and CDC sign language resources. COVID-19 droplets can travel up to 27 feet. Transmission from the asymptomatic. Humidifiers help. Drug and vaccine progress