307 research outputs found
A randomised feasibility study of serial magnetic resonance imaging to reduce treatment times in Charcot neuroarthropathy in people with diabetes (CADOM): A protocol
Background Charcot neuroarthropathy is a complication of peripheral neuropathy associated with diabetes which most frequently affects the lower limb. It can cause fractures and dislocations within the foot, which may progress to deformity and ulceration. Recommended treatment is immobilisation and offloading, with a below knee non-removable cast or boot. Duration of treatment varies from six months to more than one year. Small observational studies suggest that repeated assessment with Magnetic Resonance Imaging improves decision making about when to stop treatment, but this has not been tested in clinical trials. This study aims to explore the feasibility of using serial Magnetic Resonance Imaging without contrast in the monitoring of Charcot neuroarthropathy to reduce duration of immobilisation of the foot. A nested qualitative study aims to explore participantsâ lived experience of Charcot neuroarthropathy and of taking part in the feasibility study. Methods We will undertake a two arm, open study, and randomise 60 people with a suspected or confirmed diagnosis of Charcot neuroarthropathy from five NHS, secondary care multidisciplinary Diabetic Foot Clinics across England. Participants will be randomised 1:1 to receive Magnetic Resonance Imaging at baseline and remission up to 12 months, with repeated foot temperature measurements and x-rays (standard care plus), or standard care plus with additional three-monthly Magnetic Resonance Imaging until remission up to 12 months (intervention). Time to confirmed remission of Charcot neuroarthropathy with off-loading treatment (days) and its variance will be used to inform sample size in a full-scale trial. We will look for opportunities to improve the protocols for monitoring techniques and the clinical, patient centred, and health economic measures used in a future study. For the nested qualitative study, we will invite a purposive sample of 10-14 people able to offer maximally varying experiences from the feasibility study to take part in semi-structured interviews to be analysed using thematic analysis. Discussion The study will inform the decision whether to proceed to a full-scale trial. It will also allow deeper understanding of the lived experience of Charcot neuroarthropathy, and factors that contribute to engagement in management and contribute to the development of more effective patient centred strategies. Trial registration ISRCTN, ISRCTN, 74101606. Registered on 6 November 2017, http://www.isrctn.com/ISRCTN74101606?q=CADom&filters=&sort=&offset=1&totalResults=1&page=1&pageSize=10&searchType=basic-searc
Results from 730 kg days of the CRESST-II Dark Matter Search
The CRESST-II cryogenic Dark Matter search, aiming at detection of WIMPs via
elastic scattering off nuclei in CaWO crystals, completed 730 kg days of
data taking in 2011. We present the data collected with eight detector modules,
each with a two-channel readout; one for a phonon signal and the other for
coincidently produced scintillation light. The former provides a precise
measure of the energy deposited by an interaction, and the ratio of
scintillation light to deposited energy can be used to discriminate different
types of interacting particles and thus to distinguish possible signal events
from the dominant backgrounds. Sixty-seven events are found in the acceptance
region where a WIMP signal in the form of low energy nuclear recoils would be
expected. We estimate background contributions to this observation from four
sources: 1) "leakage" from the e/\gamma-band 2) "leakage" from the
\alpha-particle band 3) neutrons and 4) Pb-206 recoils from Po-210 decay. Using
a maximum likelihood analysis, we find, at a high statistical significance,
that these sources alone are not sufficient to explain the data. The addition
of a signal due to scattering of relatively light WIMPs could account for this
discrepancy, and we determine the associated WIMP parameters.Comment: 17 pages, 13 figure
The CRESST II Dark Matter Search
Direct Dark Matter detection with cryodetectors is briefly discussed, with
particular mention of the possibility of the identification of the recoil
nucleus. Preliminary results from the CREEST II Dark Matter search, with 730
kg-days of data, are presented. Major backgrounds and methods of identifying
and dealing with them are indicated.Comment: Talk at DSU workshop, ITP Beijing, Oct. 2011. 9 figures, 2 table
Status of the CRESST Dark Matter Search
The CRESST experiment aims for a detection of dark matter in the form of
WIMPs. These particles are expected to scatter elastically off the nuclei of a
target material, thereby depositing energy on the recoiling nucleus. CRESST
uses scintillating CaWO4 crystals as such a target. The energy deposited by an
interacting particle is primarily converted to phonons which are detected by
transition edge sensors. In addition, a small fraction of the interaction
energy is emitted from the crystals in the form of scintillation light which is
measured in coincidence with the phonon signal by a separate cryogenic light
detector for each target crystal. The ratio of light to phonon energy permits
the discrimination between the nuclear recoils expected from WIMPs and events
from radioactive backgrounds which primarily lead to electron recoils. CRESST
has shown the success of this method in a commissioning run in 2007 and, since
then, further investigated possibilities for an even better suppression of
backgrounds. Here, we report on a new class of background events observed in
the course of this work. The consequences of this observation are discussed and
we present the current status of the experiment.Comment: Proceedings of the 13th International Workshop on Low Temperature
Detectors, 4 pages, 3 figure
Composite CaWO4 Detectors for the CRESST-II Experiment
CRESST-II, standing for Cryogenic Rare Events Search with Superconducting
Thermometers phase II, is an experiment searching for Dark Matter. In the LNGS
facility in Gran Sasso, Italy, a cryogenic detector setup is operated in order
to detect WIMPs by elastic scattering off nuclei, generating phononic lattice
excitations and scintillation light. The thermometers used in the experiment
consist of a tungsten thin-film structure evaporated onto the CaWO4 absorber
crystal. The process of evaporation causes a decrease in the scintillation
light output. This, together with the need of a big-scale detector production
for the upcoming EURECA experiment lead to investigations for producing
thermometers on smaller crystals which are glued onto the absorber crystal. In
our Run 31 we tested composite detectors for the first time in the Gran Sasso
setup. They seem to produce higher light yields as hoped and could provide an
additional time based discrimination mechanism for low light yield clamp
events.Comment: Proceedings of the Thirteenth International Workshop on Low
Temperature Detectors 4 pages, 9 figure
Basic principles of stable isotope analysis in humanitarian forensic science.
While the identity of a victim of a localized disaster â such as a train or bus crash â may be established quickly through personal effects, fingerprints, dental records, and a comparison of decedent DNA to family reference specimen DNA, a different scenario presents itself in mass disasters, such as the Asian Tsunami of 2004. In the aftermath of the tsunami, visual appearance was initially used to assign âforeignâ or âindigenousâ classifications to the remains of thousands of victims. However, this visual identification approach was undermined by the speed with which bodies deteriorated under the hot and humid conditions. Time was spent populating ante-mortem DNA databases for different nationalities, which led to problems when creating a post-mortem DNA database because recovery of viable DNA was compromised due to rapid decomposition. As a consequence, only 1.3% of victims were identified by DNA; in contrast, 61% were identified based on dental examination, although this process took several months and a significant number of deceased from the 2004 Asian Tsunami still remain to be identified
Motivation and Knowledge Sharing through Social Media within Danish Organizations
Part 3: Creating Value through ApplicationsInternational audienceBased on an empirical quantitative study, this article investigates employee motivation in Danish companies and aims at determining which factors affect employeesâ knowledge sharing through social media in a working environment. Our findings pinpoint towards the potential social media have for enhancing internal communication, knowledge sharing and collaboration in organizations, but the adoption is low, at this point, due to mainly organizational and individual factors. Technological factors do not seem to affect employeesâ motivation for knowledge sharing as much as previous research has found, but it is the influence from the combination of individual and organizational factors, which affect the adoption of the platforms. A key finding in the study is that knowledge sharing is not a âsocial dilemmaâ as previous studies have found. The study shows a positive development in employeesâ willingness to share knowledge, because knowledge sharing is considered more beneficial than to hoard it
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