3,531 research outputs found
Ethyl 4-hydroxy-2,6-diphenyl-1-(2-thiomorpholinopropanoyl)-1,2,5,6-tetrahydropyridine-3-carboxylate
In the title compound, C27H32N2O4S, the thiomorpholine ring adopts a chair conformation and the tetrahydropyridine ring is in a distorted envelope conformation. The molecular structure is stabilized by an intramolecular O—H⋯O interaction and the crystal packing is stabilized by an intermolecular C—H⋯O interaction, generating an S(6) motif and a dimer of the type R
2
2(18), respectively
Bocavirus Infection in Hospitalized Children, South Korea
This study presents the first evidence of human bocavirus infection in South Korean children. The virus was detected in 27 (8.0%) of 336 tested specimens, including 17 (7.5%) of 225 virus-negative specimens, collected from children with acute lower respiratory tract infection
Sub-100-as timing jitter optical pulse trains from mode-locked Er-fiber lasers
We demonstrate sub-100-attosecond timing jitter optical pulse trains
generated from free-running, 77.6-MHz repetition-rate, mode-locked Er-fiber
lasers. At -0.002(\pm0.001) ps2 net cavity dispersion, the rms timing jitter is
70 as (224 as) integrated from 10 kHz (1 kHz) to 38.8 MHz offset frequency,
when measured by a 24-as-resolution balanced optical cross-correlator. To our
knowledge, this result corresponds to the lowest rms timing jitter measured
from any mode-locked fiber lasers so far. The measured result also agrees
fairly well with the Namiki-Haus analytic model of quantum-limited timing
jitter in stretched-pulse fiber lasers.Comment: 4 pages, 2 figures, to appear in Optics Letter
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Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization.
Glaucoma is characterized by a progressive optic nerve degeneration and retinal ganglion cell loss, but the underlying biological basis for the accompanying neurodegeneration is not known. Accumulating evidence indicates that structural and functional abnormalities of astrocytes within the optic nerve head (ONH) have a role in glaucomatous neurodegeneration. Here, we investigate the impact of activation of cyclic adenosine 3',5'-monophosphate (cAMP)/protein kinase A (PKA) pathway on mitochondrial dynamics of ONH astrocytes exposed to oxidative stress. ONH astrocytes showed a significant loss of astrocytic processes in the glial lamina of glaucomatous DBA/2J mice, accompanied by basement membrane thickening and collagen deposition in blood vessels and axonal degeneration. Serial block-face scanning electron microscopy data analysis demonstrated that numbers of total and branched mitochondria were significantly increased in ONH astrocytes, while mitochondrial length and volume density were significantly decreased. We found that hydrogen peroxide- (H2O2-) induced oxidative stress compromised not only mitochondrial bioenergetics by reducing the basal and maximal respiration but also balance of mitochondrial dynamics by decreasing dynamin-related protein 1 (Drp1) protein expression in rat ONH astrocytes. In contrast, elevated cAMP by dibutyryl-cAMP (dbcAMP) or isobutylmethylxanthine treatment significantly increased Drp1 protein expression in ONH astrocytes. Elevated cAMP exacerbated the impairment of mitochondrial dynamics and reduction of cell viability to oxidative stress in ONH astrocytes by decreasing optic atrophy type 1 (OPA1), and mitofusin (Mfn)1/2 protein expression. Following combined treatment with H2O2 and dbcAMP, PKA inhibition restored mitochondrial dynamics by increasing mitochondrial length and decreasing mitochondrial number, and this promoted cell viability in ONH astrocytes. Also, PKA inhibition significantly promoted Akt/Bax phosphorylation and Mfn1/2 oligomerization in ONH astrocytes. These results suggest that modulation of the cAMP/PKA signaling pathway may have therapeutic potential by activating Akt/Bax phosphorylation and promoting Mfn1/2 oligomerization in glaucomatous ONH astrocytes
Nicolau Syndrome after Intramuscular Injection: 3 Cases
Nicolau syndrome is a rare complication of intramuscular injection consisting of ischemic necrosis of skin, soft tissue, and muscular tissue that arises locoregionally. The characteristic pattern is pain around the injection site, developing into erythema, a livedoid dermatitis patch, and necrosis of the skin, subcutaneous fat, and muscle tissue. Three patients were injected with drugs (diclofenac sodium, ketoprofen, meperidine) for pain relief. Three patients complained of pain, and a skin lesion was observed, after which necrosis developed on their buttocks. Each patient underwent debridement and coverage. The wound healed uneventfully. We report three cases of Nicolau syndrome in the buttocks following diclofenac intramuscular injection
Regge phenomenology of pion photoproduction off the nucleon at forward angles
We present a Regge model for pion photoproduction which is basically free of
parameters within the framework of the s-channel helicity amplitude. We use
coupling constants of all exchanged mesons determined from empirical decay
widths or from the SU(3) relations together with consistency check with
existing estimates that are widely accepted in other reaction processes. Cross
sections and spin polarization asymmetries at various photon energies are
analyzed and results are obtained in better agreement with experimental data
without referring to any fitting procedure.Comment: 19 pages, 20 figures, two column, revtex
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