4,927 research outputs found
Domain-mediated interactions for protein subfamily identification
Within a protein family, proteins with the same domain often exhibit different cellular functions, despite the shared evolutionary history and molecular function of the domain. We hypothesized that domain-mediated interactions (DMIs) may categorize a protein family into subfamilies because the diversified functions of a single domain often depend on interacting partners of domains. Here we systematically identified DMI subfamilies, in which proteins share domains with DMI partners, as well as with various functional and physical interaction networks in individual species. In humans, DMI subfamily members are associated with similar diseases, including cancers, and are frequently co-associated with the same diseases. DMI information relates to the functional and evolutionary subdivisions of human kinases. In yeast, DMI subfamilies contain proteins with similar phenotypic outcomes from specific chemical treatments. Therefore, the systematic investigation here provides insights into the diverse functions of subfamilies derived from a protein family with a link-centric approach and suggests a useful resource for annotating the functions and phenotypic outcomes of proteins.11Ysciescopu
Age-related Changes in the Cellular Level of Amylase and Protein Synthesis in the Rat Parotid Gland
Age-related changes in the cellular content of secretory proteins and protein synthesis were studied in parotid glands of rats of various ages. The secretory protein content (determined by measuring the level of α-amylase activity) and the synthesis of proteins (assayed by the rate of incorporation of 3H-leucine into acid-insoluble proteins) decline with increasing age. Morphological and radioautographic studies of the gland indicate that the decline in protein synthesis is due to the reduction in the ability of secretory cells to synthesize proteins.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67245/2/10.1177_00220345810600031401.pd
Experimental constraints on the parameter space of the next-to-minimal supersymmetric standard model at LEP 2
We search for the neutral Higgs sector of the next-to-minimal supersymmetric
standard model at LEP 2. At the tree level any experimental constraints on
cannot be set by the Higgs search at LEP 2 with = 175
GeV, whereas at LEP 2 with = 192 GeV can be set by an
experimental constraint. Furthermore the tree level parameter space of the
model can be completely explored by the Higgs search at LEP 2 with =
205 GeV. Radiative corrections both to the neutral Higgs boson masses and to
the relevant couplings for the scalar Higgs productions give large
contributions to the production cross sections of the scalar Higgs bosons at
the tree level. The tree level situation at LEP 2 with = 192 GeV as
well as with = 205 GeV can be drastically changed by these effects.
We expect that a small region of the 1-loop level parameter space of the model
via the scalar Higgs production can be explored by the Higgs search at LEP 2.Comment: 14 pages (3 figures are included
Structural and magnetic study of a dilute magnetic semiconductor: Fe doped CeO2 nanoparticles
This paper reports the effect of Fe doping on the structure and room
temperature ferromagnetism of CeO2 nanoparticles. X-ray diffraction and
selective area electron diffraction measurement reflects that Ce1-xFexO2 (x =
0.0 - 0.07) nanoparticles exhibit single phase nature with cubic structure and
none of the sample showed the presence of any secondary phase. The mean
particle size calculated by using a transmission electron microscopy
measurement was found to increase with increase in Fe content. DC magnetization
measurements performed at room temperature indicates that all the samples
exhibit ferromagnetism. The saturation magnetic moment has been found to
increase with an increase in the Fe content.Comment: 16 Pages, 5 figure, 1 Table, Accepted in JN
Mitigating smart card fault injection with link-time code rewriting: a feasibility study
We present a feasibility study to protect smart card software against fault-injection attacks by means of binary code rewriting. We implemented a range of protection techniques in a link-time rewriter and evaluate and discuss the obtained coverage, the associated overhead and engineering effort, as well as its practical usability
PCN129 Mapping the Cancer-Specific EORTC QLQ-C30 and EORTC QLQ-BR23 to the Generic EQ-5D in Metastatic Breast Cancer Patients
CFD Simulation of Liquid-solid Multiphase Flow in Mud Mixer
In the present study, a computational fluid dynamics (CFD) simulation was performed to analyze the mixing phenomena associated with multi-phase flow in a mud mixing system. For the validation of CFD simulation, firstly a liquid-solid multiphase flow inside horizontal pipe was simulated and compared with the experiments and other numerical simulations. And then, the multiphase flow simulation was carried out for the mud mixer in the drilling handling system in order to understand mixing phenomena and predict the mixing efficiency. For the modeling and simulation, a commercial software, STAR-CCM+, based on a finite-volume method (FVM) was adopted. The simulation results for liquid-solid flow inside the pipe shows a good agreement with the experimental data. With the same multiphase model, the simulation for mud mixer is performed under the generalized boundary condition and then pressure drop through the mud mixer will be discussed
N=2 Topological Yang-Mills Theory on Compact K\"{a}hler Surfaces
We study a topological Yang-Mills theory with fermionic symmetry. Our
formalism is a field theoretical interpretation of the Donaldson polynomial
invariants on compact K\"{a}hler surfaces. We also study an analogous theory on
compact oriented Riemann surfaces and briefly discuss a possible application of
the Witten's non-Abelian localization formula to the problems in the case of
compact K\"{a}hler surfaces.Comment: ESENAT-93-01 & YUMS-93-10, 34pages: [Final Version] to appear in
Comm. Math. Phy
Asian and European American Cultural Values, Bicultural Competence, and Attitudes toward seeking Professional Psychological Help among Asian American Adolescents
The authors examined the extent to which Asian American adolescents who were living in Hawaii adhered to Asian and European American cultural values in relation to mental health variables including collective self-esteem (membership, private, public, importance to identity), cognitive flexibility, general self-efficacy, and attitudes toward seeking professional psychological help. Results and implications for counselors are discussed
The Glauber model and the heavy ion reaction cross section
We reexamine the Glauber model and calculate the total reaction cross section
as a function of energy in the low and intermediate energy range, where many of
the corrections in the model, are effective.
The most significant effect in this energy range is by the modification of
the trajectory due to the Coulomb field. The modification in the trajectory due
to nuclear field is also taken into account in a self consistent way.
The energy ranges in which particular corrections are effective, are
quantified and it is found that when the center of mass energy of the system
becomes 30 times the Coulomb barrier, none of the trajectory modification to
the Glauber model is really required.
The reaction cross sections for light and heavy systems, right from near
coulomb barrier to intermediate energies have been calculated. The exact
nuclear densities and free nucleon-nucleon (NN) cross sections have been used
in the calculations. The center of mass correction which is important for light
systems, has also been taken into account.
There is an excellent agreement between the calculations with the modified
Glauber model and the experimental data. This suggests that the heavy ion
reactions in this energy range can be explained by the Glauber model in terms
of free NN cross sections without incorporating any medium modification.Comment: RevTeX, 21 pages including 9 Postscript figures, submitted to Phys.
Rev.
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