Concert recording 2019-10-29

[Track 1]. From Deux melodies hebraiques. Kaddish / Maurice Ravel -- [Track 2]. From Morike Liederbuch. Der Genesene an die Hoffnung [Track 3]. Denk\u27es, o Seele! [Track 4]. Wo find\u27 ich Trost [Track 5]. Gebet / Hugo Wolf -- [Track 6]. Canata. Prelude Rondo (Peter go ring dem bells) Recitative (Sometimes I feel like a motherless child) Air (Let us break bread together) Toccata (Ride on King Jesus) / John Carter -- [Track 7]. Korean spiritual songs. Yeo-hun wanun nae mokzasini (Jehovah is my Shepherd) Psalm 23 / Unyoung Na -- [Track 8]. Narul badu opsoseo (Lord please take me) / Deok-Shin Choi -- [Track 9]. From Chants de Terre et de Ciel. I. Bail avec Mi [Track 10]. IV. Resurrection / Olivier Messiaen

"Alternative Educational Movement" of Korea Viewed from an Angle of Modernization

In der modernen Entwicklungsgeschichte Südkoreas, die auf einem radikalen Wachstum gründet, wird nun ein neues Kapitel aufgeschlagen. Die alte, nur an Wachstum und Armutsbekämpfung orientierte Modernisierungsstrategie tritt langsam in den Hintergrund, während neue Modernisierungsimpulse in der südkoreanischen Gesellschaft erwachen. Auch in dem pädagogischen Bereich ist diese Wandlung deutlich erkennbar. In dieser Hinsicht ist die "Alternativpädagogische Bewegung" in Südkorea Mitte der 1990er Jahre mit ihrem eigenen Entstehungskontext entstanden. Diese Faktoren, die die alternativpädagogische Bewegung entstehen ließen, werden aus den historischen, soziokulturellen und politischen Aspekten analysiert. Dabei werden die Merkmale und Wandlungstendenzen der alternativpädagogischen Bewegung Südkoreas herausgearbeitet. Das Ergebnis dieser Forschung bietet die Einblicke in die neue pädagogische Kultur Südkoreas, die durch einen innenorientierten Modernisierungsprozess charakterisiert sind.In the history of modern South Korea and its radical growth a new page has been opened. Its former strategy of modernization had solely centred on the growth of the nation's economy and a decrease in poverty. In Korean society new impulses of modernization have meanwhile gained ground against the slowly receding older patterns of modernization. This change is clearly seen in education as weIl. The "Alternative Education Movement", too, took its rise from this new type of modernization in the mid-1990s. These unique factors in the emergence of the "A.E.M." are analyzed in my thesis against the background of the respective historical, socio-cultural, and political aspects. In my analysis the distinctive features and trends of change in the "A.E.M." of Korea are brought to light. As a result my research presents a new dimension in the educational culture of South Korea, which can be interpreted on the basis of its internally-oriented modernization

Two novel mutations of Wiskott–Aldrich syndrome: the molecular prediction of interaction between the mutated WASP L101P with WASP-interacting protein by molecular modeling

AbstractWiskott–Aldrich syndrome (WAS) is an X-linked disorder characterized by eczema, thrombocytopenia and increased susceptibility of infections, with mutations of the WAS gene being responsible for WAS and X-linked thrombocytopenia. Herein, two novel mutations of WAS at T336C on exon 3, and at 1326–1329, a G deletion on exon 10, resulting in L101P missense mutation and frameshift mutation 444 stop, respectively, are reported. The affected patients with either mutation showed severe suppression of WAS protein (WASP) levels, T cell proliferation, and CFSE-labeled T cells division. Because WASP L101 have not shown direct nuclear Overhauser effect (NOE) contact with the WASP-interacting protein (WIP) in NMR spectroscopy, molecular modeling was performed to evaluate the molecular effect of WASP P101 to WIP peptide. It is presumed that P101 induced a conformational change in the Q99 residue of WASP and made the side chain of Q99 move away from the WIP peptide, resulting in disruption of the hydrogen bond between Q99 WASP and Y475 WIP. A possible model for the molecular pathogenesis of WAS has been proposed by analyzing the interactions of WASP and WIP using a molecular modeling study

Meteorin regulates mesendoderm development by enhancing nodal expression

During gastrulation, distinct lineage specification into three germ layers, the mesoderm, endoderm and ectoderm, occurs through an elaborate harmony between signaling molecules along the embryonic proximo-distal and anterior-posterior axes, and Nodal signaling plays a key role in the early embryonic development governing embryonic axis formation, mesoderm and endoderm specification, and left-right asymmetry determination. However, the mechanism by which Nodal expression is regulated is largely unknown. Here, we show that Meteorin regulates Nodal expression and is required for mesendoderm development. It is highly expressed in the inner cell mass of blastocysts and further in the epiblast and extra-embryonic ectoderm during gastrulation. Genetic ablation of the Meteorin gene resulted in early embryonic lethality, presumably due to impaired lineage allocation and subsequent cell accumulation. Embryoid body culture using Meteorin-null embryonic stem (ES) cells showed reduced Nodal expression and concomitant impairment of mesendoderm specification. Meteorin-null embryos displayed reduced levels of Nodal transcripts before the gastrulation stage, and impaired expression of Goosecoid, a definitive endoderm marker, during gastrulation, while the proximo-distal and anterior-posterior axes and primitive streak formation were preserved. Our results show that Meteorin is a novel regulator of Nodal transcription and is required to maintain sufficient Nodal levels for endoderm formation, thereby providing new insights in the regulation of mesendoderm allocation.open1113sciescopu

Concert recording 2021-10-18

[Track 1]. From lo song pur solo, H. 344. Solo cantata for soprano and basso continuo. I. Recitiative, lo son pur solo ; II. Aria, Sono amante / Alessandro Scarlatti - From Szene aus Goethe\u27s Faust. Gretchens Bitte, D. 564 / Franz Schubert -- Deh pietoso, oh addolorata / Giuseppe Verdi -- From Song of Almah. I. Rose of Sharon ; III. Cedar Lebanon / Andrew Beall. [Track 2]. Duet. Dirait-on from Les chansons des roses / Morten Lauridsen ; Puisqu\u27ici bas toute âme, Op. 10, No. 1 / Gabriel Fauré -- Korean art song collection. Ihwau (Pear blossom rain) ; Betle Norae (Loom song) / Won-Joo Lee -- From the musical Salzzagi opseoye. Salzzagi opseoye (Softly, please come) / Chang-Kwon Choi

Concert recording 2019-03-29

[Track 1]. Ionhontsiá:te (Mother earth). Grandmother moon for soprano and cello / Dawn Ierihò:kwats Avery -- [Track 2]. Lieux ecartez, paisible solitude from Céphale et Procris / Élisabeth Jacquet de La Guerre -- [Track 3]. Four Dickinson songs / Lori Laitman Emily Dickinson -- [Track 4]. Guendae Issume (Because you are here) / Sunae Kim -- [Track 5]. Lee Eung and Arirang (Arirang) / YoungRan Park -- [Track 6]. She tell her love [Track 7]. A boy and a girl / Stephen Caldwell -- [Track 8]. Morgen, op. 27, no. 4 [Track 9]. Heimliche Aufforderung, op. 27, no. 3 / Richard Strauss -- [Track 10]. Suleika, op. 14, no. 1 / Franz Schubert -- [Track 11]. Philine: Singet nicht in Trauertönen, op. 98a, no. 7 / Robert Schumann -- [Track 12]. Mignon: Kennst du das Land / Hugo Wolf -- [Track 13]. From Song of Almah. III. Cedar of Lebanon / Andrew Beall

Inhibition of c-Jun NH(2)-terminal kinase or extracellular signal-regulated kinase improves lung injury

BACKGROUND: Although in vitro studies have determined that the activation of mitogen-activated protein (MAP) kinases is crucial to the activation of transcription factors and regulation of the production of proinflammatory mediators, the roles of c-Jun NH(2)-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) in acute lung injury have not been elucidated. METHODS: Saline or lipopolysaccharide (LPS, 6 mg/kg of body weight) was administered intratracheally with a 1-hour pretreatment with SP600125 (a JNK inhibitor; 30 mg/kg, IO), or PD98059 (an MEK/ERK inhibitor; 30 mg/kg, IO). Rats were sacrificed 4 hours after LPS treatment. RESULTS: SP600125 or PD98059 inhibited LPS-induced phosphorylation of JNK and ERK, total protein and LDH activity in BAL fluid, and neutrophil influx into the lungs. In addition, these MAP kinase inhibitors substantially reduced LPS-induced production of inflammatory mediators, such as CINC, MMP-9, and nitric oxide. Inhibition of JNK correlated with suppression of NF-κB activation through downregulation of phosphorylation and degradation of IκB-α, while ERK inhibition only slightly influenced the NF-κB pathway. CONCLUSION: JNK and ERK play pivotal roles in LPS-induced acute lung injury. Therefore, inhibition of JNK or ERK activity has potential as an effective therapeutic strategy in interventions of inflammatory cascade-associated lung injury

Autonomous control of terminal erythropoiesis via physical interactions among erythroid cells

AbstractIn vitro erythropoiesis has been studied extensively for its application in the manufacture of transfusable erythrocytes. Unfortunately, culture conditions have not been as effective as in vivo growth conditions, where bone marrow macrophages are known to be a key regulator of erythropoiesis. This study focused on the fact that some erythroblasts are detached from macrophages and only contact other erythroblasts. We hypothesized that additional factors regulate erythroblasts, likely through either physical contact or secreted factors. To further elucidate these critical factors, human erythroblasts derived from cord blood were cultured at high density to mimic marrow conditions. This growth condition resulted in a significantly increased erythroid enucleation rate and viability. We found several novel contact-related signals in erythroblasts: intercellular adhesion molecule-4 (ICAM-4) and deleted in liver cancer-1 (DLC-1). DLC-1, a Rho-GTPase-activating protein, has not previously been reported in erythroid cells, but its interaction with ICAM-4 was demonstrated here. We further confirmed the presence of a secreted form of human ICAM-4 for the first time. When soluble ICAM-4 was added to media, cell viability and enucleation increased with decreased nuclear dysplasia, suggesting that ICAM-4 is a key factor in contact between cells. These results highlight potential new mechanisms for autonomous control of erythropoiesis. The application of these procedures to erythrocyte manufacturing could enhance in vitro erythrocyte production for clinical use