The Economics of the Right to Be Forgotten

Scholars and practitioners debate whether to expand the scope of the right to be forgotten—the right to have certain links removed from search results—to encompass global search results. The debate centers on the assumption that the expansion will increase the incidence of link removal, which reinforces privacy while hampering free speech. We develop a game-theoretic model to show that the expansion of the right to be forgotten can reduce the incidence of link removal. We also show that the expansion does not necessarily enhance the welfare of individuals who request removal and that it can either improve or reduce societal welfare. Our analysis has implications for understanding the impact of the global expansion of the right to be forgotten on privacy and free speech

Plasma transforming growth factor β1 as a biochemical marker to predict the persistence of atrial fibrillation after the surgical maze procedure

ObjectivesThe Cox maze procedure was developed as a surgical treatment for atrial fibrillation. However, atrial fibrillation recurs in some patients, and atrial remodeling in the form of fibrosis can lead to perpetuation of atrial fibrillation. To identify the predictor of the persistence of atrial fibrillation after the maze procedure using cryoablation, we evaluated the preoperative plasma transforming growth factor β1. We also examined the correlations between plasma transforming growth factor β1 levels and the degree of atrial fibrosis.MethodsPreoperative plasma transforming growth factor β1 levels were measured in 86 consecutive patients (age, 54 ± 12 years) who underwent both the open heart operation for valvular heart disease and the surgical maze procedure with cryoablation for persistent atrial fibrillation. We measured the degree of fibrosis from the tissue of the left atrium.ResultsAt 1 year's follow-up, 10 of 86 patients had persistent atrial fibrillation. Patients with persistent atrial fibrillation had higher preoperative plasma transforming growth factor β1 levels than the patients with sinus rhythm (0.44 ± 0.29 vs 0.32 ± 0.15 ng/mL, P = .03). Patients with persistent atrial fibrillation had higher mRNA expressions of collagen III and lower mRNA expressions of atrial natriuretic peptide than those with sinus rhythm, and the plasma transforming growth factor β1 levels correlated with the degree of fibrosis in the left atrium (r = 0.497, P = .022). Multiple logistic regression analysis revealed that plasma transforming growth factor β1 levels were independently associated with the postoperative persistence of atrial fibrillation at 1 year's follow-up.ConclusionsPreoperative plasma transforming growth factor β1 levels could be used to predict the persistence of atrial fibrillation at 1 year's follow-up after the surgical maze procedure by using cryoablation. Preoperative plasma transforming growth factor β1 levels were correlated with the degree of fibrosis in the left atria of patients with mitral valvular heart disease

Periprocedural Myocardial Infarction After Retrograde Approach for Chronic Total Occlusion of Coronary Artery: Demonstrated by Cardiac Magnetic Resonance Imaging

A retrograde approach through the collateral channels was recently proposed as one of the most promising current techniques for percutaneous coronary intervention of chronic total occlusion in coronary arteries (CTO). This report describes the case of a 68-year-old man in whom CTO was successfully crossed with a wire by the retrograde approach using septal collateral, but the patient suffered from a complication with septal myocardial infarction demonstrated by cardiac magnetic resonance imaging

Polygenic risk score validation using Korean genomes of 265 early-onset acute myocardial infarction patients and 636 healthy controls

Background The polygenic risk score (PRS) developed for coronary artery disease (CAD) is known to be effective for classifying patients with CAD and predicting subsequent events. However, the PRS was developed mainly based on the analysis of Caucasian genomes and has not been validated for East Asians. We aimed to evaluate the PRS in the genomes of Korean early-onset AMI patients (n = 265, age <= 50 years) following PCI and controls (n = 636) to examine whether the PRS improves risk prediction beyond conventional risk factors. Results The odds ratio of the PRS was 1.83 (95% confidence interval [CI]: 1.69-1.99) for early-onset AMI patients compared with the controls. For the classification of patients, the area under the curve (AUC) for the combined model with the six conventional risk factors (diabetes mellitus, family history of CAD, hypertension, body mass index, hypercholesterolemia, and current smoking) and PRS was 0.92 (95% CI: 0.90-0.94) while that for the six conventional risk factors was 0.91 (95% CI: 0.85-0.93). Although the AUC for PRS alone was 0.65 (95% CI: 0.61-0.69), adding the PRS to the six conventional risk factors significantly improved the accuracy of the prediction model (P = 0.015). Patients with the upper 50% of PRS showed a higher frequency of repeat revascularization (hazard ratio = 2.19, 95% CI: 1.47-3.26) than the others. Conclusions The PRS using 265 early-onset AMI genomes showed improvement in the identification of patients in the Korean population and showed potential for genomic screening in early life to complement conventional risk prediction

Impact of multivessel versus single-vessel disease on the association between low diastolic blood pressure and mortality after acute myocardial infarction with revascularization

Background: Previous studies demonstrated a J-shaped relationship between low diastolic blood pressure (DBP) and adverse clinical outcomes in patients with acute myocardial infarction (AMI) that was sensitive to revascularization. Hypothesized herein, was that this relationship differs between patients with multivessel disease (MVD) and those with single-vessel disease due to differing degrees of myocardial ischemic burden. Methods: Among 9,983 AMI patients from the Korea Acute Myocardial Infarction Registry database who underwent percutaneous coronary intervention and were followed up for a median duration of 3.2 years, average on-treatment DBP was calculated at admission, discharge, and every scheduled visit and divided into these parameters: < 70 mmHg, 70–74 mmHg, 75–79 mmHg, and ≥ 80 mmHg. The relationship between average on-treatment DBP and clinical outcomes including all-cause death, cardiovascular (CV) death, non-CV death, and hospitalization for heart failure was analyzed using the Cox regression models adjusted for clinical covariates. Results: In patients with MVD, all-cause death (hazard ratio [HR]: 1.47; 95% confidence interval [CI]: 1.06–2.04, p = 0.012) and CV death (HR: 1.59; 95% CI: 1.02–2.46, p = 0.027) were significantly increased in patients with a DBP < 70 mmHg, showing a J-shaped relationship. However, these findings were not significant for single-vessel disease. On a sensitivity analysis excluding subjects with a baseline SBP < 120 mmHg, an increased risk of a low DBP < 70 mmHg remained in MVD. Conclusions: The J-shaped relationship between low DBP and adverse clinical outcomes in AMI patients who underwent revascularization persisted in MVD, which has a high ischemic burden. These high-risk patients require cautious treatment

Online Appendices for “Endogenous Choice of a Mediator”

This Appendix provides proofs that were omitted from Appendix A. Note that I use double scripts on µ specifying both y and z, i.e., µy,z, instead of µy to prevent any confusion. Also, p denotes the prior probability of the strong type for both players. Proof of Lemma 6. [For Proposition 1: When p ′ only if y ≥ y(p) because ≤ p ∗ ] For Case 1 p < p ′: U1(µy,0|s) ≥ 0 if and U1(µy,0|s) = pµy,0(d1, ss)u1(d1, ss) + (1 − p)µy,0(d1, sw)u1(d1, sw) ≥

Endogenous Choice of a Mediator: Inefficiency of Bargaining ∗ [Job Market Paper]

In this paper, I build a theory of how privately informed parties choose mediators, which is a topic that is not well developed in the literature. I consider a bargaining problem in which two parties with private information about their types negotiate the choice of a mediator. A mediator, in my context, is equivalent to a communication mechanism that respects private information. I use a two-pronged approach, cooperative and noncooperative, to show that the selection of a mediator is endogenous and is driven by the “information leakage ” problem. With the noncooperative approach, I consider a threat-secure mediator who survives a vote against any alternative mediators. For a benchmark class of examples, I show that the threat-secure mediator exists and is unique. In the cooperative approach, I find that there exists a unique neutral bargaining solution – an incomplete information version of the Nash bargaining solution. I establish that the selected mediators in both approaches are the same. Moreover, the selected mediator is – among all the interim incentive efficient mediators – the worst for the parties ex ante and the least peaceful mediator. Therefore, I argue that the very process of selecting a mediator may exhibit an inherent inefficiency in bargaining if the parties already know their types. Thi

The Economics of the Right to Be Forgotten

Scholars and practitioners debate whether to expand the scope of the right to be forgotten—the right to have certain links removed from search results—to encompass global search results. The debate centers on the assumption that the expansion will increase the incidence of link removal, which reinforces privacy while hampering free speech. We develop a game-theoretic model to show that the expansion of the right to be forgotten can reduce the incidence of link removal. We also show that the expansion does not necessarily enhance the welfare of individuals who request removal and that it can either improve or reduce societal welfare. Our analysis has implications for understanding the impact of the global expansion of the right to be forgotten on privacy and free speech

The Economics of the Right to Be Forgotten

Scholars and practitioners debate whether to expand the scope of the right to be forgotten—the right to have certain links removed from search results—to encompass global search results. The debate centers on the assumption that the expansion will increase the incidence of link removal, which reinforces privacy while hampering free speech. We develop a game-theoretic model to show that the expansion of the right to be forgotten can reduce the incidence of link removal. We also show that the expansion does not necessarily enhance the welfare of individuals who request removal and that it can either improve or reduce societal welfare. Our analysis has implications for understanding the impact of the global expansion of the right to be forgotten on privacy and free speech