7,133 research outputs found
A single-center cost analysis of treating primary and metastatic brain cancers with either brain laser interstitial thermal therapy (LITT) or craniotomy
Time Evolution of Entropy in Gravitational Collapse
We study the time evolution of the entropy of a collapsing spherical domain
wall, from the point of view of an asymptotic observer, by investigating the
entropy of the entire system (i.e. domain wall and radiation) and induced
radiation alone during the collapse. By taking the difference, we find the
entropy of the collapsing domain wall, since this is the object which will form
a black hole. We find that for large values of time (times larger than
), the entropy of the collapsing domain wall is a constant,
which is of the same order as the Bekenstein-Hawking entropy.Comment: 9 pages, 6 figure
Validation of preoperative variables and stratification of patients to help predict benefit of cytoreductive nephrectomy in the targeted therapy ERA
Profiling of oligolignols reveals monolignol coupling conditions in lignifying poplar xylem
Lignin is an aromatic heteropolymer, abundantly present in the walls of secondary thickened cells. Although much research has been devoted to the structure and composition of the polymer to obtain insight into lignin polymerization, the low-molecular weight oligolignol fraction has escaped a detailed characterization. This fraction, in contrast to the rather inaccessible polymer, is a simple and accessible model that reveals details about the coupling of monolignols, an issue that has raised considerable controversy over the past years. We have profiled the methanol-soluble oligolignol fraction of poplar (Populus spp.) xylem, a tissue with extensive lignification. Using liquid chromatography-mass spectrometry, chemical synthesis, and nuclear magnetic resonance, we have elucidated the structures of 38 compounds, most of which were dimers, trimers, and tetramers derived from coniferyl alcohol, sinapyl alcohol, their aldehyde analogs, or vanillin. All structures support the recently challenged random chemical coupling hypothesis for lignin polymerization. Importantly, the structures of two oligomers, each containing a γ-p-hydroxybenzoylated syringyl unit, strongly suggest that sinapyl p-hydroxybenzoate is an authentic precursor for lignin polymerization in poplar
Slender-ribbon theory
Ribbons are long narrow strips possessing three distinct material length
scales (thickness, width, and length) which allow them to produce unique shapes
unobtainable by wires or filaments. For example when a ribbon has half a twist
and is bent into a circle it produces a M\"obius strip. Significant effort has
gone into determining the structural shapes of ribbons but less is know about
their behavior in viscous fluids. In this paper we determine, asymptotically,
the leading-order hydrodynamic behavior of a slender ribbon in Stokes flows.
The derivation, reminiscent of slender-body theory for filaments, assumes that
the length of the ribbon is much larger than its width, which itself is much
larger than its thickness. The final result is an integral equation for the
force density on a mathematical ruled surface, termed the ribbon plane, located
inside the ribbon. A numerical implementation of our derivation shows good
agreement with the known hydrodynamics of long flat ellipsoids, and
successfully captures the swimming behavior of artificial microscopic swimmers
recently explored experimentally. We also study the asymptotic behavior of a
ribbon bent into a helix, that of a twisted ellipsoid, and we investigate how
accurately the hydrodynamics of a ribbon can be effectively captured by that of
a slender filament. Our asymptotic results provide the fundamental framework
necessary to predict the behavior of slender ribbons at low Reynolds numbers in
a variety of biological and engineering problems.This research was funded in part by the European Union through a Marie Curie CIG Grant and the Cambridge Trusts.This is the author accepted manuscript. The final version is available from American Institute of Physics via http://dx.doi.org/10.1063/1.493856
Amyloid positron emission tomography candidates may focus more on benefits than risks of results disclosure
IntroductionGiven mounting calls to disclose biomarker test results to research participants, we explored factors underlying decisions by patients with mild cognitive impairment to receive amyloid imaging results.MethodsProspective, qualitative interviews were conducted with 59 participants (30 = mild cognitive impairment patients, 29 = care partners) from the scan arm of a randomized controlled trial on the effects of amyloid PET results disclosure in an Alzheimer Disease Research Center setting.ResultsSixty‐three percent of the participants were female, with an average age of 72.9 years, and most had greater than a high school level of education (80%). Primary motivations included: (1) better understanding one’s mild cognitive impairment etiology and prognosis to plan ahead, and (2) learning one’s brain amyloid status for knowledge’s sake, regardless of whether the information is actionable. Most participants demonstrated an adequate understanding of the scan’s limitations, yet instances of characterizing amyloid PET as a definitive test for Alzheimer’s disease occurred. Mention of potential drawbacks, such as negative psychological outcomes, was minimal, even among care partners.DiscussionFindings demonstrate a risk of disproportionate focus on possible benefits of testing among amyloid scan candidates and suggest a need to clearly emphasize the limitations of amyloid PET when counseling cognitively impaired patients and their families before testing. Future research should examine whether minimizing drawbacks at the pre‐imaging stage has adverse consequences on results disclosure.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152635/1/dad2jdadm201805003.pd
- …