Failure to activate the IFN-beta promoter by a paramyxovirus lacking an interferon antagonist

It is generally thought that pathogen-associated molecular patterns (PAMPs) responsible for triggering interferon (IFN) induction are produced during virus replication and, to limit the activation of the IFN response by these PAMPs, viruses encode antagonists of IFN induction. Here we have studied the induction of IFN by parainfluenza virus type 5 (PIV5) at the single-cell level, using a cell line expressing GFP under the control of the IFN-β promoter. We demonstrate that a recombinant PIV5 (termed PIV5-VΔC) that lacks a functional V protein (the viral IFN antagonist) does not activate the IFN-β promoter in the majority of infected cells. We conclude that viral PAMPs capable of activating the IFN induction cascade are not produced or exposed during the normal replication cycle of PIV5, and suggest instead that defective viruses are primarily responsible for inducing IFN during PIV5 infection in this syste

Asymptotic forms for hard and soft edge general β\beta conditional gap probabilities

An infinite log-gas formalism, due to Dyson, and independently Fogler and Shklovskii, is applied to the computation of conditioned gap probabilities at the hard and soft edges of random matrix $\beta$-ensembles. The conditioning is that there are $n$ eigenvalues in the gap, with $n \ll |t|$, $t$ denoting the end point of the gap. It is found that the entropy term in the formalism must be replaced by a term involving the potential drop to obtain results consistent with known asymptotic expansions in the case $n=0$. With this modification made for general $n$, the derived expansions - which are for the logarithm of the gap probabilities - are conjectured to be correct up to and including terms O$(\log|t|)$. They are shown to satisfy various consistency conditions, including an asymptotic duality formula relating $\beta$ to $4/\beta$.Comment: Replaces v2 which contains typographical errors arising from a previous unpublished draf

The dynamics of the 3D radial NLS with the combined terms

In this paper, we show the scattering and blow-up result of the radial solution with the energy below the threshold for the nonlinear Schr\"{o}dinger equation (NLS) with the combined terms iu_t + \Delta u = -|u|^4u + |u|^2u \tag{CNLS} in the energy space $H^1(\R^3)$. The threshold is given by the ground state $W$ for the energy-critical NLS: $iu_t + \Delta u = -|u|^4u$. This problem was proposed by Tao, Visan and Zhang in \cite{TaoVZ:NLS:combined}. The main difficulty is the lack of the scaling invariance. Illuminated by \cite{IbrMN:f:NLKG}, we need give the new radial profile decomposition with the scaling parameter, then apply it into the scattering theory. Our result shows that the defocusing, $\dot H^1$-subcritical perturbation $|u|^2u$ does not affect the determination of the threshold of the scattering solution of (CNLS) in the energy space.Comment: 46page

An alternative approach to regularity for the Navier-Stokes equations in critical spaces

In this paper we present an alternative viewpoint on recent studies of regularity of solutions to the Navier-Stokes equations in critical spaces. In particular, we prove that mild solutions which remain bounded in the space $\dot H^{1/2}$ do not become singular in finite time, a result which was proved in a more general setting by L. Escauriaza, G. Seregin and V. Sverak using a different approach. We use the method of "concentration-compactness" + "rigidity theorem" which was recently developed by C. Kenig and F. Merle to treat critical dispersive equations. To the authors' knowledge, this is the first instance in which this method has been applied to a parabolic equation. We remark that we have restricted our attention to a special case due only to a technical restriction, and plan to return to the general case (the $L^3$ setting) in a future publication.Comment: 41 page

Asymptotic behavior of small solutions for the discrete nonlinear Schr\"odinger and Klein-Gordon equations

We show decay estimates for the propagator of the discrete Schr\"odinger and Klein-Gordon equations in the form \norm{U(t)f}{l^\infty}\leq C (1+|t|)^{-d/3}\norm{f}{l^1}. This implies a corresponding (restricted) set of Strichartz estimates. Applications of the latter include the existence of excitation thresholds for certain regimes of the parameters and the decay of small initial data for relevant $l^p$ norms. The analytical decay estimates are corroborated with numerical results.Comment: 13 pages, 4 figure

On the 2d Zakharov system with L^2 Schr\"odinger data

We prove local in time well-posedness for the Zakharov system in two space dimensions with large initial data in L^2 x H^{-1/2} x H^{-3/2}. This is the space of optimal regularity in the sense that the data-to-solution map fails to be smooth at the origin for any rougher pair of spaces in the L^2-based Sobolev scale. Moreover, it is a natural space for the Cauchy problem in view of the subsonic limit equation, namely the focusing cubic nonlinear Schroedinger equation. The existence time we obtain depends only upon the corresponding norms of the initial data - a result which is false for the cubic nonlinear Schroedinger equation in dimension two - and it is optimal because Glangetas-Merle's solutions blow up at that time.Comment: 30 pages, 2 figures. Minor revision. Title has been change

Holder continuity of absolutely continuous spectral measures for one-frequency Schrodinger operators

We establish sharp results on the modulus of continuity of the distribution of the spectral measure for one-frequency Schrodinger operators with Diophantine frequencies in the region of absolutely continuous spectrum. More precisely, we establish 1/2-Holder continuity near almost reducible energies (an essential support of absolutely continuous spectrum). For non-perturbatively small potentials (and for the almost Mathieu operator with subcritical coupling), our results apply for all energies.Comment: 16 page

Spectral and Localization Properties for the One-Dimensional Bernoulli Discrete Dirac Operator

A 1D Dirac tight-binding model is considered and it is shown that its nonrelativistic limit is the 1D discrete Schr?odinger model. For random Bernoulli potentials taking two values (without correlations), for typical realizations and for all values of the mass, it is shown that its spectrum is pure point, whereas the zero mass case presents dynamical delocalization for specific values of the energy. The massive case presents dynamical localization (excluding some particular values of the energy). Finally, for general potentials the dynamical moments for distinct masses are compared, especially the massless and massive Bernoulli cases.Comment: no figure; 24 pages; to appear in Journal of Mathematical Physic

Zeta function regularization in Casimir effect calculations and J.S. Dowker's contribution

A summary of relevant contributions, ordered in time, to the subject of operator zeta functions and their application to physical issues is provided. The description ends with the seminal contributions of Stephen Hawking and Stuart Dowker and collaborators, considered by many authors as the actual starting point of the introduction of zeta function regularization methods in theoretical physics, in particular, for quantum vacuum fluctuation and Casimir effect calculations. After recalling a number of the strengths of this powerful and elegant method, some of its limitations are discussed. Finally, recent results of the so called operator regularization procedure are presented.Comment: 16 pages, dedicated to J.S. Dowker, version to appear in International Journal of Modern Physics