Ballard, M. (ed). 2009. Traductologie et enseignement de traduction à l’Université. Artois Presses Université. Artois, France.

This French-language collection of essays deals with the position of Translation Studies (la traductologie) within the contemporary University, and its relationship with the teaching of translation as an activity, for linguistic/pedagogical purposes and/or for the training of future professional translators. It also deals with the uses currently made of translation and Translation Studies within university departments

Daily life and emergent identities : western Britain in the Late Iron Age and Roman period.

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Nonlinear internal waves on the continental shelf: observations and KdV solutions

Numerical solutions of the Korteweg-de Vries (KdV) and extended Korteweg-de Vries (eKdV) equations are used to model the transformation of a sinusoidal internal tide as it propagates across the continental shelf. The ocean is idealized as being a two-layer fluid, justified by the fact that most of the oceanic internal wave signal is contained in the gravest mode. The model accounts for nonlinear and dispersive effects but neglects friction, rotation, and mean shear. The KdV model is run for a variety of idealized topography and stratification to understand the role of the nonlinear and dispersive effects. In all model solutions the internal tide steepens forming a sharp front. A packet of nonlinear solitary-like waves evolve from the front. A comparison between KdV and eKdV solutions are explored. The model results for realistic topography and stratification are compared with observations made at moorings off Massachusetts in the Mid Atlantic Bight, and close to shore off Oceanside, California. Several features observed in the data are also found in the model results. Differences between theory and mooring observations are discussed

Klimaservice für die Klimafolgen- und Anpassungsforschung in der Metropolregion Hamburg

Vorstellung von Projektergebnissen aus KLIMZUG-NORD bezüglich jährliche und saisonale Temperatur- und Niederschlagsänderungen zur Mitte und Ende des 21. Jahrhunderts, sowie Ergebnisse aus dem Projekt Hamburg 2K. In Hamburg 2K wird analysiert, was eine Begrenzung auf eine Temperaturänderung von 2K für Hamburg bedeutet. Ausgewertet wurden Temperatur- und Niederschlagsänderungen sowie ausgewählte Indices

Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an in Vitro Dynamic Gastrointestinal Model

The aim of the study was to investigate the impact of Crohn's disease (CD) on the performance of a lipid-based formulation of ciprofloxacin in a complex gastrointestinal simulator (TIM-1, TNO) and to compare the luminal environment in terms of bile salt and lipid composition in CD and healthy conditions. CD conditions were simulated in the TIM-1 system with a reduced concentration of porcine pancreatin and porcine bile. The bioaccessibility of ciprofloxacin was similar in simulated CD and healthy conditions considering its extent as well as its time course in the jejunum and ileum filtrate. Differences were observed in terms of the luminal concentration of triglycerides, monoglycerides, and fatty acids in the different TIM-1 compartments, indicating a reduction and delay in the lipolysis of formulation excipients in CD. The quantitative analysis of bile salts revealed higher concentrations for healthy conditions (standard TIM-1 fasted-state protocol) in the duodenum and jejunum TIM-1 compartments compared to published data in human intestinal fluids of healthy subjects. The reduced concentrations of bile salts in simulated CD conditions correspond to the levels observed in human intestinal fluids of healthy subjects in the fasted state.A lipidomics approach with ultra performance liquid chromatography (UPLC)/mass spectrometry (MS) has proven to be a time-efficient method to semiquantitatively analyze differences in fatty acid and bile salt levels between healthy and CD conditions. The dynamic luminal environment in CD and healthy conditions after administration of a lipid-based formulation can be simulated using the TIM-1 system. For ciprofloxacin, an altered luminal lipid composition had no impact on its performance indicating a low risk of altered performance in CD patients. </p

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly