Mechanical defradation of Emplacement Drifts at Yucca Mountain- A Modeling Case Study. Part I: Nonlithophysal Rock

This paper outlines rock mechanics investigations associated with mechanical degradation of planned emplacement drifts at Yucca Mountain, which is the designated site for the proposed U.S. high-level nuclear waste repository. The factors leading to drift degradation include stresses from the overburden, stresses induced by the heat released from the emplaced waste, stresses due to seismically related ground motions, and time-dependent strength degradation. The welded tuff emplacement horizon consists of two groups of rock with distinct engineering properties: nonlithophysal units and lithophysal units, based on the relative proportion of lithophysal cavities. The term 'lithophysal' refers to hollow, bubble like cavities in volcanic rock that are surrounded by a porous rim formed by fine-grained alkali feldspar, quartz, and other minerals. Lithophysae are typically a few centimeters to a few decimeters in diameter. Part I of the paper concentrates on the generally hard, strong, and fractured nonlithophysal rock. The degradation behavior of the tunnels in the nonlithophysal rock is controlled by the occurrence of keyblocks. A statistically equivalent fracture model was generated based on extensive underground fracture mapping data from the Exploratory Studies Facility at Yucca Mountain. Three-dimensional distinct block analyses, generated with the fracture patterns randomly selected from the fracture model, were developed with the consideration of in situ, thermal, and seismic loads. In this study, field data, laboratory data, and numerical analyses are well integrated to provide a solution for the unique problem of modeling drift degradation

3D-Printed PLA-Bioglass Scaffolds with Controllable Calcium Release and MSC Adhesion for Bone Tissue Engineering

Large bone defects are commonly treated by replacement with auto- and allografts, which have substantial drawbacks including limited supply, donor site morbidity, and possible tissue rejection. This study aimed to improve bone defect treatment using a custom-made filament for tissue engineering scaffolds. The filament consists of biodegradable polylactide acid (PLA) and a varying amount (up to 20%) of osteoconductive S53P4 bioglass. By employing an innovative, additive manufacturing technique, scaffolds with optimized physico-mechanical and biological properties were produced. The scaffolds feature adjustable macro- and microporosity (200–2000 µm) with adaptable mechanical properties (83–135 MPa). Additionally, controllable calcium release kinetics (0–0.25 nMol/µL after 24 h), tunable mesenchymal stem cell (MSC) adhesion potential (after 24 h by a factor of 14), and proliferation (after 168 h by a factor of 18) were attained. Microgrooves resulting from the 3D-printing process on the surface act as a nucleus for cell aggregation, thus being a potential cell niche for spheroid formation or possible cell guidance. The scaffold design with its adjustable biomechanics and the bioglass with its antimicrobial properties are of particular importance for the preclinical translation of the results. This study comprehensibly demonstrates the potential of a 3D-printed bioglass composite scaffold for the treatment of critical-sized bone defects

An overview of DLR compound rotorcraft aerodynamics and aeroacoustics activities within the CleanSky2 NACOR Project

The challenge of increasing range and speed of a rotorcraft is encountered in the scope of the European CleanSky2 “Fast Rotorcraft” project by Airbus Helicopters with the compound helicopter design RACER (RapidAndCostEfficientRotorcraft) for which the box wing and the tail parts designs are respectively protected by patent. This paper presents the DLR contributions to the RACER development. This includes the aerodynamic design of the wing and tail section as well as an overall assessment of performance and noise. In a first step the aerodynamic properties of the configuration are evaluated both isolated and with consideration of the main rotor and lateral rotor interferences by the use of actuator discs. In the second step, the investigated possibilities to improve the configurations performance are described. These include airfoil design for improved high lift performance of the wing and tail section, an optimization of the box wing circulation distribution on the upper and lower wing. Additionally, the intersection fairings were improved and the efficiency of the trim flaps was evaluated. In this regard, it could be determined for which cases an isolated approach is appropriate and when the rotor interference should be considered. At the end the evaluation of the aero acoustics of the configuration is conducted. The applied configuration shows good aerodynamic characteristics with some further cruise and off design optimization potential

Resilience and Protection of Health Care and Research Laboratory Workers During the SARS-CoV-2 Pandemic: Analysis and Case Study From an Austrian High Security Laboratory

The SARS-CoV-2 pandemic has highlighted the interdependency of healthcare systems and research organizations on manufacturers and suppliers of personnel protective equipment (PPE) and the need for well-trained personnel who can react quickly to changing working conditions. Reports on challenges faced by research laboratory workers (RLWs) are rare in contrast to the lived experience of hospital health care workers. We report on experiences gained by RLWs (e.g., molecular scientists, pathologists, autopsy assistants) who significantly contributed to combating the pandemic under particularly challenging conditions due to increased workload, sickness and interrupted PPE supply chains. RLWs perform a broad spectrum of work with SARS-CoV-2 such as autopsies, establishment of virus cultures and infection models, development and verification of diagnostics, performance of virus inactivation assays to investigate various antiviral agents including vaccines and evaluation of decontamination technologies in high containment biological laboratories (HCBL). Performance of autopsies and laboratory work increased substantially during the pandemic and thus led to highly demanding working conditions with working shifts of more than eight hours working in PPE that stressed individual limits and also the ergonomic and safety limits of PPE. We provide detailed insights into the challenges of the stressful daily laboratory routine since the pandemic began, lessons learned, and suggest solutions for better safety based on a case study of a newly established HCBL (i.e., BSL-3 laboratory) designed for autopsies and research laboratory work. Reduced personal risk, increased resilience, and stress resistance can be achieved by improved PPE components, better training, redundant safety measures, inculcating a culture of safety, and excellent teamwor

Drift Degradation Analysis

Degradation of underground openings as a function of time is a natural and expected occurrence for any subsurface excavation. Over time, changes occur to both the stress condition and the strength of the rock mass due to several interacting factors. Once the factors contributing to degradation are characterized, the effects of drift degradation can typically be mitigated through appropriate design and maintenance of the ground support system. However, for the emplacement drifts of the geologic repository at Yucca Mountain, it is necessary to characterize drift degradation over a 10,000-year period, which is well beyond the functional period of the ground support system. This document provides an analysis of the amount of drift degradation anticipated in repository emplacement drifts for discrete events and time increments extending throughout the 10,000-year regulatory period for postclosure performance. This revision of the drift degradation analysis was developed to support the license application and fulfill specific agreement items between the U.S. Nuclear Regulatory Commission (NRC) and the U.S. Department of Energy (DOE). The earlier versions of ''Drift Degradation Analysis'' (BSC 2001 [DIRS 156304]) relied primarily on the DRKBA numerical code, which provides for a probabilistic key-block assessment based on realistic fracture patterns determined from field mapping in the Exploratory Studies Facility (ESF) at Yucca Mountain. A key block is defined as a critical block in the surrounding rock mass of an excavation, which is removable and oriented in an unsafe manner such that it is likely to move into an opening unless support is provided. However, the use of the DRKBA code to determine potential rockfall data at the repository horizon during the postclosure period has several limitations: (1) The DRKBA code cannot explicitly apply dynamic loads due to seismic ground motion. (2) The DRKBA code cannot explicitly apply loads due to thermal stress. (3) The DRKBA code, which determines structurally controlled key-block failure, is not applicable for stress-controlled failure in the lithophysal units. To address these limitations, additional numerical codes have been included that can explicitly apply seismic and thermal loads, providing significant improvements to the analysis of drift degradation and extending the validity of drift degradation models

Dossier : the prevention of torture in Southern Europe

This article will focus on the specific relations between the CPT and its partners, as two round-tables in the framework of the seminar on the Prevention of Torture in Southern Europe (Onatiseminar 1997) have been devoted to this topic. One round-table dealt with the formal partners to the CPT, with reports given by an ombudsman for the police from Portugal (Antonio Rodrigo Maximiano), a penitentiary judge (Remei Bona i Puigvert) and a representative of the police (Miguel Martin Pedraz), both from Spain, under the chair of Malcolm Evans (UK). I myself chaired the other round-table, which focused on the experiences of informal partners to the CPT in the Mediterranean States. Eva Falcao from Portugal spoke on behalf of the Forum Justica e Liberdades, a national Non Governmental Organisation (NGO); Inigo Elkoro Aiastul from Spain, who works with TAT (Group Against Torture), an organisation involved in the human rights protection of Basque prisoners, represented the group of defence lawyers; and Jean-Pierre Restellini, a physician from Switzerland who gained experience as a frequent expert with the CPT, spoke from the point of view of a medical doctor. A representative of the media (Stephania Miloti from Italy) had been invited but unfortunately could not attend the meeting. In the following, some main features of the European system on the prevention of torture will be looked at in more detail to illustrate the fundamentals and existing obstacles as regards the relations between the CPT and its partners. [excerpt]peer-reviewe