Gastroprotective potential and mechanisms of action of Hedera nepalensis

Hedera nepalensis (H. nepalensis) , belonging to the family Araliaceae, is a medicinal plant traditionally used to treat stomach problems. The current study investigated the gastroprotective potential and the mechanism of action of H. nepalensis in diclofenac-and ethanol-induced ulcer models. Anti-oxidant and lipid peroxidation inhibitory prospects of H. nepalensis were checked out by free radical scavenging assay and UV spectrophotometer respectively. Effect of H. nepalensis on the pH, gastric total acidity of gastric juice and protective effects of H. nepalensis against ulcer models have been examined. Histopathological studies have been carried out. The aqueous methanol extract of H. nepalensis (100 µg/mL) showed anti-oxidant (83.55%) and lipid peroxidation inhibitory (70.88%) potential at 1000 µg/mL; the extract had no buffer potential. The extract (400 mg/kg) significantly (81.12% and 63.46%) showed gastroprotective effect in diclofenac and ethanol-induced rat ulcer models respectively. Histopathological studies confirmed the biochemical findings. FTIR analysis showed the presence of carboxylic acid, alkanes, conjugated alkanes, aldehydes and alkyl-aryl ethers. Gallic acid, M-coumaric acid and quercetin were found by HPLC analysis. H. nepalensis exhibited significant protection against diclofenac and ethanol induced gastric damage by anti-oxidant and lipid peroxidation suppression effects suggesting potential broad utility in treatment of diseases characterized with gastric damage

PHYSICAL AND INDEX PROPERTIES OF LATE PRECAMBRIAN AND CAMBRIAN SALT RANGE ROCKS OF PUNJAB

Thirteen rock types including Sandstone, Siltstone, Dolomite, Shale, Gypsum and Rock Salt collected from five different formations of Salt Range area of Pakistan were tested to assess their physical and index properties. Specific gravity, dry and wet unit weights, moisture contents, porosity, water absorption and slake durability index were determined. Results indicate that most of the rocks have their specific gravity and unit weight values in the standard range. Higher durability indices and low water absorption values of sandstones and dolomite make them suitable for construction materials. While higher porosity of Baghanwala sandstone, lower and upper Khewra sandstone indicates their potential as hydrocarbon bearing reservoir and at the same time make them an ideal candidate for greenhouse gases sequestration in the subsurface.&nbsp