Stringent bounds to spatial variations of the electron-to-proton mass ratio in the Milky Way

The ammonia method to probe variations of the electron-to-proton mass ratio, Delta_mu/mu, is applied for the first time to dense prestellar molecular clouds in the Milky Way. Carefully selected sample of 21 NH_3/CCS pairs observed in the Perseus molecular cloud provide the offset Delta V (CCS-NH_3)= 36+/-7_{stat}+/-13.5_{sys} m/s . A similar offset of Delta V = 40.8 +/- 12.9_{stat} m/s between NH_3 (J,K) = (1,1) and N_2H+ J = 1-0 has been found in an isolated dense core L183 by Pagani et al. (2009). Overall these observations provide a safe bound of a maximum offset between ammonia and the other molecules at the level of Delta V < 100 m/s. This bound corresponds to Delta_mu/mu < 1E-7, which is an order of magnitude more sensitive than available extragalactic constraints. Taken at face value the measured Delta V shows positive shifts between the line centers of NH_3 and these two other molecules and suggest a real offset, which would imply a Delta_mu/mu about 4E-8. If Delta_mu/mu follows the gradient of the local gravitational potential, then the obtained results are in conflict with laboratory atomic clock experiments in the solar system by 5 orders of magnitude, thus requiring a chameleon-type scalar field model. New measurements involving other molecules and a wider range of objects along with verification of molecular rest frequencies are currently planned to confirm these first indications.Comment: 7 pages +2 figures. Galileo Galilei Institute Conferences on Dark Matter and Dark Energ

Oscillations of the F(R) dark energy in the accelerating universe

Oscillations of the $F(R)$ dark energy around the phantom divide line, $\omega_{DE}=-1$, both during the matter era and also in the de Sitter epoch are investigated. The analysis during the de Sitter epoch is revisited by expanding the modified equations of motion around the de Sitter solution. Then, during the matter epoch, the time dependence of the dark energy perturbations is discussed by using two different local expansions. For high values of the red shift, the matter epoch is a stable point of the theory, giving the possibility to expand the $F(R)$-functions in terms of the dark energy perturbations. In the late-time matter era, the realistic case is considered where dark energy tends to a constant. The results obtained are confirmed by precise numerical computation on a specific model of exponential gravity. A novel and very detailed discussion is provided on the critical points in the matter era and on the relation of the oscillations with possible singularities.Comment: 23 pages, 11 figures, version to appear in EPJ

Cosmic Acceleration in Brans-Dicke Cosmology

We consider Brans-Dicke theory with a self-interacting potential in Einstein conformal frame. We show that an accelerating expansion is possible in a spatially flat universe for large values of the Brans-Dicke parameter consistent with local gravity experiments.Comment: 10 Pages, 3 figures, To appear in General Relativity and Gravitatio

Search for varying constants of nature from astronomical observation of molecules

The status of searches for possible variation in the constants of nature from astronomical observation of molecules is reviewed, focusing on the dimensionless constant representing the proton-electron mass ratio $\mu=m_p/m_e$. The optical detection of H$_2$ and CO molecules with large ground-based telescopes (as the ESO-VLT and the Keck telescopes), as well as the detection of H$_2$ with the Cosmic Origins Spectrograph aboard the Hubble Space Telescope is discussed in the context of varying constants, and in connection to different theoretical scenarios. Radio astronomy provides an alternative search strategy bearing the advantage that molecules as NH$_3$ (ammonia) and CH$_3$OH (methanol) can be used, which are much more sensitive to a varying $\mu$ than diatomic molecules. Current constraints are $|\Delta\mu/\mu| < 5 \times 10^{-6}$ for redshift $z=2.0-4.2$, corresponding to look-back times of 10-12.5 Gyrs, and $|\Delta\mu/\mu| < 1.5 \times 10^{-7}$ for $z=0.88$, corresponding to half the age of the Universe (both at 3$\sigma$ statistical significance). Existing bottlenecks and prospects for future improvement with novel instrumentation are discussed.Comment: Contribution to Workshop "High Performance Clocks in Space" at the International Space Science Institute, Bern 201

Strong laser fields as a probe for fundamental physics

Upcoming high-intensity laser systems will be able to probe the quantum-induced nonlinear regime of electrodynamics. So far unobserved QED phenomena such as the discovery of a nonlinear response of the quantum vacuum to macroscopic electromagnetic fields can become accessible. In addition, such laser systems provide for a flexible tool for investigating fundamental physics. Primary goals consist in verifying so far unobserved QED phenomena. Moreover, strong-field experiments can search for new light but weakly interacting degrees of freedom and are thus complementary to accelerator-driven experiments. I review recent developments in this field, focusing on photon experiments in strong electromagnetic fields. The interaction of particle-physics candidates with photons and external fields can be parameterized by low-energy effective actions and typically predict characteristic optical signatures. I perform first estimates of the accessible new-physics parameter space of high-intensity laser facilities such as POLARIS and ELI.Comment: 7 pages, Key Lecture at the ELI Workshop and School on "Fundamental Physics with Ultra-High Fields", 9 September - 2 October 2008 at Frauenworth Monastery, German

f(R)f(R) gravity constrained by PPN parameters and stochastic background of gravitational waves

We analyze seven different viable $f(R)$-gravities towards the Solar System tests and stochastic gravitational waves background. The aim is to achieve experimental bounds for the theory at local and cosmological scales in order to select models capable of addressing the accelerating cosmological expansion without cosmological constant but evading the weak field constraints. Beside large scale structure and galactic dynamics, these bounds can be considered complimentary in order to select self-consistent theories of gravity working at the infrared limit. It is demonstrated that seven viable $f(R)$-gravities under consideration not only satisfy the local tests, but additionally, pass the above PPN-and stochastic gravitational waves bounds for large classes of parameters.Comment: 23 pages, 8 figure

Cosmic Evolution in a Modified Brans-Dicke Theory

We consider Brans-Dicke theory with a self-interacting potential in Einstein conformal frame. We introduce a class of solutions in which an accelerating expansion is possible in a spatially flat universe for positive and large values of the Brans-Dicke parameter consistent with local gravity experiments. In this Einstein frame formulation, the theory appears as an interacting quintessence model in which the interaction term is given by the conformal transformation. In such an interacting model, we shall show that the solutions lead simultaneously to a constant ratio of energy densities of matter and the scalar field.Comment: 11 pages, 3 figures, To appear in Astrophysics and Space Scienc

Some Observational Consequences of Brane World Cosmologies

The presence of dark energy in the Universe is inferred directly and indirectly from a large body of observational evidence. The simplest and most theoretically appealing possibility is the vacuum energy density (cosmological constant). However, although in agreement with current observations, such a possibility exacerbates the well known cosmological constant problem, requiring a natural explanation for its small, but nonzero, value. In this paper we focus our attention on another dark energy candidate, one arising from gravitational \emph{leakage} into extra dimensions. We investigate observational constraints from current measurements of angular size of high-$z$ compact radio-sources on accelerated models based on this large scale modification of gravity. The predicted age of the Universe in the context of these models is briefly discussed. We argue that future observations will enable a more accurate test of these cosmologies and, possibly, show that such models constitute a viable possibility for the dark energy problem.Comment: 6 pages, 4 figures, to appear in Phys. Rev. D (minor revisions

A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 Delta infection

SARS-CoV-2 vaccines should induce broadly cross-reactive humoral and T cell responses to protect against emerging variants of concern (VOCs). Here, we inactivated the furin cleavage site (FCS) of spike expressed by a modified vaccinia Ankara (MVA) virus vaccine (MVA/SdFCS) and found that FCS inactivation markedly increased spike binding to human ACE2. After vaccination of mice, the MVA/SdFCS vaccine induced eightfold higher neutralizing antibodies compared with MVA/S, which expressed spike without FCS inactivation, and protected against the Beta variant. We next added nucleocapsid to the MVA/SdFCS vaccine (MVA/SdFCS-N) and tested its immunogenicity and efficacy via intramuscular (IM), buccal (BU), or sublingual (SL) routes in rhesus macaques. IM vaccination induced spike-specific IgG in serum and mucosae (nose, throat, lung, and rectum) that neutralized the homologous (WA-1/2020) and heterologous VOCs, including Delta, with minimal loss (<2-fold) of activity. IM vaccination also induced both spike- and nucleocapsid-specific CD4 and CD8 T cell responses in the blood. In contrast, the SL and BU vaccinations induced less spike-specific IgG in secretions and lower levels of polyfunctional IgG in serum compared with IM vaccination. After challenge with the SARS-CoV-2 Delta variant, the IM route induced robust protection, the BU route induced moderate protection, and the SL route induced no protection. Vaccine-induced neutralizing and non-neutralizing antibody effector functions positively correlated with protection, but only the effector functions correlated with early protection. Thus, IM vaccination with MVA/SdFCS-N vaccine elicited cross-reactive antibody and T cell responses, protecting against heterologous SARS-CoV-2 VOC more effectively than other routes of vaccination

On the Holographic RG-flow and the Low-energy, Strong Coupling, Large N Limit

From the AdS/CFT correspondence, we learn that the classical evolution of supergravity in the bulk can be reduced to a RG-flow equation for the dual low-energy, strongly coupled and large N gauge theory on the boundary. This result has been used to obtain interesting relations between the various terms in the gravitational part of the boundary effective action, in particular the term that affect the cosmological constant. It is found that once the cosmological constant is cancelled in the UV theory, the RG-flow symmetry of the boundary effective action automatically implies the existence of zero cosmological constant solutions that extend all the way into the IR. Given the standard (and well founded) contradiction between the RG-flow idea and the observational evidence of a small cosmological constant, this is considered to be an important progress, albeit incomplete, towards the final solution. Motivated by this success, it would be interesting to see whether this RG-stability extends outside the scope of strong 't Hooft coupling and large N regime that are implicitly assumed in the de Boer-Verlinde-Verlinde Hamilton-Jacobi formulation of the holographic RG-flow equations of the boundary theory. In this paper, we address this question. Taking into account the leading order corrections in the 1/N and $\alpha'/{R^2}$ parameters, we derive new bulk/boundary relations, from which one can read all the local terms in the boundary effective action. Next, we use the resulting constraints, to examine whether the RG-stability of the cosmological constant extends to the new coupling regime. It would be also interesting to use these constraints to study the Randall-Sundrum scenario in this case.Comment: 27 pages, LateX, no figures, minor changes, typos corrected and added more reference