177 research outputs found
Phthalocyanine-based dumbbell-shaped molecule: synthesis, structure and charge transport studies
International audienceWe describe the synthesis of a fully conjugated donor-acceptor-donor triad (ZnPc-BTD-ZnPc) made of zinc phthalocyanine donor fragments (ZnPc) at both ends of a benzothiadiazole-based central dye (BTD). The molecule exhibits a broad absorption in the whole visible range. The introduction of sterically demanding alkoxy chains to the ZnPc fragments is found to limit the molecular organization to a short-range columnar order and the charge-carrier mobility to moderate values, but provides outstanding solubilities in organic solvents
Prevalence of hemoglobin variants in a diabetic population at high risk of hemoglobinopathies and optimization of HbA1c monitoring by incorporating HPLC in the laboratory workup
Background: In Tunisia, diabetes mellitus and hemoglobinopathies are major public health problems. Glycated hemoglobin (HbA1c) is recommended for long-term monitoring of diabetes mellitus, but the presence of hemoglobin variants may interfere with HbA1c measurement. The aim was to determine the prevalence of hemoglobin variants in Tunisian diabetics and optimize the monitoring of diabetics using HbA1c.Methods: The study enrolled 9,792 Tunisian diabetic patients. HbA1c was measured by cation-exchange highpressure liquid chromatography (HPLC). All the chromatograms were analyzed for the presence of Hbvariants.Results: We identified 228 cases (2.33%) of Hb variants with D-10 HPLC (Bio-Rad): 191 with HbA/S trait, 27 with HbA/C trait, and 10 hemoglobin variants with the mention âVariant-Windowâ on the chromatograms and subsequently identified as HbA/S on Variant I HPLC (Bio-Rad). Thus, the prevalence of HbS was 2.05%. We did not find any homozygous variant. All HbA1c results were reported to the treating physician.Conclusions: To evaluate glycated hemoglobin in populations with a high prevalence of hemoglobinopathies, we should use the HPLC method, which is easy, economical, and reliable. Based on an algorithm, hemoglobinvariants visualized on HPLC should be reported to the physician to improve the management of patients.Keywords: hemoglobinopathies; HbA1c; HPLC; diabetes mellitus; prevalence; Tunisi
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Early operating experience with the Brookhaven National Laboratory radio frequency quadrupole accelerator
The Brookhaven National Laboratory polarized H/sup -/ injection program for the AGS utilizes a Radio Frequency Quadrupole (RFQ) for acceleration between the polarized H/sup -/ source and the Alvarez Linac. The RFQ accelerator is now in operation with low beam currents. The results of low and high power rf testing will be reported together with initial results of operation in the polarized H/sup -/ beam line
Data-Driven Optimization of Public Transit Schedule
Bus transit systems are the backbone of public transportation in the United
States. An important indicator of the quality of service in such
infrastructures is on-time performance at stops, with published transit
schedules playing an integral role governing the level of success of the
service. However there are relatively few optimization architectures leveraging
stochastic search that focus on optimizing bus timetables with the objective of
maximizing probability of bus arrivals at timepoints with delays within desired
on-time ranges. In addition to this, there is a lack of substantial research
considering monthly and seasonal variations of delay patterns integrated with
such optimization strategies. To address these,this paper makes the following
contributions to the corpus of studies on transit on-time performance
optimization: (a) an unsupervised clustering mechanism is presented which
groups months with similar seasonal delay patterns, (b) the problem is
formulated as a single-objective optimization task and a greedy algorithm, a
genetic algorithm (GA) as well as a particle swarm optimization (PSO) algorithm
are employed to solve it, (c) a detailed discussion on empirical results
comparing the algorithms are provided and sensitivity analysis on
hyper-parameters of the heuristics are presented along with execution times,
which will help practitioners looking at similar problems. The analyses
conducted are insightful in the local context of improving public transit
scheduling in the Nashville metro region as well as informative from a global
perspective as an elaborate case study which builds upon the growing corpus of
empirical studies using nature-inspired approaches to transit schedule
optimization.Comment: 20 pages, 6 figures, 2 table
Analyzing power measurements in highâP2â„ pâp elastic scattering
The analyzing power in 28 GeV/c proton/proton elastic scattering was measured at P2â„=5.95 and 6.56 (GeV/c)2 using a polarized proton target and an unpolarized proton beam at the Brookhaven National Laboratory AGS. Results indicate that the analyzing power, A, is rising sharply with P2â„.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87401/2/1123_1.pd
Genetic variability of the P120' surface protein gene of Mycoplasma hominis isolates recovered from Tunisian patients with uro-genital and infertility disorders
<p>Abstract</p> <p>Background</p> <p>Among the surface antigens of <it>Mycoplasma hominis</it>, the P120' protein was previously shown to elicit a subtle antibody response and appears to be relatively conserved. To get better insight into the evolution of this protein, we analysed the genetic variability of its surface exposed region in 27 <it>M. hominis </it>isolates recovered from the genital tract of Tunisian patients with infertility disorders.</p> <p>Methods</p> <p>All specimens were processed for culture and PCR amplification of the N-terminal surface exposed region of p120' gene. PCR products were sequenced to evaluate the genetic variability, to test for adaptive selection, and to infer the phylogenetic relationship of the <it>M. hominis </it>isolates.</p> <p>Results</p> <p>Sequence analysis showed a total of 25 single nucleotide polymorphisms distributed through 23 polymorphic sites, yielding 13 haplotypes. All but one mutation were confined within three distinct regions. Analysis of the amino acid-based phylogenetic tree showed a predominant group of 17 closely related isolates while the remaining appear to have significantly diverged.</p> <p>Conclusion</p> <p>By analysing a larger sample of <it>M. hominis </it>recovered from patients with urogenital infections, we show here that the P120' protein undergoes substantial level of genetic variability at its surface exposed region.</p
RF Induced Depolarizing Resonanaces, Spin Flip, and Partial Siberian Snakes
This research was sponsored by the National Science Foundation Grant NSF PHY-931478
A review on development and application of plant-based bioflocculants and grafted bioflocculants
Flocculation is extensively employed for clarification through sedimentation. Application of eco-friendly plant-based bioflocculants in wastewater treatment has attracted significant attention lately with high removal capability in terms of solids, turbidity, color, and dye. However, moderate flocculating property and short shelf life restrict their development. To enhance the flocculating ability, natural polysaccharides derived from plants are chemically modified by inclusion of synthetic, nonbiodegradable monomers (e.g., acrylamide) onto their backbone to produce grafted bioflocculants. This review is aimed to provide an overview of the development and flocculating efficiencies of plant-based bioflocculants and grafted bioflocculants for the first time. Furthermore, the processing methods, flocculation mechanism, and the current challenges are discussed. All the reported studies about plant-derived bioflocculants are conducted under lab-scale conditions in wastewater treatment. Hence, the possibility to apply natural bioflocculants in food and beverage, mineral, paper and pulp, and oleo-chemical and biodiesel industries is discussed and evaluated
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