28 research outputs found
Assessment of the inhalation technique and adherence to therapy and their effect on disease control in outpatients with asthma
Objectives The objective of this study was to assess correct use of inhaler devices,
adherence to inhaler corticosteroid treatment and their effects on asthma control.
Methods This study was a prospective, single-centre, observational study conducted
between July and February 2016 at Al-Makased Hospital, respiratory outpatient clinic.
Inhaler technique of asthma patients using pressurized metered-dose inhalers or dry powder
inhalers (Turbuhaler (TH) and Accuhaler DiskusTM (ACC)) were assessed against
published inhaler technique checklists. Asthma control variables measured using Asthma
Control Test (maximum 25, higher score corresponding to better asthma control) were
assessed, and adherence to asthma medications was assessed by Morisky adherence scale.
Key findings Two hundred and twenty patients were recruited in the study. The mean
age was 42.3 15.2 years and 59.1% were male. One hundred and seventeen (53.2%)
were using TH, 60 (27.3%) were using ACC and 43(19.5%) were using MDIs. Only 22
(10%) were smoker and only 48 (21.8%) patients were their asthma controlled (ACT
score >20). The devices were used correctly by 79.1% of patients using MDI, 69% of
ACC and 55.6% of TH users (P > 0.001). The most common improper step was ‘forceful
inhalation’ (65.4%) made by the MDI users, ‘Not exhaling to residual volume’ (58.7%)
made by ACC users and ‘Not inhaling deeply enough’ (52.2%) made by TH users. Multivariate
analysis showed that the likelihood of having controlled asthma was significantly
higher in those with correct inhaler techniques (OR 2.3; 95% CI: 1.08–4.77; P = 0.028),
high adherence to medications (OR 2.37; 95% CI: 1.05–4.92; P = 0.03) and having a
higher level of education (OR 2.58; 95% CI: 1.19–3.63; P = 0.018).
Conclusions It was found that asthma control was better among correct users. Repetitive
training about using devices may contribute improving inhaler technique.This research received no specific grant from any funding
agency in the public, commercial or not-for-profit sectors
Pharmaceutical care for adult asthma patients: A controlled intervention one‐year follow‐up study
Asthma is a clinical problem with social, psychological and economic burdens. To
improve patient disease management, different education programmes have been
developed. Challenges in asthma management may be partially attributed to nonadherence
or improper use of inhalers. This study aimed to implement and assess
hospital‐based pharmaceutical care services for asthmatic patients. A 12‐month, single‐
centre, randomized, controlled study was initiated in asthmatic adult patients who
had been divided into either a control or intervention group. Patients in the control
group received the usual care, and patients in the intervention group received patient
counselling per study protocol that covered asthma knowledge, control, adherence to
treatment and inhalation techniques. The main variables compared measurements at
baseline with those at 6 and 12 months. A total of 192 patients completed the study
protocol: 90 in the control group and 102 in the intervention group. The control
group included 90 patients, and the intervention group included 102 patients. Over
the course of the 12‐month follow‐up period, a significant difference was observed
between intervention and control groups with respect to asthma control (38.2%
vs 10.0%; P < .001), mean correct inhalation technique (confidence interval [CI]:
8.1, 7.8‐8.5 vs CI: 6.1; 5.6‐6.6; P = .01) and good medication adherence (60.7% vs
50.0%, P = .02). There were 34% and 25% decreases in emergency room visits and
hospital admissions, respectively, in the intervention group compared to the control
group. This study emphasizes the importance of patient counselling in asthma management
and the significant contribution that the pharmacist's intervention can have
on asthma control
Necessity and concerns about lipid-lowering medical treatments and risk factors for non-adherence: A cross-sectional study in Palestine
Aims: Strong evidence indicates that drugs reduce blood lipids and improve cardiovascular
end-points, leading to their wide usage. However, the success of these drugs
can be affected by poor patient's adherence to prescribed medication. This study
aimed to evaluate medication adherence in patients with dyslipidaemia in association
with patient beliefs about medicines.
Methods: The study was conducted from January 2019 to July 2019 at the middle
governmental primary healthcare clinics in Ramallah and Bethlehem cities, and
used a cross-sectional design. Adherence was determined using the 4-item Morisky
medication adherence scale, while beliefs were determined using the Beliefs about
Medicines Questionnaire.
Results: Of 220 patients, 185 agreed to participate in the study, resulting in a response
rate of 84.1%. Of the participants, 106 (57.3%) were men, and almost half (88,
46.5%) were ≥56 years. Medication non-adherence was high (47.6%), but a majority
(65.5%) reported believing their treatment to be necessary for their continued good
health. Accordingly, the mean necessity score (17.3, SD 3.7) significantly outweighed
(P < .001) the mean concerns score (14.0, SD 3.5). Multivariate regression demonstrated
four variables to be significantly correlated with non-adherence: illiterate
(OR = 2.52; CI: 0.9-4.3; P = .03), polypharmacy (OR = 3.18; CI: 1.9-5.7; P = .007),
having comorbidity (OR = 3.10; CI: 2.2-4.6; P = .005) and having concerns about side
effects (OR = 2.89; CI: 1.1-4.6, P = .04).
Conclusion: Non-adherence among patients taking lipid-lowering agents was high despite
most holding positive beliefs regarding medication necessity. This may be due to
concern also being high. Physicians should identify and target high-risk patients and individualise
their treatment plans in order to achieve adequate control of dyslipidaemia.We thank all workers at health clinics at Ramallah and Bethlehem
who helped in finishing this study and also we thank the participants
who willingly accepted to share for the purpose of this study
Pharmacists’ Knowledge, Attitudes and Practices Towards Herbal Remedies In West Bank, Palestine
Background:
There is an increasing trend towards consumption of
complementary and alternative herbal products in many parts of the
world.
Objectives:
The purpose of this study was to investigate the knowled
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ge and attitudes among pharmacists in West Bank, Palestine towards
the use of herbs.
Methods:
Self-administered questionnaire was designed as the study
instrument and distributed among 350 qualified pharmacists working
in government and private pharmacies in West Bank, Palestine.
Results:
The response rate was 82.9% (290/350). The mean age of
the pharmacists was 32.9 (SD=6.5) years. The majority of the phar
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macist 238 (82.1%) worked in the community pharmacies and their
experience in practice ranged from 1 to 26 years. Product package
instructions and product representative were the most consulted by
the pharmacists (128; 44.2% and 73; 25.2% respectively). General
health tonic preparations were the most widely dispensed drugs (142;
48.9%), followed by cough preparations (55; 19.0%) and slimming
agents (64; 22.1%). The Majority of pharmacists (195; 67.2%) belie
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ved herbal remedies were effective; however, about fifty percent of
the pharmacists had concern about their safety. The knowledge of
respondents about the indications of herbal medicine was good, but
their awareness of interactions, contraindications and adverse effects
was inadequate. The majority of Pharmacists (255; 87.9%) believed
that herbal product should undergo increased regulation and (215;
74.9%) believed that information available about herbal and natural
product isn't adequate
Impact of antimicrobial stewardship programme on hospitalized patients at the intensive care unit: a prospective audit and feedback study
AIMS:
Inappropriate use of antibiotics is one of the most important factors contributing to the emergence of drug resistant pathogens. The purpose of this study was to measure the clinical impact of antimicrobial stewardship programme (ASP) interventions on hospitalized patients at the Intensive care unit at Palestinian Medical Complex.
METHODS:
A prospective audit with intervention and feedback by ASP team within 48-72 h of antibiotic administration began in September 2015. Four months of pre-ASP data were compared with 4 months of post-ASP data. Data collected included clinical and demographic data; use of antimicrobials measured by defined daily doses, duration of therapy, length of stay, readmission and all-cause mortality.
RESULTS:
Overall, 176 interventions were made the ASP team with an average acceptance rate of 78.4%. The most accepted interventions were dose optimization (87.0%) followed by de-escalation based on culture results with an acceptance rate of 84.4%. ASP interventions significantly reduces antimicrobial use by 24.3% (87.3 defined daily doses/100 beds vs. 66.1 defined daily doses/100 beds P < 0.001). The median (interquartile range) of length of stay was significantly reduced post ASP [11 (3-21) vs. 7 (4-19) days; P < 0.01]. Also, the median (interquartile range) of duration of therapy was significantly reduced post-ASP [8 (5-12) days vs. 5 (3-9); P = 0.01]. There was no significant difference in overall 30-day mortality or readmission between the pre-ASP and post-ASP groups (26.9% vs. 23.9%; P = 0.1) and (26.1% vs. 24.6%; P = 0.54) respectively.
CONCLUSIONS:
Our prospective audit and feedback programme was associated with positive impact on antimicrobial use, duration of therapy and length of stay
Societal perspectives on community pharmacy services in West Bank - Palestine
Understanding the public's view of professional
competency is extremely important; however little
has been reported on the public�s perception of
community pharmacists in Palestine
Objectives: To determine the perception of
Palestinian consumers of the community pharmacist
and the services they offer
Method: This project used the survey methodology
administered by structured interviews to consumers
who attended the 39 randomly selected
pharmacies, in six main cities in Palestine. The
questionnaire had range of structured questions
covering: Consumers� patronage patterns,
consumers� interaction with community pharmacists,
consumers� views on how the pharmacist dealt with
personal health issues, procedure with regard to
handling private consultations.
Results: Of 1,017 consumers approached, 790
consumers completed the questionnaire (77.7 %).
Proximity to home and presence of knowledgeable
pharmacist were the main reasons for patients to
visit the same pharmacy. Physicians were identified
as the preferred source of advice by 57.2% and
pharmacists by 23.8%. Only 17% of respondents
considered pharmacists as health professionals
who know a lot about drugs and are concerned
about and committed to caring for the public. In
addition, 49% indicated that pharmacists spoke
more quietly cross the counter during counseling
and almost one third reported that the pharmacist
used a private area within the pharmacy. The
majority of respondents would be happy to receive
different extended services in the community
pharmacy like blood pressure monitoring.
Conclusions: Palestinian consumers have a
positive overall perception of community
pharmacists and the services they offer. Awareness
should be created amongst the public about the role
of pharmacist and the added value they can provide
as health care professional. There is a need to
consider privacy when giving patient counseling to
increase user satisfaction.Entender la visión del público de la competencia
profesional es extremamente importante; sin
embargo, se ha comunicado poco sobre la
percepción del público sobre la farmacia
comunitaria en Palestina.
Objetivos: Determinar la percepción de los
consumidores palestinos de farmacias comunitarias
y los servicios que éstas ofrecen.
Métodos: Este proyecto utilizó la metodología de
encuesta administrada a través de entrevistas
estructuradas a consumidores que visitaron 39
farmacias aleatoriamente seleccionadas en las seis
principales ciudades de Palestina. El cuestionario
tenía una serie de preguntas estructuradas que
cubrían: patrones de clientela de los consumidores,
interacción de los consumidores con los
farmacéuticos comunitarios, visión de los
consumidores de como los farmacéuticos tratan sus
problemas personales, procedimientos relativos al
manejo de las consultas privadas.
Resultados: De los 1017 consumidores que se
aproximaron, 790 completaron el cuestionario
(77,7%). La proximidad a casa y la presencia de un
farmacéutico reconocido fueron las dos razones
principales de que los pacientes visitasen la misma
farmacia. Los médicos fueron identificados como la
fuente preferida de consejo por el 52,2% y los
farmacéuticos por el 23,8%. Sólo el 17% de los
respondentes consideró a los farmacéuticos con
profesionales de la salud que sabían mucho sobre
medicamentos y que se preocupaban y se
comprometían en cuidar del público. Además, el
49% hablaba más bajo sobre el mostrador durante
el consejo y casi un tercio comunicó que el
farmacéutico usó un área privada en la farmacia. La
mayoría de los entrevistados estarían contentos por
recibir varios servicios ampliados de las farmacias
comunitarias con la monitorización de presión
arterial.
Conclusiones: Los consumidores palestinos tienen
una percepción general positiva de los
farmacéuticos comunitarios y los servicios que
ofrecen. Se debería aumentar el conocimiento del
público sobre el papel del farmacéutico y el valor
añadido que pueden proporcionar como
profesionales de la salud. Para aumentar la
satisfacción del usuario, es necesario considerar la
privacidad cuando se proporciona consej
Novel Antioxidants Protect Mitochondria from the Effects of Oligomeric Amyloid Beta and Contribute to the Maintenance of Epigenome Function
Alzheimer’s
disease is associated with metabolic deficits
and reduced mitochondrial function, with the latter due to the effects
of oligomeric amyloid beta peptide (AβO) on the respiratory
chain. Recent evidence has demonstrated reduction of epigenetic markers,
such as DNA methylation, in Alzheimer’s disease. Here we demonstrate
a link between metabolic and epigenetic deficits via reduction of
mitochondrial function which alters the expression of mediators of
epigenetic modifications. AβO-induced loss of mitochondrial
function in differentiated neuronal cells was reversed using two novel
antioxidants (<b>1</b> and <b>2</b>); both have been shown
to mitigate the effects of reactive oxygen species (ROS), and compound <b>1</b> also restores adenosine triphosphate (ATP) levels. While
both compounds were effective in reducing ROS, restoration of ATP
levels was associated with a more robust response to AβO treatment.
Our in vitro system recapitulates key aspects of data from Alzheimer’s
brain samples, the expression of epigenetic genes in which are also shown to be normalized
by the novel analogues