Progression from ocular hypertension to visual field loss in the English hospital eye service

Background There are more than one million National Health Service visits in England and Wales each year for patients with glaucoma or ocular hypertension (OHT). With the ageing population and an increase in optometric testing, the economic burden of glaucoma-related visits is predicted to increase. We examined the conversion rates of OHT to primary open-angle glaucoma (POAG) in England and assessed factors associated with risk of conversion. Methods Electronic medical records of 45 309 patients from five regionally different glaucoma clinics in England were retrospectively examined. Conversion to POAG from OHT was defined by deterioration in visual field (two consecutive tests classified as stage 1 or worse as per the glaucoma staging system 2). Cox proportional hazards models were used to examine factors (age, sex, treatment status and baseline intraocular pressure (IOP)) associated with conversion. Results The cumulative risk of conversion to POAG was 17.5% (95% CI 15.4% to 19.6%) at 5 years. Older age (HR 1.35 per decade, 95% CI 1.22 to 1.50, p<0.001) was associated with a higher risk of conversion. IOP-lowering therapy (HR 0.45, 95% CI 0.35 to 0.57, p<0.001) was associated with a lower risk of conversion. Predicted 5-year conversion rates for treated and untreated groups were 14.0% and 26.9%, respectively. Conclusion Less than one-fifth of OHT patients managed in glaucoma clinics in the UK converted to POAG over a 5-year period, suggesting many patients may require less intensive follow-up. Our study provides real-world evidence for the efficacy of current management (including IOP-lowering treatment) at reducing risk of conversion

Mermin-Ho vortex in ferromagnetic spinor Bose-Einstein condensates

The Mermin-Ho and Anderson-Toulouse coreless non-singular vortices are demonstrated to be thermodynamically stable in ferromagnetic spinor Bose-Einstein condensates with the hyperfine state F=1. The phase diagram is established in a plane of the rotation drive vs the total magnetization by comparing the energies for other competing non-axis-symmetric or singular vortices. Their stability is also checked by evaluating collective modes.Comment: 4 pages, 4 figure

Kinetic Theory of Collective Excitations and Damping in Bose-Einstein Condensed Gases

We calculate the frequencies and damping rates of the low-lying collective modes of a Bose-Einstein condensed gas at nonzero temperature. We use a complex nonlinear Schr\"odinger equation to determine the dynamics of the condensate atoms, and couple it to a Boltzmann equation for the noncondensate atoms. In this manner we take into account both collisions between noncondensate-noncondensate and condensate-noncondensate atoms. We solve the linear response of these equations, using a time-dependent gaussian trial function for the condensate wave function and a truncated power expansion for the deviation function of the thermal cloud. As a result, our calculation turns out to be characterized by two dimensionless parameters proportional to the noncondensate-noncondensate and condensate-noncondensate mean collision times. We find in general quite good agreement with experiment, both for the frequencies and damping of the collective modes.Comment: 10 pages, 8 figure

Association study of two interleukin-1 gene loci with essential hypertension in a Pakistani Pathan population

An association study of IL-1 beta -511C/T and IL-1 RN 86 bp VNTR polymorphisms with essential hypertension was carried out in a sample population of 500 Pakistani Pathan subjects selected randomly, comprising groups of 235 subjects with hypertension and 265 controls. The distribution of both genotypes and alleles was not statistically different in cases and controls. In conclusion, IL-1 beta -511C/T and IL-1 RN 86 bp VNTR do not contribute to the aetiology of essential hypertension in the Pakistani Pathan population investigated here

't Hooft-Polyakov Monopoles in an Antiferromagnetic Bose-Einstein Condensate

We show that an antiferromagnetic spin-1 Bose-Einstein condensate, which can for instance be created with Na-23 atoms in an optical trap, has not only singular line-like vortex excitations, but also allows for singular point-like topological excitations, i.e., 't Hooft-Polyakov monopoles. We discuss the static and dynamic properties ofthese monopoles.Comment: Four pages of ReVTeX and 1 postscript figur

Flow cytometric and demographic analysis of t cell acute lymphoblastic leukemia in Pakistani population.

Background: This study was carried out to analyze the proportion of T cell acute lymphoblastic leukemia (TALL) among all acute lymphoblastic leukemia (ALL) in Pakistani population and its correlation with the demographic features. Accuracy of cell surface markers used in flow cytometric analysis of the leukemic cells was also determined. Methods: Data of 209 consecutive cases of acute lymphoblastic leukemia (ALL) presenting between July 1995 and July 2003 was analyzed. Flow cytometry was performed on all ALL cases using the standard protocols. TALL markers included CD3, CD5 and CD7. Results: Proportion of TALL among known ALL Pakistani patients was 17.22%. Mean age of the TALL patients was 17.2 years. Proportion of TALL was higher in adults than in children (21.95% vs. 14.17%). Overall in this study there were more male patients affected by TALL (25/36 or 69.40%) than females (11/36 or 30.60%). The female to male ratio among TALL patients was 1:2.27. However, the proportion (%) of TALL in females was higher than males (18.96% vs. 15.82 %) i, e, 1.2:1. CD7 was found to be the most sensitive among both adults & children. It was positive in 94.4% of the TALL cases. Conclusion: Proportion of TALL among ALL in Pakistan is similar to that reported in this region, indicating a candidate association with geographical location and socioeconomic status. The reactivity of markers with TALL cells was similar to what we expected based upon literature. However, due to some aberrant and cross reactivity displayed by each marker, we strongly recommend a panel approach including B and myeloid markers to ensure a correct diagnosis of TALL

Skyrmion Physics in Bose-Einstein Ferromagnets

We show that a ferromagnetic Bose-Einstein condensate has not only line-like vortex excitations, but in general also allows for point-like topological excitations, i.e., skyrmions. We discuss the thermodynamic stability and the dynamic properties of these skyrmions for both spin-1/2 and ferromagnetic spin-1 Bose gases.Comment: 31 pages, 7 JPEG figures. To be published in Phys. Rev.

Effectively attractive Bose-Einstein condensates in a rotating toroidal trap

We examine an effectively attractive quasi-one-dimensional Bose-Einstein condensate of atoms confined in a rotating toroidal trap, as the magnitude of the coupling constant and the rotational frequency are varied. Using both a variational mean-field approach, as well as a diagonalization technique, we identify the phase diagram between a uniform and a localized state and we describe the system in the two phases.Comment: 4 pages, 4 ps figures, RevTe

MSLICE Sequencing

MSLICE Sequencing is a graphical tool for writing sequences and integrating them into RML files, as well as for producing SCMF files for uplink. When operated in a testbed environment, it also supports uplinking these SCMF files to the testbed via Chill. This software features a free-form textural sequence editor featuring syntax coloring, automatic content assistance (including command and argument completion proposals), complete with types, value ranges, unites, and descriptions from the command dictionary that appear as they are typed. The sequence editor also has a "field mode" that allows tabbing between arguments and displays type/range/units/description for each argument as it is edited. Color-coded error and warning annotations on problematic tokens are included, as well as indications of problems that are not visible in the current scroll range. "Quick Fix" suggestions are made for resolving problems, and all the features afforded by modern source editors are also included such as copy/cut/paste, undo/redo, and a sophisticated find-and-replace system optionally using regular expressions. The software offers a full XML editor for RML files, which features syntax coloring, content assistance and problem annotations as above. There is a form-based, "detail view" that allows structured editing of command arguments and sequence parameters when preferred. The "project view" shows the user s "workspace" as a tree of "resources" (projects, folders, and files) that can subsequently be opened in editors by double-clicking. Files can be added, deleted, dragged-dropped/copied-pasted between folders or projects, and these operations are undoable and redoable. A "problems view" contains a tabular list of all problems in the current workspace. Double-clicking on any row in the table opens an editor for the appropriate sequence, scrolling to the specific line with the problem, and highlighting the problematic characters. From there, one can invoke "quick fix" as described above to resolve the issue. Once resolved, saving the file causes the problem to be removed from the problem view

Damped Bogoliubov excitations of a condensate interacting with a static thermal cloud

We calculate the damping of condensate collective excitations at finite temperatures arising from the lack of equilibrium between the condensate and thermal atoms. We neglect the non-condensate dynamics by fixing the thermal cloud in static equilibrium. We derive a set of generalized Bogoliubov equations for finite temperatures that contain an explicit damping term due to collisional exchange of atoms between the two components. We have numerically solved these Bogoliubov equations to obtain the temperature dependence of the damping of the condensate modes in a harmonic trap. We compare these results with our recent work based on the Thomas-Fermi approximation.Comment: 9 pages, 3 figures included. Submitted to PR