OPTIMIZATION OF METHODS FOR DIAGNOSTICS OF PATIENTS WITH TOXIC AND CIRRHOTIC LIVER LESIONS

Chronic liver disease is a serious problem for public health service. As a result of increasing alcoholization of population, drug addiction, number of patients with parenteral hepatitis (B, C, D) the conditions for significant increase of number of patients with hepatocirrhosis appear. The aim. of our study was to determine the most optima! methods of diagnostics of patients with toxic and cirrhotic lesions of liver. The object of the research was 67 patients treated, in Irkutsk Municipal Clinical Hospital N 1 during 2007—2011 years with liver cirrhosis. All the patients had. diagnostic laparoscopy with determination. of the level of cytokines, albumins and. gamma-globulins with further clinicomorphological and. statistical analysis of the results. It was revealed that complex use of instrumental and. laboratory methods allows to diagnose liver cirrhosis at the early stage of its progress very precisely.

DIAGNOSTICS OF HELICOBACTER PYLORI INFECTION BY ENZYME IMMUNOASSAY IN PATIENTS WITH CALCULOUS CHOLECYSTITIS

In recentyears, the interest in the significance of Helicobacter pylori in various pathological processes is growing. The most studied is the role of Helicobacter pylori in gastroduodenal pathology. Gallstone disease is one of the most common diseases of the digestive system. Inflammatory changes in the biliary tract aggravate the clinical course of gallstone disease both in the preoperative and in the postoperative period and cause strictures, deformations of the extra hepatic bile ducts in the long term. One of the most threatening complications of gallstone disease is acute cholecystitis. Determination of IgG to Helicobacter pylori in complex diagnosis is important in patients with calculous cholecystitis. We conducted a prospective study of patients (n = 105) aged 30 to 50 years, suffering from different variants of calculous cholecystitis, in the preoperative and postoperative period by enzyme immunoassay. Enzyme-linked immunosorbent assay is reliable, affordable, least invasive method for diagnosing H. pylori infection. In patients with calculous cholecystitis, we marked a significant increase in IgG antibodies to Helicobacter pylori before surgical intervention and a subsequent reduction 10 days after it. Diagnosis of Helicobacter pylori infection of the gallbladder increases therapeutic efficiency and helps to develop preventive measures for complications of gallstone disease

PECULIARITIES OF THE PREVENTION OF MICROCIRCULATION DISORDERS IN PATIENTS DEPENDING ON THE BODY WEIGHT INDEX AFTER LAPAROSCOPIC CHOLECYSTECTOMY

The article is devoted to the research of indices of microcirculation and coagulation hemostasis after endosurgery treatment of gallstone disease in patients depending on the body weight index. It was established that significant microcirculatory changes are observed in the early postoperative period. These changes are caused by the disorder of active and. passive mechanisms of regulation of blood flow oscillations. The changes were more evident in patients with obesity. It is expedient to realize anticoagulant therapy for the correction of disorders of the hemostasis system and. microcirculation in the postoperative period. The ratio of early prediction of thromboembolitic complications after laparoscopic cholecystectomy was developed on the basis of this