Transient acantholytic dermatosis in a patient with prostate cancer

Transient acantholytic dermatosis (TAD) is a relatively common entity that has been also noted to occur in patients with cancer. Herein, we describe a case of transient acantholytic dermatosis occurring in a patient with a history of prostate cancer status post radiation, now being treated with combination therapy with pembrolizumab and carboplatin-pemetrexed for advanced lung adenocarcinoma. Our case emphasizes the importance of being cognizant of TAD and its associations, particularly in cancer patients

ROLE AND SIGNIFICANCE OF INTERNATIONAL BUSINESS ON THE INDIAN ECONOMY

International Business in today’s world has occupied a vitalplace among the economies of the world, particularly among thefastest growing economies like the BRICS nations. The annual rate ofgrowth in the international business sector in India is more than8%.With rich resources available in India, it has a huge advantageover other nations and is regarded as the right nation for exploringbusiness opportunities, Like highly skilled and semiskilled manpower,technologies available within the country, rich natural resources,willingness on part of government to take the world along with andbudding middle class segment. The findings of the paper are expectedto help in boosting the econom

Efficient in vitro

Efficient plant regeneration system has been developed from the nodal segments of chrysanthemum (Chrysanthemum morifolium L). Nodal segments, after being sterilized with 1.0% mercuric chloride for three minutes, were inoculated in Murashige and Skoog (MS) media with varied concentrations of indole acetic acid (IAA), benzylaminopurine (BAP) and their combinations. Different parameters including shoot initiation percentage, average number of shoots per explant, length of shoots (cm), number of leaves per shoot and number of nodes per shoot were studied during the course of study. Intermediate level (0.3 mg/l) of IAA exceeded all the other concentrations of IAA by producing 80.0 % shoot initiation, an average of 4.0 shoots per explants, 5.1 cm long shoots, 11.3 leaves and 5.6 nodes per shoot, when used alone. Similarly, intermediate level of BAP (1.0 mg/l) showed its supremacy over all the other concentrations as it produced 100% shoot initiation, 4.9 shoots per explant, 5.8 cm long shoots, 13.4 leaves and 6.3 nodes per shoot, when used alone. When the combination of different concentrations of IAA and BAP were used, significant results regarding the regeneration of chrysanthemum plantlets were also achieved. MS media supplemented with lower concentrations of IAA (0.1 and 0.2 mg/l) along with intermediate levels of BAP (1.0 and 2.0 mg/l) had a favorable effect on the regeneration of chrysanthemum plantlets using nodal segments of chrysanthemum, as compared to other concentrations and combinations. Satisfactory rooting response was obtained in half strength MS media supplemented with 0.2 mg/l indole butyric acid (IBA), followed by 0.2 mg/l naphthalene acetic acid (NAA) and IAA, respectively.Key words: Chrysanthemum, Dendranthema morifolium, growth regulators, in vitro culture, nodal segments, auxins, rooting

Rapid plant regeneration of chrysanthemum (Chrysanthemum morifolium l.) through shoot tip culture

Shoot multiplication of chrysanthemum was achieved from shoot tip explant, using MS media supplemented with different concentrations and combinations of plant growth regulators. Different parameters including shoot initiation percentage, average number of shoots per explant, length of shoots (cm), number of leaves per shoot and number of nodes per shoot were studied during the course of study. Low concentration of indole-acetic acid (IAA, 0.1 mg/l) excelled all the other concentrations in almost all the parameters studied when used alone, as maximum shoot initiation (86.6%), shoot per explants (3.9), length of shoots (4.3 cm), number of leaves (10.0) and nodes (4.8)were recorded in it. Intermediate concentration of benzyladenine purine (BAP, 1.0 mg/l) is superior to all the other BAP concentrations used when used alone. MS media fortified with 1.0 mg/l BAP hadproduced the maximum shoot initiation (93.3%), shoot per explant (4.1), length of shoots (5.0 cm) number of leaves (11.0) and nodes (5.5). Similarly, when the combination of different concentrations ofIAA and BAP were used, significant results regarding the regeneration of chrysanthemum plantlets were achieved. MS media supplemented with intermediate levels of BAP (1.0 and 2.0 mg/l) along withlower concentrations of IAA (0.1 and 0.2 mg/l) showed better results as compared to other concentrations and combinations. Satisfactory rooting response was obtained in half strength MS media supplemented with 0.2 mg/l indole butyric acid (IBA)

Ethics Analysis of the Human Embryonic Stem Cell Research Debate

Controversy regarding Human embryonic Stem Cell (hESC) research is evident in the medical and scientific community, legislative, judicial, and executive branches of the government, private companies, religious affiliations, special interest groups, and among the general American public. Stem cells are derived from adult stem cell resources, which are termed non-embryonic or from the cells of immature blastocysts termed embryonic stem cells. Non-embryonic cells do not have the ability to differentiate into other specialized tissues, whereas embryonic cells are capable of differentiating into almost any type of tissue. hESC research, which is the focus of this paper, includes the direct creation and therapeutic cloning of human embryos, known as somatic cell nuclear transfer (SCNT) during the blastocyst-stage of development, the use of surplus embryos from in vitro fertilization, and from tissue derived from extracted embryos through abortion. The purpose of hESC research is threefold: (1) to advance science and medicine, (2) prevent disease, and (3) cure certain diseases. hESC research is an ethical dilemma facing the United States of America. Opponents of hESC often cite the rights of the embryo and define the embryo at conception. Supporters of hESC research include the scientific and medical community, and private hESC research companies. The unique political system of the United States has allowed for a dichotomous policy to arise, where federal funding of hESC is prohibited, but private companies and individual states are able to legally forge a path in hESC research. The prohibition of federal funds has created an abyss between states who choose to fund hESC research and those who prohibit it. It has also set the stage for yet another private corporation to advance in hESC and place profit above the American public. The embryo is the only silent member of this debate

Reproducible and expedient rice regeneration system using in vitro grown plants

Inevitable prerequisite for expedient regeneration in rice is the selection of totipotent explant and developing an apposite combination of growth hormones. Here, we reported a reproducible regeneration protocol in which basal segments of the stem of the in vitro grown rice plants were used as ex-plant. Using the protocol, callus was developed from the exposed cells of root segments and cortical tissues of basal part of the stem. Various levels of 2,4-dichlorophenoxyacetic acid (2,4-D) were used, where 1 mg/L was found as best level for callus induction. Further, 25 combinations of kinetin and naphthalene acetic acid (NAA) were developed to investigate the regeneration response of the calli. The root-derived calli did not respond to any combination at all, whereas the nodular calli derived from the stem segments responded variably to kinetin and NAA combinations in the Murashige and Skoog (MS) medium from base to top. Higher kinetin to NAA ratios promoted embryogenesis, whereas lower ratios exhibited rhizogenesis. A combination of 3 mg/L kinetin and 1 mg/L NAA was established to be the best combination for plant regeneration through embryogenesis in rice from in vitro grown plants. Plants regenerated in vitro were successfully acclimatized in the pots, where they exhibited phenotypically indistinguishable normal growth when compared with plants developed from seed, hence the developed regeneration system for rice in these studies may be treated as one of the best strategies to in vitro clonal propagation and purification, ahead of seasonal growth of plants in the field or green house.Key words: Rice, in vitro regeneration, explants, naphthalene acetic acid (NAA), kinetin, rhizogenesis

A Study on Legal and Ethical Issues Surrounding Health Practitioner Pro Bono Services

The purpose of this paper is to explore the legal and ethical implications of pro bono health care services in the United States and abroad. The research regarding volunteer or pro bono health services has focused mainly on physician involvement in volunteer medical services, or pro bono health services, with research showing only 39% of physicians, compared to 30% of general public, taking part in volunteer services to patients and the community (Grande, D, and Armstrong, K, 2007). Historically, pro bono services were derived from the Canons of Professional Ethics in 1908 and evolved into the Model Code of Professional Responsibility in 1969 and finally the Model Rules of Professional Conduct in 1983. The World Health Organization developed the Commission on the Social Determinants of Health in 2005, which include the following goals: (1) Improving living conditions (2) Addressing the inequitable distribution of power, money, and resources, and (3) Measuring and understanding the related problems (WHO, 2008). In the final report, the four areas of concern included socioeconomic factors, patient health care accessibility, health care rationing, and patient advocacy. Pro bono health services are one method of addressing the health care accessibility and socioeconomic factors surrounding the current dilemma in health care

Botulinum toxin-A for the treatment of overactive bladder: UK contributions

Background: Botulinum toxin-A (BoNT/A) is now established second-line management for refractory overactivebladder (OAB) and recognised in many incontinence guidelines and pathways. For those with neurogenic detrusoroveractivity secondary to spinal cord injury or multiple sclerosis, the toxin is currently licensed in certain parts of theworld, including the UK. It is an effective treatment in those in whom antimuscarinics and conservative measures havefailed who have symptoms of OAB and or detrusor overactivity (DO). Methods: Treatment can be given in an outpatient setting and can be administered under local anaesthesia. Its efficacylasts for between six and 12 months. Results: It has an acceptable safety profile with the biggest risk being urinary tract infection and difficulty emptying thebladder, necessitating clean intermittent self-catheterisation (CISC). Medium-term follow-up suggests repeated injectionsare also safe and efficacious. Conclusions: The mechanism of action of the toxin is more complicated than originally thought, and it seems likelythat it affects motor and sensory nerves of the bladder. In the last 10 years much of the progress of this treatment fromearly experimental trials to mainstream clinical use, and a better understanding of how it works in the bladder, are as aresult of research conducted in the UK. This review summarises the significant and substantial evidence for BoNT/A totreat refractory OAB from UK centres. © British Association of Urological Surgeons 2013

Web Usage Mining and User Behaviour Prediction

Today, Internet is playing such a significant role in our day-to-day life. We have witnessed the evermore- interesting and upcoming publishing medium is the World Wide Web (WWW). The rapid growth in the volume of information available over the WWW and number of its� potential users� has leads to difficulties in providing effective search service for users�, resulting in decrease in the web performance. Web Usage Mining is an area, where the navigational access behaviour of users� over the web is tracked and analyzed. So that websites owner can easily identify the access patterns of its users�. By collecting and analyzing this behaviour of user activities, websites owner can enhance the quality and performance of services to catch the attention of existing as well as new customers. This research paper intends to provide an overview of past and current evaluation in users� future request prediction using Web Usage Mining