13 research outputs found
Photoactivatable Fluorophore for Stimulated Emission Depletion (STED) Microscopy and Bioconjugation Technique for Hydrophobic Labels
The use of photoactivatable dyes in STED microscopy has so far been limited by twoâphoton activation through the STED beam and by the fact that photoactivatable dyes are poorly solvable in water. Here we report ONBâ2SiR, a fluorophore that can be both photoactivated in the UV and specifically deâexcited by STED at 775 nm. Likewise, we introduce a conjugation and purification protocol to effectively label primary and secondary antibodies with moderately waterâsoluble dyes. Greatly reducing dye aggregation, our technique provides a defined and tunable degree of labeling, and improves the imaging performance of dye conjugates in general
Memory effect in cadmium telluride quantum dots doped ferroelectric liquid crystals
A pronounced memory effect has been observed in cadmium telluride quantum dots (CdTe-QDs) doped ferroelectric liquid crystals (FLCs) by using dielectric and electro-optical methods. The memory effect has been attributed to the charge storage on the CdTe-QDs upon the application of dc bias across the sample cell. The FLC molecules remain in the switched state in vicinity of the charge stored on QDs even after removal of bias. It has been observed that the memory effect depends on doping concentrations of CdTe-QDs and the FLC material used
Hole transport mechanism in organic/inorganic hybrid system based on in-situ grown cadmium telluride nanocrystals in poly(3-hexylthiophene)
The present manuscript demonstrates the hole transport mechanism in an organic/inorganic hybrid
system based on in-situ grown cadmium telluride (CdTe) nanocrystals in a poly(3-hexylthiophene)
(P3HT) matrix. The increase of hole current in the hybrid system is correlated with the formation of
a host-guest (P3HT-CdTe) charge transfer complex duly supported by photoluminescence
quenching. The hole transport mechanism in P3HT is governed by a space charge limited current
with temperature, carrier density, and field dependent mobility. Incorporation of CdTe nanocrystals
in a polymer matrix results in enhancement in the value of trap density Hb from 2.8 Ă 1018 to
5.0 Ă 1018 cmĂ3 and reduction in activation energies from 52 meV to 11 meV. At high trap density,
trap potential wells start overlapping; this results in decrease of activation energies
New Self-Organizing Optical Materials and Induced Polymorphic Phases of Their Mixtures Targeted for Energy Investigations
Herein, a new homologues series of fluorinated liquid crystal compounds, In, 4-(((4-fluorophenyl)imino)methyl)-2-methoxyphenyl 4-alkoxybenzoate were synthesized and its mesomorphic properties were investigated both experimentally and theoretically. The synthesized compounds were characterized by elemental analyzer, NMR, and FT-IR spectroscopy to deduce the molecular structures. The differential scanning calorimetry was employed to examine mesophase transitions whereas the polarized optical microscopy was used to identify the mesophases. The obtained results revealed that the purely nematic phase observed in all terminal side chains. All homologues showed to possess monotropic nematic mesophases except the derivative I8 exhibits enantiotropic property. The optimized geometrical structures of the present designed groups have been derived theoretically. The experimental data was explained using density functional theory computations. The estimated values of dipole moment, polarizability, thermal energy, and molecule electrostatic potential demonstrated that the mesophase stability and type could be illustrated. Binary phase diagram was constructed and addressed in terms of the mesomorphic temperature range and obtained polymorphic phases. It was found that incorporation of the terminal F-atom and lateral CH3O group influence both conformation and steric effect in pure and mixed states. The absorption and fluorescence emission spectra of fabricated films were recorded to elucidate the impact of terminal side chain on photophysical properties of synthesized liquid crystal. It was noted that the increase of terminal side chain length lead to reduction of optical band gap, whereas charge carrier lifetime increases
Design of Liquid Crystal Materials Based on Palmitate, Oleate, and Linoleate Derivatives for Optoelectronic Applications
Herein, liquid crystalline derivatives based on palmitate, oleate, and linoleate moieties with azomethine cores were synthesized, and their physical, chemical, optical, and photophysical properties were investigated in detail. The mesomorphic activity of these materials was examined through polarized optical microscopy (POM) and differential scanning calorimetry (DSC). The observed results revealed that the stability of the thermal mesophase depends on the terminal polar as well as on the fatty long-chain substituents. Purely smectogenic phases were detected in all three terminal side chains. A eutectic composition with a low melting temperature and a broad smectic A range was found by constructing a binary phase diagram and addressing it in terms of the mesomorphic temperature range. The energy bandgap of the palmitate-based derivative (Ia) was determined as 3.95 eV and slightly increased to 4.01 eV and 4.05 eV for the oleate (Ib) and linoleate (Ic) derivatives, respectively. The optical constants (n, Îș, Δr, and Δi) were extracted from the fitting of measured spectroscopic ellipsometer data. The steady-state spectra of these samples exhibited a broad emission in the range 400â580 nm, which was found to be blue shifted to 462 nm for both Ib and Ic derivatives. The average fluorescence decay lifetime of the Ia derivative was found to be 598 ps, which became faster for the Ib and Ic derivatives and slower for the sample with a chloride end polar group
Palladium-Catalyzed 4âFold Domino Reaction for the Synthesis of a Polymeric Double Switch
A palladium-catalyzed
4-fold domino reaction consisting of two
carbopalladation reactions and two CâH activation reactions,
followed by the introduction of an acrylate moiety, led to the tetra-substituted
helical alkene <b>A2</b>, using the dialkyne <b>A3</b> as a substrate. The alkene was copolymerized with butyl acrylate
by using the reversible additionâfragmentation chain transfer
polymerization (RAFT) to give the desired polymeric switch <b>A1</b>
1â(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators
We
present a novel series of selective androgen receptor modulators
(SARMs) which shows excellent biological activity and physical properties.
1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)-indoline-4-carbonitriles
showed potent binding to the androgen receptor (AR) and activated
AR-mediated transcription in vitro. Representative compounds demonstrated
diminished activity in promoting the intramolecular interaction between
the AR carboxyl (<i>C</i>) and amino (<i>N</i>) termini. This <i>N</i>/<i>C</i>-termini interaction
is a biomarker assay for the undesired androgenic responses in vivo.
In orchidectomized rats, daily administration of a lead compound from
this series showed anabolic activity by increasing levator ani muscle
weight. Importantly, minimal androgenic effects (increased tissue
weights) were observed in the prostate and seminal vesicles, along
with minimal repression of circulating luteinizing hormone (LH) levels
and no change in the lipid and triglyceride levels. This lead compound
completed a two week rat toxicology study, and was well tolerated
at doses up to 100 mg/kg/day, the highest dose tested, for 14 consecutive
days