1,1′-{[1,4-Phenyl­enebis(methyl­ene)]bis­(­oxy)bis­(3,1-phenyl­ene)}diethanone

In the title compound, C24H22O4, the centroid of the central benzene ring lies on a special position of 2/m site symmetry, while the terminal aromatic rings are located on a mirror plane. The central and terminal benzene rings are perpendic­ular to each other. In the crystal, the mol­ecules are connected via C—H⋯O hydrogen bonds into a three-dimensional polymeric structure. The network is further consolidated by a C—H⋯π inter­action

tert-Butyl 2-(1H-benzimidazol-1-yl)acetate

In the title compound, C13H16N2O2, the planes of the benzimidazole ring system and the acetate O—C=O fragment make a dihedral angle of 84.5 (3)°. In the crystal, mol­ecules are connected through C—H⋯N hydrogen bonds to form infinite chains in the [-110] direction

THE RELATIONSHIP BETWEEN THE LACTATE TURNPOINT AND THE TIME AT VO2 max DURING A CONSTANT VELOCITY RUN TO EXHAUSTION

The aim of present work was to examine the relationship between the running velocity at the lactate turn-point (vLTP) and the time at which VO can be sustained (TVO ) during a continuous run to exhaustion at a minimal running velocity that yields VO (vVO ). Pearson’s correlation coefficient was used to determine the association between vLTP and TVO and between other selected physiological variables. Correlations between the relative vLTP and v VO was significant (r=0.63) at the

1-Tosyl-2-[(1-tosyl-1H-benzimidazol-2-yl)methyl­sulfanyl]-1H-benzimidazole

In the title compound, C29H24N4O4S3, the two N-tosyl­benzimidazolyl unit are connected through a —S—CH2— fragment, the dihedral angle between the benzimidazole rings being 76.09 (5)°. The methyl­thio group is disordered with respect to exchange of the S and C atoms in a 0.547 (4):0.453 (4) ratio. In the crystal, C—H⋯O and C—H⋯π inter­actions connect adjacent mol­ecules into infinite layers parallel to the ab plane. The crystal packing is further stabilized by a π–π inter­action [centroid–centroid separation = 3.5187 (4) Å]

Imidazo[1,2-b]isoquinoline-5,10-dione

The title butterfly-shaped mol­ecule, C11H6N2O2, is folded slightly along the O=C⋯C=O line, the dihedral angle between the two parts being 6.42 (3)°. In the crystal, adjacent mol­ecules are linked through C—H⋯O hydrogen bonds into infinite layers parallel to the ac plane. The layers are further connected into a three-dimensional netweork via π–π inter­actions formed between pairs of anti­parallel arranged mol­ecules, with a centroid–centroid distance between the central six-membered ring and the benzene ring of 3.4349 (9) Å

1-Carb­oxy­methyl-3-octylimidazolium bromide

In the title compound, C13H23N2O2 +·Br−, the octyl chain has an all-trans conformation. In the crystal, the cations are linked by C—H⋯O bonds into a zigzag chain along the b axis. The bromide anions further link the chains via C—H⋯Br inter­actions into a two-dimensional array parallel to the ab plane. An O—H⋯Br interaction is also observed

1,1′-{[1,4-Phenyl­enebis(methyl­ene)]bis­(­oxy)bis­(4,1-phenyl­ene)}diethanone

The centroid of the central aromatic ring of the title mol­ecule, C24H22O4, is located on an inversion center. The dihedral angle between the central and terminal benzene rings is 75.00 (7)°. In the crystal, mol­ecules are linked through C—H⋯O hydrogen bonds into chains along [121]. The chains are connected into layers via C—H⋯π inter­actions

4-Hy­droxy-3-meth­oxy­benzaldehyde–nicotinamide (1/1)

In the title compound, C6H6N2O·C8H8O3, an equimolar co-crystal of nicotinamide and vanillin, the aromatic ring and the amide fragment of the nicotinamide mol­ecule make a dihedral angle of 32.6 (2)°. The vanillin mol­ecule is almost planar, with an r.m.s. deviation for all non-H atoms of 0.0094 Å. The vaniline and nicotinamide aromatic rings are nearly coplanar, the dihedral angle between them being 3.20 (9)°. In the crystal, the two components are linked through N—H⋯O and O—H⋯N hydrogen bonds into chains along the a axis. The chains are connected via C—H⋯O inter­actions, forming a three-dimensional polymeric structure

The association between ATM variants and risk of breast cancer: a systematic review and meta-analysis

Background: Ataxia telangiectasia-mutated (ATM) gene contributes to repair damaged DNA and to regulate cell cycle; therefore, ATM variants seem to increase breast cancer risk; however, the results are controversial. So we conducted a systematic review and meta-analysis to clarify the pooled association between various ATM variants and the risk of breast cancer. Methods: The relevant studies were searched through Scopus, Web of Science, PubMed and Cochrane. Stratified and subgroup analyses were performed to explore heterogeneity between studies and assess effects of study quality. The pooled estimates logarithm with standard error logarithm of odds ratio and relative risk with confidence interval were calculated. Results: This study revealed that there is association between ATM variants and the risk of breast cancer; according to the seven adjusted case-control studies, OR of this association was estimated as 1.67 (95CI: 0.73�3.82), according to nine unadjusted case-control studies, the crude OR was 2.27 (95 CI: 1.17�4.40) and according to two cohorts, the RR was estimated as 1.68 (95 CI: 1.17�2.40). Conclusions: The ATM variants are associated with an increased risk of breast cancer that ATM V2424G mutation is detected as the most predisposing factor while ATM D1853V, L546V, and S707P variants have the least predictive ability. © 2021, The Author(s)