The potential impact of the COVID-19 pandemic on global antimicrobial and biocide resistance:An AMR Insights global perspective

The COVID-19 pandemic presents a serious public health challenge in all countries. However, repercussions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on future global health are still being investigated, including the pandemic's potential effect on the emergence and spread of global antimicrobial resistance (AMR). Critically ill COVID-19 patients may develop severe complications, which may predispose patients to infection with nosocomial bacterial and/or fungal pathogens, requiring the extensive use of antibiotics. However, antibiotics may also be inappropriately used in milder cases of COVID-19 infection. Further, concerns such as increased biocide use, antimicrobial stewardship/infection control, AMR awareness, the need for diagnostics (including rapid and point-of-care diagnostics) and the usefulness of vaccination could all be components shaping the influence of the COVID-19 pandemic. In this publication, the authors present a brief overview of the COVID-19 pandemic and associated issues that could influence the pandemic's effect on global AMR.</p

The potential impact of the COVID-19 pandemic on global antimicrobial and biocide resistance : an AMR Insights global perspective

The COVID-19 pandemic presents a serious public health challenge in all countries. However, repercussions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on future global health are still being investigated, including the pandemic’s potential effect on the emergence and spread of global antimicrobial resistance (AMR). Critically ill COVID-19 patients may develop severe complications, which may predispose patients to infection with nosocomial bacterial and/or fungal pathogens, requiring the extensive use of antibiotics. However, antibiotics may also be inappropriately used in milder cases of COVID-19 infection. Further, concerns such as increased biocide use, antimicrobial stewardship/infection control, AMR awareness, the need for diagnostics (including rapid and point-of-care diagnostics) and the usefulness of vaccination could all be components shaping the influence of the COVID-19 pandemic. In this publication, the authors present a brief overview of the COVID-19 pandemic and associated issues that could influence the pandemic’s effect on global AMR.This study was supported by internal funding.https://academic.oup.com/jacamram2022School of Health Systems and Public Health (SHSPH

Rigorous Quantification of the statistical significance of COVID-19 lockdown effect on air quality: The case from ground-based measurements in Ontario, Canada

Preliminary analysis of satellite measurements from around the world showed drops in nitrogen dioxide (NO2) with lockdowns due to the COVID-19 pandemic. A number of studies have found these drops to be correlated with local decreases in transportation and/or industry. None of these studies, however, has rigorously quantified the statistical significance of these drops relative to natural meteorological variability and other factors that influence pollutant levels during similar time periods in previous years. Here, we develop a novel statistical testing framework that accounts for seasonal variability, transboundary influences, and new factors such as COVID-19 restrictions in explaining trends in several pollutant levels at 16 ground-based measurement sites in Southern Ontario, Canada. We find statistically significant and temporary drops in NO2 (11 out 16 sites) and CO (all 4 sites) in April-June 2020, with pollutant levels 20% lower than in the previous three years. Much fewer sites (2-3 out of 16) experienced statistically significant drops in O3 and PM2.5. The statistical testing framework developed here is the first of its kind applied to air quality data, and highlights the need for rigorous assessment of statistical significance, should analyses of pollutant level changes post COVID-19 lockdowns be used to inform policy decisions in Ontario, Canada. See Methods section in the manuscript

Novel tooling for direct melt impregnation of textile with variotherm injection moulding: Methodology and proof of concept

Thermoplastic compression resin transfer moulding coupled with injection moulding is an appealing process for the production of thermoplastic composites. However, its implementation at an industrial scale remains challenging as variotherm injection moulding could prevent solid skin formation in the parting line, making cavity sealing difficult. In this study, a tool for thermoplastic compression resin transfer moulding and the related methods and process parameters for an implementation at an industrial scale are presented. The validity of the concept is proved by producing and characterizing composite plates with elevated fibre volume fractions and advantageous mechanical properties at a range of production temperatures within a cycle time not exceeding 20 min. The best mechanical properties were obtained at a production temperature of 270°C with a bending strength of 477 MPa, a flexural modulus measured at 25.7 GPa and a fibre volume content of 67%.Aerospace Manufacturing Technologie

The potential impact of the COVID-19 pandemic on global antimicrobial and biocide resistance: An AMR Insights global perspective

The COVID-19 pandemic presents a serious public health challenge in all countries. However, repercussions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on future global health are still being investigated, including the pandemic's potential effect on the emergence and spread of global antimicrobial resistance (AMR). Critically ill COVID-19 patients may develop severe complications, which may predispose patients to infection with nosocomial bacterial and/or fungal pathogens, requiring the extensive use of antibiotics. However, antibiotics may also be inappropriately used in milder cases of COVID-19 infection. Further, concerns such as increased biocide use, antimicrobial stewardship/infection control, AMR awareness, the need for diagnostics (including rapid and point-of-care diagnostics) and the usefulness of vaccination could all be components shaping the influence of the COVID-19 pandemic. In this publication, the authors present a brief overview of the COVID-19 pandemic and associated issues that could influence the pandemic's effect on global AMR

The potential impact of the COVID-19 pandemic on global antimicrobial and biocide resistance: an AMR Insights global perspective.

The COVID-19 pandemic presents a serious public health challenge in all countries. However, repercussions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on future global health are still being investigated, including the pandemic's potential effect on the emergence and spread of global antimicrobial resistance (AMR). Critically ill COVID-19 patients may develop severe complications, which may predispose patients to infection with nosocomial bacterial and/or fungal pathogens, requiring the extensive use of antibiotics. However, antibiotics may also be inappropriately used in milder cases of COVID-19 infection. Further, concerns such as increased biocide use, antimicrobial stewardship/infection control, AMR awareness, the need for diagnostics (including rapid and point-of-care diagnostics) and the usefulness of vaccination could all be components shaping the influence of the COVID-19 pandemic. In this publication, the authors present a brief overview of the COVID-19 pandemic and associated issues that could influence the pandemic's effect on global AMR