Histopathology of placenta in intrauterine growth restriction (IUGR)

Background: Birth of healthy term baby depends on normal placenta. IUGR is a condition associated with placental insufficiency. There is a close relationship between IUGR and placental qualitative changes. The aim of the present study was to evaluate the morphological and histological changes in placentas of IUGR fetuses and in placentas of normal uncomplicated pregnancies and to determine the relationship that exists between morphological change and frequency of IUGR.Methods: In a cross sectional study conducted in the department of Pathology, GMC Jammu, a total of 60 placenta were received, 30 placenta of IUGR fetus (group 1-case) and 30 placenta of uncomplicated pregnancy with normal single fetus (group 2-control). Exclusion criteria: Twin pregnancy, gestational hypertension, diabetes, congenital anomaly, antepartum hemorrhage and systemic disorder.Results: Placental weights in IUGR group were significantly lower than control group. Average placental weight in IUGR group was 425 gms while in the control group (normal placenta) it was 550 gms. Infarction, intervillous thrombosis, chorionic villitis, hemorrhagic endovasculitis, placental intravascular thrombi, perivillous fibrin deposition, fibrinoid necrosis and villous edema were found to be more common in IUGR group (Group 1-case group) than Normal (Group 2- control group).Conclusions: This study highlightened that significant pathological differences were found between the placentas of IUGR fetus and normal fetus. The gross and microscopic measurement of a placenta is a good way to get proper information about IUGR and helps in management of the pregnancy

Diagnostic aid in Ayurveda - Nadi Pariksha

Nadi Pariksha is the ancient art and science of detecting the existing status of a person’s body, mind, soul and spirit. It is used as diagnostic, prognostic tool and determine the Prakruti (body constitution), Vikruti, status of Dosha in each organ and effect on Dhatus, Manas and Sukshma Sharir. It is a noninvasive science that helps to reach root cause of disease and not just the symptoms. There are very few ancient texts which have been completely dedicated to the above topic. Concept of Nadi Pariksha found in various ancient Ayurved Samhitas like, Bhavprakash, Sharangdhar Samhita, Yogratnakara, Nadi Pariksha by Ravansamhita, Nadivigyan by Kanad. Pulse diagnosis was initially identified in the books of Sharangdhar Samhita in the 13th century highlighting the correlation between Nadi and Tridosha. Later, in the 16th century it was again mentioned in ‘Bhavprakash’ scripted by Shri Bhav Mishrji. However, Nadi Pariksha gained its significance during the 17th century in Yogratnakara through 48 shlokas, detailing the science of Nadi. The examinations of Nadi Pariksha (Pulse examination) are evidence of many diseases as per Yogratnakara. In Charaka and Sushruta Samhita information about Nadi is not found separately. Nadi Parikshan requires expertise who has long experience and skill of reading the pulses for any disease diagnosis. They were popular diagnostic tools in the past but nowadays not specifically used, so there is need to re-establish their results so that they can be used in future. Several problems that remain undiagnosed even with the aid of sophisticated diagnostic tests can be accurately judged by examining the pulse

Diagnostic utility of bone marrow aspiration in bicytopenia

Background: Haematological diseases are frequently seen now a days in different age groups. Patients can present with a variety of presentations in form of cytopenia of a single lineage or in a dual combination or with pancytopenia. Our study focusses on the utility of bone marrow aspiration for diagnosis of bicytopenias by assessment of pattern of bicytopenias in peripheral smear examination. Methods: This was a retrospective study that was conducted over a period of one year in a tertiary care institute of Northern India. Cases of bicytopenia were subjected to bone marrow aspiration and parameters such as cellularity, myeloid to erythroid ratio and cytomorphological details of the cells were documented. Results: Study consisted of male predominance with maximum patients in the age group of 21-30 years. Most common bicytopenia was found to be anaemia with thrombocytopenia and normoblastic erythroid hyperplasia was the most common aetiology.The results of this study were similar to those in the earlier literature with the inference that bone marrow aspiration performed for all cases significantly helped in arriving at the diagnosis. Conclusions: Bicytopenia is a good haematological indicator for many non-malignant and malignant diseases. Knowledge of its aetiologies can help in the diagnosis and efficient management of patients. Bone marrow study forms a cost-effective tool in interpretation of bicytopenia

Spectroscopic, Thermal, Electrochemical, and Antimicrobial Studies of Mononuclear Manganese(II) Ditolyldithiophosphates

New complexes of manganese(II) corresponding to [{(ArO)2PS2}2Mn] and [{(ArO)2PS2}2Mn.nL] (Ar=o-,m-,p-CH3C6H4 and p-Cl-m-CH3C6H3; n=1, L = N2C12H8, N2C10H8; n=2, L = NC5H5, P(C6H5)3) have been synthesized and characterized by microelemental analyses (C, H, and N), magnetic susceptibility, molar conductance, thermogravimetric, cyclic voltammetry, and spectral analyses including ESI mass spectrometry, IR, and UV-visible. The presence of a four-and-six coordinated Mn atoms has been established in the complexes and adducts, respectively. Antimicrobial screening of the complexes against gram negative bacteria E. coli, K. pneumonia, and P. aeruginosa and fungus S. rolfsii has shown potential bioactivity

First Donor-Stabilized Complexes of Manganese(II) with Disubstituted diphenyldithiophosphates: synthesis, characterization, biological, and X-ray Analysis

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