Developing Marketing Strategy Of PT Angkasa Dwi Utama To America

PT. Angkasa Dwi Utama, our company has two subsidiaries convinced backpackerjalanjalan.com and tour and travel of Putra Hadi. As we know traveling increasingly in demand by many people and society, but foreigners who are have travelling hobbies, our company can provide tours to several countries in Asia but our company is more concerned to travel in Indonesia. Indonesia has many beautiful spots around the country, but these spots are not published well to the other country. Because of that we use online media for promotion of our business and the hidden beautiful spots in Indonesia, we use website, facebook, twitter, etc. This company have good management systems and interesting tour and travel packages, but this company are not doing promotion well. This company is have great potential to be better, so our team try to help this company selling the product abroad specially USA. The recommended idea from our team is using promotion by social media. We use social media because that is the quickest way to promote it without going to the targeted country. Our team is try to cooperate with another travel agent abroad which is AmericaAsia.com Our team are very optimistic with this project to help the company being International travel agent. We are hoping that our recommended idea can help the company to get more and more travel agent partnership

Optimization of Technical and Economical Objective Functions of Hybrid Renewable Energy Generation Based Genetic Algorithm

This study is aimed to optimize the technical and economic objective functions of a renewable energy hybrid generator system by using genetic algorithms (GA) in order to create a balanced and optimal power generation system configuration. The technical and economic aspects used were the Loss of Power Supply Probability (LPSP) and Annualized Cost of System (ACS), respectively. The objective functions of GA method were LPSP and ACS. The types of power plants used in this hybrid system were photovoltaic (PV), Wind Turbine (WT), battery, and Micro Hydro Power Plant (MHPP). Validation on the GA method was done by simulation in Matlab. Results of the simulation show that the use of the GA offers the most balanced system configuration with less expensive costs and a very good level of system reliability against hybrid systems. The use of the objective function with penalty factor scenario in GA is not as effective as the conventional GA, following the weakness of its evaluation results

Brachyolmia, dental anomalies and short stature (DASS): Phenotype and genotype analyses of Egyptian and Pakistani patients

Brachyolmia is a heterogeneous group of developmental disorders characterized by a short trunk, short stature, scoliosis, and generalized platyspondyly without significant deformities in the long bones. DASS (Dental Abnormalities and Short Stature), caused by alterations in the LTBP3 gene, was previously considered as a subtype of brachyolmia.The present study investigated three unrelated consanguineous families (A, B, C) with Brachyolmia and DASS from Egypt and Pakistan. In our Egyptian patients, we also observed hearing impairment. Exome sequencing was performed to determine the genetic causes of the diverse clinical conditions in the patients. Exome sequencing identified a novel homozygous splice acceptor site variant (LTBP3:c.3629-1G > T; p. ?) responsible for DASS phenotypes and a known homozygous missense variant (CABP2: c.590T > C; p.Ile197Thr) causing hearing impairment in the Egyptian patients. In addition, two previously reported homozygous frameshift variants (LTBP3:c.132delG; p.Pro45Argfs*25) and (LTBP3:c.2216delG; p.Gly739Alafs*7) were identified in Pakistani patients.This study emphasizes the vital role of LTBP3 in the axial skeleton and tooth morphogenesis and expands the mutational spectrum of LTBP3. We are reporting LTBP3 variants in seven patients of three families, majorly causing brachyolmia with dental and cardiac anomalies. Skeletal assessment documented short webbed neck, broad chest, evidences of mild long bones involvement, short distal phalanges, pes planus and osteopenic bone texture as additional associated findings expanding the clinical phenotype of DASS. The current study reveals that the hearing impairment phenotype in Egyptian patients of family A has a separate transmission mechanism independent of LTBP3