Severe Accidental Organophosphorus Poisoning in Two Children

Background: Organophosphorus (OP) compounds have intense anticholinesterase activity and are commonly used as insecticides and pesticides. OP poisoning is a global health problem and poses a threat to human health. Case Report: Here we report two sisters, aged 3 and 4 years, who had inadvertently eaten agricultural pesticides. These patients had a decreased level of consciousness, nausea, and vomiting. We do not have pralidoxime in this center and the adjacent center, so we used atropine as the primary drug in treating these patients. However, after 4 days, the 3-year-old patient felt a weakness in upper and lower limb movements. Conclusion: In the treatment of OP poisoning, it is necessary to pay special attention to delayed complications such as intermediate syndrome

A Review on Complications and Management of Aluminium Phosphide (Rice Pill) and Zinc Phosphide Poisoning

Background: Various fumigant products containing aluminium  phosphide, known as rice pills, are widely used to kill insects in many parts of Iran, including the northern provinces. Poisoning with zinc phosphide as a rat poison also has the same side effects as aluminium  phosphide. This poisoning has no specific antidote, and the treatment is auxiliary, and one of the effective auxiliary treatments is L-carnitine. This review study aimed to determine the prevalence of aluminium  phosphide poisoning and treatment with intravenous L-carnitine. Materials and Methods: This study was a narrative review conducted in 2023. Search keywords aluminium  phosphide, zinc phosphide, intravenous L-carnitine, and poisoning in Persian and English languages in databases including Magiran, PubMed, Wiley, Science Direct, web of Sciences, SID, Scopus, and Google Scholar were done from 1970 to 2022. Relevant articles were identified, and the most important and valuable points were presented after review. Results: According to the findings of most studies, aluminium  phosphide pills had the most adverse effects as toxic substances. Conclusion: Due to the prevalence of its consumption among young people with low education levels, there was a need for physicians to treat these patients as quickly as possible accurately. It is also necessary to raise awareness about its potentially dangerous side effects and to monitor closely the distribution of this poisonous pill in its distribution centers. Moreover, the quick start of supportive treatment with antioxidants and L-carnitine can help in this poisoning that does not have a specific antidote. Very effective and useful

The complications of tramadol and methadone use to women’s sexual hormone

Background and aims: Tramadol and methadone are synthetic opioid drugs that are widely used in various fields of medicine. This review article was performed to investigate the hormone disturbance of long-term tramadol and methadone use in women. Methods: Keywords were determined using the MeSH browser and then searched in ISI, Scopus, EMBASE, and PubMed databases on 25.5.2022. The articles with non-English language, articles whose full text was not retrieved, and studies that were irrelevant to the aim of this study were excluded from the investigation. Results: Methadone and tramadol affected a sexual hormone in women through an impact on the hypothalamic-pituitary-gonadal axis. They could reduce the levels of follicle stimulating hormone and luteinizing hormone, increase prolactin production, and finally, reduce gonadal steroids. Opioids also could influence thyroid and adrenal glands and subsequently increase thyroid-stimulating hormone, and reduce dehydroepiandrosterone. Eventually, this mechanism caused a disturbance in sexual hormone disturbance in women. Conclusion: Overall, long-term methadone and tramadol consumption as opioid substances could cause sexual hormone disturbance in women

The Effect of Intravenous and Oral Fluid Therapy on Women with Third Trimester Oligohydramnios of Pregnancy and the Fetus

Background & Objective: Adequate amniotic fluid volume is one of the most important aspects of fetal health and Oligohydramnios refers to amniotic fluid volume that is less than expected for gestational age. The aim of this study was to compare the trend of amniotic fluid changes in the two groups of oral and injectable before and after fluid therapy. Materials & Methods: In the present study, pregnant women with oligohydramnios in the third trimester referring to Amir Al-Momenin Hospital (Zabol, 2019) were randomly divided into two groups of case. The first group received oral water and the second group was treated with serum therapy. Eventually, all patients underwent ultrasonography and their AFI was recalculated and compared. Data was analyzed using SPSS 20 statistical software. Results: The results of the study showed that there was no statistically significant difference between the amniotic fluid index before fluid therapy in the oral and injectable (serum therapy) groups (p = 0.426). After fluid therapy, the amniotic fluid index in the oral group was significantly higher than the injected group (p <0.001). Although in both oral and injectable groups, the amniotic fluid index increased significantly after treatment (p <0.001), the increase in the oral group was significantly higher than the injectable group. Conclusion: The results of this study showed that oral and intravenous fluid therapy improves the amniotic fluid index more than injectable fluid therapy