Peritoneal carcinomatosis, an unusual and only site of metastasis from lung adenocarcinoma

Isolated peritoneal metastases of lung adenocarcinoma are very rare, even exceptional, occurring most often in the context of a multi-metastatic disease. This report presents a rare clinical case of isolated peritoneal metastasis from lung adenocarcinoma. We report a 56-year-old male who was monitored for lung adenocarcinoma whose evolution has been marked by an isolated metastatic recurrence in the peritoneum objectified by an abdominal-pelvic computed tomography (CT) and confirmed by a laparoscopy with abiopsy of the peritoneal nodules. The patient had received palliative chemotherapy with gemcitabine, cisplatin and bevacizumab. The evolution was marked by a progressive deterioration of the general condition and death two months after the third treatment cycle. Peritoneal carcinomatosis from lung adenocarcinoma is a very rare event, and is often associated with a poor prognosis.Pan African Medical Journal 2016; 2

Le psoriasis chez le nouveau-né et le nourrisson : épidémiologie, éthiopathogénie, aspects cliniques et traitement (à propos de 19 cas).

Le psoriasis est une dermatose érythémato-squameuse chronique affectant environ 3% de la population mondiale et qui représente 5% des affections dermatologiques de l’enfant. La forme familiale n’est pas négligeable. C’est une maladie inflammatoire caractérisée par une prolifération kératinocytaire anormale, c’est une pathologie multifactorielle complexe mettant en jeu des facteurs génétiques, immunologiques et environnementaux ; son étiologie exacte reste encore mal connue. Toutes les formes cliniques du psoriasis peuvent s’observer chez le nouveau-né et le nourrisson. Les psoriasis en plaques, en gouttes, du visage, du cuir chevelu et le « napkin psoriasis » représentent les aspects les plus fréquemment rencontrés. Le diagnostic du psoriasis est très souvent clinique et ne nécessite aucune exploration complémentaire. C’est une dermatose habituellement bénigne. Les formes graves sont rares chez le nouveau-né et le nourrisson. Son évolution se fait par poussées successives de survenue imprévisible avec des périodes de rémission plus ou moins longue. Le traitement n’est pas codifié, cependant les progrès réalisés dans la connaissance de l'immunopathogenèse ont donné lieu au développement de toute une série de nouvelles options thérapeutiques. Il faut tenir compte du meilleur pronostic évolutif chez l’enfant. A travers notre étude rétrospective intéressant nouveau-né et nourrissons suivis en consultation de dermatologie pédiatrique au service de pédiatrie IV à l’hôpital d’enfants de Rabat sur une période allant de 2008 à 2011 : 19 cas retenus sur des critères cliniques, nous avons étayé les différents aspects cliniques, étiopathogéniques et thérapeutiques ainsi que les perspectives d’avenir

Case Report Atypical Reversible Leucoencephalopathy Syndrome after Bevacizumab/Folfox Regimen for Metastatic Colon Cancer

We are reporting a case of multifocal reversible leucoencephalopathy syndrome induced by chemotherapy based on FolfoxBevacizumab regimen. A 44-year-old female, with no history of hypertension, received a chemotherapy based on FolfoxBevacizumab for her metastatic colon cancer (5 FU: 325 mg/m 2 d1 by intravenous infusion, Oxaliplatin 80 mg/m 2 d1, and Bevacizumab: 7.5 mg/Kg d1). During the fourth cure, she presented delirium, seizures, and visual disturbances. The computed tomography (CT) of the brain showed hypodense lesions of the white matter of frontal, parietal, and occipital lobes, which were bilateral and symmetrical. The clinical table was reversible under symptomatic treatment

Metastatic giant basal cell carcinoma: a case report

Basal cell carcinoma is the most common skin cancer, characterised by a slow growing behavior, metastasis are extremely rare, and it occurs in less than 0, 1% of all cases.Giant basal cell carcinoma is a rare form of basal cell carcinoma, more aggressive and defined as a tumor measuring more than 5 cm at its largest diameter. Only 1% of all basal cell carcinoma develops to a giant basal cell carcinoma,resulting ofpatient's negligence. Giant basal cell carcinoma is associated with higher potential of metastasis and even death, compared to ordinary basal cell carcinoma.We report a case of giant basal cell carcinoma metastaticin lung occurringin a 79 years old male patient, with a fatal evolution after one course of systemic chemotherapy.Giant basal cell carcinoma is a very rare entity, early detection of these tumors could prevent metastasis occurrence and improve the prognosis of this malignancy.The Pan African Medical Journal 2016;2

Small-Cell neuroendocrine carcinoma of nasopharynx: A case report

Extra pulmonary small cell carcinomas are extremely rare, accounting for 0.1-0.4% of all malignancies and 2.5-4% of small cell carcinomas. In the head and neck region, the most common primary sites are the larynx, salivary gland, nasal cavity, paranasal sinus, tonsil, and oral cavity. Small cell carcinomas occurring in nasopharynx are extremely rare, to our best knowledge, only four cases of primary nasopharyngeal small cell carcinoma has been described in English literature. We report another case of nasopharyngeal small cell carcinoma arising in a 46-year-old woman. She accused, for five months, nasal blockage, right hypoacousia, exophthalmos and reduced visual acuity. Cerebral and facial magnetic resonance imaging showed an extensive mass of the nasopharynx with the invasion of sphenoidal body, the diagnosis of disseminated small cell carcinoma of nasopahrynx was established. The patient received three courses of systemic chemotherapy; unfortunately, she died after the third course. The prognosis of such entity is poor and is similar to that for patients with extensive small cell lung cancer

PHYLLODES TUMOR OF THE BREAST : A CLINICOPATHOLOGICAL ANALYSIS FROM A SINGLE INSTITUTION

The aim of our study is to examine the clinical and pathological features of patients with breast phyllodes tumors and to determine features that are correlated to outcome. Forty four phyllodes tumors were assessed. There were 11 benign, 11 borderline and 22 malignant tumors. 10 of 44 patients (22.72 %) relapsed at any site. Seven patients (15.9 %) had a local recurrence and 3 patients experienced local and metastatic relapse. The 5-year and 10-year survival rates are 97% and 95 % respectively. The 5 years and 10 years DFS are 81% and 77% respectively. Grade, histological size, margin involvement impacted disease free survival. Adjuvant radiation therapy improved local control in high grade tumors although it didn’t reach significance

INVASIVE PULMONARY ASPERGILLOSIS FOLLOWING BEVACIZUMAB TREATMENT FOR NON-SMALL CELL LUNG CANCER

Bevacizumab is a recombinant humanized monoclonal antibody targeting the vascular endothelial growth factor; it is actually approved for the treatment of unresectable, locally advanced and metastatic non-small cell lung cancer in association with chemotherapy and as maintenance therapy. Infection risk due to use of bevacizumab is a very rare event. Several cases of aspergillosis in patients treated with monoclonal antibodies have been reported, mostly following treatment with tumor necrosis factor alpha blockers. We present a case of a 60 year-old patient treated for stage IV non-small cell lung cancer, who has been diagnosed with invasive aspergillosis following bevacizumab treatment, and, we postulate that bevacizumab may contribute to this infection

AGGRESSIVE MULTIPLE MYELOMA IN A YOUNG ADULT: A CASE REPORT

Multiple Myeloma is a blood cancer type B characterized by clonal proliferation of malignant plasma cells, the median age at diagnosis is 70 years, cases among younger patients are rare, and less than 0, 3 % patients are younger than 30 years in most series. We report a case of a 25-year- old women; she was suffering of a sacred pain radiating towards the left lower limb and fatigue for three months, a magnetic resonance imaging for dorso-lumbar spine showed an expansive process and multiple osteolytic lesions in 2nd, 3rd and 4th sacred vertebras. She underwent a laparotomy that revealed a heavy mass invading the sacrum and the rectum. The histological examination with immunocytochemistry analysis revealed a plasmocytoma and the diagnosis of symptomatic multiple myeloma stage III was established then she received 2 courses of chemotherapy. Despite the rarity of multiple myeloma among young patients, this diagnosis should be evoked when clinical, biological and radiological signs are in favor. It appears that there is no difference between younger and elderly patients on the presentation of the disease, although a longer survival has been reported among young patients

MANAGEMENT OF EXTRAMEDULLARY PLASMOCYTOMA OF HEAD AND NECK

Extramedullary plasmocytoma is an expansion of a single clone of immunoglobulin-secreting plasma cells without evidence of multiple myeloma. It is un uncommon entity that occurs usually in head and neck area. It is radiocurable at average doses while adjuvant chemotherapy is still controversial. Progression rates to multiple myeloma are lower than bone plasmacytoma. We report three cases of extramedullary plasmacytoma and through a literature review we discuss radiation modalities as well as evolutionary aspects

Brain metastasis from uterine malignancies: treatment modalities and prognostic factors

Isolated brain metastases from gynecologic malignancies are unusual. Advances in therapeutic modalities including surgery, whole brain radiotherapy stereotactic radiosurgery and chemotherapy improved survival and quality of life in this population. Therapeutic decision is based on patients’ specific prognostic factors. We report three cases of isolated brain metastases from gynecologic cancers and discuss treatment modalities in the light of a literature review