Metastatic Clear Cell Hidradenocarcinoma: Response to Chemotherapy and Long Disease Control

Introduction: Hidradenocarcinoma is a rare aggressive tumor arising from sweat glands that may occur from preexisting hidradenoma or most frequently appears de novo. It is often located in the head and neck. It is also characterized by a high potential of local recurrence, metastasis and poor outcome. This tumor is often radiotherapy and chemotherapy resistant.Presentation of case: We report a case of a 77-year-old man with a metastatic hidradenocarcinoma to the bone and lymph nodes who was operated 7 years ago for an hidradenoma of the right foot. He was treated with capecitabine-based chemotherapy with good tolerance and obtention of partial response during 10 months. After that, his disease progressed and he died 1 year after diagnosis.Conclusion: Hidradenocarcinoma is a cancer with a poor prognosis . Because of its low prevalence and high rate of recurrence, its treatment is still controversial. Our good result demonstrates that adjunction of chemotherapy in metastatic forms is effective for a better control and long overall survival

Gastrites chroniques à hélicobacter pylori: évaluation des systèmes OLGA et OLGIM

Helicobacter pylori (H pylori) gastritis presents a risk of cancer related to atrophy and intestinal metaplasia. Two recent classifications OLGA (Operative Link on Gastritis Assessment) and OLGIM (Operative Link on Gastritic Intestinal Metaplasia assessment) have been proposed to identify high-risk forms (stages III and IV). The aim of this study is to evaluate the OLGA and OLGIM staging systems in H pylori gastritis. A descriptive study of 100 cases of chronic H pylori gastritis was performed. The revaluation of Sydney System parameters of atrophy and intestinal metaplasia, of gastric antrum and corpus, allowed identifying respectively the stages of OLGA and OLGIM systems. The progressive risk of our H pylori gastritis was 6% according to OLGA staging and 7% according to OLGIM staging. Significant correlation was revealed between age and OLGA staging. High-risk gastritis according to OLGIM staging was significantly associated with moderate to severe atrophy. High-risk forms according to OLGA staging were associated in 80% of the cases to intestinal metaplasia. OLGA and OLGIM systems showed a highly significant positive correlation between them with a mismatch at 5% for H pylori gastritis. The OLGA and OLGIM staging systems in addition to Sydney System, allow selection of high risk forms of chronic gastritis requiring accurate observation.Keywords: Chronic gastritis, helicobacter pylori, atrophic gastritis, intestinal metaplasia, stagingPan African Medical Journal 2016; 2

Cystadénome séreux du pancréas associe à une hétérotopie pancréatique

Les hétérotopies pancréatiques (HP) sont rares. Elles peuvent se voir à tout âge avec une légère prédominance masculine.ces lésions sont le plus souvent asymptomatiques, de découverte fortuite lors d'une endoscopie digestive haute ou basse ou lors de l'examen anatomopathologique d'un organe réséqué pour d'autres motifs, et peuvent être isolée ou associée à une pathologie digestive. Nous rapportons, à travers notre observation, l'association d'une HP à un cystadénome séreux du pancréas découverte lors de l'exploration des douleurs épigastriques isolées. A travers cette observation nous nous proposons d'étudier les particularités cliniques et histologiques de cette pathologie rare.Pan African Medical Journal 2016; 2

Synthesis and Characterization of Slag-Sludge-Based Eco-Friendly Materials – Industrial Implications

Currently in Morocco, wastewater treatment plants (WWTPs) generate huge quantities of sludge from wastewater treatment. This sludge is a real concern for the environment. No regulatory text takes into account the future and management of sludge, its use in agriculture is not officially authorized and the solutions currently implemented for its elimination or recovery are done on an ad hoc basis and pose a number of difficulties for operators. The objective of the present study is to investigate the stabilization and solidification of a geopolymer based on sewage sludge and blast furnace slag (slag), as well as the possibility to use this geopolymer as a thermal insulation material. The sludge used comes from the AIN AOUDA-activated sludge type WWTP, the collected sludge is dehydrated and stabilized by slaked lime (Ca(OH)2) in the sludge treatment process. The blast furnace slag (slag) came from the plant in France. Four samples were prepared by substituting the slag with quantities (10 to 40%) of limed sludge, a quantity of sand, and a solution of sodium silicate and sodium hydroxide used as an alkaline activator. The effect of limed sludge on the physicochemical and microstructural properties of the synthesized geopolymers was evaluated using several analytical techniques, such as compressive strength, P-wave velocity, density and porosity tests, and X-ray diffraction. The results showed that the addition of 10 to 40% of limed sludge resulted in a progressive decrease in the compressive strength of the synthesized geopolymer and an increase in the thermal conductivity, which allows the use of the synthesized geopolymer as a material

Kyrle disease: report of a Tunisian case

Kyrle disease is an uncommon perforating dermatosis which is commonly associated with systemic disorders such as diabete mellitus and renal failure. A 60-year-old man, with no past medical history, consulted for purpuric, infiltrated and crusted lesions of extremities, buttocks and scalp. A punch biopsy showed a hyperkeratotic horny plug invaginating the epidermis. The diagnosis of Kyrle disease was retained. The clinicopathological features of this disease and its therapeutic problems are discussed

Psoriasis with verrucous appearance: A case reporPsoriasis report

Psoriasis verrucosa is a rare clinical variant of psoriasis with peculiar histologic features. Only few cases have been reported in the literature. We herein report a rare case of psoriasis with verrucous appearance occurring in a 63 year-old woman who presented with verrucous and scaly erythematous plaque of the legs which was developed thirty years ago. The biopsy specimen showed regular psoriasiform epidermal hyperplasia with acanthosis, hyperkeratosis, and focal spongiosis with a superficial perivascular infiltrate. The patient was diagnosed with verrucous psoriasis. Recognition of this entity should preempt confusion with verruca vulgaris or other entities capable of producing wart-like epidermal changes