Modeling of Traceability Information System for Material Flow Control Data.

This paper focuses on data modeling for traceability of material/work flow in information layer of manufacturing control system. The model is able to trace all associated data throughout the product manufacturing from order to final product. Dynamic data processing of Quality and Purchase activities are considered in data modeling as well as Order and Operation base on lots particulars. The modeling consisted of four steps and integrated as one final model. Entity-Relationships Modeling as data modeling methodology is proposed. The model is reengineered with Toad Data Modeler software in physical modeling step. The developed model promises to handle fundamental issues of a traceability system effectively. It supports for customization and real-time control of material in flow in all levels of manufacturing processes. Through enhanced visibility and dynamic store/retrieval of data, all traceability usages and applications is responded. Designed solution is initially applicable as reference data model in identical lot-base traceability system

Efficacy of Nigella sativa seeds oil in patients with Behcet’s disease: a double-blind randomized controlled trial

Objective: Nigella sativa (NS) is a herbal medicine with anti-inflammatory and anti-oxidant functions. This study was designed to evaluate the effect of oral administration of NS seeds oil on the treatment of Behcet’s disease (BD). Materials and methods:In this double-blind randomized controlled study, 130 patients with BD were screened and 71 patients with BD were randomly allocated to the treatment (n=37) and control (n=34) groups. Finally, 32 and 30 patients in the treatment and control groups, respectively, completed the study.The study protocol was registered in the Iranian Registry of Clinical Trials (IRCT) with registration No. IRCT201511086975N5. Treatment and control groups received soft gels containing 1000 mg NS oil or 1000 mg placebo per day for 12 months, respectively. Disease activity using the Iranian Behcet’s disease dynamic activity measure (IBDDAM), total inflammatory activity index (TIAI) and Behcet’s disease current activity form (BDCAF) were evaluated in all patients before initiation of the trial and every 2 months, for 12 months. Results: Disease activity decreased in the study groups; difference between the two groups was not significant. No serious adverse events were seen in the treatment and control groups. Conclusion: NS oil at the dose of 1000 mg/day is not effective in controlling BD activity

Assessment of quality of life in patients with lower limb osteoarthritis

Introduction: Osteoarthritis (OA) is a progressive disease, which directly influences individual’s quality of life (QOL). In current study, we decided to assess the QOL in patients with lower limb OA to find an association between patients’ QOL and demographic factors. Methods: In this cross-sectional study, a total of 203 OA patients aged over 50 years and 200 healthy controls matched with regard to age and gender were included. Short Form 12-item Health Survey (SF-12) was used to evaluate QOL. Results: The mean±standard deviation (SD) age of OA patients and control group was 69.82±11.49 and 68.18±10.54 years, respectively. 63% of patients and 56% of control group were females. Most of SF-12 domains including physical functioning, role physical, general health, social functioning, and role emotional were significantly lower in OA patients compared with the control group (P<0.05). Moreover, bodily pain domain was significantly higher in OA patients compared with the control group (P=0.038). There was a considerable correlation between most SF-12 domains with age and sex (P<0.05); whereas considerable correlation was just noticed between role physical domain with body mass index (BMI) (P<0.001). Additionally, Vitality considerably was associated with marital status (P=0.038). Conclusion: QOL in lower limb OA patients was compared with healthy subjects and this impairment was in association with some demographic factors

Design and modeling of one-port SAW resonator at 2.45 GHz for wireless application base on GaPO4

This paper presents the full design, operational principle, structure and frequency response simulation of one-port Surface Acoustic Wave (SAW) Resonator using Micro Wave Office (MWO) and MATLAB used for passive wireless sensing of various measurands. Since SAW Resonators are widely used in radio frequency sensing application, the development and evolution of present day SAW devices has been possible only due to simultaneous efforts to simulate these devices and also it is desirable to evaluate the device prior to fabrication especially in cases where the characteristic of device material and dimensions have a major influence on the performance of the overall system. The equivalent circuit model approach has been used to simulate the frequency response of one-port SAW resonator base on gallium orthophosphate (GaPO4) with 5° cut-angle at 2.45 GHz under ISM band frequency for high temperature wireless application and it appears that this modeling is suitable for near resonance frequency, also measuring dielectric permittivity of GaPO 4 at this frequency for use of modeling

Analysis of Methylation and Expression Profile of Foxp3 Gene in Patients with Behçet’s Syndrome

Forkhead box P3 (Foxp3) gene is an important means in the Treg cells function, in both maintenances of immune tolerance and regulation of response. Epigenetic modifications of the foxp3 gene at its regulatory regions control the chromatin accessibility for the transcription factors and other transcriptional regulators in order to control Foxp3 expression. In addition, the methylation status of CpG islands within the Foxp3 promoter and regulatory elements regulate the expression of Foxp3. This study was performed to assess the role of the foxp3 gene in patients with Behçet’s syndrome (BS). Venous blood samples were collected from all participants and peripheral blood mononuclear cells (PBMC) were extracted through Ficoll-Hypaque method. Genomic DNA was randomly sheared by sonication and immunoprecipitated with a monoclonal antibody. The status methylation of the foxp3 gene was estimated in 108 blood samples of active BS patients and healthy individuals (controls); using methylation DNA immunoprecipitation (MeDIP) technique. Expression analysis was carried out; using Real-time PCR. The expression of foxp3 gene in the patients' group (mean±SD: 1.79±1.12) was significantly lower than the healthy group (mean±SD: 2.73±1.33) (p<001). Also, the methylation levels of Foxp3 promoter showed that its level in patients (mean±SD: 2.3±1.16) was higher than the healthy group (mean±SD: 1.85±0.59). However, this increase was not statistically significant (p>0.05). Also, these results indicated that increasing the amount of methylation of the foxp3 gene by reducing its expression leads to an increase and intensifying of the disease. The decrease in Foxp3 expression is possibly associated with hypermethylation of the gene, and it can be considered as a risk factor for BS. Future studies may be needed to identify the capability of specific DNA methylation alterations in this syndrome

Femoral head avascular necrosis of in a young cushingoid opium addicted patient in the context of new combined opioid substance with corticosteroids

Key Clinical Message AVN should be considered in addicted to oral opium patient without history of glucocorticoid consumption who present with pelvic pain, due to recent reports of the illegal and secret addition of glucocorticoid in new combination substance with opium

Treatment of palindromic rheumatism: A systematic review

Objectives Palindromic rheumatism (PR) characterised by self-resolving attacks of arthritis and peri-arthritis that may progress to other autoimmune connective tissue diseases (CTDs). The aim of this systematic review was to analyse the effectiveness of different treatments on PR. Methods Articles were collected from Cochrane, PubMed, Science Direct, Scopus, ProQuest, Ebsco, Google Scholar, MEDLINE and EMBASE. Search keywords were ``palindromic rheumatism,'' ``palindromic rheumatism and remission,'' ``palindromic rheumatism and course,'' ``palindromic rheumatism and prognosis,'' ``palindromic rheumatism and treatment'' and ``palindromic rheumatism and therapy.'' The studies that were included met the following criteria: (a) adult patients aged >= 16 with PR; (b) being on treatment with medications defined as those that were developed for the treatment of inflammatory arthritis and (c) including outcome measures to evaluate the efficacy of the treatment including remission rate and progression to other diseases. Results Twenty-four studies met the inclusion criteria. Although case series and retrospective studies showed that conventional disease-modifying antirheumatic drugs (DMARDs) can control attacks of the disease, 15%-70% of patients with PR evolve to autoimmune CTDs during several years, despite treatment with DMARDs. A retrospective study showed that tight control strategy could control attacks of the disease and prevent its progression to RA. The evidence provided from available studies is insufficient to determine that DMARDs can prevent the progression of PR to autoimmune CTDs. Conclusion. Although case series and retrospective studies showed that DMARDs can control attacks of the disease, our review suggests that randomised clinical trials and prospective studies with adequate sample size are needed to prove that DMARDs can prevent progression of PR to autoimmune CTDs and which DMARDs are preferred for the treatment of PR

Methylation status of interleukin-6 gene promoter in patients with Behçet's disease

Background: IL-6 mRNA expression is significantly high in many autoimmune diseases such as Behc¸ et’s disease; this is often related with more aggressive phenotypes. Nevertheless, the essential molecular process for its high expression has not been completely realized. The aim of this study was undertaken to estimate the gene copy number variation and promoter methylation to IL-6’s high expression. Methods: This study was performed on 51 patients and 61 healthy controls. Initially, DNA and RNA were extracted from all specimens. Promoter methylation levels of IL-6 were evaluated by MeDIPqPCR technique. Also, IL-6 gene expression was measured by Real-time PCR. After that, we evaluated the relationship between gene expression and methylation, as well as their relationship with clinical specification. Results: As we expected, the expression level of IL-6 gene increased significantly in the patient group compared to the healthy subjects. Also, the relative promoter methylation level of the IL-6 mRNA was significantly lower in patient group compared to healthy group (p < 0.001). Discussion: We disclosed that the promoter hypomethylation may be considered as one of the main defects for IL-6 mRNA high expression in patients with Behc¸ et’s disease

Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial

Objectives: Nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. Numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. The aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of Nigella sativa oil in patients with rheumatoid arthritis (RA). Materials and Methods: Forty-two patients with RA were assigned into two groups in this randomized, double blind, placebo-controlled clinical trial. Subjects in intervention group received two capsules, 500 mg each, of Nigella sativa oil, each day for 8 weeks. The other group consumed two capsules as placebo per day for the same period of time. Serum TNF-α, IL-10, and whole blood levels of oxidative stress parameters were measured at baseline and end of the trial. Results: The serum level of IL-10 was increased in the Nigella sativa group (