Growth hormone receptor deficiency (Laron syndrome) in black African siblings

Non-Caucasians with growth honnone receptor (GHR) deficiency/Lamn syndrome among the approximately 180 recognised cases are rare, and include a Japanese and 3 African Americans. Black African siblings, a brother and a sister seen initially at 11 years 9 months and 5 years 6 months of age respectively were -7,4 and -8,0 on the standard deviation score for height. They had characteristic features and biochemical findings including prominent forehead; depressed nasal bridge; central adiposity; high-pitched voices; micropenis; high GH levels and low levels of insulin-like growth factor (IGF)-I, IGF-II, insulin-like growth factor-binding protein 3 (IGFBP-3), and GH-binding protein (the solubilised extracellular domain of the GH cell surface receptor). Molecular genetic studies revealed a dinucleotide deletion in both siblings on exon 7 of the GHR gene, a mutation not found in any other G.HRdeficient patient studied, including the North Americans of African origin. Since African Americans have a substantial admixture of Caucasian genes, n is of interest to document the presence of this ccndnion in siblings from Afric

Pre-Service Teachers Perceptions of Inclusive Education at a University of Technology in South Africa

Currently inclusive education is one of the contemporary issues in education in both developed and developing countries though some countries are struggling to effectively implement it Research has demonstrated that inclusive education can only be firmly implemented if there is a proper curriculum appropriate resources and good teacher pedagogical and knowledge skills It is therefore imperative for teacher education to empower pre-service teachers with necessary knowledge and pedagogical skills to teach inclusively The article focused on Bachelor of Education B Ed 3rd year student teachers perceptions and views regarding inclusive education curriculum implementation at a University of Technology in South Africa UoT A qualitative research approach was employed with a case study design Purposive sampling was used to select 120 participants from 3rd year Bachelor of Education students from a University of technology in South Africa Structured focus group interviews were used to collect data and data was analysed using thematic analysi

Growth hormone receptor deficiency (Laron syndrome) in black African siblings

Non-Caucasians with growth honnone receptor (GHR) deficiency/Laron syndrome among the approximately 180 recognised cases are rare, and include a Japanese and 3 African Americans. Black African siblings, a brother and a sister seen initially at 11 years 9 months and 5 years 6 months of age respectively were -7,4 and -8,0 on the standard deviation score for height. They had characteristic features and biochemical findings including prominent forehead; depressed nasal bridge; central adiposity; high-pitched voices; micropenis; high GH levels and low levels of insulin-like growth factor (IGF)-I, IGF-II, insulin-like growth factor-binding protein 3 (IGFBP-3), and GH-binding protein (the solubilised extracellular domain of the GH cell surface receptor). Molecular genetic studies revealed a dinucleotide deletion in both siblings on exon 7 of the GHR gene, a mutation not found in any other G.HR-deficient patient studied, including the North Americans of African origin. Since African Americans have a substantial admixture of Caucasian genes, it is of interest to document the presence of this condition in siblings from Afric