8 research outputs found
An Efficient Three Component One-Pot Synthesis of 5-Amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine-6-carbonitriles
A series of novel 5-amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine-6-carbonitriles were synthesized by a one-pot reaction of 3-amino-1,2,4-triazole, malononitrile and aryl aldehydes in the presence of 20 mol% NaOH in ethanol under heating or ultrasonic irradiation. The structures of the target compounds were confirmed by inspection of their 1H- NMR, 13C-NMR, IR and MS spectra. The advantages of this method are short reaction times, good yields, high selectivity and operational simplicity
Photoredox-Catalyzed Deoxygenative Intramolecular Acylation of Biarylcarboxylic Acids: Access to Fluorenones
An
efficient deoxygenative radical cyclization reaction has been
reported for the synthesis of fluorenones by employing various biarylcarboxylic
acids via photoredox catalysis. Attractive features of this process
include generation of acyl radical, which quickly underdone intramolecular
radical cyclization. This method marks the first photocatalytic intramolecular
acyl radical coupling for constructing carbon–carbon bond,
which further synthesizes the valuable fluorenone products with mild
conditions, good yields, and good functional-group compatibility