Castile Evaporite Karst Potential Map of the Gypsum Plain, Eddy County, New Mexico and Culberson County, Texas: A GIS Methodological Comparison

Castile Formation gypsum crops out over ,1,800 km2 in the western Delaware Basin where it forms the majority of the Gypsum Plain. Karst development is well recognized in the Gypsum Plain (i.e., filled and open sinkholes with associated caves); however, the spatial occurrence has been poorly known. In order to evaluate the extent and distribution of karst development within the Castile portion of the Gypsum Plain, combined field and Geographic Information System (GIS) studies were conducted, which enable a first approximation of regional speleogenesis and delineate karst-related natural resources for management. Field studies included physical mapping of 50, 1-km2 sites, including identification of karst features (sinkholes, caves, and springs) and geomorphic mapping. GIS-based studies involved analyses of karst features based on public data, including Digital Elevation Model (DEM), Digital Raster Graphic, (DRG) and Digital Orthophoto Quad (DOQ) formats. GIS analyses consistently underestimate the actual extent and density of karst development, based on karst features identified during field studies. However, DOQ analyses coupled with field studies appears to produce accurate models of karst development. As a result, a karst potential map of the Castile outcrop region was developed which reveals that karst development within the Castile Formation is highly clustered. Approximately 40% of the region effectively exhibits no karst development (,1 feature/km2). Two small regions (,3 km2 each) display intense karst development (.40 features/km2) located within the northern extent of the Gypsum Plain, while many regions of significant karst development (.15 features/km2) are distributed more widely. The clustered distribution of karst development suggests that speleogenesis within the Castile Formation is dominated by hypogenic, transverse processes

Epigene and Hypogene Karst Manifestations of the Castile Formation: Eddy County, New Mexico and Culberson County, Texas, USA

Permian evaporites of the Castile Formation crop out over ~1,800 km2 in the western Delaware Basin (Eddy County, New Mexico and Culberson County, Texas, USA) with abundant and diverse karst manifestations. Epigene karst occurs as well-developed karren on exposed bedrock, while sinkholes dominate the erosional landscape, including both solutional and collapse forms. Sinkhole analyses suggest that more than half of all sinks are the result of upward stoping of subsurface voids, while many solutional sinks are commonly the result of overprinting of collapsed forms. Epigene caves are laterally limited with rapid aperture decreases away from insurgence, with passages developed along fractures and anticline fold axes. Hypogene karst occurs as diverse manifestations, forming the deepest and longest caves within the region as well as abundant zones of brecciation. Hypogene caves exhibit a wide range of morphologies from complex maze and anastomotic patterns to simple, steeply dipping patterns, but all hypogene caves exhibit morphologic features (i.e. risers, outlet cupolas and half-tubes) that provide a definitive suite of evidence of dissolution within a mixed convection (forced and free convection) hydrologic system. Extensive blanket breccias, abundant breccia pipes and numerous occurrences of calcitized evaporites indicate widespread hypogene speleogenesis throughout the entire Castile Formation. Although most cave and karst development within the Castile outcrop region appears to have hypogene origins, epigene processes are actively overprinting features, creating a complex speleogenetic evolution within the Castile Formation

The guide dog as a mobility aid part 2: perceived changes to travel habits

This article describes the second of a two-part study that examined the effects of a guide dog as an aid to mobility. The first part, which is also published in this issue, showed that dogs were perceived to significantly improve travel performance, irrespective of the participants' orientation and mobility skills before receiving the dog. The second part of the study describes the changes a dog makes to travel habits. In this second part, the travel habits of 50 people who were blind or vision impaired were examined retrospectively before and after they received a dog. The results indicate that dogs were used more frequently than other mobility aids except when it was more convenient to use a human guide or a long cane, as for example on a very short journey. People travelled independently more often and went further, with greater ease and enjoyment when travelling with a dog. The use of a dog appeared to reduce problems with access and the need to avoid certain journeys. However, dogs also caused difficulties, especially in social situations where they were no/welcomed,and in crowded, cramped or dog-populated environments. More advantages than disadvantages were identified when comparing a dog to other mobility aids

Long-term site fidelity of endangered smalltooth sawfish (Pristis pectinata) from different mothers

Understanding how endangered species use nursery habitats is vital for recovery planning. Research on the smalltooth sawfish (Pristis pectinata) has shown that areas of estuarine nurseries, called hotspots, are used consistently. The objectives of our study were 1) to determine whether 10 young-of-the-year smalltooth sawfish in an artificial, non-main-stem portion (i.e., a seawall canal system) of a hotspot were descended from one or different mothers and 2) to document long-term habitat use by these individuals. At least 4 mothers contributed to the group, which comprised siblings, half-siblings, and unrelated individuals. Young sawfish exhibited site fidelity to their capture location, spending 61% of their time there. Continuous residency lasted as long as 86 days, but these fish made small-scale diel

A comparison of welfare outcomes for weaner and mature Bos indicus bulls surgically or tension band castrated with or without analgesia: 1. Behavioural responses

Tension-band castration of cattle is gaining favour because it is relatively simple to perform and is promoted by retailers of the devices as a humane castration method. Furthermore, retailers encourage delaying castration to exploit the superior growth rates of bulls compared with steers. Two experiments were conducted, under tropical conditions, comparing tension banding and surgical castration of weaner (7-10 months old) and mature (22-25 months old) Bos indicus bulls with and without pain management (ketoprofen or saline injected intramuscularly immediately prior to castration). Welfare outcomes were assessed using a wide range of measures; this paper reports on the behavioural responses of the bulls and an accompanying paper reports on other measures. Behavioural data were collected at intervals by direct observation and continuously via data loggers on the hind leg of the bulls to 4 weeks post-castration. Tension-banded bulls performed less movement in the crush/chute than the surgically castrated bulls during the procedures (weaner: 2.63 vs. 5.69,

The Ursinus Weekly, April 7, 1977

Ursinus news in brief: New CCC organized; Class elections to be held; Volunteers needed at Norristown; Exec. Comm. meets with Pres.; Late examination fee cancelled; Night school requirement changed • WCC meets food service rep. • New asst. to Harris chosen • Cub and Key inducts new members • Comment: A fond farewell to a close friend; Initial optimism of a new editor • Weekly special: FBI warns of more terrorist attacks • Letters to the editor • Movie attack: Bomb renamed • A low-scale of relief • Alumni assoc. gives gift • Dog Day afternoon • Forum review: Horrors recalled • Meisters prepare tour • Women\u27s basketball reaches nationals • USGA survey • Senior dance • 1977 baseball: title bound? • Bears begin seasonhttps://digitalcommons.ursinus.edu/weekly/1069/thumbnail.jp

Intelligence within BAOR and NATO's Northern Army Group

During the Cold War the UK's principal military role was its commitment to the North Atlantic Treaty Organisation (NATO) through the British Army of the Rhine (BAOR), together with wartime command of NATO's Northern Army Group. The possibility of a surprise attack by the numerically superior Warsaw Pact forces ensured that great importance was attached to intelligence, warning and rapid mobilisation. As yet we know very little about the intelligence dimension of BAOR and its interface with NATO allies. This article attempts to address these neglected issues, ending with the impact of the 1973 Yom Kippur War upon NATO thinking about warning and surprise in the mid-1970s. It concludes that the arrangements made by Whitehall for support to BAOR from national assets during crisis or transition to war were - at best - improbable. Accordingly, over the years, BAOR developed its own unique assets in the realm of both intelligence collection and special operations in order to prepare for the possible outbreak of conflict

A comparison of welfare outcomes for weaner and mature Bos indicus bulls surgically or tension ban castrated with or without analgesia: 2. responses related to stress, health and productivity

Tension banding castration of cattle is gaining favour because it is relatively simple to perform and is promoted by retailers of the banders as a humane castration method. Two experiments were conducted, under tropical conditions using Bos indicus bulls comparing tension banding (Band) and surgical (Surgical) castration of weaner (7-10 months old) and mature (22-25 months old) bulls with and without pain management (NSAID (ketoprofen) or saline injected intramuscularly immediately prior to castration). Welfare outcomes were assessed using a range of measures; this paper reports on some physiological, morbidity and productivity-related responses to augment the behavioural responses reported in an accompanying paper. Blood samples were taken on the day of castration (day 0) at the time of restraint (0. min) and 30. min (weaners) or 40. min (mature bulls), 2. h, and 7. h; and days 1, 2, 3, 7, 14, 21 and 28 post-castration. Plasmas from day 0 were assayed for cortisol, creatine kinase, total protein and packed cell volume. Plasmas from the other samples were assayed for cortisol and haptoglobin (plus the 0. min sample). Liveweights were recorded approximately weekly to 6 weeks and at 2 and 3 months post-castration. Castration sites were checked at these same times to 2 months post-castration to score the extent of healing and presence of sepsis. Cortisol concentrations (mean. ±. s.e. nmol/L) were significantly (

Enhancing the efficacy of glycolytic blockade in cancer cells via RAD51 inhibition.

Targeting the early steps of the glycolysis pathway in cancers is a well-established therapeutic strategy; however, the doses required to elicit a therapeutic effect on the cancer can be toxic to the patient. Consequently, numerous preclinical and clinical studies have combined glycolytic blockade with other therapies. However, most of these other therapies do not specifically target cancer cells, and thus adversely affect normal tissue. Here we first show that a diverse number of cancer models - spontaneous, patient-derived xenografted tumor samples, and xenografted human cancer cells - can be efficiently targeted by 2-deoxy-D-Glucose (2DG), a well-known glycolytic inhibitor. Next, we tested the cancer-cell specificity of a therapeutic compound using the MEC1 cell line, a chronic lymphocytic leukemia (CLL) cell line that expresses activation induced cytidine deaminase (AID). We show that MEC1 cells, are susceptible to 4,4\u27-Diisothiocyano-2,2\u27-stilbenedisulfonic acid (DIDS), a specific RAD51 inhibitor. We then combine 2DG and DIDS, each at a lower dose and demonstrate that this combination is more efficacious than fludarabine, the current standard- of- care treatment for CLL. This suggests that the therapeutic blockade of glycolysis together with the therapeutic inhibition of RAD51-dependent homologous recombination can be a potentially beneficial combination for targeting AID positive cancer cells with minimal adverse effects on normal tissue. IMPLICATIONS: Combination therapy targeting glycolysis and specific RAD51 function shows increased efficacy as compared to standard of care treatments in leukemias

The effect of nutrition and body condition of triplet-bearing ewes during late pregnancy on the behaviour of ewes and lambs

Objective Triplet-born lambs are less likely to survive to weaning than twin-born or single-born lambs. Appropriate ewe-lamb bonding behaviours and lamb vigour behaviours are necessary for survival of lambs. The aim of this experiment was to determine whether maternal nutrition during late pregnancy influenced behaviour of the ewe and her lambs soon after birth, and to determine whether mid-pregnancy body condition score (BCS) influenced any behavioural response. Methods The experiments included ewes that were in BCS 2.0, 2.5, or 3.0 in mid-pregnancy and were fed either ad libitum or to pregnancy-maintenance requirements in late-pregnancy (day 115 until 136 in experiment one, and day 128 until 141 in experiment two). The time taken for lambs to stand, contact dam, suck from dam and follow dam was recorded three to 18 h after birth. The number of high- and low-pitched bleats emitted by the ewe and lambs was recorded, along with maternal behaviour score (MBS) of the ewe. Lambs in experiment two underwent a maternal-recognition test at 12 or 24 h. Results There were significant effects of feeding treatment on bleating behaviour of ewes and lambs, but these were inconsistent among BCS groups and between experiments. Lamb vigour behaviours were not affected by feeding treatment. In experiment one, there was no effect of feeding treatment or BCS on MBS, but in experiment two, ewes in BCS3 in mid-pregnancy had greater MBS than ewes in BCS2 in mid-pregnancy (MBS 3.1/5 vs MBS 2.1/5; p<0.05). Conclusion Given there were no repeatable effects on behaviour of ewes and lambs, ad libitum feeding rather than feeding for pregnancy-maintenance requirements cannot be used to improve behaviours soon after birth of triplet-bearing ewes in BCS 2–3 and their lambs in extensive pastoral conditions