N-methyl-N-alkylpyrrolidinium nonafluoro-1-butanesulfonate salts : Ionic liquid properties and plastic crystal behaviour

A series of N-methyl-N-alkylpyrrolidinium nonafluoro-1-butanesulfonate salts were synthesised and characterised. The thermophysical characteristics of this family of salts have been investigated with respect to potential use as ionic liquids and solid electrolytes. N-Methyl-N-butylpyrrolidinium nonafluoro-1-butanesulfonate (p1,4NfO) has the lowest melting point of the family, at 94 &deg;C. Electrochemical analysis of p1,4 NfO in the liquid state shows an electrochemical window of ~6 V. All compounds exhibit one or more solid&ndash;solid transitions at sub-ambient temperatures, indicating the existence of plastic crystal phases.<br /

A comparison of injuries, crashes, and outcomes for pediatric rear occupants in traffic motor vehicle collisions

BACKGROUND This study was initiated was initiated to describe pediatric rear-occupant motor vehicle collision (MVC) injuries, including injury patterns and outcomes as well as characteristics associated with severe injury to the head and abdomen. METHODS A retrospective cohort of severely injured (Injury Severity Score [ISS] \u3e 12) pediatric (age \u3c18 years) patients involved in a traffic MVC as a rear occupant and treated at one of two Ontario trauma centers (2001–2010) was studied was studied. Demographic, injury, crash and outcome data were obtained from the trauma registries. Data were statistically compared by two pediatric age groups: children (0–8 years; requiring a child or booster seat) versus adolescents (9–17 years; requiring a lap-shoulder belt). RESULTS There were 36 children (34%) and 70 adolescents (66%) severely injured as rear occupants in MVCs. Despite similar ISS (p = 0.716) and mortality rates (p = 0.680) between age groups, there were significant differences in injury patterns and risk factors. Children were more likely to have severe head injuries (78% vs. 39%, p \u3c 0.001) associated with a lack of an age-appropriate child restraints (odds ratio [OR], 3.5; 95% confidence interval [CI], 1.1–10.8; p = 0.029), middle seating (OR, 6.2; 95% CI, 1.5–26.1; p = 0.013), and side-impact crashes (p = 0.007). Adolescents were more likely to have severe abdominal injuries (23% vs. 6%, p \u3c 0.001) associated with the use of lap-shoulder belts (OR, 3.8; 95% CI, 1.1–13.3; p = 0.034), single-vehicle MVCs (p = 0.007), and vehicle extrications (p = 0.035). CONCLUSION While safer than the front seat for children, additional study is needed on the restraint systems and the potential for injury to pediatric rear occupants in an MVC. Our data suggest that pediatric age groups differ in injuries, risk factors, and MVC impacts. Recommendations for improved protection of child occupants and preferred seating positions are required

Tracking Landscape-Scale Movements of Snow Buntings and Weather-Driven Changes in Flock Composition During the Temperate Winter

Nomadic movements of migratory birds are difficult to study, as the scale is beyond the capabilities of hand-held telemetry (10 s of kms) but too fine-scale for long-range tracking devices like geolocators (50–100 km accuracy). Recent widespread installation of automated telemetry receiving stations allowed us, for the first time, to quantify and test predictions about within-winter movements of a presumed nomadic species, the Snow Bunting (Pletrophenax nivalis). We deployed coded radio-transmitters on 40 individual Snow Buntings during two winters (2015-16 and 2016-17) in southern Ontario, Canada, and tracked movements over a 300 by 300 km area with 69–77 active radio-receiving stations (Motus Wildlife Tracking Network). To complement our tracking data, we also examined the influence of weather on the demographics of winter flocks at a single wintering site over 6 consecutive years (n = 9312 tagged birds). We recorded movements of 25 Snow Buntings from the deployment sites to 1–6 different radio recievers (mean 2.68 locations/bird). Birds traveled a minimum average distance of 49 km between detections (range: 3 to 490 km) in the core wintering period of Dec-Feb, and cumulative total movements ranged from 3 to 740 km (average 121 ± 46 km). In March distances between detections increased to an average of 110 km, suggesting an extended early-migration period. Overall, older birds (after-second year or older) tended to move more (higher cumulative distances traveled) than younger (first winter) birds, even during the Dec-Feb period. The long-term banding data revealed that larger, male birds were more likely to be captured in colder and snowier weather, relative to female and smaller birds, suggesting that they can withstand these conditions more easily owing to their body size. We have provided the first direct-tracking data on nomadic winter movements of Snow Buntings, and tested the hypothesis that winter weather drives flock composition at a single site. Site-specific banding data suggest that weather-related changes in flock composition could explain the nomadic, landscape-scale movements of Snow Buntings we observed by using automated telemetry. Future work should explore the importance of resource availability, competition, and predation risk as drivers of winter movements in Snow Buntings

Operative Management of Symptomatic, Metachronous Carotid Body Tumors Involving the Skull Base and Its Neurological Sequelae

A 44-year-old morbidly obese woman with a history of right carotid body tumor (CBT) resection presented with a symptomatic, nonfunctional, left Shamblin-III CBT. Abutment of the skull base precluded distal internal carotid artery control for arterial reconstruction, favoring parent vessel sacrifice after an asymptomatic provocative test. She underwent CBT resection with anticipated sacrifice of cranial nerves X and XII and the common carotid artery and its branches, developing baroreceptor failure syndrome and sequelae of cranial nerve sacrifice. When facing a symptomatic, metachronous CBT abutting the skull base, upfront operative intervention with adjuvant radiation for residual tumor optimizes curative resection

Clockwise evolution in the hardness-intensity diagram of the black hole X-ray binary Swift J1910.2-0546

We present a detailed study of optical data from the 2012 outburst of the candidate black hole X-ray binary Swift J1910.2-0546 using the Faulkes Telescope and Las Cumbres Observatory (LCO). We analyse the peculiar spectral state changes of Swift J1910.2-0546 in different energy bands, and characterise how the optical and UV emission correlates with the unusual spectral state evolution. Using various diagnostic tools like the optical/X-ray correlation and spectral energy distributions, we disentangle the different emission processes contributing towards the optical flux of the system. When Swift J1910.2-0546 transitions to the pure hard state, we find significant optical brightening of the source along with a dramatic change in the optical colour due to the onset of a jet during the spectral state transition. For the rest of the spectral states, the optical/UV emission is mostly dominated by an X-ray irradiated disk. From our high cadence optical study, we have discovered a putative modulation. Assuming that this modulation arises from a superhump, we suggest Swift J1910.2-0546 to have an orbital period of 2.25-2.47 hr, which would make it the shortest orbital period black hole X-ray binary known to date. Finally, from the state transition luminosity of the source, we find that the distance to the source is likely to be ~4.5-20.8 kpc, which is also supported by the comparative position of the source in the global optical/X-ray correlation of a large sample of black hole and neutron star X-ray binaries.Comment: Published at MNRAS, 12 page

Seven reflares, a mini-outburst and an outburst : High amplitude optical variations in the black hole X-ray binary Swift J1910.2-0546

We present long-term (2012-2022) optical monitoring of the candidate black hole X-ray binary Swift J1910.2-0546 with the Faulkes Telescopes and Las Cumbres Observatory (LCO) network. Following its initial bright 2012 outburst, we find that the source displayed a series of at least 7 quasi-periodic, high amplitude (~3 mags) optical reflares in 2013, with a recurrence time increasing from ~42 days to ~49 days. In 2014, the source experienced a mini-outburst with two peaks in the optical. We also study the recent 2022 outburst of the source at optical wavelengths, and perform a comparative analysis with the earlier rebrightenings. A single X-ray detection and only two radio detections were obtained during the 2013 reflaring period, and only optical detections were acquired in 2014. During the reflaring in both 2013 and 2014, the source showed bluer-when-brighter behavior, having optical colors consistent with a blackbody heating and cooling between 4500 and 9500 K, i.e. the temperature range in which hydrogen starts to ionize. Finally, we compare the flaring behavior of the source to re-brightening events in other X-ray binaries. We show that the repeated reflarings of Swift J1910.2-0546 are highly unusual, and propose that they arise from a sequence of repetitive heating and cooling front reflections travelling through the accretion disk.Comment: Accepted for publication in ApJ, appendix will appear at the published version of the pape

Autonomic Dysregulation in Adolescent Concussion Is Sex- and Posture-Dependent

Objective: To study autonomic responses to postural changes in concussed adolescents. The influence of sex was also studied. Design: Longitudinal cohort observational study. Participants: Concussed adolescents (CONC; n = 65; 26 male adolescents; age 15 ± 1 years, range = 12-18 years) and a control (CTRL) group of nonconcussed adolescents of similar age and sport (CTRL; n = 54; 29 male adolescents; age 14 ± 1 years, range = 12-18 years). Interventions: Concussed participants were monitored through 6 weekly visits throughout usual physician care. Control participants underwent 2 visits separated by at least 1 week to account for intrapersonal variation in testing measures. Main Outcome Measures: Heart rate variability as the root mean square of successive differences in R–R intervals (RMSSD), heart rate (HR), and blood pressure [mean arterial pressure (MAP) and diastolic blood pressure (DBP)] were measured in supine, sitting, and standing postures. Results: A mixed analysis of variance revealed a group 3 sex 3 posture interaction (P = 0.04) where seated values of RMSSD were less in concussed female participants versus control female participants (42 ± 4 vs 61 ± 7 ms; P = 0.01; Mann–Whitney rank test). Compared with CTRL, CONC exhibited increased pretesting seated DBP (69 ± 1 vs 74 ± 1 mm Hg; P\u3c 0.01), MAP (83 ± 1 vs 86 ± 1 mm Hg; P = 0.02), and baseline seated HR (72 ± 1 vs 77 ± 2 bpm; P = 0.03). Values of DBP (P = 0.03) and MAP (P, 0.01) improved at clinical discharge, whereas the RMSSD in female participants did not (P \u3e 0.5). Data are mean ± SEM. Conclusions: A modest reduction in female cardiac autonomic regulation was observed during seated postures. Alterations in seated concussed DBP and MAP, but not RMSSD, resolved at clinical discharge (median = 37 days). The results indicate that, in adolescents, concussion may impair cardiovagal function in a sex- and posture-dependent manner. The findings also suggest that BP metrics, but not RMSSD, are associated with clinical concussion recovery

Autonomic Dysregulation in Adolescent Concussion Is Sex- and Posture-Dependent

Objective: To study autonomic responses to postural changes in concussed adolescents. The influence of sex was also studied. Design: Longitudinal cohort observational study. Participants: Concussed adolescents (CONC; n = 65; 26 male adolescents; age 15 ± 1 years, range = 12-18 years) and a control (CTRL) group of nonconcussed adolescents of similar age and sport (CTRL; n = 54; 29 male adolescents; age 14 ± 1 years, range = 12-18 years). Interventions: Concussed participants were monitored through 6 weekly visits throughout usual physician care. Control participants underwent 2 visits separated by at least 1 week to account for intrapersonal variation in testing measures. Main Outcome Measures: Heart rate variability as the root mean square of successive differences in R–R intervals (RMSSD), heart rate (HR), and blood pressure [mean arterial pressure (MAP) and diastolic blood pressure (DBP)] were measured in supine, sitting, and standing postures. Results: A mixed analysis of variance revealed a group 3 sex 3 posture interaction (P = 0.04) where seated values of RMSSD were less in concussed female participants versus control female participants (42 ± 4 vs 61 ± 7 ms; P = 0.01; Mann–Whitney rank test). Compared with CTRL, CONC exhibited increased pretesting seated DBP (69 ± 1 vs 74 ± 1 mm Hg; P\u3c 0.01), MAP (83 ± 1 vs 86 ± 1 mm Hg; P = 0.02), and baseline seated HR (72 ± 1 vs 77 ± 2 bpm; P = 0.03). Values of DBP (P = 0.03) and MAP (P, 0.01) improved at clinical discharge, whereas the RMSSD in female participants did not (P \u3e 0.5). Data are mean ± SEM. Conclusions: A modest reduction in female cardiac autonomic regulation was observed during seated postures. Alterations in seated concussed DBP and MAP, but not RMSSD, resolved at clinical discharge (median = 37 days). The results indicate that, in adolescents, concussion may impair cardiovagal function in a sex- and posture-dependent manner. The findings also suggest that BP metrics, but not RMSSD, are associated with clinical concussion recovery

Wearable Electrochemical Sensors for Monitoring Performance Athletes

Nowadays, wearable sensors such as heart rate monitors and pedometers are in common use. The use of wearable systems such as these for personalized exercise regimes for health and rehabilitation is particularly interesting. In particular, the true potential of wearable chemical sensors, which for the real-time ambulatory monitoring of bodily fluids such as tears, sweat, urine and blood has not been realized. Here we present a brief introduction into the fields of ionogels and organic electrochemical transistors, and in particular, the concept of an OECT transistor incorporated into a sticking-plaster, along with a printable “ionogel” to provide a wearable biosensor platform