Study of weak magnetism by precision spectrum shape measurements in nuclear beta decay

Nuclear beta decays play an important role in uncovering the nature of the weak interaction. The weak magnetism (WM) form factor, bWM, is generally a small correction to the beta decay rate that arises at first order as an interference term between the dominant Gamow-Teller and the magnetic dipole contributions to the weak current. This form factor is still poorly known for nuclei with higher atomic number. We performed a careful analysis of the measured beta spectrum shape for Gamow-Teller transitions in $^{114}$In and $^{32}$P nuclei. The precision spectrum shape measurements were carried out using the miniBETA spectrometer consisting of a low-mass, low-Z multi-wire gas tracker and a plastic scintillator energy detector. The preliminary results for the weak magnetism extraction for $^{114}$In and $^{32}$P nuclei are presented

Gas electron tracking detector for beta decay experiments

For identification and 3D-tracking of low-energy electrons a new type of gas-based detector was designed that minimizes scattering and energy loss. The current version of the detector is a combination of a plastic scintillator, serving as a trigger source and energy detector, and a hexagonally structured multi-wire drift chamber (MWDC), filled with a mixture of helium and isobutane gas. The drift time information is used to track particles in the plane perpendicular to the wires, while a charge division technique provides spatial information along the wires. The gas tracker was successfully used in the miniBETA project as a beta spectrometer for a measurement of the weak magnetism form factor in nuclear beta decay. The precision of the three-dimensional electron tracking, in combination with low-mass, low-Z materials and identification of backscattering from scintillator, facilitated a reduction of the main systematics effects. At certain conditions, a spatial resolution better than 0.5 mm was obtained in the plane perpendicular to the wires, while resolutions of about 6 mm were achieved along wires. Thanks to precise tracking information, it is possible to eliminate electrons and other particles not originating from the desired decay with high efficiency. Additionally, using the coincidence between MWDC and scintillator, background from gamma emission typically accompanying radioactive decays, was highly suppressed. An overview of different event topologies is presented together with the tracker's ability to correctly recognize them. The analysis is supported by Monte Carlo simulations using Geant4 and Garfield++ packages. Finally, the preliminary results from the 114In spectrum study are presented.Comment: 5 pages, 3 figures, accepted for publication in JINST - PSD12(2021

BRAND – search for BSM physics at TeV scale by exploring transverse polarization of electrons emitted in neutron decay

Neutron and nuclear beta decay correlation coefficients are linearly sensitive to the exotic scalar and tensor interactions that are not included in the Standard Model (SM). The proposed experiment will measure simultaneously 11 neutron correlation coefficients (a, a, B, D, H, L, N, R, S, U, V) where 7 of them (H, L, N, R, S, U, V) depend on the transverse electron polarization – a quantity that vanishes for the SM weak interaction. The neutron decay correlation coefficients H, L, S, U, V were never attempted experimentally before. The expected ultimate sensitivity of the proposed experiment that currently takes off on the cold neutron beamline PF1B at the Institut Laue-Langevin, Grenoble, France, is comparable to that of the planned electron spectrum shape measurements in neutron and nuclear β decays but offers completely different systematics and additional sensitivity to imaginary parts of the scalar and tensor couplings

Whole exome sequencing of patients with varicella-zoster virus and herpes simplex virus induced acute retinal necrosis reveals rare disease-associated genetic variants

Purpose: Herpes simplex virus (HSV) and varicella-zoster virus (VZV) are neurotropic human alphaherpesviruses endemic worldwide. Upon primary infection, both viruses establish lifelong latency in neurons and reactivate intermittently to cause a variety of mild to severe diseases. Acute retinal necrosis (ARN) is a rare, sight-threatening eye disease induced by ocular VZV or HSV infection. The virus and host factors involved in ARN pathogenesis remain incompletely described. We hypothesize an underlying genetic defect in at least part of ARN cases. Methods: We collected blood from 17 patients with HSV-or VZV-induced ARN, isolated DNA and performed Whole Exome Sequencing by Illumina followed by analysis in Varseq with criteria of CADD score &gt; 15 and frequency in GnomAD &lt; 0.1% combined with biological filters. Gene modifications relative to healthy control genomes were filtered according to high quality and read-depth, low frequency, high deleteriousness predictions and biological relevance. Results: We identified a total of 50 potentially disease-causing genetic variants, including missense, frameshift and splice site variants and on in-frame deletion in 16 of the 17 patients. The vast majority of these genes are involved in innate immunity, followed by adaptive immunity, autophagy, and apoptosis; in several instances variants within a given gene or pathway was identified in several patients.Discussion: We propose that the identified variants may contribute to insufficient viral control and increased necrosis ocular disease presentation in the patients and serve as a knowledge base and starting point for the development of improved diagnostic, prophylactic, and therapeutic applications.</p

Whole exome sequencing of patients with varicella-zoster virus and herpes simplex virus induced acute retinal necrosis reveals rare disease-associated genetic variants

Purpose: Herpes simplex virus (HSV) and varicella-zoster virus (VZV) are neurotropic human alphaherpesviruses endemic worldwide. Upon primary infection, both viruses establish lifelong latency in neurons and reactivate intermittently to cause a variety of mild to severe diseases. Acute retinal necrosis (ARN) is a rare, sight-threatening eye disease induced by ocular VZV or HSV infection. The virus and host factors involved in ARN pathogenesis remain incompletely described. We hypothesize an underlying genetic defect in at least part of ARN cases. Methods: We collected blood from 17 patients with HSV-or VZV-induced ARN, isolated DNA and performed Whole Exome Sequencing by Illumina followed by analysis in Varseq with criteria of CADD score > 15 and frequency in GnomAD < 0.1% combined with biological filters. Gene modifications relative to healthy control genomes were filtered according to high quality and read-depth, low frequency, high deleteriousness predictions and biological relevance. Results: We identified a total of 50 potentially disease-causing genetic variants, including missense, frameshift and splice site variants and on in-frame deletion in 16 of the 17 patients. The vast majority of these genes are involved in innate immunity, followed by adaptive immunity, autophagy, and apoptosis; in several instances variants within a given gene or pathway was identified in several patients. Discussion: We propose that the identified variants may contribute to insufficient viral control and increased necrosis ocular disease presentation in the patients and serve as a knowledge base and starting point for the development of improved diagnostic, prophylactic, and therapeutic applications

INITIAL TESTS OF MiniBETA SPECTROMETER PERFORMANCE

© 2018 Jagellonian University. All rights reserved. MiniBETA is a new spectrometer incorporating a low-pressure multiwire drift chamber (MWDC). It is designed for beta spectrum shape measurements and to improve knowledge on electron backscattering in the about 100 keV to a few MeV region. After the commissioning phase, which we report on here, the spectrometer will first be used for the latter purpose. This will help reducing the systematic uncertainty in beta spectrum shape measurements. The performance of the trajectory recognition algorithm was investigated using cosmic muons as the source of the primary ionization. For the initial test, the chamber was filled with a mixture of helium-isobutane (50/50) at 600 mbar. A single cell efficiency η higher than 0.98 within almost the entire cell was achieved and the single cell spatial resolution in the drift plane reached σ = 0:4 mm for most of the cells in the chamber.status: publishe