(20S)-22-Acetoxymethyl-6β-meth­oxy-3α,5-dihydro-3′H-cyclo­propa[3α,5]-5α-pregnane

In the title steroid derivative, C25H40O3, the fused cyclo­propane unit that corresponds to a part of the A ring has a β-configuration and the associated cyclo­pentane ring an envelope-shaped conformation

(20R,24R,25S)-3α,7α,12α,27-Tetra­acet­oxy-24,26-ep­oxy-5β-cholestane

In the title anhydro­scymnol tetra­acetate, C35H54O9, the fused chair conformation of the cyclo­hexane A/B ring junction is cis with a 5β-H configuration. The compound has a trimethyl­ene oxide ring at position 24,26 and four acetate groups at the 3α,7α,12α,27 positions

(20S)-22-Iodo­methyl-6β-meth­oxy-3α,5-dihydro-3′H-cyclo­propa[3α,5]-5α-pregnane

In the title steroid derivative, C23H37IO, the fused cyclo­propane unit that comprises part of the A ring has a β-configuration, and the associated cyclo­pentane ring has an envelope conformation

(8S,9R,10S,11S,13S,14S,16S,17R)-4,4-Dichloro-16β-methyl-3,20-dioxo-17,21-bis­(propano­yloxy)-5β,8β-epoxy­pregna-1,9-diene

The title compound, C28H34Cl2O7, is a derivative of the glucocorticoid steroid beclomethasone dipropionate. It features an expoxide linkage [angle at oxygen = 96.6 (2)°]. The dichlorocyclohexenone ring adopts an envelope conformation, with the C atom bearing the two Cl substituents representing the flap. The dichloro­methyl C atom deviates by 0.471 (4) Å from the plane defined by the other five atoms, whose maximum r.m.s. deviation is 0.04 Å

3-Methyl-5α-cholest-2-ene

In the title cholestane derivative, C28H48 [systematic name: (1S,2S,7R,10R,11R,14R,15R)-2,5,10,15-tetra­methyl-14-[(2R)-6-methyl­heptan-2-yl]tetra­cyclo­[8.7.0.02,7.011,15]hepta­dec-4-ene], the cyclo­hexene ring adopts a half-chair conformation. The parent 5α-cholest-2-ene and the equivalent fragment of the title compound are almost superimposable (r.m.s. deviation = 0.033 Å)

17-Deoxoestrone [estra-1,3,5(10)-trien-3-ol]–methanol (3/1)

Three independent mol­ecules of the title estrone derivative and a mol­ecule of methanol comprise the asymmetric unit of the title compound [systematic name: 13-methyl-6,7,8,9,11,12,13,14,15,16-deca­hydro­cyclo­penta­[a]phenanthren-3-ol–meth­an­ol (3/1)], 3C18H24O·CH3OH. Two of the estrone mol­ecules exhibit 50:50 disorder (one displays whole-mol­ecule disorder and the other partial disorder in the fused five- and six-membered rings) so that five (partial) mol­ecular conformations are discernable. The conformation of the six-membered ring abutting the aromatic ring is close to a half-chair in all five components. The conformation of the six-membered ring fused to the five-membered ring is based on a chair with varying degrees of distortion ranging from minor to significant. Two distinct conformations are found for the five-membered ring: in four mol­ecules, the five-membered ring is twisted about the bond linking it to the six-membered ring, and in the other, the five-membered ring is an envelope with the quaternary C atom being the flap atom. The crystal packing features O—H⋯O hydrogen bonding whereby the four mol­ecules comprising the asymmetric unit are linked into a supra­molecular chain along the b axis

5,22-Stigmastadien-3β-yl p-toluene­sulfonate

The asymmetric unit of the title compound {systematic name: (3S,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methyl­hept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodeca­hydro-1H-cyclo­penta­[a]phenanthren-3-yl p-toluene­sulfonate}, C36H54O3S, comprises two independent mol­ecules that differ significantly in terms of the relative orientations of the peripheral groups; the conformation about the C=C bond of the side chain is E. In the crystal, mol­ecules associate into linear supra­molecular chains aligned along the a axis via C—H⋯O inter­actions

(20R)-24-Bromo-5β-cholane

In the title compound (5S,8R,9R,10R,13S,14S,17R,20R)-24-bromo-5β-cholane, C24H41Br, the fused-chair conformation of the cyclo­hexane A/B ring junction is cis with a 5β-H configuration

Phenolic Compound, Triterpene and Steroids From The Leaves and Bark of Dysoxylum Macrocarpum

The bark and leaves of Dysoxylum macrocarpum (Meliaceace) yielded four compounds, two compounds from the leaves; 5-hydroxy-7-methoxy-2-methyl-4H-chromen-4-one (Eugenin) DM1, which was new as crystal and squalene DM2, while two more compounds were found from the bark; stigmasterol DM3 and sitosterol DM4. The present work involves extraction, isolation and purification of compounds by using column chromatography followed by preparative TLC. Structural elucidation has been done through several spectroscopic methods, notably UV, IR, MS (HRMS, GCMS, and LCMS), 1D, 2D-NMR 1H NMR, 13CNMR, COSY, DEPT, HMQC, HMBC, and single crystal X-ray diffraction analysis

3-Iodo-8β,9α,14α-estra-1,3,5(10)-trien-17-one

In the title compound, C18H21IO, the cyclo­hexane ring adopts a chair conformation, whereas the cyclo­pentane ring and the ten-membered tetra­line portions each adopt an envelope conformation. For the five-membered ring, the methine C atom deviates by 0.638 (4) Å (r.m.s. of the four other atoms is 0.005 Å) and for the ten-membered ring, the methine C atom constituting the flap deviates by 0.671 (3) Å (r.m.s. of the other nine atoms is 0.066 Å)