(Quantum) Collision Attacks on Reduced Simpira v2

Simpira v2 is an AES-based permutation proposed by Gueron and Mouha at ASIACRYPT 2016. In this paper, we build an improved MILP model to count the differential and linear active Sboxes for Simpira v2, which achieves tighter bounds of the minimum number of active Sboxes for a few versions of Simpira v2. Then, based on the new model, we find some new truncated differentials for Simpira v2 and give a series (quantum) collision attacks on two versions of reduced Simpira v2

(Quantum) Collision Attacks on Reduced Simpira v2

Simpira v2 is an AES-based permutation proposed by Gueron and Mouha at ASIACRYPT 2016. In this paper, we build an improved MILP model to count the differential and linear active Sboxes for Simpira v2, which achieves tighter bounds of the minimum number of active Sboxes for a few versions of Simpira v2. Then, based on the new model, we find some new truncated differentials for Simpira v2 and give a series (quantum) collision attacks on two versions of reduced Simpira v2

Deterioration of Mechanical Properties of Axial Compression Concrete Columns with Corroded Stirrups Coupling on Load and Chloride

To research the deterioration of the mechanical properties of stirrup-corroded concrete columns under the effect of load and chloride, accelerated corrosion and load carrying capacity tests were carried out on concrete columns subjected to long-term axial loading by means of dry and wet cycles with extra electric currents. The test results showed that under the effect of axial load and chloride, the corrosion-induced cracks of stirrup-corroded concrete columns mainly developed along the direction of the longitudinal reinforcing steel bars (cracks along longitudinal reinforcing steel bars caused by corrosion) and there were almost no corrosion-induced cracks along the direction of the corroded stirrups. The length and maximum width of the corrosion-induced cracks increased with the stirrup corrosion rate, but the average width of the corrosion-induced cracks did not change significantly. After the stirrup-corroded column reached the ultimate load, the concrete cover spalled off in pieces along the corrosion-induced cracks and loading cracks, the core concrete was crushed, and the test column produced obvious brittle failure. With the increase in the corrosion rate of stirrups, the stiffness and ultimate bearing capacity of the column decreased. Considering factors such as damage to the column section caused by stirrup corrosion, the decrease in the lateral restraint effect of the corroded stirrup on the longitudinal reinforcing steel bars, and buckling of the longitudinal reinforcing steel bars, the ultimate bearing capacity prediction model of the short column subjected to axial compression due to stirrup corrosion was established. The calculated values of the model were in good agreement with the measured values, indicating the model has good applicability

Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer’s Disease

Through drug discovery strategies of repurposing and redeveloping existing drugs, a series of novel tadalafil derivatives were rationally designed, synthesized, and evaluated to seek dual-target AChE/PDE5 inhibitors as good candidate drugs for Alzheimer’s disease (AD). Among these derivatives, <b>1p</b> and <b>1w</b> exhibited excellent selective dual-target AChE/PDE5 inhibitory activities and improved blood-brain barrier (BBB) penetrability. Importantly, <b>1w·Cit</b> (citrate of <b>1w</b>) could reverse the cognitive dysfunction of scopolamine-induced AD mice and exhibited an excellent effect on enhancing cAMP response element-binding protein (CREB) phosphorylation in vivo, a crucial factor in memory formation and synaptic plasticity. Moreover, the molecular docking simulations of <b>1w</b> with hAChE and hPDE5A confirmed that our design strategy was rational. In summary, our research provides a potential selective dual-target AChE/PDE5 inhibitor as a good candidate drug for the treatment of AD, and it could also be regarded as a small molecule probe to validate the novel AD therapeutic approach in vivo