Primary Plasmacytoma of The Testis with no Evidence of Multiple Myeloma: a New Case Report and Literature Review

Plasmacytomas of the testis are extremely rare tumours, especially when occurring in the absence of a previous or concurrent diagnosis of multiple myeloma. We report a new case of solitary testicular plasmacytoma, with immunohistochemical studies showing monoclonal cytoplasmic production of IgG lambda light chains, in a 51-year-old man who had no evidence of multiple myeloma 3 years after the orchiectomy.Key Words: Testis, plasmacytoma, multiple myelom

Epistasis and genotype-by-environment interaction of grain protein content in durum wheat

Parental, F1 , F 2 , BC 1 and BC 2 generations of four crosses involving four cultivars of durum wheat (Triticum durum Desf.) were evaluated at two sites in Tunisia. A three-parameter model was found inadequate for all cases except crosses Chili x Cocorit 71 at site Sidi Thabet and Inrat 69 x Karim at both sites. In most cases a digenic epistatic model was sufficient to explain variation in generation means. Dominance effects (h) and additive x additive epistasis (i) (when significant) were more important than additive (d) effects and other epistatic components. Considering the genotype-by-environment interaction, the non-interactive model (m, d, h, e) was found adequate. Additive variance was higher than environmental variance in three crosses at both sites. The estimated values of narrow-sense heritability were dependent upon the cross and the sites and were 0%-85%. The results indicate that appropriate choice of environment and selection in later generations would increase grain protein content in durum wheat

Fibrocytes and the tissue niche in lung repair

Human fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of markers related to leukocytes, hematopoietic stem cells and a diverse set of fibroblast phenotypes. Fibrocytes can be recruited from the circulation to the tissue where they further can differentiate and proliferate into various mesenchymal cell types depending on the tissue niche. This local tissue niche is important because it modulates the fibrocytes and coordinates their role in tissue behaviour and repair. However, plasticity of a niche may be co-opted in chronic airway diseases such as asthma, idiopathic pulmonary fibrosis and obliterative bronchiolitis. This review will therefore focus on a possible role of fibrocytes in pathological tissue repair processes in those diseases

Cas Clinique Le myélolipome surrénalien: une entité rare

Le myélolipome surrénalien est une tumeur rare, bénigne et non fonctionnelle de la surrénale, souvent asymptomatique. Il peut se compliquer de douleur ou d'hémorragie rétropéritonéale. L'imagerie médicale permet le plus souvent d'évoquer le diagnostic et de le différencier des autres incidentalomes surrénaliens en mettant en évidence sa composante graisseuse. Le caractère compliqué, symptomatique ou volumineux du myélolipome surrénalien doit faire indiquer son exérèse chirurgicale. Nous rapportons le cas d'un gros myélolipome surrénalien symptomatique découvert chez un homme de 44 ans ayant nécessité un traitement chirurgical Keywords: Incidentalome surrénalien, myélolipome African Journal Of Urology Vol.14 (3) 2007: pp. 174-17

Successful Treatment of Homozygous Cystinuria with Captopril

No Abstract. African Journal of Urology Vol. 13 (2) 2007: pp. 119-12

Laterality of Symptomatic Recurrent Calcium Nephrolithiasis

Objective: Although it is presumed that both kidneys excrete similar urinary constituents, it is a general observation that the majority of patients present with unilateral stone disease. The aim of this work was to study the laterality of recurrence in calcium stone formers. Patients and Methods: In a retrospective study of 154 patients treated for recurrent symptomatic nephrolithiasis at our institution between January 1982 and December 2006, the side of stone formation was determined by an analysis of radiographic fi ndings and symptomatic history. Patients with hydronephrosis, major renal anatomic anomalies and non-calcium stones were excluded from the study. The features of unilateral stone forming and bilateral stone forming were compared. Statistical analysis was done using Student\'s t-test. Results: Of the 154 patients, 102 were males and 52 females with a male-to-female ratio of 1:2. One hundred and fourteen patients had unilateral stones (Group A), 64 (56%) on the left and 50 (44%) on the right side. In 40 patients they were bilateral (Group B). Comparing Groups A and B, the mean age at the fi rst stone episode was 41.5 versus 38.3 years, the mean interval between the fi rst stone and recurrence was 9.6 versus 9.9 years, and the mean follow-up was 13.3 versus 14.9 years (differences not statistically signifi cant). In Group A, 101 patients (89%) had unilateral stone recurrence episodes with 86 of these 101 patients (85%) developing stones on the same side as the primary stone. Of the 40 patients with bilateral stone formation, 30 patients (75%) had bilateral stone recurrence episodes. Conclusion: Recurrent stone formers commonly present withcalculi on the same side and the etiology of this phenomenon is unclear, but anatomic and external triggers should be considered. Keywords: Laterality, kidney, renal stones, recurrence, urinary calculi.African Journal Of Urology Vol.14 (3) 2007: pp. 143-14

Pure Primary Small Cell Carcinoma of the Bladder- A propos of 5 Cases

Objective: Pure primary small cell carcinoma (PSCC) of the bladder is a rare tumor, and patients commonly present with metastatic disease. No prospective studies evaluating the most efficient treatment have been published. We reviewed our experience with treating these tumors to evaluate their histopathological characteristics and clinical outcome. Patients and Methods: This study presents our experience in 5 patients with PSCC of the bladder during a 7-year period. The patients\' tumor characteristics, therapy, follow-up and survival status were documented. Results: All patients were male with a mean age of 67 years. The main clinical presentation was macroscopic hematuria. All tumors were invasive at the time of diagnosis. Systemic chemotherapy was given in 4 patients, and one patient was treated by radical cystectomy. The overall median survival was 17 months. Conclusion: PSCC of the bladder should be considered a systemic disease, because most patients present with metastases. Prospective studies are needed to determine the optimal treatment. Keywords: bladder neoplasm, chemotherapy, chromogranin, small cell carcinoma, synaptophysinAfrican Journal of Urology Vol. 13 (3) 2007: pp. 193-19

Les strategies de selection pour l'amelioration des cereales

National audienc