El papel de la experiencia en la relación entre confianza y resultados de la cooperación entre PYMEs en economías en transición

To achieve successful cooperative inter-firm relationships, trust between the partners is a key factor. As trust that is based on the self-commitment of the partners to behave in a non-opportunistic way (maxim-based trust) takes time to evolve and relies upon the cooperation experience of the partners, we expect that the positive performance impact of maxim-based trust grows over time. The purpose of this paper is to test the moderating effect of cooperation experience on the relationship between maxim-based trust and performance in the context of cooperating small and medium sized enterprises (SMEs) in two transformation economies (Czech Republic and Slovenia): Based on a sample of 124 SMEs, a moderated regression analysis reveals that trust and cooperation experience impact positively on performance. However, we could not detect a moderated relationship. We conclude that maxim-based trust may be an effective and efficent coordinating mechanism in the dynamic context of cooperating SMEs in transformation economies, but the absence of a moderating effect indicates that firms do not seem to increase the effects of maxim-based trust over time._______________________________________________La confianza es uno de los elementos principales que permiten obtener éxito en las relaciones de cooperación entre empresas. La confianza basada en el propio compromiso de las empresas and que no es fruto de un comportamiento oportunista (maxim-based trust) se desarrolla a través la experiencia en cooperación entre las empresas, por lo que surge con el tiempo. Por ello, consideramos que los efectos positivos de este tipo de confianza aumentan conforme pasa el tiempo. El objetivo de este trabajo es medir los efectos que la experiencia en cooperación provoca sobre la relación entre la confianza basada en el compromiso (maxim-based trust) and los resultados obtenidos de la misma en el caso de la colaboración entre pequeñas and medianas empresas (pymes) en dos economías en transición (República Checa and Eslovenia): El análisis de regresión moderada, basado en una muestra de 124 pymes, muestra que la confianza and la experiencia en cooperación ejercen un impacto positivo sobre los resultados, aunque no se observa relación moderada. Concluimos que la confianza basada en el compromiso (maximbased trust) puede ser un mecanismo de coordinación efectivo and eficiente en el contexto dinámico de la cooperación entre pymes en economías en transición. No obstante, la ausencia de efecto moderador indica que los efectos en las empresas de la confianza basada en la el compromiso no aumentan con el tiempo

Beyond market neutrality? Central banks and the problem of climate change

Starting with a landmark 2015 speech by Mark Carney on the ‘Tragedy of the Horizon’, climate change entered central banking discourse, causing some of its key convictions to come under new scrutiny. This article traces how initially climate change was firmly embedded in a conventional framework of ‘market completion’ that would allow financial markets to price in the negative externality. Yet, over the course of the last seven years, central banks have repositioned their role regarding this problem, taking on a much more active stance which calls into question the notion of ’market neutrality’. To trace these discursive changes, this article identifies three discursive layers formed around market-based mechanisms, responsible investment and monetary policy. We show that in the unfolding of the debate, the issue of climate change has altered the self-understanding of central bankers and driven them towards a more active stance where they acknowledge that central bankers shape and make, and not only ‘mirror’, market forces

Enterprise Architecture Planning: Analyses of Requirements from Practice and Research

Enterprise architecture management (EAM) has become an increasingly important topic in practice due to the growing complexity of organizations and their underlying IT. While there is a strong interest in Enterprise Architecture (EA) modeling, evaluation, and frameworks, a lack of knowledge remains in the research field of EA planning. We conducted a series of expert interviews on the topic of EA planning. From these interviews we were able to extract requirements for EA planning from practice as the foundation of our analyses. Additionally, we conducted a structured literature review to elicit requirements for EA planning from a research perspective. This paper combines the results of both the practitioner interviews and the literature review to emphasize the gaps between the two worlds. As a result, we identified that current research does not adequately address the pressing problems of EA planning in practice

Alternative Conformations of HIV-1 V3 Loops Mimic β Hairpins in Chemokines, Suggesting a Mechanism for Coreceptor Selectivity

AbstractThe V3 loop of the HIV-1 envelope glycoprotein gp120 is involved in binding to the CCR5 and CXCR4 coreceptors. The structure of an HIV-1MN V3 peptide bound to the Fv of the broadly neutralizing human monoclonal antibody 447-52D was solved by NMR and found to be a β hairpin. This structure of V3MN was found to have conformation and sequence similarities to β hairpins in CD8 and CCR5 ligands MIP-1α, MIP-1β, and RANTES and differed from the β hairpin of a V3IIIB peptide bound to the strain-specific murine anti-gp120IIIB antibody 0.5β. In contrast to the structure of the bound V3MN peptide, the V3IIIB peptide resembles a β hairpin in SDF-1, a CXCR4 ligand. These data suggest that the 447-52D-bound V3MN and the 0.5β-bound V3IIIB structures represent alternative V3 conformations responsible for selective interactions with CCR5 and CXCR4, respectively

Abundance changes of neophytes and native species indicate a thermophilisation and eutrophisation of the Swiss flora during the 20th century

During the 20th century human activities drastically altered the natural environment at global and local scales by habitat destruction, urbanisation, intensive agriculture, and climate warming. This anthropogenic pressure has modified species distributions and abundances, and led to the increased spread of neophytes. However, the determination of the magnitude, direction, and drivers of changes remains challenging as comparable historic data is often lacking. Here, we analysed the floristic shifts during the 20th century based on a historic (1900–1930) and current (2000–2017) floristic survey of the canton of Zurich (Switzerland; 1729 km2) in combination with Landolt ecological indicator values (EIVs) for vascular plants. We used two complementary approaches to quantify the floristic shifts using EIVs for temperature, moisture, continentality, nutrients, soil pH and available light. 1) Regarding 244 map tiles with each a 3 × 3 km2 area, we compared the average EIVs for neophytes (i.e., novel species arriving of expanding in the study area) and native species (i.e., species present in Switzerland for centuries). 2) Based on standardized species abundances in the historic and the current flora, we analysed the directed changes by comparing the species’ EIVs of different frequency classes for both the historic and current floristic surveys. Our results showed, that neophyte species arriving or spreading in the study area indicate both a thermophilisation and an eutrophisation. The observed shift in average EIVs for temperature corresponded to about 2 ◦C, which is in line with the calculated difference in niche centroids for neophytes and native species based on their global distribution (1.78 ◦C). The indicated thermophilisation and eutrophisation relate to the decrease in abundances of cold-adapted species and species of nutrient poor environments as well as the increase of warm-adapted and nitrophilous/ruderal species. Directed changes in the flora of the study area are likely to be driven by both climatic changes and land-use changes. Increases in trade activity, anthropogenic habitat disturbances and rising temperatures facilitate the establishment and spread of neophytes from warmer and drier regions. In parallel, wetland area and wetland species strongly decreased as well as species thriving on nutrient-poor sites due to intensified agriculture and nitrogen deposition

Abnormal Resting-State Network Presence in Females with Overactive Bladder

Overactive bladder (OAB) is a global problem reducing the quality of life of patients and increasing the costs of any healthcare system. The etiology of OAB is understudied but likely involves supraspinal network alterations. Here, we characterized supraspinal resting-state functional connectivity in 12 OAB patients and 12 healthy controls (HC) who were younger than 60 years. Independent component analysis showed that OAB patients had a weaker presence of the salience (Cohen's d = 0.9) and default mode network (Cohen's d = 1.1) and weaker directed connectivity between the fronto-parietal network and salience network with a longer lag time compared to HC. A region of interest analysis demonstrated weaker connectivity in OAB compared to HC (Cohen's d > 1.6 or 1.9). The degree of deviation in supraspinal connectivity in OAB patients (relative to HC) appears to be an indicator of the severity of the lower urinary tract symptoms and an indication that such symptoms are directly related to functional supraspinal alterations. Thus, future OAB therapy options should also consider supraspinal targets, while neuroimaging techniques should be given more consideration in the quest for better phenotyping of OAB

Geriatrische Assessments und Diagnostik beim älteren Patienten

As is the case with younger patients, the treatment decisions for elderly patients with thoracic tumours are primarily based on the results of the usual routine diagnostics. Standardised assessments of existing comorbidities and geriatric assessments may provide information which are of particular relevance for intensive and/or complex therapy modalities and which may require early corresponding intervention or measures for support

Internet interventions for mental health in university students:A systematic review and meta-analysis

OBJECTIVES: Mental health disorders are highly prevalent among university students. Universities could be an optimal setting to provide evidence-based care through the Internet. As part of the World Mental Health International College Student initiative, this systematic review and meta-analysis synthesizes data on the efficacy of Internet-based interventions for university students' mental health. METHOD: A systematic literature search of bibliographical databases (CENTRAL, MEDLINE, and PsycINFO) for randomized trials examining psychological interventions for the mental health (depression, anxiety, stress, sleep problems, and eating disorder symptoms), well-being, and functioning of university students was performed through April 30, 2018. RESULTS: Forty-eight studies were included. Twenty-three studies (48%) were rated to have low risk of bias. Small intervention effects were found on depression (g = 0.18, 95% confidence interval [CI; 0.08, 0.27]), anxiety (g = 0.27, 95% CI [0.13, 0.40]), and stress (g = 0.20, 95% CI [0.02, 0.38]). Moderate effects were found on eating disorder symptoms (g = 0.52, 95% CI [0.22-0.83]) and role functioning (g = 0.41, 95% CI [0.26, 0.56]). Effects on well-being were non-significant (g = 0.15, 95% CI [-0.20, 0.50]). Heterogeneity was moderate to substantial in many analyses. After adjusting for publication bias, effects on anxiety were not significant anymore. DISCUSSION: Internet interventions for university students' mental health can have significant small-to-moderate effects on a range of conditions. However, more research is needed to determine student subsets for which Internet-based interventions are most effective and to explore ways to increase treatment effectiveness. © 2018 John Wiley & Sons, Ltd. KEYWORDS: Internet; college; mental disorders; meta-analysis; psychotherap

Tumor cell network integration in glioma represents a stemness feature

BACKGROUND: Malignant gliomas including glioblastomas are characterized by a striking cellular heterogeneity, which includes a subpopulation of glioma cells that becomes highly resistant by integration into tumor microtube (TM)-connected multicellular networks. METHODS: A novel functional approach to detect, isolate, and characterize glioma cell subpopulations with respect to in vivo network integration is established, combining a dye staining method with intravital two-photon microscopy, Fluorescence-Activated Cell Sorting (FACS), molecular profiling, and gene reporter studies. RESULTS: Glioblastoma cells that are part of the TM-connected tumor network show activated neurodevelopmental and glioma progression gene expression pathways. Importantly, many of them revealed profiles indicative of increased cellular stemness, including high expression of nestin. TM-connected glioblastoma cells also had a higher potential for reinitiation of brain tumor growth. Long-term tracking of tumor cell nestin expression in vivo revealed a stronger TM network integration and higher radioresistance of the nestin-high subpopulation. Glioblastoma cells that were both nestin-high and network-integrated were particularly able to adapt to radiotherapy with increased TM formation. CONCLUSION: Multiple stem-like features are strongly enriched in a fraction of network-integrated glioma cells, explaining their particular resilience