82 research outputs found

    Homogenization and Trends Analysis of Monthly Precipitation Series in the Fez-Meknes Region, Morocco

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    High quality and long-term precipitation data are required to study the variability and trends of rainfall and the impact of climate change. In developing countries like Morocco, the quality of climate data collected from various weather stations faces numerous obstacles. This paper presents methods for collecting, correcting, reconstructing, and homogenizing precipitation series of Morocco’s Fez-Meknes region from 1961 to 2019. Data collected from national specialized agencies based on 83 rain gauge stations was processed through an algorithm specially designed for the homogenization of climatic data (Climatol). We applied the Mann-Kendall test and Sen’s slope estimator to raw and homogenized data to calculate rainfall trend magnitudes and significance. The homogenization process allows for the detection of a larger number of stations with statistically significant negative trends with 95% and 90% confidence levels, particularly in the mountain ranges, that threatens the main sources of water in the largest watershed in the country. The regionalization of our rain gauge stations is highlighted and compared to previous studies. The monthly and annual means of raw and homogenized data show minor differences over the three main climate zones of the region

    Calogero model with Yukawa like interaction

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    We study an extension of one dimensional Calogero model involving strongly coupled and electrically charged particles. Besides Calogero term g2x2\frac{g}{% 2x^{2}}, there is an extra factor described by a Yukawa like coupling modeling short distance interactions. Mimicking Calogero analysis and using developments in formal series of the wave function Ψ(x)\Psi (x) factorised as xϵΦ(x)x^{\epsilon}\Phi (x) with ϵ(ϵ−1)=g\epsilon (\epsilon -1) =g, we develop a technique to approach the spectrum of the generalized system and show that information on full spectrum is captured by Φ(x)\Phi (x) and Φ′′(x)\Phi ^{\prime \prime}(x) at the singular point x=0x=0 of the potential. Convergence of ∫dx∣Ψ(x)∣2% \int dx| \Psi (x) | ^{2} requires ϵ>−1/2\epsilon >-{1/2} and is shown to be sensitive to the zero mode of Φ(x)\Phi (x) at x=0x=0. \textbf{Key words}: \textit{Hamitonian systems, quantum integrability, Calogero model, Yukawa like potential.}Comment: 12 pages, 1 figur

    Change of initial oral antidiabetic therapy in type 2 diabetic patients

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    Objective To explore the 'real-life' therapy of type 2 diabetes mellitus with oral antidiabetic drugs (OADs). Methods From the PHARMO Record Linkage System comprising linked drug dispensing and clinical laboratory data from approximately 2.5 million individuals in the Netherlands, among others, new users of OADs were identified in the period 1999-2004. New users, aged 30 years and older, without insulin use before cohort entry date and with at least one year follow-up were included. We determined per initial therapy patient characteristics and first therapy change. Results Overall 35,514 patients were included. Metformin and sulfonylureas (SU) were the most frequent initial therapy. Patients on thiazolidinedione (TZD) monotherapy had lower percentages baseline HbA1c ≥ 7% compared to patients on metformin and SU. The proportion of patients still on initial therapy after one year ranged from 46% (TZDs) to around 60% (SU). Among patients starting on monotherapy, add-on (15-20%) and discontinuation (16-25%) of therapy occurred most frequently. In patients starting on combination therapy, a switch occurred in 30% of the patients. Conclusion In more than 40% of the patients a change in initial OAD-therapy is already observed in the first year of therapy. Maintaining patients on initial therapy remains a challenge

    Prevention du cancer du col uterin : Depistage et prise en charge des neoplasies intra-epitheliales du col uterin

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    La prévention secondaire du cancer du col utérin est basée sur le dépistage, le diagnostic et le traitement des néoplasies cervicales intra-épithéliales, avec un suivi post-thérapeutique adéquat. L’objectif de notre travail est de montrer l’importance de cette prévention avec analyse de la situation dans notre formation. Notre étude est une analyse rétrospective de 53 cas de CIN, traités dans le service de Gynécologie-Obstétrique (MI) de la Maternité Suissi du CHU Ibn Sina de Rabat, durant une période de 10 ans allant de 1998 à 2007. La moyenne d’âge est de 44,4 ans avec des extrêmes de 29 et 72 ans. Presque la moitié des patientes sont des grandes multipares (45,4 %). Ces patientes sont mariées à un âge précoce (64 % des patientes chez qui ce paramètre a été précisé sont mariées avant 20 ans), et sont non ménopausées dans 72 % des cas. La notion de prise de contraception orale est retrouvée dans 38 % des cas. L’infection génitale à répétition est rapportée dans 51 % des cas. 76 % des patientes étaient symptomatiques, avec une symptomatologie faite de métrorragie et de leucorrhées. L’étude cyto-colpo-histologique a montré une prédominance des CIN 3 (52 %) suivies des CIS (17 %), les CIN 1 représentent 13 % et les CIN 2 représentent 11 %. Avec découverte de carcinome invasif sur 5 pièces opératoires (9 % des cas). Le traitement conservateur par conisation n’a été envisagé que chez 15 % des patientes, tandis que le reste des patientes ont subi un traitement radical. 62,5 % des patientes ont adhéré à un suivi post-thérapeutique régulier. L’évolution est marquée par une guérison chez toutes les patientes suivies. Ce qui montre l’importance de la prise en charge des CIN et la nécessité d’instaurer un programme de dépistage organisé dans notre pays
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