Molecular interactions of phytochemicals with the active site residues in the binding site 1 of the target proteins, MexB of <i>P. aeruginosa</i> and AcrB of <i>E. coli</i>.

<p>Molecular interactions of phytochemicals with the active site residues in the binding site 1 of the target proteins, MexB of <i>P. aeruginosa</i> and AcrB of <i>E. coli</i>.</p

Effect of efflux inhibitor, CCCP and phytochemicals in accumulation of ethidium bromide in <i>E. coli</i> strain.

<p>Effect of efflux inhibitor, CCCP and phytochemicals in accumulation of ethidium bromide in <i>E. coli</i> strain.</p

Flow chart of Virtual screening, pharmacophore-based filtering and experimental screening strategy for identifying efflux inhibitors.

<p>Flow chart of Virtual screening, pharmacophore-based filtering and experimental screening strategy for identifying efflux inhibitors.</p

Alignment of protein sequences of MexB and AcrB.

<p>Sequences in box are the conserved residues in the binding site of MC-207110 in AcrB and MexB.</p

Effect of efflux inhibitor, CCCP and phytochemicals in accumulation of ethidium bromide in <i>P. aeruginosa</i> strain.

<p>Effect of efflux inhibitor, CCCP and phytochemicals in accumulation of ethidium bromide in <i>P. aeruginosa</i> strain.</p

Interaction of selected phytochemicals with the active site residues in the binding site 2 of the integral membrane proteins MexB of <i>P. aeruginosa</i> and AcrB of <i>E. coli</i>.

<p>Interaction with MexB of <i>P. aeruginosa</i>: 4a - lanatoside C, 4c – scopolamine, 4e – umbelliferone; Interaction with AcrB of <i>E. coli</i>: 4b – lanatoside C, 4d – scopolamine, 4f - umbelliferone.</p