High Energy Physics

This proposal is for the continuation of the High Energy Physics Program at the University of California, Riverside. In 1990, we will concentrate on analysis of LEP data from the OPAL detector. We expect to record 10{sup 5} Z`s by the end of 1989 and 10{sup 6} in 1990. This data will be used to measure the number of quark-lepton families in the universe. In the second half of 1990 we will also be occupied with the installation of the D-Zero detector in the Tevatron Collider and the preparation of software for the 1991 run. A new initiative made possible by generous university support is a laboratory for detector development at UCR. The focus will be on silicon strip tracking detectors both for the D-Zero upgrade and for SSC physics. The theory program will pursue further various mass-generating radiative mechanisms for understanding small quark and lepton masses as well as some novel phenomenological aspects of supersymmetry

High Energy Physics

Hadron collider studies will focus on: (i) the search for the top quark with the newly installed D0 detector at the Fermilab Tevatron collider, (ii) the upgrade of the D0 detector to match the new main injector luminosity and (iii) R&D on silicon microstrip tracking devices for the SSC. High statistics studies of Z{sup 0} decay will continue with the OPAL detector at LEP. These studies will include a direct measurement of Z decay to neutrinos, the search for Higgs and heavy quark decays of Z. Preparations for the Large Scintillation Neutrino Detector (LSND) to measure neutrino oscillations at LAMPF will focus on data acquisition and testing of photomultiplier tubes. In the theoretical area E. Ma will concentrate on mass-generating radiative mechanisms for light quarks and leptons in renormalizable gauge field theories. J. Wudka`s program includes a detailed investigation of the magnetic-flip approach to the solar neutrino

Reconciling Present Neutrino Puzzles: Sterile Neutrinos as Mirror Neutrinos

We suggest that recent neutrino puzzles that are the solar and atmospheric neutrino deficits as well as the possible neutrino oscillations reported by the LSND experiment and the possibility of massive neutrinos providing the hot component of the cosmological dark matter, can all be naturally explained by assuming existence of a mirror world described by an ``electroweak'' gauge symmetry $[SU(2)\times U(1)]'$, with the breaking scale larger by about factor of 30 than the scale of the standard $SU(2)\times U(1)$ model. An interesting aspect of this model is that the sterile neutrinos arise from the hidden mirror sector of the theory and thus their lightness is more natural than in the usual neutrino mass scenarios. The needed pattern of the neutrino mass matrix in this model is obtained by assuming a conserved ZKM-type global lepton number $\bar L=L_e+L_\mu-L_\tau$, which is violated by Planck scale effects. One implication of our proposal is that bulk of the dark matter in the universe is a warm dark matter consisting of few KeV mass particles rather than the 100 GeV range particles of the currently popular cold dark matter scenarios.Comment: 10 pages, Latex, no figure

Neutrino propagation in a random magnetic field

The active-sterile neutrino conversion probability is calculated for neutrino propagating in a medium in the presence of random magnetic field fluctuations. Necessary condition for the probability to be positive definite is obtained. Using this necessary condition we put constraint on the neutrino magnetic moment from active-sterile electron neutrino conversion in the early universe hot plasma and in supernova.Comment: 11 page

The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer

The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential mediator of this resistance. This study aims to provide further evidence that MyD88 positive cancer cells are clinically significant, stem-like and reproducibly detectable for the purposes of prognostic stratification. Expression of TLR4 and MyD88 was assessed immunohistochemically in 198 paraffin-embedded ovarian tissues and in an embryonal carcinoma model of cancer stemness. In parallel, expression of TLR4 and MyD88 mRNA and regulatory microRNAs (miR-21 and miR-146a) was assessed, as well as in a series of chemosensitive and resistant cancer cells lines. Functional analysis of the pathway was assessed in chemoresistant SKOV-3 ovarian cancer cells. TLR4 and MyD88 expression can be reproducibly assessed via immunohistochemistry using a semi-quantitative scoring system. TLR4 expression was present in all ovarian epithelium (normal and neoplastic), whereas MyD88 was restricted to neoplastic cells, independent of tumour grade and associated with reduced progression-free and overall survival, in an immunohistological specific subset of serous carcinomas, p<0.05. MiR-21 and miR-146a expression was significantly increased in MyD88 negative cancers (p<0.05), indicating their participation in regulation. Significant alterations in MyD88 mRNA expression were observed between chemosensitive and chemoresistant cells and tissue. Knockdown of TLR4 in SKOV-3 ovarian cells recovered chemosensitivity. Knockdown of MyD88 alone did not. MyD88 expression was down-regulated in differentiated embryonal carcinoma (NTera2) cells, supporting the MyD88+ cancer stem cell hypothesis. Our findings demonstrate that expression of MyD88 is associated with significantly reduced patient survival and altered microRNA levels and suggest an intact/functioning TLR4/MyD88 pathway is required for acquisition of the chemoresistant phenotype. Ex vivo manipulation of ovarian cancer stem cell (CSC) differentiation can decrease MyD88 expression, providing a potentially valuable CSC model for ovarian cancer

Neutrino Decay as an Explanation of Atmospheric Neutrino Observations

We show that the observed zenith angle dependence of the atmospheric neutrinos can be accounted for by neutrino decay. Furthermore, it is possible to account for all neutrino anomalies with just three flavors.Comment: 4 pages, 1 figur

Final report on impact of catchment scale processes and climate change on cause-effect and recovery-chains

Catchment wide integrated basin management requires knowledge on cause-effect and recovery chains within water bodies as well as on the interactions between water bodies and categories. In the WISER WP6.4 recovery processes in rivers, lakes and estuarine and coastal waters were evaluated. The major objectives were: - to analyse and compare (cause-effect and) recovery chains within water categories based on processes and structural and functional features; - to detect commonalities among different chains in different water categories ( to compare recovery chains between water categories); - to link recovery chains to over-arching biological processes and global change; - to develop a method to combine recovery effects in a summarising ‘catchment’ metric. The main stressors studied to reach these objectives were acidification, eutrophication and hydromorphological changes

Freshwater umbrella - the effects of nitrogen deposition & climate change on freshwaters in the UK

In upland areas of the UK located away from direct human disturbance through agriculture, industrial activities and urban pollution, atmospheric pollution poses one of the major threats to the chemical and biological quality of lakes and streams. One of the most important groups of pollutants is nitrogen (N) compounds, including oxidised forms of N called NOx, generated mainly by fossil fuel combustion especially in motor vehicles, and reduced forms of N (ammonia gas or dissolved ammonium compounds) generated mainly from agricultural activities and livestock. These nitrogen compounds may dissolve in rain or soilwater to form acids, or may be taken up as nutrients by plants and soil microbes in upland catchments, and then subsequently released in acid form associated with nitrate leaching at a later date. It is well established that nitrate leaching contributes to acidification of upland waters, with damage to aquatic ecosystems including plants, invertebrates and fish. However it has recently been suggested that nitrate leaching may also be associated with nutrient enrichment of upland waters that contain biological communities adapted to very low nutrient levels

Spin-Flavour Oscillations and Neutrinos from SN1987A

The neutrino signal from SN1987A is analysed with respect to spin-flavour oscillations between electron antineutrinos, $\bar{\nu}_{e}$, and muon neutrinos, $\nu_{\mu}$, by means of a maximum likelihood analysis. Following Jegerlehner et al. best fit values for the total energy released in neutrinos, $E_t$, and the temperature of the electron antineutrino, $T_{\bar{\nu}_{e}}$, for a range of mixing parameters and progenitor models are calculated. In particular the dependence of the inferred quantities on the metallicity of the supernova is investigated and the uncertainties involved in using the neutrino signal to determine the neutrino magnetic moment are pointed out.Comment: 14 pages, RevTeX, 4 figures, to appear in Physical Review

Cosmic microwave background polarization, Faraday rotation and stochastic gravity-waves backgrounds

A magnetic field, coherent over the horizon size at the decoupling and strong enough to rotate the polarization plane of the CMBR, can be generated from the electromagnetic vacuum fluctuations amplified by the space-time evolution of the dilaton coupling. The possible relevance of this result for superstring inspired cosmological models is discussed. Particular attention will be paid to the connection between Faraday rotation signals and stochastic gravity-wave backgrounds.Comment: 24 A4 pages in Latex style plus two figures combined into an eps file, accepted for publication in Physical Review