7 research outputs found
Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial
- Author
- A. Aminian
- A. Ancion
- A. Anesini
- A. Asif
- A. Bogdanovic
- A. Bogdanovic
- A. Bogdanovic
- A. Casado
- A. Csepregi
- A. Cziraki
- A. Darago
- A. Djokovic
- A. Djordjevic Dikic
- A. Dominguez
- A. Fernandez
- A. Frankiewicz
- A. Frimerman
- A. Gambaro
- A. Gelei
- A. Goldberg
- A. Hernandez
- A. Ka\u2dbdzielski
- A. Korda
- A. Kosztin
- A. Kovacs
- A. Mazurek
- A. Mijovic
- A. Mu~noz
- A. Nagy
- A. Nemetz
- A. Ochala
- A. Radinov
- A. Ristic Andjelkov
- A. Rossi
- A. Ruck
- A. Shotan
- A. Shturman
- A. Vazan
- A. Yordanov
- Alexandre Bertrand
- Alexandrovska University Hospital
- Andreka . M. Atanasova Hungary: Gottsegen Gyo\ua8 rgy Orszagos Kardiologiai Inte\ub4zet: P.
- Andreka Peter
- AOUI Verona \u2013 Borgo Trento Hospital: C. Vassanelli
- Arandjelovic Aleksandra
- Atar Shaul
- AZ Glorieux: A. Heyse
- B. El Nakadi
- B. Kittka
- B. Magyari
- B. Muk
- B. Obrenovic Kircanski
- B. Polgar
- Bartunek Jozef
- Barzilai Medical Center: A. Katz
- Bayes Genis Antoni
- Behfar Atta
- Beleslin Branko
- Bieganski Hospital: J. Kasprzak
- C. Bergamini
- C. Biagioni
- C. Botev
- C. Camporini
- C. Crljenica
- C. Doyen
- C. Jenei
- C. Labata
- C. Lombardi
- C. Monti
- C. Pascual
- C. Plymen
- C. Silva
- C. Sylve\ub4n
- Cardiology Clinic: A. Arandjelovic
- Cardiology Clinic: B. Beleslin
- Cardiology Clinic: P. Seferovic
- Cardiology Department: S. Radovanovic
- CHU Mont Godinne UCL: A. Guedes
- City Hospital Clinic Cardiology Center: I. Petrov
- Clinic of Emergency Internal Medicine
- Clinical Center of Kragujevac: N. Jagic
- Clinical Centre of Serbia
- Clinical Centre of Serbia
- Clinical Hospital Center Bezanijska Kosa
- Cotter Gad
- D. Ljubinka Spain: Hospital Universitario Germans Trias I. Pujol: A. Bayes Genis
- D. S. Blondheim
- D. Boljevic
- D. Ciecwierz
- D. Cotra
- D. Dalla Mura
- D. Fiutowska
- D. Haval Qawoq
- D. Markovic
- D. Mcloman
- D. Nenov
- D. Nikolic
- D. Orlic
- D. Russo
- D. Saleem
- D. Simeunovic
- D. Su\ua8rder
- D. Trifunovic
- Davison Beth A
- Debreceni Egyetem Orvos e\ub4s Ege\ub4szse\ub4gtudomanyi Centrum Altalanos Orvostudomanyi Kar Kardiologia Inte\ub4zet: I. Edes
- Dolatabadi Dariouch
- Domaine Universitaire du Sart Tilman: V. Legrand
- E. Baudoux
- E. Chiari
- E. De Vuyst
- E. Dimitrov
- E. Drasar
- E. Ferrer
- E. Gara
- E. Gaszewska Zurek
- E. Gunyeli
- E. Hadzhiev
- E. Pasotti
- E. Zatarain
- Edes Istvan
- El Nakadi Badih
- F. Carrasco
- F. Jouhra
- F. Van Durme
- Fernandez Aviles Francisco
- Filippatos Gerasimos S
- G. Dolci United Kingdom: Kings College Hospital: J. Hill
- G. Amin Youssef
- G. Dimitrov
- G. Foldes
- G. Fontos
- G. Kerecsen
- G. Loncar
- G. Loughlin
- G. Misic
- G. Pesarini Poland: Jagiellonian University Department of Cardiac
- G. Ponti
- G. Raczak
- G. Szombath
- G. Tzvetkova
- G. Uzonyi
- G. Vajda
- Gelev Valeri L
- Gersh Bernard J
- Gornosla\u2dbskie Centrum Medyczne Sla\u2dbskie j. Akademii Medycznej: W. Wojakowski
- Gruchala Marcin
- Gu\ue9d\ue8s Antoine
- H. Alizadeh
- H. Stoyanov
- Hajjar Roger J
- Halabi Majdi
- Henry Timothy D
- Hernandez Garcia Jose Maria
- Heyndrickx Guy R
- Heyse Alex
- Hillel Yaffe Medical Center: M. Shochat
- Ho\u2c6pital Civil de Charleroi: D. Dolatabadi
- Horvath Ivan G
- Hospital Clinico San Carlos: P. Jimenez Quevedo
- Hospital Clinico Universitario Virgen de la Victoria: J. M. Hernandez Garcia
- Hospital General Universitario Gregorio Mara~non: F. Fernandez Aviles
- I. Amine
- I. Blankoff
- I. Bonadei
- I. Garvanski
- I. Marciniak
- I. Milinkovic
- I. Nedeljkovic
- I. Orlov
- I. Petrova
- I. Rosenfeld
- I. Stopczynska
- I. Tasheva Dimitrova
- I. Webb
- I. Zheleva Kichukova
- J. J. Gomez deDiego
- J. M. Garcia Pinilla
- J. Anguita
- J. Bartunek
- J. Bellwon
- J. Bermejo
- J. Byrne
- J. Ciosek
- J. Fabian
- J. Fo\ua8rstedt Switzerland: CardioCentro Ticino
- J. Jafari
- J. Lalmand
- J. Podolec
- J. Ruiz
- J. Saric
- J. Skopal
- J. Stepanovic
- J. Tresnjak
- J. Verschuere
- J. Wdowczyk
- J. Wroblewska
- Jagic Nikola
- Jimenez Quevedo Pilar
- K. Aehab
- K. Karamfiloff
- K. Kichukov
- K. Leblanc
- K. Mosakowska
- K. Zmudka
- Kasprzak Jaroslaw D
- Katz Amos
- Kiss . M.
- Krampera Mauro
- L. Arobov Italy: A. O. Spedali Civili di Brescia: M. Metra
- L. Perez de Isla Sweden: Karolinska University Hospital: A. Mansson Broberg
- L. Akria
- L. Balogh
- L. Chiumiento
- L. Davin
- L. Drabik
- L. Gabriel
- L. Geller
- L. Inama
- L. Nikitasov
- L. Tekieli
- L. Tomovic
- L. Turchetto
- L. Vladimirova
- L. Zanolla
- Legrand Victor
- M. A. Cicoria
- M. E. Ferna ndez Santos
- M. P. Queipo de Llano
- M. Andre\ub4
- M. Angelova
- M. Banovic
- M. Banovic
- M. Batlle
- M. Biggiogero
- M. Brezins
- M. Chmielecki
- M. Dobric
- M. Dupont
- M. Dzieciuch Rojek
- M. Dzierzak
- M. Gujic
- M. Janssens
- M. Jimenez Navarro
- M. Kilimnik
- M. Kozlowski
- M. Magatelli
- M. Markiewicz
- M. Markiewicz Serbia: Clinical Hospital Center Zvezdara
- M. Mielczarek
- M. Minchev
- M. Moccetti
- M. Mombelli
- M. Nedeljkovic
- M. Olszowska
- M. Plewka
- M. Rossi
- M. Rozmyslowska
- M. Rynkiewicz
- M. Sobczak
- M. Sreckovic
- M. Tarnawska
- M. Tasic
- M. Taszner
- M. Tesic
- M. Wraga
- M. Zielinska
- Merkely Bela
- Metra Marco
- MH Ege\ub4szse\ub4gu\ua8gyi Ko\ua8zpont Kardiologiai Osztaly: N. Nyolczas
- Military Medical Academy: S. Obradovic
- Moccetti Tiziano
- Musialek Piotr
- N. Cvetinovic
- N. Dally
- N. Djenic
- N. Sekularac
- N. Sydo
- N. Vallejo
- N. Zornic
- Nazareth Hospital EMMS: M. Omory N. Kogan Nielsen
- Nyolczas No\ue9mi
- O. Gach
- O. Markovic
- O. Petrovic
- O. Radev
- O. Rodriguez Leor
- O. Sofer
- Obradovic Slobodan
- OLV Ziekenhuis Aalst \u2013 Cardiologie: M. Vanderheyden
- P. Meeus Bulgaria: Tokuda Hospital Sofia: V. Gelev
- P. Blomberg
- P. Djurdjevic
- P. Dubois
- P. Farkas
- P. Gurnet
- P. Lancellotti
- P. Lipiec
- P. Podolec
- P. Polomski
- P. Rubis
- P. Weijner Mik
- Pe\ub4csi Tudomanyegyetem Klinikai Ko\ua8zpont Sz\u131vgyogyaszati Klinika: I. Horvath
- Penicka . M.
- Petrov Ivo
- Plazak . W.
- Povsic Thomas J
- R. A. Gonzalez
- R. Dulgheru
- R. Dworakowski
- R. Faludi
- R. Guerra
- R. Krecki
- R. Melamed
- R. Murzilli
- R. Nadolna
- R. Parapunova
- R. Sanz Ruiz
- R. Tarnovska Kadreva
- R. Winter
- Radovanovic Slavica
- Ribichini Flavio
- Ribichini Flavio Luciano
- S. 0ordevic
- S. Burakowski
- S. Dworowy
- S. Gergely
- S. Hinic
- S. Maspoli
- S. Meisel
- S. Polledri
- S. Sardovski
- S. Seldrum
- S. Stamenkovic
- S. Verstreken
- S. Vukotic
- S. Zivkovic
- Sanz Ruiz Ricardo
- Seferovic Petar M
- Semmelweis Egyetem Varosmajori Sz\u131v e\ub4s Ergyogyaszati Klinika: B. Merkely
- Seron Aymeric
- Sherman Warren
- Shochat Michael K
- sites Belgium: Ziekenhuis Oost Limburg: J. Dens
- Sofia: D. Vassilev
- Stough Wendy Gattis
- Switzerland: T. Moccetti
- T. Borsanyi
- T. Drogenikov
- T. Fulop
- T. Jadczyk
- T. Levinas
- T. Mcdonagh
- T. Plaev
- T. Rechcinski
- Teerlink John R
- Tendera Michal
- Terzic Andre
- U. Sutor
- Uniwersyteckie Centrum Kliniczne: M. Gruchala
- V. Bisenic
- V. Carubelli
- V. D\u2019Orio
- V. Giga
- V. Lazzarini
- V. Locicero
- V. Malenkovic
- V. Miloradovic
- V. Potter
- V. Vuckovic
- V. Vukcevic
- Vanderheyden Marc
- Vascular Diseases at John Paul II Hospital in Krakow: P. Musialek
- W. Cybulski
- W. Mullens
- W. Orczyk
- W. Wanha
- W. Wijns
- Waldman Scott A
- Wijns W. i. l. l. i. a. m. Collaborators Clinical investigators
- Wojakowski Wojciech
- Y. M. Smyth Israel:Western Galilee Hospital: S. Atar
- Y. Barshay
- Y. De Bruyne
- Z. Bari Ireland: HRB Clinical Research Facility: F. Sharif
- Z. Jovic
- Z. Parma
- Z. Stankov
- Z. Walter
- Ziv Medical Center: M. Halabi
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort
Baseline characteristics and risk profiles of participants in the ISCHEMIA randomized clinical trial
- Author
- Abdelhamid M
- Abdul-Nour K
- Abernethy WB
- Al-Amoodi M
- Al-Mallah MH
- Alexander KP
- Alfakih K
- Ali Z
- Almousalli O
- Alvarez C
- Alves Junior AR
- Amati R
- Anstrom K
- Apostolovic S
- Arif I
- Arnold S
- Arsanjani R
- Aspberg J
- Badami U
- Bainey KR
- Ballantyne C
- Banerjee S
- Bangalore S
- Barone-Rochette G
- Barr C
- Barua RS
- Beleslin BD
- Beltrame JF
- Berger J
- Berman DS
- Berman DS
- Berry C
- Bershtein LL
- Bhargava B
- Bhargava B
- Blancas MG
- Bockeria L
- Boden WE
- Boden WE
- Bokhari S
- Booth D
- Booth D
- Braganza D
- Briguori C
- Broderick S
- Budoff M
- Bugiardini R
- Burt F
- Calabro P
- Calfas KJ
- Call JT
- Cannan C
- Caramori PR
- Carvalho AC
- Carvalho AC
- Celutkiene J
- Cemerlic-Adjic N
- Cha J
- Chaitman BR
- Chaitman BR
- Chauhan A
- Cheema AN
- Cheema AN
- Chen J
- Cheng G
- Cheong B
- Chernyavskiy AM
- Chernyavskiy AM
- Chilton R
- Chow BJW
- Christopher J
- Christopher J
- Christopher J
- Chua T
- Cohen DJ
- Cohen RA
- Conway DSG
- Coram R
- Costantini C
- Courtis J
- Cyr D
- Cyr DD
- Daba L
- Dajani K
- Dall'Orto F
- Dauber IM
- Davidovic G
- Davidson M
- De Belder MA
- De Quadros AS
- De Silva R
- Deedwania P
- Dekleva MN
- Demchenko EA
- Demkow M
- Devlin GP
- Dharmarajan L
- Di Chiara A
- Diaz A
- Diaz R
- Doerr R
- Doerr R
- Donnelly P
- Downes TR
- Dracoulakis MDA
- Drozdz J
- Dwivedi SK
- Dzavik V
- El Mahmoud R
- El Shahawy M
- El-Hajjar M
- El-Hajjar M
- Escobedo J
- Escobedo J
- Fang X
- Ferguson B
- Fernandez-Aviles F
- Ferreira N
- Figal JC
- Figueiredo E
- Fleg J
- Fontos G
- Foo D
- Friedman JD
- Friedrich M
- Fu X
- Fukuda K
- Furber A
- Gadkari MA
- Gajos G
- Galiwango P
- Galvani M
- Gamma RA
- Garg P
- Gemignani A
- Genereux P
- Genereux P
- Gerlach RJ
- Giedd K
- Girotra S
- Glover JD
- Goetschalckx K
- Goetschalckx K
- Goldberg JL
- Goldweit R
- Gonzalez Juanatey JR
- Good AP
- Goodman SG
- Goodman SG
- Gopal D
- Gordon PC
- Gosselin G
- Gosselin G
- Govindan SC
- Grant P
- Guzman L
- Hachamovitch R
- Hage F
- Haldis T
- Hameed A
- Hamroff GS
- Hamzeh I
- Hannan J
- Harrell F
- Harrington R
- Hayes SW
- Hedgepeth CM
- Heitner JF
- Held C
- Held C
- Henderson R
- Henriksen P
- Hillis GS
- Hinic S
- Hochberg CP
- Hochman JS
- Hoole SP
- Howarth AG
- Hoye A
- Hoye A
- Hu B
- Huber K
- Hueb W
- Hung C-L
- Hung J
- Jang JJ
- Jeetley P
- Jeffries N
- Jezior M
- Ji Z
- Jiang L
- Johnston N
- Jones P
- Juang GJ
- Kachru R
- Kalarus Z
- Kaul U
- Kedev S
- Kedhi E
- Keltai M
- Kerecsen G
- Kerner A
- Khairuddin A
- Khouri MG
- Kinlay S
- Kirby R
- Kobashigawa J
- Kohn JA
- Kohsaka S
- Krishnam MS
- Kronenberg M
- Kuanprasert S
- Kullo I
- Kumar A
- Kumkumian G
- Kwong R
- Kwong RY
- Labovitz AJ
- Lader EW
- Lam A
- Lang IM
- Laucevicius A
- Leipsic J
- Lesiak M
- Li D
- Li Q
- Lin W
- Lindsay SJ
- Little RW
- Loboz-Grudzien K
- Lopes RD
- Lopes RD
- Lopez-Sendon J
- Lopez-Sendon JL
- Lopez-Sendon JL
- Luckie M
- Luena JEC
- Lui CY
- Lyubarova R
- Ma Y
- Maggioni A
- Maggioni AP
- Mancini GBJ
- Manjunath CN
- Marin-Neto JA
- Mark DB
- Mark DB
- Maron DJ
- Maron DJ
- Martin ET
- Marzo K
- Mastouri RA
- Mathew A
- Mathur A
- Mattina D
- Mavromatis K
- Mazurek T
- McFalls EO
- McGarvey JFX
- McManus B
- Meadows JL
- Mehta PK
- Mehta S
- Merkely B
- Merz CNB
- Mesquita CT
- Meyer TM
- Mikhail G
- Miller T
- Min JK
- Min JK
- Miro V
- Moccetti T
- Mongeon FP
- Monti L
- Moorman A
- Moriarty AJ
- Mortara A
- Mumma M
- Musial WJ
- Nageh T
- Naik S
- Nakanishi R
- Newman J
- Nguyen PK
- Nickenig G
- Nicollet E
- Nie S-P
- Nishimura S
- Ntsekhe M
- Nwosu S
- O'Brien SM
- O'Brien SM
- Okane P
- Old W
- Oomman A
- Orso F
- Ortuno FM
- Pandit N
- Pedalino RP
- Perna GP
- Peteiro J
- Peteiro J
- Phaneuf DC
- Phillips L
- Picard MH
- Picard MH
- Pinto FJ
- Poh K-K
- Polanczyk CA
- Pop C
- Popescu BA
- Potluri S
- Provasoli S
- Pruszczyk P
- Racca E
- Ramos R
- Ramos WEM
- Rayos G
- Reczuch KW
- Reynolds HR
- Ribeiro da Silva EE
- Riezebos RK
- Robbins IH
- Rockhold F
- Rodriguez F
- Rosas EA
- Rosenberg YD
- Rosenberg YD
- Rubio M
- Russo A
- Rutkin B
- Ruzyllo W
- Ruzyllo W
- Saba S
- Sahul Z
- Salerno WD
- Saraiva JF
- Satheesh S
- Scherrer-Crosbie M
- Schiavi L
- Schuchlenz H
- Schulze PC
- Sechtem U
- Sedlis SP
- Seedhom A
- Selvanayagam JB
- Selvanayagam JB
- Senior R
- Senior R
- Setty S
- Shammas NW
- Shapiro MD
- Sharir T
- Shaw LJ
- Shaw LJ
- Sicuro M
- Sidhu M
- Sionis A
- Sirker AA
- Slama MS
- Smanio PEP
- Sobolewska J
- Sokhon K
- Sokol SI
- Spertus JA
- Spertus JA
- Spizzieri C
- Stafford J
- Stankovic G
- Steg P-G
- Steg P-G
- Stenberg R
- Stewart RAH
- Stone GW
- Stone GW
- Stone PH
- Stone PH
- Su X
- Sudarshan S
- Suryapranata H
- Sweeny J
- Szwed H
- Szwed H
- Tamis-Holland JE
- Tarantini G
- Thambar ST
- Thomas S
- Thuaire C
- Travill C
- Trejo (Gutierrez) JF
- Tumelero R
- Turner MC
- Udell J
- Uxa A
- Valeti US
- Van de Werf F
- Varga A
- Vertes A
- Vitola JV
- Vorobiof G
- Wander GS
- Wander GS
- Wang J
- Wang S
- Weintraub W
- Weitz S
- White HD
- White HD
- Wiesel J
- Williams D
- Winchester DE
- Witherow FN
- Witkowski A
- Wohns D
- Wong G
- Wu Y
- Wyman R
- Yamwong S
- Yang B
- Yang X
- Yasuda S
- Youn T
- Yu Q
- Zarka A
- Zeng H
- Zeng Q
- Zeng X
- Zhang H
- Zhang L
- Zhang S
- Zhao Y
- Zurick A
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 21/12/2018
- Field of study
Importance It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. Objective To describe baseline characteristics of participants enrolled and randomized in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial and to evaluate whether qualification by stress imaging or nonimaging exercise tolerance test (ETT) influenced risk profiles. Design, Setting, and Participants The ISCHEMIA trial recruited patients with SIHD with moderate or severe ischemia on stress testing. Blinded coronary computed tomography angiography was performed in most participants and reviewed by a core laboratory to exclude left main stenosis of at least 50% or no obstructive coronary artery disease (CAD) (<50% for imaging stress test and <70% for ETT). The study included 341 enrolling sites (320 randomizing) in 38 countries and patients with SIHD and moderate or severe ischemia on stress testing. Data presented were extracted on December 17, 2018. Main Outcomes and Measures Enrolled, excluded, and randomized participants’ baseline characteristics. No clinical outcomes are reported. Results A total of 8518 patients were enrolled, and 5179 were randomized. Common reasons for exclusion were core laboratory determination of insufficient ischemia, unprotected left main stenosis of at least 50%, or no stenosis that met study obstructive CAD criteria on study coronary computed tomography angiography. Randomized participants had a median age of 64 years, with 1168 women (22.6%), 1726 nonwhite participants (33.7%), 748 Hispanic participants (15.5%), 2122 with diabetes (41.0%), and 4643 with a history of angina (89.7%). Among the 3909 participants randomized after stress imaging, core laboratory assessment of ischemia severity (in 3901 participants) was severe in 1748 (44.8%), moderate in 1600 (41.0%), mild in 317 (8.1%) and none or uninterpretable in 236 (6.0%), Among the 1270 participants who were randomized after nonimaging ETT, core laboratory determination of ischemia severity (in 1266 participants) was severe (an eligibility criterion) in 1051 (83.0%), moderate in 101 (8.0%), mild in 34 (2.7%) and none or uninterpretable in 80 (6.3%). Among the 3912 of 5179 randomized participants who underwent coronary computed tomography angiography, 79.0% had multivessel CAD (n = 2679 of 3390) and 86.8% had left anterior descending (LAD) stenosis (n = 3190 of 3677) (proximal in 46.8% [n = 1749 of 3739]). Participants undergoing ETT had greater frequency of 3-vessel CAD, LAD, and proximal LAD stenosis than participants undergoing stress imaging. Conclusions and Relevance The ISCHEMIA trial randomized an SIHD population with moderate or severe ischemia on stress testing, of whom most had multivessel CAD. Trial Registration ClinicalTrials.gov Identifier: NCT0147152
Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/01/2019
- Field of study
Importance: It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. Objective: To describe baseline characteristics of participants enrolled and randomized in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial and to evaluate whether qualification by stress imaging or nonimaging exercise tolerance test (ETT) influenced risk profiles. Design, Setting, and Participants: The ISCHEMIA trial recruited patients with SIHD with moderate or severe ischemia on stress testing. Blinded coronary computed tomography angiography was performed in most participants and reviewed by a core laboratory to exclude left main stenosis of at least 50% or no obstructive coronary artery disease (CAD) (<50% for imaging stress test and <70% for ETT). The study included 341 enrolling sites (320 randomizing) in 38 countries and patients with SIHD and moderate or severe ischemia on stress testing. Data presented were extracted on December 17, 2018. Main Outcomes and Measures: Enrolled, excluded, and randomized participants' baseline characteristics. No clinical outcomes are reported. Results: A total of 8518 patients were enrolled, and 5179 were randomized. Common reasons for exclusion were core laboratory determination of insufficient ischemia, unprotected left main stenosis of at least 50%, or no stenosis that met study obstructive CAD criteria on study coronary computed tomography angiography. Randomized participants had a median age of 64 years, with 1168 women (22.6%), 1726 nonwhite participants (33.7%), 748 Hispanic participants (15.5%), 2122 with diabetes (41.0%), and 4643 with a history of angina (89.7%). Among the 3909 participants randomized after stress imaging, core laboratory assessment of ischemia severity (in 3901 participants) was severe in 1748 (44.8%), moderate in 1600 (41.0%), mild in 317 (8.1%) and none or uninterpretable in 236 (6.0%), Among the 1270 participants who were randomized after nonimaging ETT, core laboratory determination of ischemia severity (in 1266 participants) was severe (an eligibility criterion) in 1051 (83.0%), moderate in 101 (8.0%), mild in 34 (2.7%) and none or uninterpretable in 80 (6.3%). Among the 3912 of 5179 randomized participants who underwent coronary computed tomography angiography, 79.0% had multivessel CAD (n = 2679 of 3390) and 86.8% had left anterior descending (LAD) stenosis (n = 3190 of 3677) (proximal in 46.8% [n = 1749 of 3739]). Participants undergoing ETT had greater frequency of 3-vessel CAD, LAD, and proximal LAD stenosis than participants undergoing stress imaging. Conclusions and Relevance: The ISCHEMIA trial randomized an SIHD population with moderate or severe ischemia on stress testing, of whom most had multivessel CAD
Abstracts
- Author
- A. A. Lammertsma
- A. A. Lammertsma
- A. A. Lammertsma
- A. A. Lammertsma
- A. A. Lammertsma
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- A. Baali
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- A. Berezin
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- A. C. Ng
- A. C. T. Ng
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- A. Colli
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- A. Cuocolo
- A. Cuocolo
- A. Cwetsch
- A. D. Annoni
- A. D. Annoni
- A. D. Annoni
- A. D. Hepner
- A. D. J. Almeida
- A. D. Small
- A. D. Small
- A. D. Windhorst
- A. D. Windhorst
- A. D. Windhorst
- A. Dabiri
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- A. Delhommais
- A. Dharampal
- A. Djokovic
- A. Dos Santos
- A. E. Iskandrian
- A. Elvan
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- A. Evangelista Masip
- A. F. Jacobson
- A. Falcao
- A. Falcao
- A. Farzaneh-Far
- A. Flotats
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- A. Formenti
- A. Formenti
- A. Formenti
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- A. Formenti
- A. Formenti
- A. Formenti
- A. Garcia-Burillo
- A. Gaspar
- A. Gaspar
- A. Gencoglu
- A. Gencoglu
- A. Gimelli
- A. Gimelli
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- A. Giordano
- A. Giordano
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- A. Giorgetti
- A. Gomaa
- A. Gonzalez
- A. Goyeneche Achigar
- A. Guo
- A. Gutstein
- A. Gutstein
- A. H. Allam
- A. H. Allam
- A. H. Nureldin
- A. Hoffmeier
- A. I. Mcghie
- A. I. Santos
- A. Ikeda
- A. Iskandrian
- A. J. Einstein
- A. J. Einstein
- A. J. M. Rijnders
- A. J. Sinusas
- A. J. Witkowska-Grzeslo
- A. Jacobson
- A. Jacobson
- A. Jimenez-Heffernan
- A. Jimenez-Heffernan
- A. Jimenez-Heffernan
- A. Johansen
- A. Karu
- A. Kasai
- A. Kawamura
- A. Kisko
- A. Kjaer
- A. Kouzoumi
- A. Kowalewska
- A. Kusch
- A. L. Bartorelli
- A. L. Bartorelli
- A. L. Bartorelli
- A. L. Bartorelli
- A. L. Bartorelli
- A. L. Bartorelli
- A. L. Bartorelli
- A. Lahiri
- A. Lahiri
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- A. Lahiri
- A. Lahiri
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- A. Lankford
- A. Lankford
- A. Legasto
- A. Levine
- A. M. Alessio
- A. M. Beek
- A. M. Beek
- A. M. Falcao
- A. M. Gusakova
- A. M. Lebech
- A. M. Mavinkurve-Groothuis
- A. M. Peters
- A. M. Schmidt
- A. M. Stel
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- A. Maheshwari
- A. Maheshwari
- A. Martin De Arriba
- A. Martin De Arriba
- A. Martinez-Moeller
- A. Meave
- A. Meave
- A. Meave
- A. Meave
- A. Meddahi-Pelle
- A. Mlynarska
- A. Mlynarska
- A. Mlynarska
- A. Mlynarska
- A. Moelker
- A. Moelker
- A. Mohani
- A. Moreira
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- A. Moreira
- A. N. Kitsiou
- A. Namiki
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- A. Notghi
- A. Nureldin
- A. Okizaki
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- A. Ortega
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- A. P. Pazhenkottil
- A. Pankova
- A. Pankova
- A. Paolino
- A. Patel
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- A. Peix
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- A. Persson
- A. Peter
- A. Petiet
- A. Ponte
- A. Prata
- A. Pupi
- A. Quercioli
- A. Quercioli
- A. Ricalde
- A. Ricalde
- A. Rice
- A. Rohani
- A. Roivainen
- A. Roivainen
- A. Rosero
- A. Rosero
- A. Rossi
- A. Rossi
- A. Rossi
- A. Rossi
- A. Ruibal Morell
- A. Russo
- A. S. Dharampal
- A. S. Koh
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- A. Salacata
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- A. Saraste
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- A. Saraste
- A. Saraste
- A. Saraste
- A. Sato
- A. Sattar
- A. Savic-Radojevic
- A. Sellem
- A. Sharef
- A. Siddique
- A. Sinusas
- A. Sinusas
- A. Solodky
- A. Solodky
- A. Srivastava
- A. Staudenherz
- A. Stefanelli
- A. Theodorakos
- A. Thom
- A. Tobaruela
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- A. Tobaruela
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- A. Uitterdijk
- A. Van Tosh
- A. Van Tosh
- A. Vara
- A. Vonk-Noordegraaf
- A. Vonk-Noordegraaf
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- A. Walker
- A. Witkowski
- A. Yalfimov
- A. Yerramasu
- A. Yerramasu
- A. Yerramasu
- A. Yerramasu
- A. Yerramasu
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- C. Albarran
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- C. Allaart
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- C. Amarelli
- C. Artigas
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- C. Coaguila
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- C. D'amore
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- C. E. Veltman
- C. E. Veltman
- C. Fiorentini
- C. Fiorentini
- C. Fiorentini
- C. Fiorentini
- C. Fiorentini
- C. Fiorentini
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- C. Templin
- C. Tonge
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- C. Tortorelli
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- C. Vigorito
- C. W. Heegaard
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- D. Andreini
- D. Andreini
- D. Andreini
- D. Andreini
- D. Andreini
- D. Andreini
- D. Andreini
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- D. Belzer
- D. Berman
- D. Berman
- D. Bialostozky
- D. Birnie
- D. Caeiro
- D. Casset-Senon
- D. Chang Min
- D. Chyun
- D. Coisne
- D. Collins
- D. Daou
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- D. Daou
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- D. Dey
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- D. E. Kliner
- D. Garcia-Dorado
- D. Garcia-Dorado
- D. Garcia-Dorado
- D. Garcia-Dorado
- D. Garcia-Dorado Garcia
- D. Gasparini
- D. Genovesi
- D. Genovesi
- D. Goodman
- D. Goodman
- D. J. Duncker
- D. Jakobsson
- D. K. Glover
- D. K. Kajdasz
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- D. Le Guludec
- D. Lebedev
- D. Leite
- D. Leite
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- D. Leon Duran
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- D. Lipkin
- D. Lipkin
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- D. Natale
- D. Nielsen
- D. O. Hodge
- D. Padua
- D. Patel
- D. Pontillo
- D. Pop Gjorcheva
- D. Pop Gorceva
- D. Pop-Gorceva
- D. Ramos
- D. Ramos
- D. Ramos
- D. Rhodes
- D. Rovithis
- D. S. Berman
- D. S. Berman
- D. S. Bulugahapitya
- D. Sharma
- D. Shimbo
- D. Shimbo
- D. T. Matsuoka
- D. Trabattoni
- D. Truong
- D. V. Anand
- D. V. Anand
- D. V. Ryzhkova
- D. V. Simic
- D. W. Motherwell
- D. Washburn
- D. Weisenberger
- E. Alexanderson Rosas
- E. Alexanderson Rosas
- E. Alexanderson Rosas
- E. Alexanderson Rosas
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- E. Alhaj
- E. Batista
- E. Bertella
- E. Bertella
- E. Bertella
- E. Bertella
- E. Bertella
- E. Bertella
- E. Bertella
- E. Bertella
- E. Bertella
- E. C. Thompson
- E. Correia
- E. Despotopoulos
- E. Di Lorenzo
- E. Duronto
- E. E. Van Der Wall
- E. E. Van Der Wall
- E. E. Van Der Wall
- E. E. Van Der Wall
- E. E. Van Der Wall
- E. E. Van Der Wall
- E. E. Van Der Wall
- E. Entok
- E. Ficaro
- E. H. Boersma
- E. Hatzistamatiou
- E. Hoey
- E. J. Chun
- E. J. Sijbrands
- E. Kaczmarska
- E. Kaczmarska
- E. Kaya
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- E. Komar
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- E. Lankinen
- E. Leung
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- E. Mena
- E. Mena
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- E. Olsson
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- E. Pereira
- E. Piperkova
- E. Raaijmakers
- E. Reyes
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- E. Romero
- E. Romero
- E. Romero
- E. S. J. Kroner
- E. S. J. Kroner
- E. Sanchez De Mora
- E. Sanchez De Mora
- E. Sanchez De Mora
- E. Sari
- E. Tragardh Johansson
- E. Tragardh Johansson
- E. V. Garcia
- E. V. Garcia
- E. V. Garcia
- E. V. Garcia
- E. V. Scabbia
- E. Vallejo
- E. Vallejo
- E. Van Der Wall
- E. Vardareli
- E. Velasco Alonso
- E. Velasco Alonso
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- E. Weidl
- E. Yamashita
- F. Aldaas
- F. Aldaas
- F. Alves
- F. Alves
- F. Angelozzi
- F. Baldascino
- F. Bellocci
- F. Benvissuto
- F. Bertagna
- F. Blackwell
- F. Bussolini
- F. Chaubet
- F. Collado
- F. Collado
- F. Collado
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- F. Feihl
- F. Fiore Melacrinis
- F. Godinho
- F. Godinho
- F. Gomez-Caminero
- F. Gomez-Caminero
- F. Hyafil
- F. J. Hurtado-Mauricio
- F. J. Ten Cate
- F. J. Ten Cate
- F. Khalid
- F. Lee
- F. M. Bengel
- F. M. Bengel
- F. M. Collado
- F. Maggi
- F. Manganelli
- F. Miyake
- F. Mut
- F. Mut
- F. Nasreen
- F. Nicoud
- F. P. Esteves
- F. P. Machado
- F. P. Machado
- F. P. Pollice
- F. P. Pollice
- F. Perna
- F. R. De Graaf
- F. R. De Graaf
- F. R. De Graaf
- F. R. De Graaf
- F. R. De Graaf
- F. Rahman
- F. Ricci
- F. Roffe
- F. Rotondi
- F. Rouzet
- F. Rouzet
- F. Todua
- F. Triposkiadis
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- F. U. Chowdhury
- F. Van Der Kley
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- F. Ventura
- F. Wackers
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- F. Y. J. Keng
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- F. Zijlstra
- G. A. Slavich
- G. Adelmaksoub
- G. Alexanderson
- G. Allenbach
- G. Antelava
- G. Ascoli
- G. Ballerini
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- G. Ballerini
- G. Ballerini
- G. Ballerini
- G. Bencardino
- G. Bhat
- G. Blanco Palacios
- G. Borrelli
- G. Cannizzaro
- G. Cantinho
- G. Cerisano
- G. Chandok
- G. Colice
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- G. Costa
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- G. Cuberas-Borros
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- G. D. Bae
- G. Davis
- G. De Leon
- G. Depuey
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- G. Dobrozemsky
- G. Durmus Altun
- G. Fagioli
- G. Feuchtner
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- G. Friedrich
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- G. Germano
- G. Giamouzis
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- G. Guilhermina
- G. H. Min
- G. Henriksen
- G. J. Horszczaruk
- G. J. R. Ten Kate
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- G. Jensen
- G. Karayannis
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- G. Kerecsen
- G. M. Mccurrach
- G. M. Nasr
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- G. M. Nasr
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- G. Marsche
- G. Marti Aguasca
- G. Melendez
- G. Mendoza
- G. P. Krestin
- G. P. Krestin
- G. P. Krestin
- G. P. Perna
- G. P. Perna
- G. Pavon-Djavid
- G. Pelargonio
- G. Peluso
- G. Piccoli
- G. Platsch
- G. Ponta
- G. Pontone
- G. Pontone
- G. Pontone
- G. Pontone
- G. Pontone
- G. Pontone
- G. Pontone
- G. Pontone
- G. Pontone
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- G. Rodriguez
- G. Ruiter
- G. Ruiter
- G. Ruiter
- G. S. Thomas
- G. S. Thomas
- G. S. Thomas
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- G. Savenkova
- G. Sitafidis
- G. Steurer
- G. Tamborini
- G. Terroso
- G. Vera Janavel
- G. Wells
- G. Wisenberg
- G. Y. Kozmann
- G. Yaman
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- H. A. R. Hany
- H. Adachi
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- H. Aoki
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- H. Bahri
- H. Cuellar Calabria
- H. F. Mathiesen
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- H. Fukuda
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- H. Fukuda
- H. Fukuda
- H. Fukuda
- H. Fukuda
- H. G. Marrero
- H. Gutte
- H. Hammami
- H. Hase
- H. Hase
- H. Hase
- H. Hashemizadeh
- H. Higashino
- H. Hiraoka
- H. Hirayama
- H. Hommel
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- H. Hoshizaki
- H. Hoshizaki
- H. Hoshizaki
- H. Iida
- H. Ilarraza
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- H. J. Harms
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- H. J. Harms
- H. J. Harms
- H. J. Lessig
- H. J. Verberne
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- H. Masai
- H. Masai
- H. Masai
- H. Muderrisoglu
- H. Nagaraj
- H. Pena
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- H. Rousseau
- H. Saglam
- H. Sano
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- H. Sherif
- H. Sliem
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- H. Slimen
- H. Tsutsui
- H. Ueda
- H. Ukkonen
- H. W. M. Van Laarhoven
- H. Wakabayashi
- H. Wieczorek
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- I. Badr
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- I. Balogh
- I. Bruno
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- I. Casans-Tormo
- I. Danad
- I. Danad
- I. E. K. Laitinen
- I. Enriksson
- I. Henriksson
- I. K. Russel
- I. Kosa
- I. Kovalev
- I. Laynez Cerdena
- I. Mats
- I. Mats
- I. Matsunari
- I. Matsunari
- I. Michalowska
- I. Michalowska
- I. Nanbu
- I. P. Clements
- I. Peovska
- I. Peovska
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- I. Rutten-Vermeltfoort
- I. S. Kostina
- I. Sazonova
- I. Shawky
- I. Slim
- I. Tsiantis
- I. Vassanyi
- I. Vassiliadis
- I. Vilardi
- I. Y. U. Proskokova
- J. A. Bonilla Arjona
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- J. A. F. Ramires
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- S. Reder
- S. Reiffers
- S. Rotevatn
- S. Sahni
- S. Sakabe
- S. Schmidt
- S. Schmidt
- S. Sedej
- S. Sethi
- S. Simsek
- S. Stojanovski
- S. Svensson
- S. Tadic
- S. Tandon
- S. Thorn
- S. V. Nesterov
- S. V. Solav
- S. Venuraju
- S. Venuraju
- S. Venuraju
- S. Venuraju
- S. Venuraju
- S. Venuraju
- S. Vernotico
- S. Weismueller
- S. Yamada
- S. Yamashina
- S. Ylaherttuala
- S.- E. Svensson
- T. A. Panasenko
- T. Aach
- T. Aach
- T. Aburano
- T. Adachi
- T. Akasaka
- T. Aksoy
- T. Aziz
- T. Bach-Gansmo
- T. Bahceci
- T. Bahceci
- T. Dey
- T. Dey
- T. El Kammash
- T. El Khouly
- T. Faria
- T. Furuhashi
- T. Furuhashi
- T. Furuhashi
- T. Furuhashi
- T. Furuhashi
- T. Germans
- T. Gonzalez
- T. Gonzalez-Alujas
- T. Haghfelt
- T. Ikeda
- T. Ishikawa
- T. Ishizu
- T. K. Ip
- T. Katsikis
- T. Khawaja
- T. Khawaja
- T. Kokki
- T. Kunimasa
- T. Kunimasa
- T. Kunimasa
- T. Kunimasa
- T. Kunimasa
- T. Kunimasa
- T. Kunimasa
- T. L. Faber
- T. L. Faber
- T. M. Bateman
- T. M. Hernandez
- T. Massardo
- T. Mazurek
- T. Miller
- T. Miller
- T. Mirza
- T. Mochizuki
- T. Naveed
- T. Nishimura
- T. Nishimura
- T. Noponen
- T. Omura
- T. P. Willems
- T. Parveen
- T. Pedrazzini
- T. Pirotte
- T. S. J. Chua
- T. S. J. Chua
- T. Saanijoki
- T. Savunen
- T. Schindler
- T. Schindler
- T. Schindler
- T. Seko
- T. Simic
- T. Spieker
- T. Suzuki
- T. Swadia
- T. Toyama
- T. Toyama
- T. Toyama
- T. Toyama
- T. Traub-Weidinger
- T. Uchiyama
- T. V. Kuzmina
- T. Vakhtangadze
- T. Vieira
- T. W. Galema
- T. Yaylali
- U. Baber
- U. Raval
- U. S. Kristoffersen
- V. A. Pinas
- V. A. Uusitalo
- V. Akbari
- V. Aliaga
- V. Berti
- V. Chavarri
- V. Chernov
- V. Delgado
- V. Delgado
- V. Delgado
- V. Delgado
- V. Dunet
- V. Dunet
- V. Gama
- V. Gama Ribeiro
- V. Gulyaev
- V. La Delfa
- V. Majstorov
- V. Majstorov
- V. Majstorov
- V. Marijanski
- V. Mendoza
- V. Mwansa
- V. Oikonen
- V. Parvanova
- V. Pineda
- V. Pubul
- V. Saushkin
- V. Seden
- V. Soukhov
- V. Stoll
- V. Tsatkin
- V. V. Saushkin
- V. Veloso
- W. A. Chalela
- W. A. Chalela
- W. A. Chalela
- W. Acampa
- W. Bruni
- W. Burchert
- W. J. Laarse
- W. J. Van Der Giessen
- W. J. Van Der Laarse
- W. J. Van Der Laarse
- W. L. Duvall
- W. L. Duvall
- W. Martin
- W. Martin
- W. Qureshi
- W. Ruzyllo
- W. Ruzyllo
- W. Saushkin
- W. Van Der Bruggen
- X. B. Pan
- X. B. Pan
- X. B. Pan
- X. Shen
- Y. Akashi
- Y. Arita
- Y. Brodov
- Y. E. Appelman
- Y. E. Appelman
- Y. Fernandez
- Y. Fernandez
- Y. Fernandez
- Y. Fernandez
- Y. G. C. J. America
- Y. Golzar
- Y. Hashikawa
- Y. Hasid
- Y. Ishikawa
- Y. J. Akashi
- Y. J. Akashi
- Y. Kakefuda
- Y. Kirihara
- Y. Liu
- Y. Liu
- Y. Matsuzawa
- Y. Miyake
- Y. Miyake
- Y. Sang Geun
- Y. Seo
- Y. Srour
- Y. Srour
- Y. Takahashi
- Y. Takeishi
- Y. Tekabe
- Y. U. B. Lishmanov
- Y. U. Lishmanov
- Y. U. Lishmanov
- Y. U. Lishmanov
- Y. U. Lishmanov
- Y. U. Saushkina
- Y. Urano
- Y. Y. Wong
- Y. Y. Wong
- Y. Y. Wong
- Y. Yamasaki
- Y. Yoshida
- Y. Yoshimura
- Y.- H. Liu
- Z. Dzielinska
- Z. Dzielinska
- Z. Dzielinska
- Z. Keidar
- Z. S. Szelid
- Z. Starr
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Health-status outcomes with invasive or conservative care in coronary disease
- Author
- Alexander K.P.
- Baloch K.
- Bangalore S.
- Boden W.E.
- Cohen D.J.
- Diaz A.
- Gosselin G.
- Harrell F.E.
- Hochman J.S.
- ISCHEMIA Research Group: Joseph Ricci A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Raba\ue7a, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fern\ue1ndez Mart\uednez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, Andr\ue9 Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andr\ue9s Garc\ueda-Rinc\uf3n, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej \u141abyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Pe\uf1aranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel \uc5kerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezi\u144ska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Bego\uf1a Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard J\ue4ger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Car\uedsi A Polanczyk, Carita Krannila, Carla Vicente, Carl-\uc9ric Gagn\ue9, Carlo Briguori, Carlos Pe\uf1a Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Bj\uf6rklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cort\ue9s, Claudia Escobar, Cl\ue1udia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adri\ue1n Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elih\ufa Dur\ue1n-Cort\ue9s, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnaci\uf3n Alonso-\uc1lvarez, Eric Nicollet, Eric Peterson, Erick Alex\ue1nderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eust\ue1quio Ribeiro Silva, F Marin Ortu\uf1o, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Fl\ue1via Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely \uc1goston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidovi\u107, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Llad\uf3, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, In\ueas Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, Jo\ue3o Reynaldo Abbud, Jo\ue3o V Vitola, Joaqu\uedn V Pe\uf1afiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, Jos\ue9 A Ortega-Ram\uedrez, Jos\ue9 Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, Jos\ue9 J Cuenca-Castillo, Jose L Diez, Jos\ue9 Luis Narro Villanueva, Jos\ue9 Luiz da Vieira, Jos\ue9 M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padr\uf3, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio C\ue9sar Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna \u141uczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna \u141oboz-Grudzie\u144, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kuku\u142a, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura Keinaite, Laura Sarti, Laurel Kolakaluri, Lawrence M Phillips, Lawrence Friedman, Lawrence Phillips, Lazar Velicki, Leah Howell, Leandro C Maranan, Leanne Cox, Ledjalem Daba, Lei Zhang, Lekshmi Dharmarajan, Leo Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Leszek Sokalski, Li Hai Yan, Li Li, Lia Nijmeijer, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilia Schiavi, Lilian Mazza Barbosa, Lillian L Khor, Lina Felix-Stern, Linda L Hall, Linda M Hollenweger, Linda Arcand, Linda Davidson-Ray, Linda Schwarz, Lindsey N Sikora, Lingping Chi, Lino Patricio, Liping Zhang, Lisa Chaytor, Lisa Hatch, Lisa McCloy, Lisa Wong, Liselotte Persson, Lixin Jiang, Liz Low, Ljiljana Pupic, Lo\uefc Bi\ue8re, Lorenzo Monti, Lori Christensen, Lori Pritchard, Loriane Black, Lori-Ann Desimone, Lori-Ann Larmand, Lorraine McGregor, Louise Morby, Louise Thomson, Luc Harvey, Luciana de P\ue1dua Baptista, Lucilla Garcia, Ludivine Eliahou, Ludmila Helmer, Luis F Smidt, Luis Bernanrdes, Luis Guzman, Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Vald\ue9s Ch\ue1varri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena \u141anocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Ma\u142gorzta Celi\u144ska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Val\ue9rio Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C Quinn, Maria A Alfonso, Maria Antonieta Pereira Moraes, Mar\ueda Dolores Mart\uednez-Ru\uedz, Mar\ueda Fernanda Canales, Maria In\ueas Caetano, Maria P Corral, Maria P\ue9rez Garc\ueda, Maria Victoria Actis, Maria Aguirre, Maria Andreasson, Maria Aprile, Maria Colton, Maria Eugenia Martin, Maria Lasala, Maria Lorenzo, Maria Posada, Maria Shier, Maria Thottam, Mariana V Furtado, Mariana Yumi Okada, Marianna D A Dracoulakis, Marianne De Andrade, Mariano Rubio, Marie Essermark, Marielle Scherrer-Crosbie, Marija T Petrovic, Marija Zdravkovic, Marilyn Black, Marina Garcia, Mario J Garcia, Mariola Szulik, Marisa Orgera, Mark A de Belder, Mark Harbinson, Mark Hyun, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Marcinkiewicz-Siemion, Marta Swiderek, Martha Meyer, Martina Ceseri, Martina Tricoli, Marvin Kronenberg, Mary Williams, Mary Ann Champagne, Mary Colleen Rogge, Mary R Soltau, Mary Streif, Massimo Villella, Massoud Leesar, Matei Claudia, Mateusz Solecki, Mat\uedas Nicol\ue1s Mungo, Matthew Wall Jr, Matthew Budoff, Matthew Jezior, Matthew Luckie, Matthias Friedrich, Mauren P Haeffner, Maximilian Tscharre, Max-Paul Winter, Mayana Almeida, Mayil S Krishnam, Mayuri Patel, Meenakshi Mishra, Megan Manocchia, Meghana Kakade, Melanie J Munro, Melissa D Chaplin, Melissa LeFevre, Mervyn Andiapen, Michael A Gibson, Michael B Rubens, Michael C Turner, Michael D Shapiro, Michael W Lee, Michael Berlowitz, Michael Davidson, Michael Mack, Michael McDaniel, Michael Mumma, Michal Wlodarczyk, Michel G Khouri, Michel S Slama, Michele Rawlins, Michelle M Bonner, Michelle M Seib, Michelle Chang, Michelle Crowder, Michelle Dixon, Michelle Mayon, Michelle McEvoy, Michelle Yee, Miguel M Fernandes, Miguel Nobre Menezes, Miguel Souto Bayarri, Miguel Barrero, Mikhail T Torosoff, Milan R Dobric, Milan Dobric, Milica Nikola Dekleva, Milind Avdhoot Gadkari, Millie Gomez, Min Tun Kyaw, Miriam Brooks, Miroslav Stevo Martinovic, Mitchel B Lustre, Mohammad Tariq Vakani, Mohammad El-Hajjar, Mohammed Al-Amoodi, Mohammed Hussain, Mohammed Saleem, Mois\ue9s Blanco-Calvo, Mois\ue9s Jim\ue9nez-Santos, Mona Bhatia, Monica Rosca, Monika Laukyte, Montserrat Gracida Blanca, Montserrat Vila Perales, Mouaz H Al-Mallah, Moys\ue9s de Oliveira Filho, Mpiko Ntsekhe, Muhamed Saric, Mulei Chen, Myriam Brousseau, Myrthes Emy Takiuti, Nada Cemerlic-Adjic, Nadia Asif, Nadia Gakou, Nafisa Hussain, Nana O Katamadze, Nancy L Clapp, Nancy Aedy, Nandita Nataraj, Nanette K Wenger, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Natalie Spitzer, Natasha C Putnam, Naved Aslam, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Nevena Garcevic, Ngaire Meadows, Nhi N Tran, Nicholas Danchin, Nicki Lakeman, Nicola Johnston, Nicolas W Shammas, Nicole Saint Vrestil, Nicole Deming, Nier Zhong, Niket Patel, Nikola N Boskovic, Nikolaos Karogiannis, Nikos Werner, Nina Johnston, Ning Zhang, Ning Zhou, Niree Hindoyan, Nirmal Kumar, Nitika Chadha, Nitish Naik, Nodira Aripova, Noloyiso Mtana, Nona A Eskelson, Noor Syamira Mokhtar, Noppon Taksaudom, Nor Asiah Basri, Nora Marchelletta, Norma Hogg, Nungshi Jungla, Nuno Ferreira, Oksana A Lubyanaya, Olga B Nikolaeva, Olga Ca\uf1avate, Olga Sobrino, Olga Walesiak, Olga Walter, Olga Zdo\u144czyk, Olivia J Lim, Olivia Anaya, Olivia Mancilla, Olivier Dubourg, Olugbenga Bello, Omar Almousalli, Omar Thompson, Oni Olurinde, Or Harel, Osama Raheem, Oscar M\ue9ndiz, 3scar Prada-Delgado, Oz Shapira, P Christian Schulze, Pachara Panpunuan, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Julian, Pamela Ouyang, Pamela Sigel, Pamela Woodard, Panpan Zhou, Paola Emanuela Poggio, Paola Smanio, Paolo Calabro, Paramjit Jeetley, Pascal Goube, Patricia K Nguyen, Patricia Alarie, Patricia Arakelian, Patricia Arsenault, Patricia Blaise, Patricia Brito, Patricia Cowper, Patricia Endsley, Patricia Mieses, Patrick B Alexander, Patrick Donnelly, Patrick Wilmot, Patrycja Lebioda, Paul C Gordon, Paul Der Mesropian, Paul Galiwango, Paul Hauptman, Paul Kennedy, Paula Beardsley, Paula Garc\ueda-Gonz\ue1lez, Paulo Cury Rezende, Paulo Ricardo Caramori, Pavel S Kozlov, Pedro Canas Silva, Pedro Gabriel Melo Barros E Silva, Pedro P\uedccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peeyush Jain, Peiyu He, Peter A McCullough, Peter H Stone, Peter M Pollak, Peter Douglass, Peter Henriksen, Peter OKane, Peter Ong, Philip Jones, Philip Rogal, Philippe G\ue9n\ue9reux, Philippe Menasche, Philippe Rheault, Phoebe Goold, Pierre Gervais, Pierre Michaud, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Piotr Slomka, Piyamitr Sritara, Poay-Huan Loh, Poonam Sonawane, Pouneh Samadi, Pragnesh P Parikh, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Precilia Vasquez, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puja K Mehta, Purvez Grant, Pushpa Naik, Qi Zhong, Qian Zhao, Qiang Zhou, Qianqian Yuan, Qin Yu, Qingxian Li, Qiulan Xie, Qiutang Zeng, R J Vindhya, R James Gerlach, Rachel King, Rada Vu\u10di\u107, Radmila Lyubarova, Radoslaw Pracon, Raewyn Fisher, Rafael Beyar, Rafael Diaz, Rafael Selgas, Raffaele Bugiardini, Raffaele Fanelli, Raisa Kavalakkat, V S Rajalekshmi, Rajat S Barua, Rajeev Menon, Rajesh Gopalan Nair, Rajesh Francis, Rajiv Narang, Rakesh Yadav, Ralph Alan Huston, T Ramakrishnan, Ramesh de Silva, Rami El Mahmoud, Ramiro Carvalho, Ramon de Jes\ufas-P\ue9rez, Ramona Stevens, Ran Leng, Ranjan Kachru, Ranjit Kumar Nath, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Raymond W Little, Raymundo Ocaranza Sanchez, Rebecca J Wimmer, Rebecca Bariciano, Rebecca Otis, Rebekah R Herrmann, Reem Yunis, Reinette Hampson, Renato Abdala Karam, Renee C Hessian, Renee Kaneshiro, Reshma Ravindran, Reto Andreas Gamma, Reyna Bhandari, Reza Arsanjani, Ricardo L Lopes, Ricardo Mendes Oliveira, Ricardo Costa, Richa Bhatt, Richard F Davies, Richard H J Trimlett, Richard Goldweit, Rik Hermanides, Rine Nakanishi, Rinu R Sidh, Risha Patel, Rita Coram, Rizwan A Siddiqui, Rob S Beanlands, Robert J Hamburger, Robert K Riezebos, Robert M Donnino, Robert Bojar, Robert Chilton, Robert Guyton, Robert Henderson, Robert Kornberg, Robert Leber, Robert Mao, Robert Stenberg, Roberta P Santos, Roberto Ren\ue9 Favaloro, Roberto Amati, Rodolfo G S D Lima, Rodrigo J Cerci, Rogerio Tumelero, Rohit Tandon, Roma Tewari, Romalisa Miranda-Peats, Ron Wald, Ronald A Mastouri, Ronald G Morford, Ronald G Schwartz, Ronald P Pedalino, Rongrong Hu, Ronnell A Hansen, Ronny A Cohen, Rory Hachamovitch, Rosa Homem, Rosa Sandonato, Rosane Laimer, Rosann Gans, Roxanne Yost, Roy Mathew, Rub\ue9n Bale\uf3n-Espinosa, Ruben Ramos, Rubine Gevorgyan, Rui Ferreira, Rui Jing, Ruth P\ue9rez-Fern\ue1ndez, S K Dwivedi, S Ramakrishnan, Saadat Khan, Sabahat Bokhari, Sabu Thomas, Sadath Lubna, Sajeeda Parveen Khan, Sajeev Chakanalil Govindan, Saket Girotra, Saleem Kassam, Sallie Canada, Salvador Cruz-Flores, Samaa Mohamed, Samantha Ly, Sameh El Kaffas, Samia Massalha, Sampoornima Setty, Samuel Nwosu, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandra M Rivest, Sandra S Zier, Sandra Ahoud, Sandy Carr, Sanjay Ganapathi, Sanjay Shetty, Sanjeev Sharma, Santa Jimenez, Santhosh Satheesh, Santiago A Garcia, Sara Fernandez, Sara Karlsson, Sara Salkind, Sara Temiyasathit, Sarah Medina Rodriguez, Sarah Beaudry, Sarah Hadjih, Sarah Williams, Sarah Zahrani, Sarju Ralhan, Sasa Hinic, Sasko Kedev, Satinder Singh, Satoshi Yasuda, Satvic Cholenahally Manjunath, Sau Lee, Scott M Kaczkowski, Scott Kinlay, Sean W Hayes, Sebastian Sobczak, Senait Asier, Sergey A Sayganov, Seth I Sokol, Shaheen Pandie, Shaiful Azmi Yahaya, Shamir Mehta, Shao-Ping Nie, Sharad Chandra, Sharder Islam, Sharon Tai, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Sherron C Crook, Shigeyuki Nishimura, Shintaro Nakano, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shobana Ganesan, Shruti Pandey, Shuyang Zhang, Shweta Hande, Siddharth Gadage, Sik-Yin V Tan, Silvia Zottis Poletti, Silvia Riera, Silvia Valbuena, Simon Walsh, Simona Maspoli, Simone Savaris, Si-Ting Feng, So Yang Cho, Solomon Yakubov, Songlin Zhu, Songtao Wang, Sonia Guerrero, Sonika Gupta, Sonja Salinger Martinovic, Sonya Brons, Sorin Brener, Sothinathan Gurunathan, Souheil Saba, Soundarya Nayak, Sowjanya Reddy, Srinivasa Potluri, Sriram Sudarshan, Srun Kuanprasert, Stacie Van Oosterhout, Stamatios Lerakis, Stanley E Cobos, Stefan C Bertog, Stefan M Simovi\u107, Stefan Weikl, Stefano Di Marco, Stefano Provasoli, Stephanie A Tirado, Stephanie C Boer, Stephanie M Lane, Stephanie Ferket, Stephanie Kelly, Stephanie Wasmiller, Stephen H McKellar, Stephen P Hoole, Stephen Fremes, Stephen Preston, Steve Leung, Steven A Fein, Steven J Lindsay, Steven P Sedlis, Steven Giovannone, Steven Michael, Steven Weitz, Stijn van Vugt, Subhash Banerjee, Sudhir Naik, Suellen Hosino, Sukie Desire, Sukit Yamwong, Suku T Thambar, Sulagna Mookherjee, Suman Singh, Sundeep Mishra, Sunil Kumar Verma, Supap Kulthawong, Supatchara Khwakhong, Surendra Naik, Suresh Babu, Surin Woragidpoonpol, Suryaprakash Narayanappa, Susan Derbyshire, Susan Gent, Susan Mathus, Susan Milbrandt, Susan Moore, Susan Regan, Susan Stinson, Susan Webber, Susana Silva, Susanna Stevens, Susanne Gruensfelder, Suthara Aramcharoen, Suvarna Kolhe, Suzana Tavares, Suzanne Arnold, Suzanne Welsh, Svetlana Apostolovic, Swapna Kunhunny, Ta-Chuan Hung, Taissa Zappernick, Tali Sharir, Talita Silva, Tamara Colai\ue1covo Soares, Tapan Umesh Pillay, Tarun K Mittal, Tatiana Trifonova, Tauane Bello Duarte, Tauqir Huk, T\ue9odora Dutoiu, Terrance Chua, Terry Weyand, Thabitha Charles, Theodoros Kofidis, Theresa McCreary, Thierry Lefevre, Thippeekaa Arumairajah, Thitipong Tepsuwan, Thomas J Mulhearn, Thomas M Meyer, Thomas P Rocco, Thomas R Downes, Thomas Crain, Thomas Haldis, Thomas Mathew, Thomas Redick, Thounaojam Indira Devi, Thuraia Nageh, Tia Cauthren, Tiago Silva, Tiffany Little, Tijana Andric, Tina Harding, Titus Lau, Tiziana Formisano, Tiziano Moccetti, Tomasz Ciurus, Tomasz Mazurek, Tomasz Tarchalski, Toshiyuki Nagai, Tri Tran, Tricia Youn, Trish Tucker, Trudie Milner, Tuhina Bose, Tushar Kotecha, Udo Sechtem, Uma S Valeti, Umberto Cucchini, Umesh Badami, Upendra Kaul, V K Bahl, V S Narain, Valentina Casali, Valeria Godoy, Valerie Robesyn, Vamshi P Priya, Vandana Yadav, Vera McKinney, Veronica De Lenges, Veronica Tinnirello, Vicente Miro, Victor Navarro, Victoria Gumerova, Victoria Hernandez, Vidya Seeratan, Vijay Kumar, Vikentiy Y Kozulin, Viktoria Bulkley, Vilmar Veiga Jr, Vincent Setang, C P Vineeth, Virginai Pubull Nu\uf1ez, Virginia Fern\ue1ndez-Figares, Vitor Gomes, Viviana Gabriel, Viviane Dos Santos, Viviane Almeida, Vlad A Iliescu, Vladan Mudrenovic, Vladimir Dzavik, Vojislav L Giga, Walter Enrique Mogrovejo, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Warangkana Mekara, Wassim Nona, Wayne Old, Wayne Pennachi, Weerachai Nawarawong, Wei Chen, Wei Su, Weibing Xing, Wei-Ren Lan, Wenda Crawford, Wendy L Stewart, Wendy Drewes, Wenhua Lin, William B Abernethy, William D Salerno, William F Fearon, William Vergoni, William Weintraub, Winnie C Sia, Wlodzimierz J Musial, Xacobe Flores-R\uedos, Xavier Garcia-Moll Marimon, Xi Su, Xiang Ma, Xiangqiong Gu, Xiao Wang, Xiaomei Li, Xiaowei Yao, Xin Fu, Xin Su, Xin Zeng, Xinchun Yang, Xiuhong Li, Xuehua Fang, Xutong Wang, Yaming Geng, Yan Yan, Yanek P\ue9pin-Dubois, Yanfu Wang, Yang Wang, Yanmeng Tian, Yaping Huang, Yechen Han, Yesenia Zambrano, Yi-Hsuan Yang, Ying Tung Sia, Yining Yang, Yitong Ma, Yolayfi Peralta, Yongjian Wu, Yu Kunwu, Yu Zhao, Yudong Peng, Yueh-Hung Lin, Yulan Zhao, Yumei Dong, Yunhai Zhao, Yutthaphan Wannasopha, Yvonne Taul, Zakir Sahul, Zalina Kudzoeva, Zbigniew Kalarus, Zeljko Z Markovic, Zhen Huang, Zheng Ji, Zhenyu Liu, Zhou Yue, Zhulin Zhang, Zhuxi Li, Zile Singh Meharwal, Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits
- Jones P.G.
- Mark D.B
- Maron D.J.
- Mavromatis K.
- Mavromichalis S.
- Newman J.D.
- O'Brien S.M.
- Reynolds H.R.
- Rosenberg Y.
- Spertus J.A.
- Stone G.W.
- Weintraub W.S.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial was to assess angina-related health status among these patients. METHODS We assessed angina-related symptoms, function, and quality of life with the Seattle Angina Questionnaire (SAQ) at randomization, at months 1.5, 3, and 6, and every 6 months thereafter in participants who had been randomly assigned to an invasive treatment strategy (2295 participants) or a conservative strategy (2322). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate differences between the treatment groups. The primary outcome of this health-status analysis was the SAQ summary score (scores range from 0 to 100, with higher scores indicating better health status). All analyses were performed in the overall population and according to baseline angina frequency. RESULTS At baseline, 35% of patients reported having no angina in the previous month. SAQ summary scores increased in both treatment groups, with increases at 3, 12, and 36 months that were 4.1 points (95% credible interval, 3.2 to 5.0), 4.2 points (95% credible interval, 3.3 to 5.1), and 2.9 points (95% credible interval, 2.2 to 3.7) higher with the invasive strategy than with the conservative strategy. Differences were larger among participants who had more frequent angina at baseline (8.5 vs. 0.1 points at 3 months and 5.3 vs. 1.2 points at 36 months among participants with daily or weekly angina as compared with no angina). CONCLUSIONS In the overall trial population with moderate or severe ischemia, which included 35% of participants without angina at baseline, patients randomly assigned to the invasive strategy had greater improvement in angina-related health status than those assigned to the conservative strategy. The modest mean differences favoring the invasive strategy in the overall group reflected minimal differences among asymptomatic patients and larger differences among patients who had had angina at baseline
Initial invasive or conservative strategy for stable coronary disease
- Author
- Alexander K.P.
- Ali Z.A.
- Bangalore S.
- Berger J.S.
- Berman D.S.
- Bhargava B.
- Bockeria O.
- Boden W.E.
- Broderick S.
- Bruce Ferguson T.
- Chaitman B.R.
- Demkow M.
- Doerr R.
- Elghamaz A.
- Gabriel Steg P.
- Goodman S.G.
- Gosselin G.
- Harrell F.E.
- Harrington R.A.
- Held C.
- Hochman J.S.
- Hueb W.A.
- ISCHEMIA Research Group: Joseph Ricci A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Raba\ue7a, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fern\ue1ndez Mart\uednez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, Andr\ue9 Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andr\ue9s Garc\ueda-Rinc\uf3n, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej \u141abyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Pe\uf1aranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel \uc5kerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezi\u144ska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Bego\uf1a Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard J\ue4ger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Car\uedsi A Polanczyk, Carita Krannila, Carla Vicente, Carl-\uc9ric Gagn\ue9, Carlo Briguori, Carlos Pe\uf1a Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Bj\uf6rklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cort\ue9s, Claudia Escobar, Cl\ue1udia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adri\ue1n Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elih\ufa Dur\ue1n-Cort\ue9s, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnaci\uf3n Alonso-\uc1lvarez, Eric Nicollet, Eric Peterson, Erick Alex\ue1nderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eust\ue1quio Ribeiro Silva, F Marin Ortu\uf1o, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Fl\ue1via Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely \uc1goston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidovi\u107, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Llad\uf3, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, In\ueas Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, Jo\ue3o Reynaldo Abbud, Jo\ue3o V Vitola, Joaqu\uedn V Pe\uf1afiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, Jos\ue9 A Ortega-Ram\uedrez, Jos\ue9 Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, Jos\ue9 J Cuenca-Castillo, Jose L Diez, Jos\ue9 Luis Narro Villanueva, Jos\ue9 Luiz da Vieira, Jos\ue9 M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padr\uf3, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio C\ue9sar Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna \u141uczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna \u141oboz-Grudzie\u144, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kuku\u142a, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura Keinaite, Laura Sarti, Laurel Kolakaluri, Lawrence M Phillips, Lawrence Friedman, Lawrence Phillips, Lazar Velicki, Leah Howell, Leandro C Maranan, Leanne Cox, Ledjalem Daba, Lei Zhang, Lekshmi Dharmarajan, Leo Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Leszek Sokalski, Li Hai Yan, Li Li, Lia Nijmeijer, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilia Schiavi, Lilian Mazza Barbosa, Lillian L Khor, Lina Felix-Stern, Linda L Hall, Linda M Hollenweger, Linda Arcand, Linda Davidson-Ray, Linda Schwarz, Lindsey N Sikora, Lingping Chi, Lino Patricio, Liping Zhang, Lisa Chaytor, Lisa Hatch, Lisa McCloy, Lisa Wong, Liselotte Persson, Lixin Jiang, Liz Low, Ljiljana Pupic, Lo\uefc Bi\ue8re, Lorenzo Monti, Lori Christensen, Lori Pritchard, Loriane Black, Lori-Ann Desimone, Lori-Ann Larmand, Lorraine McGregor, Louise Morby, Louise Thomson, Luc Harvey, Luciana de P\ue1dua Baptista, Lucilla Garcia, Ludivine Eliahou, Ludmila Helmer, Luis F Smidt, Luis Bernanrdes, Luis Guzman, Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Vald\ue9s Ch\ue1varri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena \u141anocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Ma\u142gorzta Celi\u144ska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Val\ue9rio Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C Quinn, Maria A Alfonso, Maria Antonieta Pereira Moraes, Mar\ueda Dolores Mart\uednez-Ru\uedz, Mar\ueda Fernanda Canales, Maria In\ueas Caetano, Maria P Corral, Maria P\ue9rez Garc\ueda, Maria Victoria Actis, Maria Aguirre, Maria Andreasson, Maria Aprile, Maria Colton, Maria Eugenia Martin, Maria Lasala, Maria Lorenzo, Maria Posada, Maria Shier, Maria Thottam, Mariana V Furtado, Mariana Yumi Okada, Marianna D A Dracoulakis, Marianne De Andrade, Mariano Rubio, Marie Essermark, Marielle Scherrer-Crosbie, Marija T Petrovic, Marija Zdravkovic, Marilyn Black, Marina Garcia, Mario J Garcia, Mariola Szulik, Marisa Orgera, Mark A de Belder, Mark Harbinson, Mark Hyun, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Marcinkiewicz-Siemion, Marta Swiderek, Martha Meyer, Martina Ceseri, Martina Tricoli, Marvin Kronenberg, Mary Williams, Mary Ann Champagne, Mary Colleen Rogge, Mary R Soltau, Mary Streif, Massimo Villella, Massoud Leesar, Matei Claudia, Mateusz Solecki, Mat\uedas Nicol\ue1s Mungo, Matthew Wall Jr, Matthew Budoff, Matthew Jezior, Matthew Luckie, Matthias Friedrich, Mauren P Haeffner, Maximilian Tscharre, Max-Paul Winter, Mayana Almeida, Mayil S Krishnam, Mayuri Patel, Meenakshi Mishra, Megan Manocchia, Meghana Kakade, Melanie J Munro, Melissa D Chaplin, Melissa LeFevre, Mervyn Andiapen, Michael A Gibson, Michael B Rubens, Michael C Turner, Michael D Shapiro, Michael W Lee, Michael Berlowitz, Michael Davidson, Michael Mack, Michael McDaniel, Michael Mumma, Michal Wlodarczyk, Michel G Khouri, Michel S Slama, Michele Rawlins, Michelle M Bonner, Michelle M Seib, Michelle Chang, Michelle Crowder, Michelle Dixon, Michelle Mayon, Michelle McEvoy, Michelle Yee, Miguel M Fernandes, Miguel Nobre Menezes, Miguel Souto Bayarri, Miguel Barrero, Mikhail T Torosoff, Milan R Dobric, Milan Dobric, Milica Nikola Dekleva, Milind Avdhoot Gadkari, Millie Gomez, Min Tun Kyaw, Miriam Brooks, Miroslav Stevo Martinovic, Mitchel B Lustre, Mohammad Tariq Vakani, Mohammad El-Hajjar, Mohammed Al-Amoodi, Mohammed Hussain, Mohammed Saleem, Mois\ue9s Blanco-Calvo, Mois\ue9s Jim\ue9nez-Santos, Mona Bhatia, Monica Rosca, Monika Laukyte, Montserrat Gracida Blanca, Montserrat Vila Perales, Mouaz H Al-Mallah, Moys\ue9s de Oliveira Filho, Mpiko Ntsekhe, Muhamed Saric, Mulei Chen, Myriam Brousseau, Myrthes Emy Takiuti, Nada Cemerlic-Adjic, Nadia Asif, Nadia Gakou, Nafisa Hussain, Nana O Katamadze, Nancy L Clapp, Nancy Aedy, Nandita Nataraj, Nanette K Wenger, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Natalie Spitzer, Natasha C Putnam, Naved Aslam, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Nevena Garcevic, Ngaire Meadows, Nhi N Tran, Nicholas Danchin, Nicki Lakeman, Nicola Johnston, Nicolas W Shammas, Nicole Saint Vrestil, Nicole Deming, Nier Zhong, Niket Patel, Nikola N Boskovic, Nikolaos Karogiannis, Nikos Werner, Nina Johnston, Ning Zhang, Ning Zhou, Niree Hindoyan, Nirmal Kumar, Nitika Chadha, Nitish Naik, Nodira Aripova, Noloyiso Mtana, Nona A Eskelson, Noor Syamira Mokhtar, Noppon Taksaudom, Nor Asiah Basri, Nora Marchelletta, Norma Hogg, Nungshi Jungla, Nuno Ferreira, Oksana A Lubyanaya, Olga B Nikolaeva, Olga Ca\uf1avate, Olga Sobrino, Olga Walesiak, Olga Walter, Olga Zdo\u144czyk, Olivia J Lim, Olivia Anaya, Olivia Mancilla, Olivier Dubourg, Olugbenga Bello, Omar Almousalli, Omar Thompson, Oni Olurinde, Or Harel, Osama Raheem, Oscar M\ue9ndiz, 3scar Prada-Delgado, Oz Shapira, P Christian Schulze, Pachara Panpunuan, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Julian, Pamela Ouyang, Pamela Sigel, Pamela Woodard, Panpan Zhou, Paola Emanuela Poggio, Paola Smanio, Paolo Calabro, Paramjit Jeetley, Pascal Goube, Patricia K Nguyen, Patricia Alarie, Patricia Arakelian, Patricia Arsenault, Patricia Blaise, Patricia Brito, Patricia Cowper, Patricia Endsley, Patricia Mieses, Patrick B Alexander, Patrick Donnelly, Patrick Wilmot, Patrycja Lebioda, Paul C Gordon, Paul Der Mesropian, Paul Galiwango, Paul Hauptman, Paul Kennedy, Paula Beardsley, Paula Garc\ueda-Gonz\ue1lez, Paulo Cury Rezende, Paulo Ricardo Caramori, Pavel S Kozlov, Pedro Canas Silva, Pedro Gabriel Melo Barros E Silva, Pedro P\uedccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peeyush Jain, Peiyu He, Peter A McCullough, Peter H Stone, Peter M Pollak, Peter Douglass, Peter Henriksen, Peter OKane, Peter Ong, Philip Jones, Philip Rogal, Philippe G\ue9n\ue9reux, Philippe Menasche, Philippe Rheault, Phoebe Goold, Pierre Gervais, Pierre Michaud, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Piotr Slomka, Piyamitr Sritara, Poay-Huan Loh, Poonam Sonawane, Pouneh Samadi, Pragnesh P Parikh, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Precilia Vasquez, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puja K 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Oliveira, Ricardo Costa, Richa Bhatt, Richard F Davies, Richard H J Trimlett, Richard Goldweit, Rik Hermanides, Rine Nakanishi, Rinu R Sidh, Risha Patel, Rita Coram, Rizwan A Siddiqui, Rob S Beanlands, Robert J Hamburger, Robert K Riezebos, Robert M Donnino, Robert Bojar, Robert Chilton, Robert Guyton, Robert Henderson, Robert Kornberg, Robert Leber, Robert Mao, Robert Stenberg, Roberta P Santos, Roberto Ren\ue9 Favaloro, Roberto Amati, Rodolfo G S D Lima, Rodrigo J Cerci, Rogerio Tumelero, Rohit Tandon, Roma Tewari, Romalisa Miranda-Peats, Ron Wald, Ronald A Mastouri, Ronald G Morford, Ronald G Schwartz, Ronald P Pedalino, Rongrong Hu, Ronnell A Hansen, Ronny A Cohen, Rory Hachamovitch, Rosa Homem, Rosa Sandonato, Rosane Laimer, Rosann Gans, Roxanne Yost, Roy Mathew, Rub\ue9n Bale\uf3n-Espinosa, Ruben Ramos, Rubine Gevorgyan, Rui Ferreira, Rui Jing, Ruth P\ue9rez-Fern\ue1ndez, S K Dwivedi, S Ramakrishnan, Saadat Khan, Sabahat Bokhari, Sabu Thomas, Sadath Lubna, Sajeeda Parveen Khan, Sajeev Chakanalil Govindan, Saket Girotra, Saleem Kassam, Sallie Canada, Salvador Cruz-Flores, Samaa Mohamed, Samantha Ly, Sameh El Kaffas, Samia Massalha, Sampoornima Setty, Samuel Nwosu, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandra M Rivest, Sandra S Zier, Sandra Ahoud, Sandy Carr, Sanjay Ganapathi, Sanjay Shetty, Sanjeev Sharma, Santa Jimenez, Santhosh Satheesh, Santiago A Garcia, Sara Fernandez, Sara Karlsson, Sara Salkind, Sara Temiyasathit, Sarah Medina Rodriguez, Sarah Beaudry, Sarah Hadjih, Sarah Williams, Sarah Zahrani, Sarju Ralhan, Sasa Hinic, Sasko Kedev, Satinder Singh, Satoshi Yasuda, Satvic Cholenahally Manjunath, Sau Lee, Scott M Kaczkowski, Scott Kinlay, Sean W Hayes, Sebastian Sobczak, Senait Asier, Sergey A Sayganov, Seth I Sokol, Shaheen Pandie, Shaiful Azmi Yahaya, Shamir Mehta, Shao-Ping Nie, Sharad Chandra, Sharder Islam, Sharon Tai, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Sherron C Crook, Shigeyuki Nishimura, Shintaro Nakano, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shobana Ganesan, Shruti Pandey, Shuyang Zhang, Shweta Hande, Siddharth Gadage, Sik-Yin V Tan, Silvia Zottis Poletti, Silvia Riera, Silvia Valbuena, Simon Walsh, Simona Maspoli, Simone Savaris, Si-Ting Feng, So Yang Cho, Solomon Yakubov, Songlin Zhu, Songtao Wang, Sonia Guerrero, Sonika Gupta, Sonja Salinger Martinovic, Sonya Brons, Sorin Brener, Sothinathan Gurunathan, Souheil Saba, Soundarya Nayak, Sowjanya Reddy, Srinivasa Potluri, Sriram Sudarshan, Srun Kuanprasert, Stacie Van Oosterhout, Stamatios Lerakis, Stanley E Cobos, Stefan C Bertog, Stefan M Simovi\u107, Stefan Weikl, Stefano Di Marco, Stefano Provasoli, Stephanie A Tirado, Stephanie C Boer, Stephanie M Lane, Stephanie Ferket, Stephanie Kelly, Stephanie Wasmiller, Stephen H McKellar, Stephen P Hoole, Stephen Fremes, Stephen Preston, Steve Leung, Steven A Fein, Steven J Lindsay, Steven P Sedlis, Steven Giovannone, Steven Michael, Steven Weitz, Stijn van Vugt, Subhash Banerjee, Sudhir Naik, Suellen Hosino, Sukie Desire, Sukit Yamwong, Suku T Thambar, Sulagna Mookherjee, Suman Singh, Sundeep Mishra, Sunil Kumar Verma, Supap Kulthawong, Supatchara Khwakhong, Surendra Naik, Suresh Babu, Surin Woragidpoonpol, Suryaprakash Narayanappa, Susan Derbyshire, Susan Gent, Susan Mathus, Susan Milbrandt, Susan Moore, Susan Regan, Susan Stinson, Susan Webber, Susana Silva, Susanna Stevens, Susanne Gruensfelder, Suthara Aramcharoen, Suvarna Kolhe, Suzana Tavares, Suzanne Arnold, Suzanne Welsh, Svetlana Apostolovic, Swapna Kunhunny, Ta-Chuan Hung, Taissa Zappernick, Tali Sharir, Talita Silva, Tamara Colai\ue1covo Soares, Tapan Umesh Pillay, Tarun K Mittal, Tatiana Trifonova, Tauane Bello Duarte, Tauqir Huk, T\ue9odora Dutoiu, Terrance Chua, Terry Weyand, Thabitha Charles, Theodoros Kofidis, Theresa McCreary, Thierry Lefevre, Thippeekaa Arumairajah, Thitipong Tepsuwan, Thomas J Mulhearn, Thomas M Meyer, Thomas P Rocco, Thomas R Downes, Thomas Crain, Thomas Haldis, Thomas Mathew, Thomas 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Warangkana Mekara, Wassim Nona, Wayne Old, Wayne Pennachi, Weerachai Nawarawong, Wei Chen, Wei Su, Weibing Xing, Wei-Ren Lan, Wenda Crawford, Wendy L Stewart, Wendy Drewes, Wenhua Lin, William B Abernethy, William D Salerno, William F Fearon, William Vergoni, William Weintraub, Winnie C Sia, Wlodzimierz J Musial, Xacobe Flores-R\uedos, Xavier Garcia-Moll Marimon, Xi Su, Xiang Ma, Xiangqiong Gu, Xiao Wang, Xiaomei Li, Xiaowei Yao, Xin Fu, Xin Su, Xin Zeng, Xinchun Yang, Xiuhong Li, Xuehua Fang, Xutong Wang, Yaming Geng, Yan Yan, Yanek P\ue9pin-Dubois, Yanfu Wang, Yang Wang, Yanmeng Tian, Yaping Huang, Yechen Han, Yesenia Zambrano, Yi-Hsuan Yang, Ying Tung Sia, Yining Yang, Yitong Ma, Yolayfi Peralta, Yongjian Wu, Yu Kunwu, Yu Zhao, Yudong Peng, Yueh-Hung Lin, Yulan Zhao, Yumei Dong, Yunhai Zhao, Yutthaphan Wannasopha, Yvonne Taul, Zakir Sahul, Zalina Kudzoeva, Zbigniew Kalarus, Zeljko Z Markovic, Zhen Huang, Zheng Ji, Zhenyu Liu, Zhou Yue, Zhulin Zhang, Zhuxi Li, Zile Singh Meharwal, Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits
- Jeffries N.O.
- John Mancini G.B.
- Keltai M.
- Kirby R.
- Kohsaka S.
- Krishnan M.N.
- Kwong R.Y.
- Lopes R.D.
- Lopez-Sendon J.
- Maggioni A.P.
- Mark D.B.
- Maron D.J.
- Mavromatis K.
- Mavromichalis S.
- Miller T.D.
- Min J.K.
- Moorthy N.
- Newman J.D.
- O'Brien S.M.
- Peteiro J.
- Picard M.H.
- Reynolds H.R.
- Rockhold F.W.
- Rosenberg Y
- Ruzyllo W.
- Selvanayagam J.B.
- Senior R.
- Shaw L.J.
- Sidhu M.S.
- Spertus J.A.
- Stone G.W.
- Szwed H.
- White H.D.
- Williams D.O.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, 121.8 percentage points; 95% CI, 124.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used