SDRTV-to-HDRTV Conversion via Spatial-Temporal Feature Fusion

HDR(High Dynamic Range) video can reproduce realistic scenes more realistically, with a wider gamut and broader brightness range. HDR video resources are still scarce, and most videos are still stored in SDR (Standard Dynamic Range) format. Therefore, SDRTV-to-HDRTV Conversion (SDR video to HDR video) can significantly enhance the user's video viewing experience. Since the correlation between adjacent video frames is very high, the method utilizing the information of multiple frames can improve the quality of the converted HDRTV. Therefore, we propose a multi-frame fusion neural network \textbf{DSLNet} for SDRTV to HDRTV conversion. We first propose a dynamic spatial-temporal feature alignment module \textbf{DMFA}, which can align and fuse multi-frame. Then a novel spatial-temporal feature modulation module \textbf{STFM}, STFM extracts spatial-temporal information of adjacent frames for more accurate feature modulation. Finally, we design a quality enhancement module \textbf{LKQE} with large kernels, which can enhance the quality of generated HDR videos. To evaluate the performance of the proposed method, we construct a corresponding multi-frame dataset using HDR video of the HDR10 standard to conduct a comprehensive evaluation of different methods. The experimental results show that our method obtains state-of-the-art performance. The dataset and code will be released.Comment: 8 page

Early warning technique research of surface subsidence for safe mining in underground goaf in Karst Plateau zone

Underground mining in Karst Plateau landform area may cause the loss of support for the upper rock stratum, resulting in rock collapse and large-scale subsidence of the ground surface. Also, the formation of a large-scale goafs may further lead to geo-hazards such as collapse, water gushing, slope instability and so on in the area. To reduce the impact of goaf settlement on local strata stability, this paper established a standardized safe mining detection model for goafs based on the geological safety characteristics of mining goafs. With reference to the statistical analysis of the geological conditions in the mining area, a numerical model with 358 goafs and the proposed mining area was established using FLAC3D numerical software. The surface subsidence and variations of plastic zone in the mining area were comprehensively analyzed. The results indicated that there was a correlation between the stability of the mining area and the geological occurrence conditions of the goafs. By quantitatively taking the values from standardized safety mining detection models, the standardized safety mining detection and warning technique was finally established. The findings can provide technical guidance for safety detection and early warning in the whole process of underground goaf mining in Karst Plateau karst development zone

Recent developments of neuroprotective agents for degenerative retinal disorders

Retinal degeneration is a debilitating ocular complication characterized by the progressive loss of photoreceptors and other retinal neurons, which are caused by a group of retinal diseases affecting various age groups, and increasingly prevalent in the elderly. Age-related macular degeneration, diabetic retinopathy and glaucoma are among the most common complex degenerative retinal disorders, posing significant public health problems worldwide largely due to the aging society and the lack of effective therapeutics. Whilst pathoetiologies vary, if left untreated, loss of retinal neurons can result in an acquired degeneration and ultimately severe visual impairment. Irrespective of underlined etiology, loss of neurons and supporting cells including retinal pigment epithelium, microvascular endothelium, and glia, converges as the common endpoint of retinal degeneration and therefore discovery or repurposing of therapies to protect retinal neurons directly or indirectly are under intensive investigation. This review overviews recent developments of potential neuroprotectants including neuropeptides, exosomes, mitochondrial-derived peptides, complement inhibitors, senolytics, autophagy enhancers and antioxidants either still experimentally or in clinical trials. Effective treatments that possess direct or indirect neuroprotective properties would significantly lift the burden of visual handicap

Towards Robust SDRTV-to-HDRTV via Dual Inverse Degradation Network

Recently, the transformation of standard dynamic range TV (SDRTV) to high dynamic range TV (HDRTV) is in high demand due to the scarcity of HDRTV content. However, the conversion of SDRTV to HDRTV often amplifies the existing coding artifacts in SDRTV which deteriorate the visual quality of the output. In this study, we propose a dual inverse degradation SDRTV-to-HDRTV network DIDNet to address the issue of coding artifact restoration in converted HDRTV, which has not been previously studied. Specifically, we propose a temporal-spatial feature alignment module and dual modulation convolution to remove coding artifacts and enhance color restoration ability. Furthermore, a wavelet attention module is proposed to improve SDRTV features in the frequency domain. An auxiliary loss is introduced to decouple the learning process for effectively restoring from dual degradation. The proposed method outperforms the current state-of-the-art method in terms of quantitative results, visual quality, and inference times, thus enhancing the performance of the SDRTV-to-HDRTV method in real-world scenarios.Comment: 10 page

Treatment of diabetic retinopathy through neuropeptide Y-mediated enhancement of neurovascular microenvironment

Diabetic retinopathy (DR) is one of the most severe clinical manifestations of diabetes mellitus and a major cause of blindness. DR is principally a microvascular disease, although the pathogenesis also involves metabolic reactive intermediates which induce neuronal and glial activation resulting in disruption of the neurovascular unit and regulation of the microvasculature. However, the impact of neural/glial activation in DR remains controversial, notwithstanding our understanding as to when neural/glial activation occurs in the course of disease. The objective of this study was to determine a potential protective role of neuropeptide Y (NPY) using an established model of DR permissive to N‐methyl‐D‐aspartate (NMDA)‐induced excitotoxic apoptosis of retinal ganglion cells (RGC) and vascular endothelial growth factor (VEGF)‐induced vascular leakage. In vitro evaluation using primary retinal endothelial cells demonstrates that NPY promotes vascular integrity, demonstrated by maintained tight junction protein expression and reduced permeability in response to VEGF treatment. Furthermore, ex vivo assessment of retinal tissue explants shows that NPY can protect RGC from excitotoxic‐induced apoptosis. In vivo clinical imaging and ex vivo tissue analysis in the diabetic model permitted assessment of NPY treatment in relation to neural and endothelial changes. The neuroprotective effects of NPY were confirmed by attenuating NMDA‐induced retinal neural apoptosis and able to maintain inner retinal vascular integrity. These findings could have important clinical implications and offer novel therapeutic approaches for the treatment in the early stages of DR

Aurintricarboxylic Acid is a Canonical Disruptor of the TAZ-TEAD Transcriptional Complex

Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we report that the pharmacologically active small molecule aurintricarboxylic acid (ATA) acts as a disruptor of the TAZ-TEAD complex. ATA was identified in a high-throughput screen using a TAZ-TEAD AlphaLISA assay that was tailored to identify disruptors of this transcriptional complex. We further used fluorescence polarization assays both to confirm disruption of the TAZ-TEAD complex and to demonstrate that ATA binds to interface 3. We have previously shown that cell-based models that express the oncogenic TAZ-CAMTA1 (TC) fusion protein display enhanced TEAD transcriptional activity because TC functions as an activated form of TAZ. Utilizing cell-based studies and our TC model system, we performed TC/TEAD reporter, RNA-Seq, and qPCR assays and found that ATA inhibits TC/TEAD transcriptional activity. Further, disruption of TC/TEAD and TAZ/TEAD interaction by ATA abrogated anchorage-independent growth, the phenotype most closely linked to dysregulated TAZ/TEAD activity. Therefore, this study demonstrates that ATA is a novel small molecule that has the ability to disrupt the undruggable TAZ-TEAD interface

Impaired Toll-like receptor 2-mediated Th1 and Th17/22 cytokines secretion in human peripheral blood mononuclear cells from patients with atopic dermatitis

Background: Impaired Toll-like receptor 2 (TLR2) function has been associated with the pathogenesis of atopic dermatitis (AD). However, there are only few studies reporting on the TLR2-induced immunological responses of circulating leucocytes of AD patients. We thus investigated the expression and secretion of Th1, Th2 and Th17/22 cytokines triggered by TLR2 ligands in human peripheral blood mononuclear cells (PBMCs) from AD patients. Expression of TLR2, 1, 6 and high-affinity receptor for IgE (Fc epsilon RI) were further investigated to evaluate the outcome of immune response in AD. Methods: Expression of TLR2, 1, 6 and Fc epsilon RI in PBMCs from AD patients and healthy individuals were measured by qPCR. Subsequent to stimulation with TLR2 ligands PGN and Pam3CSK4, expression and secretion of Th1, Th2 and Th17/22 cytokines were investigated by qPCR and ELISA. Results: The levels of TLR2, 1, 6 mRNA were not altered in both groups of subjects while that of Fc epsilon RI was increased in AD patients. Subsequent to the activation by TLR2 ligands, PBMCs from AD patients significantly released less IFN-gamma, IL-17F and IL-22 than those from healthy controls while no detectable level of release was observed with the other cytokines. In contrast, significantly higher levels of mRNA expression for TNF-alpha, IL5, IL-17A and IL-22 were observed in TLR2 activated PBMCs of AD patients than those of healthy control. Conclusions: PBMCs from AD patients are defective in the secretion of Th1 and Th17/22 cytokines in response to TLR2 ligands. The inconsistent increased expression of the mRNA for the corresponding Th1 cytokines and the Th2 cytokines IL-5 suggested that there may be alterations of downstream signaling events in the cytokine release mechanisms of PBMCs that are associated with the development of AD.National Natural Science Foundation of China [81401299, 81271755]; Natural Science Foundation of Guangdong Province [2014A030313711]; Shenzhen Research Grant [JCYJ20130329110752139, JCYJ20130329110752142]SCI(E)[email protected]; [email protected]

MAKET KRATON PLERED CIRCA : 1675

Maket ini berusaha mengangkat suatu program yang subjeknya cukup menantang yakni, Kraton Plered yang keberadaannya sekarang sudah hancur rata dengan tanah. Pertimbangan kurikuler historis didaktis tetap menjadi acuan seleksi subjek model dan dilakukan secara objektif saintifik, Tentatif Historis Imajinasi Berdasarkan Kesaksian Sejarah Tujuan Penelitian ini adalah sebuah analisis historis pertumbuhan dan perkembangan Kraton Plered serta merupakan visualisasi Kraton Plered beserta lingkungan sekitarnya pada masa Kasultanan Amangkurat Agung (I). Penelitian ini menggunakan metode sejarah yakni, diawali dari penentuan subjek, perumusan problema, survai, pengumpulan sumber, analisa sumber, kesimpulan sementara dan berakhir dengan seminar umum, follow up hasil seminar, disimpulkan dalam bentuk grafis (peta, diagram, Chart, denah, irisan, tampak depan, samping, dan atas) "BLUEPRINT". Berdasarkan blueprint, kerja fisik pembuatan maket dilakukan, yang meliputi langkah memotong, merakit, memasang dan finishing. Hasil penelitian merupakan rekonstruksi sebuah model tiga dimensi berupa maket Kraton Plered beserta kelengkapannya, seperti ilustrasi, fotografi, poster, peta, makalah, bibliografi, dokumen, audio visual, dan sebagainya. Kesemuanya untuk sementara disimpan di Ruang Disply Laboratorium Sejarah, FKIP Unversitas PGRI Yogyakarta, Kampus Unit I lantai I gedung B