X-Ray Eclipse Timing in the LMXB EXO0748-676

Orbital period changes are an important diagnostic for understanding low mass X-ray binary (LMXB) accretion-induced angular momentum exchange and overall system evolution. We present our most recent results for the eclipse timing of the LMXB EXO0748-676. Since its discovery in 1985 it has apparently undergone three distinct orbital period "epochs", each characterized by a different orbital period than the previous epoch. We outline the orbital period behavior for EXO0748-676 over the past 18 years and discuss the implications of this behavior in light of current theoretical ideas for LMXB evolution.Comment: 4 Pages, 3 Figures, Submitted to the X-Ray Timing 2003: Rossi and Beyond conference, November 200

Possible Magnetic Activity in the Low Mass X-ray Binary EXO 0748-676

We report evidence of magnetic activity associated with the secondary star in the EXO 0748-676 low mass X-ray binary system. An analysis of a sequence of five consecutive X-ray eclipses observed during December 2003 with the RXTE satellite brings out a feature occurring during ingress we interpret as the X-ray photoelectric absorption shadow, as seen by an observer at Earth, of a plasma structure suspended above the surface of the secondary star. The light curve feature consists of an initial drop in count rate to near zero (the absorption shadow) with a very short rebound to a significant fraction of the pre-ingress count rate and then a final plunge to totality over a total time scale of ~25 s. The ingress feature persists for at least 5 consecutive orbital periods (a total of ~19 hr), and possibly up to 5 days in our data. Our data also show significant post-egress dipping during this eclipse sequence, unusual for this source, indicating possible secondary star mass ejection during this episode.Comment: Accepted by Astrophysical Journal Letters; 11 Pages including 3 figures and 1 tabl

A Strong X-Ray Burst from the Low Mass X-Ray Binary EXO0748-676

We have observed an unusually strong X-ray burst as a part of our regular eclipse timing observations of the low mass binary system EXO0748-676. The burst peak flux was 5.2x10^-8 ergs cm^-2 s^-1, approximately five times the normal peak X-ray burst flux observed from this source by RXTE. Spectral fits to the data strongly suggest that photospheric radius expansion occurred during the burst. In this Letter we examine the properties of this X-ray burst, which is the first example of a radius expansion burst from EXO0748-676 observed by RXTE. We find no evidence for coherent burst oscillations. Assuming that the peak burst luminosity is the Eddington luminosity for a 1.4 solar mass neutron star we derive a distance to EXO0748-676 of 7.7 kpc for a helium-dominated burst photosphere and 5.9 kpc for a hydrogen-dominated burst photosphere.Comment: 15 pages including 2 figures and 1 table. Accepted for publication in the Astrophysical Journa

Development and validation of 'AutoRIF': Software for the automated analysis of radiation-induced foci

Copyright @ 2012 McVean et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.This article has been made available through the Brunel Open Access Publishing Fund.Background: The quantification of radiation-induced foci (RIF) to investigate the induction and subsequent repair of DNA double strands breaks is now commonplace. Over the last decade systems specific for the automatic quantification of RIF have been developed for this purpose, however to ask more mechanistic questions on the spatio-temporal aspects of RIF, an automated RIF analysis platform that also quantifies RIF size/volume and relative three-dimensional (3D) distribution of RIF within individual nuclei, is required. Results: A java-based image analysis system has been developed (AutoRIF) that quantifies the number, size/volume and relative nuclear locations of RIF within 3D nuclear volumes. Our approach identifies nuclei using the dynamic Otsu threshold and RIF by enhanced Laplacian filtering and maximum entropy thresholding steps and, has an application ‘batch optimisation’ process to ensure reproducible quantification of RIF. AutoRIF was validated by comparing output against manual quantification of the same 2D and 3D image stacks with results showing excellent concordance over a whole range of sample time points (and therefore range of total RIF/nucleus) after low-LET radiation exposure. Conclusions: This high-throughput automated RIF analysis system generates data with greater depth of information and reproducibility than that which can be achieved manually and may contribute toward the standardisation of RIF analysis. In particular, AutoRIF is a powerful tool for studying spatio-temporal relationships of RIF using a range of DNA damage response markers and can be run independently of other software, enabling most personal computers to perform image analysis. Future considerations for AutoRIF will likely include more complex algorithms that enable multiplex analysis for increasing combinations of cellular markers.This article is made available through the Brunel Open Access Publishing Fund

Patterns for renaming and stamping out object-oriented models.

Modern system engineering is supported by a families of modelling languages; each member of a specific family addresses a different aspect of the application domain. Constructing families of modelling languages is facilitated by the use of packages and templates. Packages are containers of modelling elements. Packages may be specialised and merged. Renamings may be applied to packages. Templates are parameteric packages. New packages are constructed by supplying arguments to a template. Packages and templates rely on the following underlying technology: specialisation; merging; renaming and stamping. Specialisation and merging have been described elsewhere; this paper defines mechanisms for renaming and stamping